Movement Disorders (revue)

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Excessive daytime sleepiness in de novo and treated Parkinson's disease

Identifieur interne : 000691 ( PascalFrancis/Curation ); précédent : 000690; suivant : 000692

Excessive daytime sleepiness in de novo and treated Parkinson's disease

Auteurs : Giovanni Fabbrini [Italie] ; Piero Barbanti [Italie] ; Cinzia Aurilia [Italie] ; Nicola Vanacore [Italie] ; Caterina Pauletti [Italie] ; Giuseppe Meco [Italie]

Source :

RBID : Pascal:02-0584326

Descripteurs français

English descriptors

Abstract

Excessive daytime sleepiness (EDS) in Parkinson's disease (PD) is due to either treatment-related factors or the disease itself. The study of this disturbing phenomenon in de novo parkinsonian patients may contribute to a better understanding of its pathophysiology. We conducted a case control study in which we compared 25 PD patients who had never been treated before with dopaminergic drugs (de novo PD), 50 PD patients being treated with dopaminergic drugs (treated PD), and 25 healthy control subjects, all of whom were matched for age and gender. EDS was measured by means of the Epworth Sleepiness Scale (ESS) and quality of sleep by means of the Pittsburgh Sleep Quality Index (PSQI). ESS and PSQI scores were not statistically different between de novo PD patients and controls, whereas they were significantly higher in treated PD. Differences in ESS score variability were best explained by the treatment effect, whereas there was no clear correlation between PSQI and any of the clinical variables considered.
pA  
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A03   1    @0 Mov. disord.
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A08 01  1  ENG  @1 Excessive daytime sleepiness in de novo and treated Parkinson's disease
A11 01  1    @1 FABBRINI (Giovanni)
A11 02  1    @1 BARBANTI (Piero)
A11 03  1    @1 AURILIA (Cinzia)
A11 04  1    @1 VANACORE (Nicola)
A11 05  1    @1 PAULETTI (Caterina)
A11 06  1    @1 MECO (Giuseppe)
A14 01      @1 Department of Neurological Sciences, University La Sapienza @2 Rome @3 ITA @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut.
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A47 01  1    @0 02-0584326
A60       @1 P
A61       @0 A
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C01 01    ENG  @0 Excessive daytime sleepiness (EDS) in Parkinson's disease (PD) is due to either treatment-related factors or the disease itself. The study of this disturbing phenomenon in de novo parkinsonian patients may contribute to a better understanding of its pathophysiology. We conducted a case control study in which we compared 25 PD patients who had never been treated before with dopaminergic drugs (de novo PD), 50 PD patients being treated with dopaminergic drugs (treated PD), and 25 healthy control subjects, all of whom were matched for age and gender. EDS was measured by means of the Epworth Sleepiness Scale (ESS) and quality of sleep by means of the Pittsburgh Sleep Quality Index (PSQI). ESS and PSQI scores were not statistically different between de novo PD patients and controls, whereas they were significantly higher in treated PD. Differences in ESS score variability were best explained by the treatment effect, whereas there was no clear correlation between PSQI and any of the clinical variables considered.
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C03 02  X  ENG  @0 Day @5 05
C03 02  X  SPA  @0 Día @5 05
C03 03  X  FRE  @0 De novo @5 16
C03 03  X  ENG  @0 De novo @5 16
C03 03  X  SPA  @0 De novo @5 16
C03 04  X  FRE  @0 Physiopathologie @5 17
C03 04  X  ENG  @0 Pathophysiology @5 17
C03 04  X  SPA  @0 Fisiopatología @5 17
C03 05  X  FRE  @0 Homme @5 20
C03 05  X  ENG  @0 Human @5 20
C03 05  X  SPA  @0 Hombre @5 20
C07 01  X  FRE  @0 Trouble sommeil @5 45
C07 01  X  ENG  @0 Sleep disorder @5 45
C07 01  X  SPA  @0 Trastorno sueño @5 45
N21       @1 343
N82       @1 PSI

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Pascal:02-0584326

Le document en format XML

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