Movement Disorders (revue)

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Lack of association between progressive supranuclear palsy and arterial hypertension: A clinicopathological study

Identifieur interne : 000859 ( PascalFrancis/Curation ); précédent : 000858; suivant : 000860

Lack of association between progressive supranuclear palsy and arterial hypertension: A clinicopathological study

Auteurs : Carlo Colosimo [Italie, Royaume-Uni] ; Yasushi Osaki [Royaume-Uni] ; Nicola Vanacore [Italie] ; Andrew J. Lees [Royaume-Uni]

Source :

RBID : Pascal:03-0380304

Descripteurs français

English descriptors

Abstract

It has been reported that up to 80% of patients clinically diagnosed as having progressive supranuclear palsy (PSP) may have arterial hypertension (HT). Because previous studies were performed on patients with presumed diagnosis of PSP, we tried to replicate these studies in a series of pathologically confirmed patients. Seventy-three patients with a neuropathological diagnosis of PSP autopsied at the Queen Square Brain Bank for Neurological Disorders in London were collected between 1989 and 1999. For the purpose of this study, patients were considered hypertensive if a blood pressure above 140/90 mm Hg was found in the clinical records. The prevalence of HT in PSP patients at the first and at the last visit during their neurological disease was compared with that found in a series of 21 normal controls who donated their brain to the same institution. Overall, 29 of 73 (39.7%) of the patients were recorded as having HT at the first visit during the disease course; this ratio increased to 42 of 73 (57.5%) at the last visit before death. When these figures were compared to the 21 normal controls (11 of 21 with HT, 52.4%), we were unable to find an increased prevalence of HT in PSP (odds ratio, 0.60; 95% confidence interval, 0.20-1.76). Therefore, HT does not represent an important clinical feature of this neurodegenerative disorder, although cerebrovascular disease can masquerade clinically as PSP.
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A11 03  1    @1 VANACORE (Nicola)
A11 04  1    @1 LEES (Andrew J.)
A14 01      @1 Dipartimento di Scienze Neurologiche, Università La Sapienza @2 Rome @3 ITA @Z 1 aut. @Z 3 aut.
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C01 01    ENG  @0 It has been reported that up to 80% of patients clinically diagnosed as having progressive supranuclear palsy (PSP) may have arterial hypertension (HT). Because previous studies were performed on patients with presumed diagnosis of PSP, we tried to replicate these studies in a series of pathologically confirmed patients. Seventy-three patients with a neuropathological diagnosis of PSP autopsied at the Queen Square Brain Bank for Neurological Disorders in London were collected between 1989 and 1999. For the purpose of this study, patients were considered hypertensive if a blood pressure above 140/90 mm Hg was found in the clinical records. The prevalence of HT in PSP patients at the first and at the last visit during their neurological disease was compared with that found in a series of 21 normal controls who donated their brain to the same institution. Overall, 29 of 73 (39.7%) of the patients were recorded as having HT at the first visit during the disease course; this ratio increased to 42 of 73 (57.5%) at the last visit before death. When these figures were compared to the 21 normal controls (11 of 21 with HT, 52.4%), we were unable to find an increased prevalence of HT in PSP (odds ratio, 0.60; 95% confidence interval, 0.20-1.76). Therefore, HT does not represent an important clinical feature of this neurodegenerative disorder, although cerebrovascular disease can masquerade clinically as PSP.
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C07 03  X  SPA  @0 Oculomotricidad síndrome @5 46
C07 04  X  FRE  @0 Système nerveux pathologie @5 47
C07 04  X  ENG  @0 Nervous system diseases @5 47
C07 04  X  SPA  @0 Sistema nervioso patología @5 47
C07 05  X  FRE  @0 Système nerveux central pathologie @5 48
C07 05  X  ENG  @0 Central nervous system disease @5 48
C07 05  X  SPA  @0 Sistema nervosio central patología @5 48
C07 06  X  FRE  @0 Tronc cérébral syndrome @5 49
C07 06  X  ENG  @0 Brain stem syndrome @5 49
C07 06  X  SPA  @0 Tallo encefalico sindrome @5 49
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C07 08  X  SPA  @0 Enfermedad degenerativa @5 51
N21       @1 265
N82       @1 PSI

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<div type="abstract" xml:lang="en">It has been reported that up to 80% of patients clinically diagnosed as having progressive supranuclear palsy (PSP) may have arterial hypertension (HT). Because previous studies were performed on patients with presumed diagnosis of PSP, we tried to replicate these studies in a series of pathologically confirmed patients. Seventy-three patients with a neuropathological diagnosis of PSP autopsied at the Queen Square Brain Bank for Neurological Disorders in London were collected between 1989 and 1999. For the purpose of this study, patients were considered hypertensive if a blood pressure above 140/90 mm Hg was found in the clinical records. The prevalence of HT in PSP patients at the first and at the last visit during their neurological disease was compared with that found in a series of 21 normal controls who donated their brain to the same institution. Overall, 29 of 73 (39.7%) of the patients were recorded as having HT at the first visit during the disease course; this ratio increased to 42 of 73 (57.5%) at the last visit before death. When these figures were compared to the 21 normal controls (11 of 21 with HT, 52.4%), we were unable to find an increased prevalence of HT in PSP (odds ratio, 0.60; 95% confidence interval, 0.20-1.76). Therefore, HT does not represent an important clinical feature of this neurodegenerative disorder, although cerebrovascular disease can masquerade clinically as PSP.</div>
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</fC07>
<fC07 i1="03" i2="X" l="SPA">
<s0>Oculomotricidad síndrome</s0>
<s5>46</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE">
<s0>Système nerveux pathologie</s0>
<s5>47</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG">
<s0>Nervous system diseases</s0>
<s5>47</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA">
<s0>Sistema nervioso patología</s0>
<s5>47</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE">
<s0>Système nerveux central pathologie</s0>
<s5>48</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG">
<s0>Central nervous system disease</s0>
<s5>48</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA">
<s0>Sistema nervosio central patología</s0>
<s5>48</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE">
<s0>Tronc cérébral syndrome</s0>
<s5>49</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG">
<s0>Brain stem syndrome</s0>
<s5>49</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA">
<s0>Tallo encefalico sindrome</s0>
<s5>49</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE">
<s0>Encéphale pathologie</s0>
<s5>50</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG">
<s0>Cerebral disorder</s0>
<s5>50</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA">
<s0>Encéfalo patología</s0>
<s5>50</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE">
<s0>Maladie dégénérative</s0>
<s5>51</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG">
<s0>Degenerative disease</s0>
<s5>51</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA">
<s0>Enfermedad degenerativa</s0>
<s5>51</s5>
</fC07>
<fN21>
<s1>265</s1>
</fN21>
<fN82>
<s1>PSI</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

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