MovDisordV3, PascalFrancis, Corpus, bibRecord, 001606

GAD antibody positive paraneoplastic stiff person syndrome in a patient with renal cell carcinoma

Identifieur interne : 001606 ( PascalFrancis/Corpus ); précédent : 001605; suivant : 001607

GAD antibody positive paraneoplastic stiff person syndrome in a patient with renal cell carcinoma

Auteurs : John C. Mchugh ; Brian Murray ; Radhakrishnan Renganathan ; Sean Connolly ; Tim Lynch

Source :

Movement disorders [ 0885-3185 ] ; 2007.

RBID : Pascal:07-0391090

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Paranéoplasique syndrome, Homme raide syndrome, Hypernéphrome, Carcinome.

English descriptors

KwdEn :
- Carcinoma, Grawitz tumor, Nervous system diseases, Paraneoplastic syndrome, Stiff man syndrome.

Abstract

Stiff person syndrome (SPS) is an unusual cause of muscle rigidity and spasms. It is believed to have an autoimmune pathogenesis and is associated with autoantibodies to glutamic acid decarboxylase (GAD). Paraneoplastic SPS (PSPS) has been described mainly in relation to breast cancer and is associated with antibodies to amphiphysin. Few reports of PSPS document the finding of GAD autoantibodies. We present the first reported case of anti-GAD positive PSPS in a 53-year-old male with occult renal carcinoma. Clinical benefit was marked following nephrectomy and intravenous immunoglobulin treatment. Renal carcinoma should be considered in patients with SPS.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A03		`1`		`@0 Mov. disord.`
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A06				`@2 9`
A08	`01`	`1`	`ENG`	`@1 GAD antibody positive paraneoplastic stiff person syndrome in a patient with renal cell carcinoma`
A11	`01`	`1`		`@1 MCHUGH (John C.)`
A11	`02`	`1`		`@1 MURRAY (Brian)`
A11	`03`	`1`		`@1 RENGANATHAN (Radhakrishnan)`
A11	`04`	`1`		`@1 CONNOLLY (Sean)`
A11	`05`	`1`		`@1 LYNCH (Tim)`
A14	`01`			`@1 Department of Neurology, Mater Misericordiae University Hospital @2 Dublin @3 IRL @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 5 aut.`
A14	`02`			`@1 Department of Clinical Neurophysiology, St Vincent's University Hospital, Elm Park @2 Dublin @3 IRL @Z 4 aut.`
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A43	`01`			`@1 INIST @2 20953 @5 354000146732490230`
A44				`@0 0000 @1 © 2007 INIST-CNRS. All rights reserved.`
A45				`@0 15 ref.`
A47	`01`	`1`		`@0 07-0391090`
A60				`@1 P @3 CC`
A61				`@0 A`
A64	`01`	`1`		`@0 Movement disorders`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 Stiff person syndrome (SPS) is an unusual cause of muscle rigidity and spasms. It is believed to have an autoimmune pathogenesis and is associated with autoantibodies to glutamic acid decarboxylase (GAD). Paraneoplastic SPS (PSPS) has been described mainly in relation to breast cancer and is associated with antibodies to amphiphysin. Few reports of PSPS document the finding of GAD autoantibodies. We present the first reported case of anti-GAD positive PSPS in a 53-year-old male with occult renal carcinoma. Clinical benefit was marked following nephrectomy and intravenous immunoglobulin treatment. Renal carcinoma should be considered in patients with SPS.
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C03	`01`	`X`	`SPA`	`@0 Sistema nervioso patología @5 01`
C03	`02`	`X`	`FRE`	`@0 Paranéoplasique syndrome @5 02`
C03	`02`	`X`	`ENG`	`@0 Paraneoplastic syndrome @5 02`
C03	`02`	`X`	`SPA`	`@0 Paraneoplásico síndrome @5 02`
C03	`03`	`X`	`FRE`	`@0 Homme raide syndrome @5 03`
C03	`03`	`X`	`ENG`	`@0 Stiff man syndrome @5 03`
C03	`03`	`X`	`SPA`	`@0 Hombre rígido síndrome @5 03`
C03	`04`	`X`	`FRE`	`@0 Hypernéphrome @5 04`
C03	`04`	`X`	`ENG`	`@0 Grawitz tumor @5 04`
C03	`04`	`X`	`SPA`	`@0 Hipernefroma @5 04`
C03	`05`	`X`	`FRE`	`@0 Carcinome @5 78`
C03	`05`	`X`	`ENG`	`@0 Carcinoma @5 78`
C03	`05`	`X`	`SPA`	`@0 Carcinoma @5 78`
C07	`01`	`X`	`FRE`	`@0 Muscle strié pathologie @5 37`
C07	`01`	`X`	`ENG`	`@0 Striated muscle disease @5 37`
C07	`01`	`X`	`SPA`	`@0 Músculo estriado patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Appareil urinaire pathologie @5 38`
C07	`02`	`X`	`ENG`	`@0 Urinary system disease @5 38`
C07	`02`	`X`	`SPA`	`@0 Aparato urinario patología @5 38`
C07	`03`	`X`	`FRE`	`@0 Rein pathologie @5 39`
C07	`03`	`X`	`ENG`	`@0 Kidney disease @5 39`
C07	`03`	`X`	`SPA`	`@0 Riñón patología @5 39`
C07	`04`	`X`	`FRE`	`@0 Tumeur maligne @5 40`
C07	`04`	`X`	`ENG`	`@0 Malignant tumor @5 40`
C07	`04`	`X`	`SPA`	`@0 Tumor maligno @5 40`
N21				`@1 253`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 07-0391090 INIST
ET :	GAD antibody positive paraneoplastic stiff person syndrome in a patient with renal cell carcinoma
AU :	MCHUGH (John C.); MURRAY (Brian); RENGANATHAN (Radhakrishnan); CONNOLLY (Sean); LYNCH (Tim)
AF :	Department of Neurology, Mater Misericordiae University Hospital/Dublin/Irlande (1 aut., 2 aut., 3 aut., 5 aut.); Department of Clinical Neurophysiology, St Vincent's University Hospital, Elm Park/Dublin/Irlande (4 aut.)
DT :	Publication en série; Courte communication, note brève; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 9; Pp. 1343-1346; Bibl. 15 ref.
LA :	Anglais
EA :	Stiff person syndrome (SPS) is an unusual cause of muscle rigidity and spasms. It is believed to have an autoimmune pathogenesis and is associated with autoantibodies to glutamic acid decarboxylase (GAD). Paraneoplastic SPS (PSPS) has been described mainly in relation to breast cancer and is associated with antibodies to amphiphysin. Few reports of PSPS document the finding of GAD autoantibodies. We present the first reported case of anti-GAD positive PSPS in a 53-year-old male with occult renal carcinoma. Clinical benefit was marked following nephrectomy and intravenous immunoglobulin treatment. Renal carcinoma should be considered in patients with SPS.
CC :	002B17; 002B17F; 002A25L
FD :	Système nerveux pathologie; Paranéoplasique syndrome; Homme raide syndrome; Hypernéphrome; Carcinome
FG :	Muscle strié pathologie; Appareil urinaire pathologie; Rein pathologie; Tumeur maligne
ED :	Nervous system diseases; Paraneoplastic syndrome; Stiff man syndrome; Grawitz tumor; Carcinoma
EG :	Striated muscle disease; Urinary system disease; Kidney disease; Malignant tumor
SD :	Sistema nervioso patología; Paraneoplásico síndrome; Hombre rígido síndrome; Hipernefroma; Carcinoma
LO :	INIST-20953.354000146732490230
ID :	07-0391090

Links to Exploration step

Pascal:07-0391090

Le document en format XML

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<front><div type="abstract" xml:lang="en">Stiff person syndrome (SPS) is an unusual cause of muscle rigidity and spasms. It is believed to have an autoimmune pathogenesis and is associated with autoantibodies to glutamic acid decarboxylase (GAD). Paraneoplastic SPS (PSPS) has been described mainly in relation to breast cancer and is associated with antibodies to amphiphysin. Few reports of PSPS document the finding of GAD autoantibodies. We present the first reported case of anti-GAD positive PSPS in a 53-year-old male with occult renal carcinoma. Clinical benefit was marked following nephrectomy and intravenous immunoglobulin treatment. Renal carcinoma should be considered in patients with SPS.</div>
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<ET>GAD antibody positive paraneoplastic stiff person syndrome in a patient with renal cell carcinoma</ET>
<AU>MCHUGH (John C.); MURRAY (Brian); RENGANATHAN (Radhakrishnan); CONNOLLY (Sean); LYNCH (Tim)</AU>
<AF>Department of Neurology, Mater Misericordiae University Hospital/Dublin/Irlande (1 aut., 2 aut., 3 aut., 5 aut.); Department of Clinical Neurophysiology, St Vincent's University Hospital, Elm Park/Dublin/Irlande (4 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 9; Pp. 1343-1346; Bibl. 15 ref.</SO>
<LA>Anglais</LA>
<EA>Stiff person syndrome (SPS) is an unusual cause of muscle rigidity and spasms. It is believed to have an autoimmune pathogenesis and is associated with autoantibodies to glutamic acid decarboxylase (GAD). Paraneoplastic SPS (PSPS) has been described mainly in relation to breast cancer and is associated with antibodies to amphiphysin. Few reports of PSPS document the finding of GAD autoantibodies. We present the first reported case of anti-GAD positive PSPS in a 53-year-old male with occult renal carcinoma. Clinical benefit was marked following nephrectomy and intravenous immunoglobulin treatment. Renal carcinoma should be considered in patients with SPS.</EA>
<CC>002B17; 002B17F; 002A25L</CC>
<FD>Système nerveux pathologie; Paranéoplasique syndrome; Homme raide syndrome; Hypernéphrome; Carcinome</FD>
<FG>Muscle strié pathologie; Appareil urinaire pathologie; Rein pathologie; Tumeur maligne</FG>
<ED>Nervous system diseases; Paraneoplastic syndrome; Stiff man syndrome; Grawitz tumor; Carcinoma</ED>
<EG>Striated muscle disease; Urinary system disease; Kidney disease; Malignant tumor</EG>
<SD>Sistema nervioso patología; Paraneoplásico síndrome; Hombre rígido síndrome; Hipernefroma; Carcinoma</SD>
<LO>INIST-20953.354000146732490230</LO>
<ID>07-0391090</ID>
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	Movement Disorders (revue)
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Movement Disorders (revue)

GAD antibody positive paraneoplastic stiff person syndrome in a patient with renal cell carcinoma

GAD antibody positive paraneoplastic stiff person syndrome in a patient with renal cell carcinoma

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