MovDisordV3, PascalFrancis, Corpus, bibRecord, 001A15

Diffusion tensor imaging in presymptomatic and early huntington's disease : Selective white matter pathology and its relationship to clinical measures

Identifieur interne : 001A15 ( PascalFrancis/Corpus ); précédent : 001A14; suivant : 001A16

Diffusion tensor imaging in presymptomatic and early huntington's disease : Selective white matter pathology and its relationship to clinical measures

Auteurs : H. Diana Rosas ; David S. Tuch ; Nathanael D. Hevelone ; Alexandra K. Zaleta ; Mark Vangel ; Steven M. Hersch ; David H. Salat

Source :

Movement disorders [ 0885-3185 ] ; 2006.

RBID : Pascal:06-0518081

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Chorée Huntington, Tenseur de diffusion, Substance blanche, Anatomopathologie, Imagerie de diffusion.

English descriptors

KwdEn :
- Anatomic pathology, Diffusion imaging, Diffusion tensor, Huntington disease, Nervous system diseases, White matter.

Abstract

Atrophy of cortical and subcortical gray matter is apparent in Huntington's disease (HD) before symptoms manifest. We hypothesized that the white matter (WM) connecting cortical and subcortical regions must also be affected early and that select clinical symptoms were related to systems degeneration. We used diffusion tensor magnetic resonance imaging (DTI) to examine the regional nature of WM abnormalities in early HD, including the preclinical period, and to determine whether regional changes correlated with clinical features. We studied individuals in early stages (HD), presymptomatic individuals known to carry the genetic mutation that causes HD (Pre-HD), and matched healthy controls. DTI indices of tissue integrity were obtained from several regions of interest, including the corpus callosum (CC), internal capsule (IC), and basal ganglia, were compared across groups by t tests, and were correlated to cognitive and clinical measures. WM alterations were found throughout the CC, in the anterior and posterior limbs of the IC, and in frontal subcortical WM in HD subjects, supporting the selective involvement of the pyramidal tracts in HD; a similar distribution of changes was seen in Pre-HD subjects, supporting presymptomatic alterations. There was a significant relationship between select DTI measures and cognitive performance. Alterations in diffusion indices were also seen in the striatum that were independent of atrophy. Our findings support that WM alterations occur very early in HD. The distribution of the changes suggests that these changes contribute to the disruption of pyramidal and extrapyramidal circuits and also support a role of compromised cortical circuitry in early cognitive and subtle motor impairment during the preclinical stages of HD.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A08	`01`	`1`	`ENG`	`@1 Diffusion tensor imaging in presymptomatic and early huntington's disease : Selective white matter pathology and its relationship to clinical measures`
A11	`01`	`1`		`@1 ROSAS (H. Diana)`
A11	`02`	`1`		`@1 TUCH (David S.)`
A11	`03`	`1`		`@1 HEVELONE (Nathanael D.)`
A11	`04`	`1`		`@1 ZALETA (Alexandra K.)`
A11	`05`	`1`		`@1 VANGEL (Mark)`
A11	`06`	`1`		`@1 HERSCH (Steven M.)`
A11	`07`	`1`		`@1 SALAT (David H.)`
A14	`01`			`@1 Department of Neurology, Massachusetts General Hospital and Harvard Medical School @2 Boston, Massachusetts @3 USA @Z 1 aut. @Z 6 aut.`
A14	`02`			`@1 Center for Neuroimaging of Aging and Neurodegenerative Diseases, Massachusetts General Hospital and Harvard Medical School @2 Boston, Massachusetts @3 USA @Z 1 aut. @Z 3 aut. @Z 4 aut. @Z 7 aut.`
A14	`03`			`@1 Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School @2 Charlestown, Massachusetts @3 USA @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 7 aut.`
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A44				`@0 0000 @1 © 2006 INIST-CNRS. All rights reserved.`
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C01	`01`		`ENG`	@0 Atrophy of cortical and subcortical gray matter is apparent in Huntington's disease (HD) before symptoms manifest. We hypothesized that the white matter (WM) connecting cortical and subcortical regions must also be affected early and that select clinical symptoms were related to systems degeneration. We used diffusion tensor magnetic resonance imaging (DTI) to examine the regional nature of WM abnormalities in early HD, including the preclinical period, and to determine whether regional changes correlated with clinical features. We studied individuals in early stages (HD), presymptomatic individuals known to carry the genetic mutation that causes HD (Pre-HD), and matched healthy controls. DTI indices of tissue integrity were obtained from several regions of interest, including the corpus callosum (CC), internal capsule (IC), and basal ganglia, were compared across groups by t tests, and were correlated to cognitive and clinical measures. WM alterations were found throughout the CC, in the anterior and posterior limbs of the IC, and in frontal subcortical WM in HD subjects, supporting the selective involvement of the pyramidal tracts in HD; a similar distribution of changes was seen in Pre-HD subjects, supporting presymptomatic alterations. There was a significant relationship between select DTI measures and cognitive performance. Alterations in diffusion indices were also seen in the striatum that were independent of atrophy. Our findings support that WM alterations occur very early in HD. The distribution of the changes suggests that these changes contribute to the disruption of pyramidal and extrapyramidal circuits and also support a role of compromised cortical circuitry in early cognitive and subtle motor impairment during the preclinical stages of HD.
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C03	`05`	`X`	`ENG`	`@0 Anatomic pathology @5 11`
C03	`05`	`X`	`SPA`	`@0 Anatomía patológica @5 11`
C03	`06`	`X`	`FRE`	`@0 Imagerie de diffusion @4 CD @5 96`
C03	`06`	`X`	`ENG`	`@0 Diffusion imaging @4 CD @5 96`
C07	`01`	`X`	`FRE`	`@0 Encéphale pathologie @5 37`
C07	`01`	`X`	`ENG`	`@0 Cerebral disorder @5 37`
C07	`01`	`X`	`SPA`	`@0 Encéfalo patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Extrapyramidal syndrome @5 38`
C07	`02`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 38`
C07	`02`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 38`
C07	`03`	`X`	`FRE`	`@0 Maladie dégénérative @5 39`
C07	`03`	`X`	`ENG`	`@0 Degenerative disease @5 39`
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C07	`04`	`X`	`FRE`	`@0 Maladie héréditaire @5 40`
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N44	`01`			`@1 OTO`
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Format Inist (serveur)

NO :	PASCAL 06-0518081 INIST
ET :	Diffusion tensor imaging in presymptomatic and early huntington's disease : Selective white matter pathology and its relationship to clinical measures
AU :	ROSAS (H. Diana); TUCH (David S.); HEVELONE (Nathanael D.); ZALETA (Alexandra K.); VANGEL (Mark); HERSCH (Steven M.); SALAT (David H.)
AF :	Department of Neurology, Massachusetts General Hospital and Harvard Medical School/Boston, Massachusetts/Etats-Unis (1 aut., 6 aut.); Center for Neuroimaging of Aging and Neurodegenerative Diseases, Massachusetts General Hospital and Harvard Medical School/Boston, Massachusetts/Etats-Unis (1 aut., 3 aut., 4 aut., 7 aut.); Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School/Charlestown, Massachusetts/Etats-Unis (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 7 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2006; Vol. 21; No. 9; Pp. 1317-1325; Bibl. 42 ref.
LA :	Anglais
EA :	Atrophy of cortical and subcortical gray matter is apparent in Huntington's disease (HD) before symptoms manifest. We hypothesized that the white matter (WM) connecting cortical and subcortical regions must also be affected early and that select clinical symptoms were related to systems degeneration. We used diffusion tensor magnetic resonance imaging (DTI) to examine the regional nature of WM abnormalities in early HD, including the preclinical period, and to determine whether regional changes correlated with clinical features. We studied individuals in early stages (HD), presymptomatic individuals known to carry the genetic mutation that causes HD (Pre-HD), and matched healthy controls. DTI indices of tissue integrity were obtained from several regions of interest, including the corpus callosum (CC), internal capsule (IC), and basal ganglia, were compared across groups by t tests, and were correlated to cognitive and clinical measures. WM alterations were found throughout the CC, in the anterior and posterior limbs of the IC, and in frontal subcortical WM in HD subjects, supporting the selective involvement of the pyramidal tracts in HD; a similar distribution of changes was seen in Pre-HD subjects, supporting presymptomatic alterations. There was a significant relationship between select DTI measures and cognitive performance. Alterations in diffusion indices were also seen in the striatum that were independent of atrophy. Our findings support that WM alterations occur very early in HD. The distribution of the changes suggests that these changes contribute to the disruption of pyramidal and extrapyramidal circuits and also support a role of compromised cortical circuitry in early cognitive and subtle motor impairment during the preclinical stages of HD.
CC :	002B17; 002B17G; 002B24A06
FD :	Système nerveux pathologie; Chorée Huntington; Tenseur de diffusion; Substance blanche; Anatomopathologie; Imagerie de diffusion
FG :	Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Maladie héréditaire; Système nerveux central pathologie
ED :	Nervous system diseases; Huntington disease; Diffusion tensor; White matter; Anatomic pathology; Diffusion imaging
EG :	Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Genetic disease; Central nervous system disease
SD :	Sistema nervioso patología; Corea Huntington; Tensor de difusión; Substancia blanca; Anatomía patológica
LO :	INIST-20953.354000158780860030
ID :	06-0518081

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Pascal:06-0518081

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<author><name sortKey="Vangel, Mark" sort="Vangel, Mark" uniqKey="Vangel M" first="Mark" last="Vangel">Mark Vangel</name>
<affiliation><inist:fA14 i1="03"><s1>Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School</s1>
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<author><name sortKey="Hersch, Steven M" sort="Hersch, Steven M" uniqKey="Hersch S" first="Steven M." last="Hersch">Steven M. Hersch</name>
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<s2>Boston, Massachusetts</s2>
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<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2006">2006</date>
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<seriesStmt><title level="j" type="main">Movement disorders</title>
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<term>Diffusion imaging</term>
<term>Diffusion tensor</term>
<term>Huntington disease</term>
<term>Nervous system diseases</term>
<term>White matter</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
<term>Chorée Huntington</term>
<term>Tenseur de diffusion</term>
<term>Substance blanche</term>
<term>Anatomopathologie</term>
<term>Imagerie de diffusion</term>
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<front><div type="abstract" xml:lang="en">Atrophy of cortical and subcortical gray matter is apparent in Huntington's disease (HD) before symptoms manifest. We hypothesized that the white matter (WM) connecting cortical and subcortical regions must also be affected early and that select clinical symptoms were related to systems degeneration. We used diffusion tensor magnetic resonance imaging (DTI) to examine the regional nature of WM abnormalities in early HD, including the preclinical period, and to determine whether regional changes correlated with clinical features. We studied individuals in early stages (HD), presymptomatic individuals known to carry the genetic mutation that causes HD (Pre-HD), and matched healthy controls. DTI indices of tissue integrity were obtained from several regions of interest, including the corpus callosum (CC), internal capsule (IC), and basal ganglia, were compared across groups by t tests, and were correlated to cognitive and clinical measures. WM alterations were found throughout the CC, in the anterior and posterior limbs of the IC, and in frontal subcortical WM in HD subjects, supporting the selective involvement of the pyramidal tracts in HD; a similar distribution of changes was seen in Pre-HD subjects, supporting presymptomatic alterations. There was a significant relationship between select DTI measures and cognitive performance. Alterations in diffusion indices were also seen in the striatum that were independent of atrophy. Our findings support that WM alterations occur very early in HD. The distribution of the changes suggests that these changes contribute to the disruption of pyramidal and extrapyramidal circuits and also support a role of compromised cortical circuitry in early cognitive and subtle motor impairment during the preclinical stages of HD.</div>
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<fA11 i1="07" i2="1"><s1>SALAT (David H.)</s1>
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<fA14 i1="01"><s1>Department of Neurology, Massachusetts General Hospital and Harvard Medical School</s1>
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<fC01 i1="01" l="ENG"><s0>Atrophy of cortical and subcortical gray matter is apparent in Huntington's disease (HD) before symptoms manifest. We hypothesized that the white matter (WM) connecting cortical and subcortical regions must also be affected early and that select clinical symptoms were related to systems degeneration. We used diffusion tensor magnetic resonance imaging (DTI) to examine the regional nature of WM abnormalities in early HD, including the preclinical period, and to determine whether regional changes correlated with clinical features. We studied individuals in early stages (HD), presymptomatic individuals known to carry the genetic mutation that causes HD (Pre-HD), and matched healthy controls. DTI indices of tissue integrity were obtained from several regions of interest, including the corpus callosum (CC), internal capsule (IC), and basal ganglia, were compared across groups by t tests, and were correlated to cognitive and clinical measures. WM alterations were found throughout the CC, in the anterior and posterior limbs of the IC, and in frontal subcortical WM in HD subjects, supporting the selective involvement of the pyramidal tracts in HD; a similar distribution of changes was seen in Pre-HD subjects, supporting presymptomatic alterations. There was a significant relationship between select DTI measures and cognitive performance. Alterations in diffusion indices were also seen in the striatum that were independent of atrophy. Our findings support that WM alterations occur very early in HD. The distribution of the changes suggests that these changes contribute to the disruption of pyramidal and extrapyramidal circuits and also support a role of compromised cortical circuitry in early cognitive and subtle motor impairment during the preclinical stages of HD.</s0>
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<ET>Diffusion tensor imaging in presymptomatic and early huntington's disease : Selective white matter pathology and its relationship to clinical measures</ET>
<AU>ROSAS (H. Diana); TUCH (David S.); HEVELONE (Nathanael D.); ZALETA (Alexandra K.); VANGEL (Mark); HERSCH (Steven M.); SALAT (David H.)</AU>
<AF>Department of Neurology, Massachusetts General Hospital and Harvard Medical School/Boston, Massachusetts/Etats-Unis (1 aut., 6 aut.); Center for Neuroimaging of Aging and Neurodegenerative Diseases, Massachusetts General Hospital and Harvard Medical School/Boston, Massachusetts/Etats-Unis (1 aut., 3 aut., 4 aut., 7 aut.); Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School/Charlestown, Massachusetts/Etats-Unis (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 7 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
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<EA>Atrophy of cortical and subcortical gray matter is apparent in Huntington's disease (HD) before symptoms manifest. We hypothesized that the white matter (WM) connecting cortical and subcortical regions must also be affected early and that select clinical symptoms were related to systems degeneration. We used diffusion tensor magnetic resonance imaging (DTI) to examine the regional nature of WM abnormalities in early HD, including the preclinical period, and to determine whether regional changes correlated with clinical features. We studied individuals in early stages (HD), presymptomatic individuals known to carry the genetic mutation that causes HD (Pre-HD), and matched healthy controls. DTI indices of tissue integrity were obtained from several regions of interest, including the corpus callosum (CC), internal capsule (IC), and basal ganglia, were compared across groups by t tests, and were correlated to cognitive and clinical measures. WM alterations were found throughout the CC, in the anterior and posterior limbs of the IC, and in frontal subcortical WM in HD subjects, supporting the selective involvement of the pyramidal tracts in HD; a similar distribution of changes was seen in Pre-HD subjects, supporting presymptomatic alterations. There was a significant relationship between select DTI measures and cognitive performance. Alterations in diffusion indices were also seen in the striatum that were independent of atrophy. Our findings support that WM alterations occur very early in HD. The distribution of the changes suggests that these changes contribute to the disruption of pyramidal and extrapyramidal circuits and also support a role of compromised cortical circuitry in early cognitive and subtle motor impairment during the preclinical stages of HD.</EA>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Diffusion tensor imaging in presymptomatic and early huntington's disease : Selective white matter pathology and its relationship to clinical measures

Diffusion tensor imaging in presymptomatic and early huntington's disease : Selective white matter pathology and its relationship to clinical measures

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