MovDisordV3, PascalFrancis, Corpus, bibRecord, 002A15

Impairment of eyeblink classical conditioning in progressive supranuclear palsy

Identifieur interne : 002A15 ( PascalFrancis/Corpus ); précédent : 002A14; suivant : 002A16

Impairment of eyeblink classical conditioning in progressive supranuclear palsy

Auteurs : Martin Sommer ; Jordan Grafman ; Irene Litvan ; Mark Hallett

Source :

Movement disorders [ 0885-3185 ] ; 2001.

RBID : Pascal:01-0335016

Descripteurs français

Pascal (Inist)
- Ophtalmoplégie supranucléaire, Apprentissage implicite, Mémoire verbale, Mémoire explicite, Conditionnement classique, Clignement palpébral, Temps réaction, California Verbal Learning Test, Exploration, Diagnostic.

English descriptors

KwdEn :
- Blinking, California Verbal Learning Test, Classical conditioning, Diagnosis, Explicit memory, Exploration, Implicit learning, Reaction time, Supranuclear ophthalmoplegia, Verbal memory.

Abstract

In a previous study we showed that learning in eyeblink classical conditioning (EBCC) is normal in Parkinson's disease (PD) and that the serial reaction time task (SRTT) is only marginally impaired. Since pathological lesions are more widespread in the atypical parkinsonian disorder of progressive supranuclear palsy (PSP) than in PD, we hypothesized that PSP patients may show more profound deficits in the EBCC and SRTT learning tasks. We therefore investigated EBCC with a delay and two trace paradigms, an SRTT and the California Verbal Learning Test (CVLT) in eight patients with PSP and an age-matched control group. In all EBCC paradigms, we found a significant difference between groups with no significant learning in PSP patients. In the SRTT, implicit learning may have been impaired, but verbal and manual sequence recall were only marginally impaired. Verbal memory was significantly worse in PSP patients than in the control group. Our study shows a dissociated pattern of learning abilities in PSP, where the EBCC as a measure of implicit learning is impaired, the explicit sequence detection in the SRTT is relatively preserved, and the verbal memory impaired. We hypothesize that the PSP patients' deficits in EBCC learning may be due to lesions of deep cerebellar nuclei. There may be a clinical role for EBCC in distinguishing PD and PSP patients.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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Format Inist (serveur)

NO :	PASCAL 01-0335016 INIST
ET :	Impairment of eyeblink classical conditioning in progressive supranuclear palsy
AU :	SOMMER (Martin); GRAFMAN (Jordan); LITVAN (Irene); HALLETT (Mark)
AF :	Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health/Bethesda, Maryland/Etats-Unis (1 aut., 3 aut., 4 aut.); Cognitive Neuroscience Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health/Bethesda, Maryland/Etats-Unis (2 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2001; Vol. 16; No. 2; Pp. 240-251; Bibl. 47 ref.
LA :	Anglais
EA :	In a previous study we showed that learning in eyeblink classical conditioning (EBCC) is normal in Parkinson's disease (PD) and that the serial reaction time task (SRTT) is only marginally impaired. Since pathological lesions are more widespread in the atypical parkinsonian disorder of progressive supranuclear palsy (PSP) than in PD, we hypothesized that PSP patients may show more profound deficits in the EBCC and SRTT learning tasks. We therefore investigated EBCC with a delay and two trace paradigms, an SRTT and the California Verbal Learning Test (CVLT) in eight patients with PSP and an age-matched control group. In all EBCC paradigms, we found a significant difference between groups with no significant learning in PSP patients. In the SRTT, implicit learning may have been impaired, but verbal and manual sequence recall were only marginally impaired. Verbal memory was significantly worse in PSP patients than in the control group. Our study shows a dissociated pattern of learning abilities in PSP, where the EBCC as a measure of implicit learning is impaired, the explicit sequence detection in the SRTT is relatively preserved, and the verbal memory impaired. We hypothesize that the PSP patients' deficits in EBCC learning may be due to lesions of deep cerebellar nuclei. There may be a clinical role for EBCC in distinguishing PD and PSP patients.
CC :	002B17G
FD :	Ophtalmoplégie supranucléaire; Apprentissage implicite; Mémoire verbale; Mémoire explicite; Conditionnement classique; Clignement palpébral; Temps réaction; California Verbal Learning Test; Exploration; Diagnostic
FG :	Oeil pathologie; Oculomotricité syndrome; Système nerveux pathologie; Système nerveux central pathologie; Tronc cérébral syndrome; Encéphale pathologie; Maladie dégénérative; Cognition
ED :	Supranuclear ophthalmoplegia; Implicit learning; Verbal memory; Explicit memory; Classical conditioning; Blinking; Reaction time; California Verbal Learning Test; Exploration; Diagnosis
EG :	Eye disease; Oculomotor syndrome; Nervous system diseases; Central nervous system disease; Brain stem syndrome; Cerebral disorder; Degenerative disease; Cognition
SD :	Oftalmoplejía supranuclear; Aprendizaje implícito; Memoria verbal; Memoria explícita; Condicionamiento clásico; Parpadeo; Tiempo reacción; California Verbal Learning Test; Exploración; Diagnóstico
LO :	INIST-20953.354000096545190100
ID :	01-0335016

Links to Exploration step

Pascal:01-0335016

Le document en format XML

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<front><div type="abstract" xml:lang="en">In a previous study we showed that learning in eyeblink classical conditioning (EBCC) is normal in Parkinson's disease (PD) and that the serial reaction time task (SRTT) is only marginally impaired. Since pathological lesions are more widespread in the atypical parkinsonian disorder of progressive supranuclear palsy (PSP) than in PD, we hypothesized that PSP patients may show more profound deficits in the EBCC and SRTT learning tasks. We therefore investigated EBCC with a delay and two trace paradigms, an SRTT and the California Verbal Learning Test (CVLT) in eight patients with PSP and an age-matched control group. In all EBCC paradigms, we found a significant difference between groups with no significant learning in PSP patients. In the SRTT, implicit learning may have been impaired, but verbal and manual sequence recall were only marginally impaired. Verbal memory was significantly worse in PSP patients than in the control group. Our study shows a dissociated pattern of learning abilities in PSP, where the EBCC as a measure of implicit learning is impaired, the explicit sequence detection in the SRTT is relatively preserved, and the verbal memory impaired. We hypothesize that the PSP patients' deficits in EBCC learning may be due to lesions of deep cerebellar nuclei. There may be a clinical role for EBCC in distinguishing PD and PSP patients.</div>
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<s5>10</s5>
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<s5>11</s5>
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<s5>11</s5>
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<s5>11</s5>
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<s5>13</s5>
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<fC03 i1="08" i2="X" l="FRE"><s0>California Verbal Learning Test</s0>
<s2>NP</s2>
<s5>14</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>California Verbal Learning Test</s0>
<s2>NP</s2>
<s5>14</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>California Verbal Learning Test</s0>
<s2>NP</s2>
<s5>14</s5>
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<s5>17</s5>
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<fC03 i1="09" i2="X" l="ENG"><s0>Exploration</s0>
<s5>17</s5>
</fC03>
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<s5>18</s5>
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<s5>18</s5>
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<s5>18</s5>
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<s5>37</s5>
</fC07>
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<s5>37</s5>
</fC07>
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<s5>37</s5>
</fC07>
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<s5>38</s5>
</fC07>
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<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Oculomotricidad síndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>39</s5>
</fC07>
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<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Tronc cérébral syndrome</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Brain stem syndrome</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Tallo encefalico sindrome</s0>
<s5>41</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>42</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>43</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>43</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>43</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Cognition</s0>
<s5>53</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Cognition</s0>
<s5>53</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Cognición</s0>
<s5>53</s5>
</fC07>
<fN21><s1>232</s1>
</fN21>
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<server><NO>PASCAL 01-0335016 INIST</NO>
<ET>Impairment of eyeblink classical conditioning in progressive supranuclear palsy</ET>
<AU>SOMMER (Martin); GRAFMAN (Jordan); LITVAN (Irene); HALLETT (Mark)</AU>
<AF>Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health/Bethesda, Maryland/Etats-Unis (1 aut., 3 aut., 4 aut.); Cognitive Neuroscience Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health/Bethesda, Maryland/Etats-Unis (2 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2001; Vol. 16; No. 2; Pp. 240-251; Bibl. 47 ref.</SO>
<LA>Anglais</LA>
<EA>In a previous study we showed that learning in eyeblink classical conditioning (EBCC) is normal in Parkinson's disease (PD) and that the serial reaction time task (SRTT) is only marginally impaired. Since pathological lesions are more widespread in the atypical parkinsonian disorder of progressive supranuclear palsy (PSP) than in PD, we hypothesized that PSP patients may show more profound deficits in the EBCC and SRTT learning tasks. We therefore investigated EBCC with a delay and two trace paradigms, an SRTT and the California Verbal Learning Test (CVLT) in eight patients with PSP and an age-matched control group. In all EBCC paradigms, we found a significant difference between groups with no significant learning in PSP patients. In the SRTT, implicit learning may have been impaired, but verbal and manual sequence recall were only marginally impaired. Verbal memory was significantly worse in PSP patients than in the control group. Our study shows a dissociated pattern of learning abilities in PSP, where the EBCC as a measure of implicit learning is impaired, the explicit sequence detection in the SRTT is relatively preserved, and the verbal memory impaired. We hypothesize that the PSP patients' deficits in EBCC learning may be due to lesions of deep cerebellar nuclei. There may be a clinical role for EBCC in distinguishing PD and PSP patients.</EA>
<CC>002B17G</CC>
<FD>Ophtalmoplégie supranucléaire; Apprentissage implicite; Mémoire verbale; Mémoire explicite; Conditionnement classique; Clignement palpébral; Temps réaction; California Verbal Learning Test; Exploration; Diagnostic</FD>
<FG>Oeil pathologie; Oculomotricité syndrome; Système nerveux pathologie; Système nerveux central pathologie; Tronc cérébral syndrome; Encéphale pathologie; Maladie dégénérative; Cognition</FG>
<ED>Supranuclear ophthalmoplegia; Implicit learning; Verbal memory; Explicit memory; Classical conditioning; Blinking; Reaction time; California Verbal Learning Test; Exploration; Diagnosis</ED>
<EG>Eye disease; Oculomotor syndrome; Nervous system diseases; Central nervous system disease; Brain stem syndrome; Cerebral disorder; Degenerative disease; Cognition</EG>
<SD>Oftalmoplejía supranuclear; Aprendizaje implícito; Memoria verbal; Memoria explícita; Condicionamiento clásico; Parpadeo; Tiempo reacción; California Verbal Learning Test; Exploración; Diagnóstico</SD>
<LO>INIST-20953.354000096545190100</LO>
<ID>01-0335016</ID>
</server>
</inist>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Impairment of eyeblink classical conditioning in progressive supranuclear palsy

Impairment of eyeblink classical conditioning in progressive supranuclear palsy

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