MovDisordV3, PascalFrancis, Corpus, bibRecord, 001A14

Striatal dopa and glucose metabolism in PD patients with freezing of gait

Identifieur interne : 001A14 ( PascalFrancis/Corpus ); précédent : 001A13; suivant : 001A15

Striatal dopa and glucose metabolism in PD patients with freezing of gait

Auteurs : Anna L. Bartels ; Bauke M. De Jong ; Nir Giladi ; Joanna D. Schaafsma ; R. Paul Maguire ; Lammy Veenma ; Jan Pruim ; Yacov Balash ; Moussa B. H. Youdim ; Klaus L. Leenders

Source :

Movement disorders [ 0885-3185 ] ; 2006.

RBID : Pascal:06-0518082

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Parkinson maladie, Dopa, Glucose, Métabolisme, Homme, Congélation, Tomoscintigraphie, Positon, Tomographie émission positon.

English descriptors

KwdEn :
- Dopa, Emission tomography, Freezing, Glucose, Human, Metabolism, Nervous system diseases, Parkinson disease, Positron, Positron emission tomography.

Abstract

In Parkinson's disease (PD), freezing suggests sudden and transient blocks of motor behavior during initiating or continuous repetitive movements. Its underlying pathophysiology remains unclear. The objective of this study is to compare striatal dopamine metabolism and cerebral glucose metabolism between PD patients with and without freezing of gait (FOG). A total of 10 PD patients with FOG at off and 7 PD patients without FOG underwent brain positron emission tomography with ¹⁸[F]-6-fluoro-levodopa (FDOPA) and ¹⁸[F]-tluordesoxy-glucose (FDG). Striatum decarboxylase activity was expressed by metabolic influx constants of the striatum related to the occipital lobe (Kocc). FDG uptake in caudate and putamen was normalized to global FDG uptake. Region of interest (ROI) analysis of striatal regions was used, as well as voxel-based analysis by statistical parametric mapping (SPM). ROI analysis did not reveal differences in striatal FDOPA and FDG uptake between the groups. SPM showed lower putaminal FDOPA uptake (P = 0.05 uncorrected) with increased FDG uptake (P = 0.01 uncorrected) in freezing PD, whereas caudate uptake of the two tracers was reduced. Freezing-related cortical FDG decrease was found in (right) parietal regions. In conclusion, in freezing PD, caudate uptake of FDG and FDOPA was reduced, whereas putamen FDOPA decrease was associated with FDG increase. Right hemisphere circuitry seemed to be more affected in freezing patients.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A08	`01`	`1`	`ENG`	`@1 Striatal dopa and glucose metabolism in PD patients with freezing of gait`
A11	`01`	`1`		`@1 BARTELS (Anna L.)`
A11	`02`	`1`		`@1 DE JONG (Bauke M.)`
A11	`03`	`1`		`@1 GILADI (Nir)`
A11	`04`	`1`		`@1 SCHAAFSMA (Joanna D.)`
A11	`05`	`1`		`@1 MAGUIRE (R. Paul)`
A11	`06`	`1`		`@1 VEENMA (Lammy)`
A11	`07`	`1`		`@1 PRUIM (Jan)`
A11	`08`	`1`		`@1 BALASH (Yacov)`
A11	`09`	`1`		`@1 YOUDIM (Moussa B. H.)`
A11	`10`	`1`		`@1 LEENDERS (Klaus L.)`
A14	`01`			`@1 Neurology Department of the University Medical Center Groningen @3 NLD @Z 1 aut. @Z 2 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut. @Z 10 aut.`
A14	`02`			`@1 Neurology Department of the Tel Aviv Sourasky Medical Center, Sackler School of Medicine @2 Tel Aviv @3 ISR @Z 3 aut. @Z 8 aut.`
A14	`03`			`@1 PET Centre of the University Medical Center Groningen @3 NLD @Z 7 aut.`
A14	`04`			`@1 Eve Topf and National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases, Technion-Faculty of Medicine @2 Haifa @3 ISR @Z 9 aut.`
A20				`@1 1326-1332`
A21				`@1 2006`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 20953 @5 354000158780860040`
A44				`@0 0000 @1 © 2006 INIST-CNRS. All rights reserved.`
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A47	`01`	`1`		`@0 06-0518082`
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A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 In Parkinson's disease (PD), freezing suggests sudden and transient blocks of motor behavior during initiating or continuous repetitive movements. Its underlying pathophysiology remains unclear. The objective of this study is to compare striatal dopamine metabolism and cerebral glucose metabolism between PD patients with and without freezing of gait (FOG). A total of 10 PD patients with FOG at off and 7 PD patients without FOG underwent brain positron emission tomography with ¹⁸[F]-6-fluoro-levodopa (FDOPA) and ¹⁸[F]-tluordesoxy-glucose (FDG). Striatum decarboxylase activity was expressed by metabolic influx constants of the striatum related to the occipital lobe (Kocc). FDG uptake in caudate and putamen was normalized to global FDG uptake. Region of interest (ROI) analysis of striatal regions was used, as well as voxel-based analysis by statistical parametric mapping (SPM). ROI analysis did not reveal differences in striatal FDOPA and FDG uptake between the groups. SPM showed lower putaminal FDOPA uptake (P = 0.05 uncorrected) with increased FDG uptake (P = 0.01 uncorrected) in freezing PD, whereas caudate uptake of the two tracers was reduced. Freezing-related cortical FDG decrease was found in (right) parietal regions. In conclusion, in freezing PD, caudate uptake of FDG and FDOPA was reduced, whereas putamen FDOPA decrease was associated with FDG increase. Right hemisphere circuitry seemed to be more affected in freezing patients.
C02	`01`	`X`		`@0 002B17`
C02	`02`	`X`		`@0 002B17F`
C02	`03`	`X`		`@0 002B16B`
C03	`01`	`X`	`FRE`	`@0 Système nerveux pathologie @5 01`
C03	`01`	`X`	`ENG`	`@0 Nervous system diseases @5 01`
C03	`01`	`X`	`SPA`	`@0 Sistema nervioso patología @5 01`
C03	`02`	`X`	`FRE`	`@0 Parkinson maladie @5 02`
C03	`02`	`X`	`ENG`	`@0 Parkinson disease @5 02`
C03	`02`	`X`	`SPA`	`@0 Parkinson enfermedad @5 02`
C03	`03`	`X`	`FRE`	`@0 Dopa @2 NK @2 FR @5 09`
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C03	`03`	`X`	`SPA`	`@0 Dopa @2 NK @2 FR @5 09`
C03	`04`	`X`	`FRE`	`@0 Glucose @2 NK @5 10`
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C03	`04`	`X`	`SPA`	`@0 Glucosa @2 NK @5 10`
C03	`05`	`X`	`FRE`	`@0 Métabolisme @5 11`
C03	`05`	`X`	`ENG`	`@0 Metabolism @5 11`
C03	`05`	`X`	`SPA`	`@0 Metabolismo @5 11`
C03	`06`	`X`	`FRE`	`@0 Homme @5 12`
C03	`06`	`X`	`ENG`	`@0 Human @5 12`
C03	`06`	`X`	`SPA`	`@0 Hombre @5 12`
C03	`07`	`X`	`FRE`	`@0 Congélation @5 13`
C03	`07`	`X`	`ENG`	`@0 Freezing @5 13`
C03	`07`	`X`	`SPA`	`@0 Congelación @5 13`
C03	`08`	`X`	`FRE`	`@0 Tomoscintigraphie @5 14`
C03	`08`	`X`	`ENG`	`@0 Emission tomography @5 14`
C03	`08`	`X`	`SPA`	`@0 Tomocentelleografía @5 14`
C03	`09`	`X`	`FRE`	`@0 Positon @5 15`
C03	`09`	`X`	`ENG`	`@0 Positron @5 15`
C03	`09`	`X`	`SPA`	`@0 Positrón @5 15`
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C03	`10`	`X`	`ENG`	`@0 Positron emission tomography @5 16`
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C07	`01`	`X`	`FRE`	`@0 Encéphale pathologie @5 37`
C07	`01`	`X`	`ENG`	`@0 Cerebral disorder @5 37`
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C07	`02`	`X`	`FRE`	`@0 Extrapyramidal syndrome @5 38`
C07	`02`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 38`
C07	`02`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 38`
C07	`03`	`X`	`FRE`	`@0 Maladie dégénérative @5 39`
C07	`03`	`X`	`ENG`	`@0 Degenerative disease @5 39`
C07	`03`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 39`
C07	`04`	`X`	`FRE`	`@0 Système nerveux central pathologie @5 40`
C07	`04`	`X`	`ENG`	`@0 Central nervous system disease @5 40`
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N21				`@1 338`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 06-0518082 INIST
ET :	Striatal dopa and glucose metabolism in PD patients with freezing of gait
AU :	BARTELS (Anna L.); DE JONG (Bauke M.); GILADI (Nir); SCHAAFSMA (Joanna D.); MAGUIRE (R. Paul); VEENMA (Lammy); PRUIM (Jan); BALASH (Yacov); YOUDIM (Moussa B. H.); LEENDERS (Klaus L.)
AF :	Neurology Department of the University Medical Center Groningen/Pays-Bas (1 aut., 2 aut., 4 aut., 5 aut., 6 aut., 10 aut.); Neurology Department of the Tel Aviv Sourasky Medical Center, Sackler School of Medicine/Tel Aviv/Israël (3 aut., 8 aut.); PET Centre of the University Medical Center Groningen/Pays-Bas (7 aut.); Eve Topf and National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases, Technion-Faculty of Medicine/Haifa/Israël (9 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2006; Vol. 21; No. 9; Pp. 1326-1332; Bibl. 39 ref.
LA :	Anglais
EA :	In Parkinson's disease (PD), freezing suggests sudden and transient blocks of motor behavior during initiating or continuous repetitive movements. Its underlying pathophysiology remains unclear. The objective of this study is to compare striatal dopamine metabolism and cerebral glucose metabolism between PD patients with and without freezing of gait (FOG). A total of 10 PD patients with FOG at off and 7 PD patients without FOG underwent brain positron emission tomography with ¹⁸[F]-6-fluoro-levodopa (FDOPA) and ¹⁸[F]-tluordesoxy-glucose (FDG). Striatum decarboxylase activity was expressed by metabolic influx constants of the striatum related to the occipital lobe (Kocc). FDG uptake in caudate and putamen was normalized to global FDG uptake. Region of interest (ROI) analysis of striatal regions was used, as well as voxel-based analysis by statistical parametric mapping (SPM). ROI analysis did not reveal differences in striatal FDOPA and FDG uptake between the groups. SPM showed lower putaminal FDOPA uptake (P = 0.05 uncorrected) with increased FDG uptake (P = 0.01 uncorrected) in freezing PD, whereas caudate uptake of the two tracers was reduced. Freezing-related cortical FDG decrease was found in (right) parietal regions. In conclusion, in freezing PD, caudate uptake of FDG and FDOPA was reduced, whereas putamen FDOPA decrease was associated with FDG increase. Right hemisphere circuitry seemed to be more affected in freezing patients.
CC :	002B17; 002B17F; 002B16B
FD :	Système nerveux pathologie; Parkinson maladie; Dopa; Glucose; Métabolisme; Homme; Congélation; Tomoscintigraphie; Positon; Tomographie émission positon
FG :	Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie
ED :	Nervous system diseases; Parkinson disease; Dopa; Glucose; Metabolism; Human; Freezing; Emission tomography; Positron; Positron emission tomography
EG :	Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD :	Sistema nervioso patología; Parkinson enfermedad; Dopa; Glucosa; Metabolismo; Hombre; Congelación; Tomocentelleografía; Positrón; Tomografía emisión positrones
LO :	INIST-20953.354000158780860040
ID :	06-0518082

Links to Exploration step

Pascal:06-0518082

Le document en format XML

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<author><name sortKey="Youdim, Moussa B H" sort="Youdim, Moussa B H" uniqKey="Youdim M" first="Moussa B. H." last="Youdim">Moussa B. H. Youdim</name>
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<author><name sortKey="Veenma, Lammy" sort="Veenma, Lammy" uniqKey="Veenma L" first="Lammy" last="Veenma">Lammy Veenma</name>
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<author><name sortKey="Pruim, Jan" sort="Pruim, Jan" uniqKey="Pruim J" first="Jan" last="Pruim">Jan Pruim</name>
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<author><name sortKey="Balash, Yacov" sort="Balash, Yacov" uniqKey="Balash Y" first="Yacov" last="Balash">Yacov Balash</name>
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<author><name sortKey="Youdim, Moussa B H" sort="Youdim, Moussa B H" uniqKey="Youdim M" first="Moussa B. H." last="Youdim">Moussa B. H. Youdim</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dopa</term>
<term>Emission tomography</term>
<term>Freezing</term>
<term>Glucose</term>
<term>Human</term>
<term>Metabolism</term>
<term>Nervous system diseases</term>
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<term>Positron</term>
<term>Positron emission tomography</term>
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<term>Parkinson maladie</term>
<term>Dopa</term>
<term>Glucose</term>
<term>Métabolisme</term>
<term>Homme</term>
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<front><div type="abstract" xml:lang="en">In Parkinson's disease (PD), freezing suggests sudden and transient blocks of motor behavior during initiating or continuous repetitive movements. Its underlying pathophysiology remains unclear. The objective of this study is to compare striatal dopamine metabolism and cerebral glucose metabolism between PD patients with and without freezing of gait (FOG). A total of 10 PD patients with FOG at off and 7 PD patients without FOG underwent brain positron emission tomography with <sup>18</sup>
[F]-6-fluoro-levodopa (FDOPA) and <sup>18</sup>
[F]-tluordesoxy-glucose (FDG). Striatum decarboxylase activity was expressed by metabolic influx constants of the striatum related to the occipital lobe (Kocc). FDG uptake in caudate and putamen was normalized to global FDG uptake. Region of interest (ROI) analysis of striatal regions was used, as well as voxel-based analysis by statistical parametric mapping (SPM). ROI analysis did not reveal differences in striatal FDOPA and FDG uptake between the groups. SPM showed lower putaminal FDOPA uptake (P = 0.05 uncorrected) with increased FDG uptake (P = 0.01 uncorrected) in freezing PD, whereas caudate uptake of the two tracers was reduced. Freezing-related cortical FDG decrease was found in (right) parietal regions. In conclusion, in freezing PD, caudate uptake of FDG and FDOPA was reduced, whereas putamen FDOPA decrease was associated with FDG increase. Right hemisphere circuitry seemed to be more affected in freezing patients.</div>
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[F]-6-fluoro-levodopa (FDOPA) and <sup>18</sup>
[F]-tluordesoxy-glucose (FDG). Striatum decarboxylase activity was expressed by metabolic influx constants of the striatum related to the occipital lobe (Kocc). FDG uptake in caudate and putamen was normalized to global FDG uptake. Region of interest (ROI) analysis of striatal regions was used, as well as voxel-based analysis by statistical parametric mapping (SPM). ROI analysis did not reveal differences in striatal FDOPA and FDG uptake between the groups. SPM showed lower putaminal FDOPA uptake (P = 0.05 uncorrected) with increased FDG uptake (P = 0.01 uncorrected) in freezing PD, whereas caudate uptake of the two tracers was reduced. Freezing-related cortical FDG decrease was found in (right) parietal regions. In conclusion, in freezing PD, caudate uptake of FDG and FDOPA was reduced, whereas putamen FDOPA decrease was associated with FDG increase. Right hemisphere circuitry seemed to be more affected in freezing patients.</s0>
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<ET>Striatal dopa and glucose metabolism in PD patients with freezing of gait</ET>
<AU>BARTELS (Anna L.); DE JONG (Bauke M.); GILADI (Nir); SCHAAFSMA (Joanna D.); MAGUIRE (R. Paul); VEENMA (Lammy); PRUIM (Jan); BALASH (Yacov); YOUDIM (Moussa B. H.); LEENDERS (Klaus L.)</AU>
<AF>Neurology Department of the University Medical Center Groningen/Pays-Bas (1 aut., 2 aut., 4 aut., 5 aut., 6 aut., 10 aut.); Neurology Department of the Tel Aviv Sourasky Medical Center, Sackler School of Medicine/Tel Aviv/Israël (3 aut., 8 aut.); PET Centre of the University Medical Center Groningen/Pays-Bas (7 aut.); Eve Topf and National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases, Technion-Faculty of Medicine/Haifa/Israël (9 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2006; Vol. 21; No. 9; Pp. 1326-1332; Bibl. 39 ref.</SO>
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<EA>In Parkinson's disease (PD), freezing suggests sudden and transient blocks of motor behavior during initiating or continuous repetitive movements. Its underlying pathophysiology remains unclear. The objective of this study is to compare striatal dopamine metabolism and cerebral glucose metabolism between PD patients with and without freezing of gait (FOG). A total of 10 PD patients with FOG at off and 7 PD patients without FOG underwent brain positron emission tomography with <sup>18</sup>
[F]-6-fluoro-levodopa (FDOPA) and <sup>18</sup>
[F]-tluordesoxy-glucose (FDG). Striatum decarboxylase activity was expressed by metabolic influx constants of the striatum related to the occipital lobe (Kocc). FDG uptake in caudate and putamen was normalized to global FDG uptake. Region of interest (ROI) analysis of striatal regions was used, as well as voxel-based analysis by statistical parametric mapping (SPM). ROI analysis did not reveal differences in striatal FDOPA and FDG uptake between the groups. SPM showed lower putaminal FDOPA uptake (P = 0.05 uncorrected) with increased FDG uptake (P = 0.01 uncorrected) in freezing PD, whereas caudate uptake of the two tracers was reduced. Freezing-related cortical FDG decrease was found in (right) parietal regions. In conclusion, in freezing PD, caudate uptake of FDG and FDOPA was reduced, whereas putamen FDOPA decrease was associated with FDG increase. Right hemisphere circuitry seemed to be more affected in freezing patients.</EA>
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<FG>Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie</FG>
<ED>Nervous system diseases; Parkinson disease; Dopa; Glucose; Metabolism; Human; Freezing; Emission tomography; Positron; Positron emission tomography</ED>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Striatal dopa and glucose metabolism in PD patients with freezing of gait

Striatal dopa and glucose metabolism in PD patients with freezing of gait

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