MovDisordV3, PascalFrancis, Corpus, bibRecord, 002112

Imaging of activated microglia with PET and [11C]PK 11195 in corticobasal degeneration

Identifieur interne : 002112 ( PascalFrancis/Corpus ); précédent : 002111; suivant : 002113

Imaging of activated microglia with PET and [11C]PK 11195 in corticobasal degeneration

Auteurs : K. Henkel ; J. Karitzky ; M. Schmid ; I. Mader ; G. Glatting ; J. W. Unger ; B. Neumaier ; A. C. Ludolph ; S. N. Reske ; G. B. Landwehrmeyer

Source :

Movement disorders [ 0885-3185 ] ; 2004.

RBID : Pascal:04-0455135

Descripteurs français

Pascal (Inist)
- Dégénérescence, Microglie, Positon, Système nerveux pathologie, Tomoscintigraphie.

English descriptors

KwdEn :
- Degeneration, Emission tomography, Microglia, Nervous system diseases, Positron.

Abstract

Positron emission tomography (PET) using [¹¹C]PK 11195, a ligand for peripheral benzodiazepine receptor binding sites, offers the opportunity to image activated microglia in vivo. This tool may therefore be used to display the occurrence of microglial activation in the course of neurodegeneration. A patient with the clinical diagnosis of corticobasal degeneration (CBD) and left-sided symptoms was studied using fluorodeoxyglucose (FDG) and [¹¹C]PK 11195 PET. We found a marked right hemispheric hypometabolism and asymmetric microglial activation in corresponding areas of the basal ganglia and right temporal and parietal cortex. [¹¹C]PK 11195 PET suggests involvement of microglial activation in the pathogenesis of CBD.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 0885-3185`
A03		`1`		`@0 Mov. disord.`
A05				`@2 19`
A06				`@2 7`
A08	`01`	`1`	`ENG`	`@1 Imaging of activated microglia with PET and [¹¹C]PK 11195 in corticobasal degeneration`
A11	`01`	`1`		`@1 HENKEL (K.)`
A11	`02`	`1`		`@1 KARITZKY (J.)`
A11	`03`	`1`		`@1 SCHMID (M.)`
A11	`04`	`1`		`@1 MADER (I.)`
A11	`05`	`1`		`@1 GLATTING (G.)`
A11	`06`	`1`		`@1 UNGER (J. W.)`
A11	`07`	`1`		`@1 NEUMAIER (B.)`
A11	`08`	`1`		`@1 LUDOLPH (A. C.)`
A11	`09`	`1`		`@1 RESKE (S. N.)`
A11	`10`	`1`		`@1 LANDWEHRMEYER (G. B.)`
A14	`01`			`@1 Department of Neurology University of Ulm @2 Ulm @3 DEU @Z 1 aut. @Z 2 aut. @Z 6 aut. @Z 8 aut. @Z 10 aut.`
A14	`02`			`@1 Department of Nuclear Medicine, University of Ulm @2 Ulm @3 DEU @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 5 aut. @Z 7 aut. @Z 9 aut.`
A14	`03`			`@1 Department of Neuroradiology, University of Tübingen @2 Tübingen @3 DEU @Z 4 aut.`
A20				`@1 817-821`
A21				`@1 2004`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 20953 @5 354000113929420110`
A44				`@0 0000 @1 © 2004 INIST-CNRS. All rights reserved.`
A45				`@0 13 ref.`
A47	`01`	`1`		`@0 04-0455135`
A60				`@1 P @3 CC`
A61				`@0 A`
A64	`01`	`1`		`@0 Movement disorders`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 Positron emission tomography (PET) using [¹¹C]PK 11195, a ligand for peripheral benzodiazepine receptor binding sites, offers the opportunity to image activated microglia in vivo. This tool may therefore be used to display the occurrence of microglial activation in the course of neurodegeneration. A patient with the clinical diagnosis of corticobasal degeneration (CBD) and left-sided symptoms was studied using fluorodeoxyglucose (FDG) and [¹¹C]PK 11195 PET. We found a marked right hemispheric hypometabolism and asymmetric microglial activation in corresponding areas of the basal ganglia and right temporal and parietal cortex. [¹¹C]PK 11195 PET suggests involvement of microglial activation in the pathogenesis of CBD.
C02	`01`	`X`		`@0 002B17`
C03	`01`	`X`	`FRE`	`@0 Dégénérescence @5 01`
C03	`01`	`X`	`ENG`	`@0 Degeneration @5 01`
C03	`01`	`X`	`SPA`	`@0 Degeneración @5 01`
C03	`02`	`X`	`FRE`	`@0 Microglie @5 02`
C03	`02`	`X`	`ENG`	`@0 Microglia @5 02`
C03	`02`	`X`	`SPA`	`@0 Microglia @5 02`
C03	`03`	`X`	`FRE`	`@0 Positon @5 03`
C03	`03`	`X`	`ENG`	`@0 Positron @5 03`
C03	`03`	`X`	`SPA`	`@0 Positrón @5 03`
C03	`04`	`X`	`FRE`	`@0 Système nerveux pathologie @5 04`
C03	`04`	`X`	`ENG`	`@0 Nervous system diseases @5 04`
C03	`04`	`X`	`SPA`	`@0 Sistema nervioso patología @5 04`
C03	`05`	`X`	`FRE`	`@0 Tomoscintigraphie @5 05`
C03	`05`	`X`	`ENG`	`@0 Emission tomography @5 05`
C03	`05`	`X`	`SPA`	`@0 Tomocentelleografía @5 05`
C07	`01`	`X`	`FRE`	`@0 Névroglie @5 37`
C07	`01`	`X`	`ENG`	`@0 Neuroglia @5 37`
C07	`01`	`X`	`SPA`	`@0 Neuroglia @5 37`
C07	`02`	`X`	`FRE`	`@0 Exploration radioisotopique @5 38`
C07	`02`	`X`	`ENG`	`@0 Radionuclide study @5 38`
C07	`02`	`X`	`SPA`	`@0 Exploración radioisotópica @5 38`
N21				`@1 257`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 04-0455135 INIST
ET :	Imaging of activated microglia with PET and [¹¹C]PK 11195 in corticobasal degeneration
AU :	HENKEL (K.); KARITZKY (J.); SCHMID (M.); MADER (I.); GLATTING (G.); UNGER (J. W.); NEUMAIER (B.); LUDOLPH (A. C.); RESKE (S. N.); LANDWEHRMEYER (G. B.)
AF :	Department of Neurology University of Ulm/Ulm/Allemagne (1 aut., 2 aut., 6 aut., 8 aut., 10 aut.); Department of Nuclear Medicine, University of Ulm/Ulm/Allemagne (1 aut., 2 aut., 3 aut., 5 aut., 7 aut., 9 aut.); Department of Neuroradiology, University of Tübingen/Tübingen/Allemagne (4 aut.)
DT :	Publication en série; Courte communication, note brève; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2004; Vol. 19; No. 7; Pp. 817-821; Bibl. 13 ref.
LA :	Anglais
EA :	Positron emission tomography (PET) using [¹¹C]PK 11195, a ligand for peripheral benzodiazepine receptor binding sites, offers the opportunity to image activated microglia in vivo. This tool may therefore be used to display the occurrence of microglial activation in the course of neurodegeneration. A patient with the clinical diagnosis of corticobasal degeneration (CBD) and left-sided symptoms was studied using fluorodeoxyglucose (FDG) and [¹¹C]PK 11195 PET. We found a marked right hemispheric hypometabolism and asymmetric microglial activation in corresponding areas of the basal ganglia and right temporal and parietal cortex. [¹¹C]PK 11195 PET suggests involvement of microglial activation in the pathogenesis of CBD.
CC :	002B17
FD :	Dégénérescence; Microglie; Positon; Système nerveux pathologie; Tomoscintigraphie
FG :	Névroglie; Exploration radioisotopique
ED :	Degeneration; Microglia; Positron; Nervous system diseases; Emission tomography
EG :	Neuroglia; Radionuclide study
SD :	Degeneración; Microglia; Positrón; Sistema nervioso patología; Tomocentelleografía
LO :	INIST-20953.354000113929420110
ID :	04-0455135

Links to Exploration step

Pascal:04-0455135

Le document en format XML

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<series><title level="j" type="main">Movement disorders</title>
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<front><div type="abstract" xml:lang="en">Positron emission tomography (PET) using [<sup>11</sup>
C]PK 11195, a ligand for peripheral benzodiazepine receptor binding sites, offers the opportunity to image activated microglia in vivo. This tool may therefore be used to display the occurrence of microglial activation in the course of neurodegeneration. A patient with the clinical diagnosis of corticobasal degeneration (CBD) and left-sided symptoms was studied using fluorodeoxyglucose (FDG) and [<sup>11</sup>
C]PK 11195 PET. We found a marked right hemispheric hypometabolism and asymmetric microglial activation in corresponding areas of the basal ganglia and right temporal and parietal cortex. [<sup>11</sup>
C]PK 11195 PET suggests involvement of microglial activation in the pathogenesis of CBD.</div>
</front>
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<AF>Department of Neurology University of Ulm/Ulm/Allemagne (1 aut., 2 aut., 6 aut., 8 aut., 10 aut.); Department of Nuclear Medicine, University of Ulm/Ulm/Allemagne (1 aut., 2 aut., 3 aut., 5 aut., 7 aut., 9 aut.); Department of Neuroradiology, University of Tübingen/Tübingen/Allemagne (4 aut.)</AF>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Imaging of activated microglia with PET and [11C]PK 11195 in corticobasal degeneration

Imaging of activated microglia with PET and [11C]PK 11195 in corticobasal degeneration

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