MovDisordV3, PascalFrancis, Corpus, bibRecord, 001592

Short-term cortical plasticity in patients with dystonia : A study with repetitive transcranial magnetic stimulation

Identifieur interne : 001592 ( PascalFrancis/Corpus ); précédent : 001591; suivant : 001593

Short-term cortical plasticity in patients with dystonia : A study with repetitive transcranial magnetic stimulation

Auteurs : Francesca Gilio ; Antonio Suppa ; Matteo Bologna ; Cinzia Lorenzano ; Giovanni Fabbrini ; Alfredo Berardelli

Source :

Movement disorders [ 0885-3185 ] ; 2007.

RBID : Pascal:07-0393264

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Dystonie, Court terme, Plasticité, Homme, Stimulus répétitif, Potentiel évoqué moteur, Stimulation magnétique transcrânienne.

English descriptors

KwdEn :
- Dystonia, Human, Motor evoked potential, Nervous system diseases, Plasticity, Repetitive stimulus, Short term, Transcranial magnetic stimulation.

Abstract

Repetitive transcranial magnetic stimulation (rTMS) delivered at 5 Hz frequency and suprathreshold (RMT) intensity produces a progressive facilitation of motor-evoked potential (MEP) amplitude that outlasts the end of stimulation. This phenomenon is related to a short-term enhancement of cortical excitatory interneurones. In this study, we investigated whether 5 Hz-rTMS elicits similar MEP facilitation during stimulation and similar facilitatory after-effects in patients with upper limb dystonia and healthy subjects. Trains of 5, 10, and 20 stimuli were delivered at 120% RMT over the primary motor cortex with the subjects at rest. rTMS-trains were followed by single test stimuli delivered at various interstimulus intervals (0.5-10 s) at 120% RMT using a conditioning-test paradigm. Single conditioning stimuli were also delivered. The effects of suprathreshold 1 Hz-rTMS were also tested. The MEP amplitude during the course of the trains and of the test stimuli was measured. In control experiments, we investigated the role of the afferent inputs elicited by muscle twitches after ulnar nerve stimulation on the MEP amplitude. In patients and healthy subjects, MEP amplitude increased significantly during the course of 5 Hz-trains. In both groups the MEP facilitation outlasted the end of 5 Hz-rTMS, however the facilitatory after-effects were more pronounced and lasted longer in patients than in healthy subjects. MEP amplitudes during and after 1 Hz-rTMS remained unchanged. Ulnar nerve stimulation did not change the test MEP amplitude. We conclude that in patients with upper limb dystonia there is an abnormal recovery from MEP facilitation after suprathreshold 5 Hz-rTMS suggesting an abnormal pattern of short-term cortical plasticity.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 0885-3185`
A03		`1`		`@0 Mov. disord.`
A05				`@2 22`
A06				`@2 10`
A08	`01`	`1`	`ENG`	`@1 Short-term cortical plasticity in patients with dystonia : A study with repetitive transcranial magnetic stimulation`
A11	`01`	`1`		`@1 GILIO (Francesca)`
A11	`02`	`1`		`@1 SUPPA (Antonio)`
A11	`03`	`1`		`@1 BOLOGNA (Matteo)`
A11	`04`	`1`		`@1 LORENZANO (Cinzia)`
A11	`05`	`1`		`@1 FABBRINI (Giovanni)`
A11	`06`	`1`		`@1 BERARDELLI (Alfredo)`
A14	`01`			`@1 Department of Neurological Sciences and Neuromed Institute (IRCCS), University of Rome "La Sapienza" @2 Rome @3 ITA @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut.`
A20				`@1 1436-1443`
A21				`@1 2007`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 20953 @5 354000161473330100`
A44				`@0 0000 @1 © 2007 INIST-CNRS. All rights reserved.`
A45				`@0 33 ref.`
A47	`01`	`1`		`@0 07-0393264`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Movement disorders`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 Repetitive transcranial magnetic stimulation (rTMS) delivered at 5 Hz frequency and suprathreshold (RMT) intensity produces a progressive facilitation of motor-evoked potential (MEP) amplitude that outlasts the end of stimulation. This phenomenon is related to a short-term enhancement of cortical excitatory interneurones. In this study, we investigated whether 5 Hz-rTMS elicits similar MEP facilitation during stimulation and similar facilitatory after-effects in patients with upper limb dystonia and healthy subjects. Trains of 5, 10, and 20 stimuli were delivered at 120% RMT over the primary motor cortex with the subjects at rest. rTMS-trains were followed by single test stimuli delivered at various interstimulus intervals (0.5-10 s) at 120% RMT using a conditioning-test paradigm. Single conditioning stimuli were also delivered. The effects of suprathreshold 1 Hz-rTMS were also tested. The MEP amplitude during the course of the trains and of the test stimuli was measured. In control experiments, we investigated the role of the afferent inputs elicited by muscle twitches after ulnar nerve stimulation on the MEP amplitude. In patients and healthy subjects, MEP amplitude increased significantly during the course of 5 Hz-trains. In both groups the MEP facilitation outlasted the end of 5 Hz-rTMS, however the facilitatory after-effects were more pronounced and lasted longer in patients than in healthy subjects. MEP amplitudes during and after 1 Hz-rTMS remained unchanged. Ulnar nerve stimulation did not change the test MEP amplitude. We conclude that in patients with upper limb dystonia there is an abnormal recovery from MEP facilitation after suprathreshold 5 Hz-rTMS suggesting an abnormal pattern of short-term cortical plasticity.
C02	`01`	`X`		`@0 002B17`
C02	`02`	`X`		`@0 002B17H`
C02	`03`	`X`		`@0 002B17F`
C03	`01`	`X`	`FRE`	`@0 Système nerveux pathologie @5 01`
C03	`01`	`X`	`ENG`	`@0 Nervous system diseases @5 01`
C03	`01`	`X`	`SPA`	`@0 Sistema nervioso patología @5 01`
C03	`02`	`X`	`FRE`	`@0 Dystonie @5 02`
C03	`02`	`X`	`ENG`	`@0 Dystonia @5 02`
C03	`02`	`X`	`SPA`	`@0 Distonía @5 02`
C03	`03`	`X`	`FRE`	`@0 Court terme @5 09`
C03	`03`	`X`	`ENG`	`@0 Short term @5 09`
C03	`03`	`X`	`SPA`	`@0 Corto plazo @5 09`
C03	`04`	`X`	`FRE`	`@0 Plasticité @5 10`
C03	`04`	`X`	`ENG`	`@0 Plasticity @5 10`
C03	`04`	`X`	`SPA`	`@0 Plasticidad @5 10`
C03	`05`	`X`	`FRE`	`@0 Homme @5 11`
C03	`05`	`X`	`ENG`	`@0 Human @5 11`
C03	`05`	`X`	`SPA`	`@0 Hombre @5 11`
C03	`06`	`X`	`FRE`	`@0 Stimulus répétitif @5 12`
C03	`06`	`X`	`ENG`	`@0 Repetitive stimulus @5 12`
C03	`06`	`X`	`SPA`	`@0 Estímulo repetitivo @5 12`
C03	`07`	`X`	`FRE`	`@0 Potentiel évoqué moteur @5 13`
C03	`07`	`X`	`ENG`	`@0 Motor evoked potential @5 13`
C03	`07`	`X`	`SPA`	`@0 Potencial evocado motor @5 13`
C03	`08`	`X`	`FRE`	`@0 Stimulation magnétique transcrânienne @4 CD @5 96`
C03	`08`	`X`	`ENG`	`@0 Transcranial magnetic stimulation @4 CD @5 96`
C07	`01`	`X`	`FRE`	`@0 Extrapyramidal syndrome @5 37`
C07	`01`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 37`
C07	`01`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 37`
C07	`02`	`X`	`FRE`	`@0 Mouvement involontaire @5 38`
C07	`02`	`X`	`ENG`	`@0 Involuntary movement @5 38`
C07	`02`	`X`	`SPA`	`@0 Movimiento involuntario @5 38`
C07	`03`	`X`	`FRE`	`@0 Muscle strié pathologie @5 39`
C07	`03`	`X`	`ENG`	`@0 Striated muscle disease @5 39`
C07	`03`	`X`	`SPA`	`@0 Músculo estriado patología @5 39`
C07	`04`	`X`	`FRE`	`@0 Trouble neurologique @5 40`
C07	`04`	`X`	`ENG`	`@0 Neurological disorder @5 40`
C07	`04`	`X`	`SPA`	`@0 Trastorno neurológico @5 40`
C07	`05`	`X`	`FRE`	`@0 Electrophysiologie @5 41`
C07	`05`	`X`	`ENG`	`@0 Electrophysiology @5 41`
C07	`05`	`X`	`SPA`	`@0 Electrofisiología @5 41`
C07	`06`	`X`	`FRE`	`@0 Encéphale pathologie @5 42`
C07	`06`	`X`	`ENG`	`@0 Cerebral disorder @5 42`
C07	`06`	`X`	`SPA`	`@0 Encéfalo patología @5 42`
C07	`07`	`X`	`FRE`	`@0 Système nerveux central pathologie @5 43`
C07	`07`	`X`	`ENG`	`@0 Central nervous system disease @5 43`
C07	`07`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 43`
N21				`@1 253`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 07-0393264 INIST
ET :	Short-term cortical plasticity in patients with dystonia : A study with repetitive transcranial magnetic stimulation
AU :	GILIO (Francesca); SUPPA (Antonio); BOLOGNA (Matteo); LORENZANO (Cinzia); FABBRINI (Giovanni); BERARDELLI (Alfredo)
AF :	Department of Neurological Sciences and Neuromed Institute (IRCCS), University of Rome "La Sapienza"/Rome/Italie (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 10; Pp. 1436-1443; Bibl. 33 ref.
LA :	Anglais
EA :	Repetitive transcranial magnetic stimulation (rTMS) delivered at 5 Hz frequency and suprathreshold (RMT) intensity produces a progressive facilitation of motor-evoked potential (MEP) amplitude that outlasts the end of stimulation. This phenomenon is related to a short-term enhancement of cortical excitatory interneurones. In this study, we investigated whether 5 Hz-rTMS elicits similar MEP facilitation during stimulation and similar facilitatory after-effects in patients with upper limb dystonia and healthy subjects. Trains of 5, 10, and 20 stimuli were delivered at 120% RMT over the primary motor cortex with the subjects at rest. rTMS-trains were followed by single test stimuli delivered at various interstimulus intervals (0.5-10 s) at 120% RMT using a conditioning-test paradigm. Single conditioning stimuli were also delivered. The effects of suprathreshold 1 Hz-rTMS were also tested. The MEP amplitude during the course of the trains and of the test stimuli was measured. In control experiments, we investigated the role of the afferent inputs elicited by muscle twitches after ulnar nerve stimulation on the MEP amplitude. In patients and healthy subjects, MEP amplitude increased significantly during the course of 5 Hz-trains. In both groups the MEP facilitation outlasted the end of 5 Hz-rTMS, however the facilitatory after-effects were more pronounced and lasted longer in patients than in healthy subjects. MEP amplitudes during and after 1 Hz-rTMS remained unchanged. Ulnar nerve stimulation did not change the test MEP amplitude. We conclude that in patients with upper limb dystonia there is an abnormal recovery from MEP facilitation after suprathreshold 5 Hz-rTMS suggesting an abnormal pattern of short-term cortical plasticity.
CC :	002B17; 002B17H; 002B17F
FD :	Système nerveux pathologie; Dystonie; Court terme; Plasticité; Homme; Stimulus répétitif; Potentiel évoqué moteur; Stimulation magnétique transcrânienne
FG :	Extrapyramidal syndrome; Mouvement involontaire; Muscle strié pathologie; Trouble neurologique; Electrophysiologie; Encéphale pathologie; Système nerveux central pathologie
ED :	Nervous system diseases; Dystonia; Short term; Plasticity; Human; Repetitive stimulus; Motor evoked potential; Transcranial magnetic stimulation
EG :	Extrapyramidal syndrome; Involuntary movement; Striated muscle disease; Neurological disorder; Electrophysiology; Cerebral disorder; Central nervous system disease
SD :	Sistema nervioso patología; Distonía; Corto plazo; Plasticidad; Hombre; Estímulo repetitivo; Potencial evocado motor
LO :	INIST-20953.354000161473330100
ID :	07-0393264

Links to Exploration step

Pascal:07-0393264

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Short-term cortical plasticity in patients with dystonia : A study with repetitive transcranial magnetic stimulation</title>
<author><name sortKey="Gilio, Francesca" sort="Gilio, Francesca" uniqKey="Gilio F" first="Francesca" last="Gilio">Francesca Gilio</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurological Sciences and Neuromed Institute (IRCCS), University of Rome "La Sapienza"</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Suppa, Antonio" sort="Suppa, Antonio" uniqKey="Suppa A" first="Antonio" last="Suppa">Antonio Suppa</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurological Sciences and Neuromed Institute (IRCCS), University of Rome "La Sapienza"</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Bologna, Matteo" sort="Bologna, Matteo" uniqKey="Bologna M" first="Matteo" last="Bologna">Matteo Bologna</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurological Sciences and Neuromed Institute (IRCCS), University of Rome "La Sapienza"</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Lorenzano, Cinzia" sort="Lorenzano, Cinzia" uniqKey="Lorenzano C" first="Cinzia" last="Lorenzano">Cinzia Lorenzano</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurological Sciences and Neuromed Institute (IRCCS), University of Rome "La Sapienza"</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Fabbrini, Giovanni" sort="Fabbrini, Giovanni" uniqKey="Fabbrini G" first="Giovanni" last="Fabbrini">Giovanni Fabbrini</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurological Sciences and Neuromed Institute (IRCCS), University of Rome "La Sapienza"</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Berardelli, Alfredo" sort="Berardelli, Alfredo" uniqKey="Berardelli A" first="Alfredo" last="Berardelli">Alfredo Berardelli</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurological Sciences and Neuromed Institute (IRCCS), University of Rome "La Sapienza"</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">07-0393264</idno>
<date when="2007">2007</date>
<idno type="stanalyst">PASCAL 07-0393264 INIST</idno>
<idno type="RBID">Pascal:07-0393264</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001592</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Short-term cortical plasticity in patients with dystonia : A study with repetitive transcranial magnetic stimulation</title>
<author><name sortKey="Gilio, Francesca" sort="Gilio, Francesca" uniqKey="Gilio F" first="Francesca" last="Gilio">Francesca Gilio</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurological Sciences and Neuromed Institute (IRCCS), University of Rome "La Sapienza"</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Suppa, Antonio" sort="Suppa, Antonio" uniqKey="Suppa A" first="Antonio" last="Suppa">Antonio Suppa</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurological Sciences and Neuromed Institute (IRCCS), University of Rome "La Sapienza"</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Bologna, Matteo" sort="Bologna, Matteo" uniqKey="Bologna M" first="Matteo" last="Bologna">Matteo Bologna</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurological Sciences and Neuromed Institute (IRCCS), University of Rome "La Sapienza"</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Lorenzano, Cinzia" sort="Lorenzano, Cinzia" uniqKey="Lorenzano C" first="Cinzia" last="Lorenzano">Cinzia Lorenzano</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurological Sciences and Neuromed Institute (IRCCS), University of Rome "La Sapienza"</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Fabbrini, Giovanni" sort="Fabbrini, Giovanni" uniqKey="Fabbrini G" first="Giovanni" last="Fabbrini">Giovanni Fabbrini</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurological Sciences and Neuromed Institute (IRCCS), University of Rome "La Sapienza"</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Berardelli, Alfredo" sort="Berardelli, Alfredo" uniqKey="Berardelli A" first="Alfredo" last="Berardelli">Alfredo Berardelli</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurological Sciences and Neuromed Institute (IRCCS), University of Rome "La Sapienza"</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2007">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dystonia</term>
<term>Human</term>
<term>Motor evoked potential</term>
<term>Nervous system diseases</term>
<term>Plasticity</term>
<term>Repetitive stimulus</term>
<term>Short term</term>
<term>Transcranial magnetic stimulation</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
<term>Dystonie</term>
<term>Court terme</term>
<term>Plasticité</term>
<term>Homme</term>
<term>Stimulus répétitif</term>
<term>Potentiel évoqué moteur</term>
<term>Stimulation magnétique transcrânienne</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Repetitive transcranial magnetic stimulation (rTMS) delivered at 5 Hz frequency and suprathreshold (RMT) intensity produces a progressive facilitation of motor-evoked potential (MEP) amplitude that outlasts the end of stimulation. This phenomenon is related to a short-term enhancement of cortical excitatory interneurones. In this study, we investigated whether 5 Hz-rTMS elicits similar MEP facilitation during stimulation and similar facilitatory after-effects in patients with upper limb dystonia and healthy subjects. Trains of 5, 10, and 20 stimuli were delivered at 120% RMT over the primary motor cortex with the subjects at rest. rTMS-trains were followed by single test stimuli delivered at various interstimulus intervals (0.5-10 s) at 120% RMT using a conditioning-test paradigm. Single conditioning stimuli were also delivered. The effects of suprathreshold 1 Hz-rTMS were also tested. The MEP amplitude during the course of the trains and of the test stimuli was measured. In control experiments, we investigated the role of the afferent inputs elicited by muscle twitches after ulnar nerve stimulation on the MEP amplitude. In patients and healthy subjects, MEP amplitude increased significantly during the course of 5 Hz-trains. In both groups the MEP facilitation outlasted the end of 5 Hz-rTMS, however the facilitatory after-effects were more pronounced and lasted longer in patients than in healthy subjects. MEP amplitudes during and after 1 Hz-rTMS remained unchanged. Ulnar nerve stimulation did not change the test MEP amplitude. We conclude that in patients with upper limb dystonia there is an abnormal recovery from MEP facilitation after suprathreshold 5 Hz-rTMS suggesting an abnormal pattern of short-term cortical plasticity.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0>
</fA01>
<fA03 i2="1"><s0>Mov. disord.</s0>
</fA03>
<fA05><s2>22</s2>
</fA05>
<fA06><s2>10</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Short-term cortical plasticity in patients with dystonia : A study with repetitive transcranial magnetic stimulation</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>GILIO (Francesca)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>SUPPA (Antonio)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>BOLOGNA (Matteo)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>LORENZANO (Cinzia)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>FABBRINI (Giovanni)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>BERARDELLI (Alfredo)</s1>
</fA11>
<fA14 i1="01"><s1>Department of Neurological Sciences and Neuromed Institute (IRCCS), University of Rome "La Sapienza"</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</fA14>
<fA20><s1>1436-1443</s1>
</fA20>
<fA21><s1>2007</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>20953</s2>
<s5>354000161473330100</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2007 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>33 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>07-0393264</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Movement disorders</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Repetitive transcranial magnetic stimulation (rTMS) delivered at 5 Hz frequency and suprathreshold (RMT) intensity produces a progressive facilitation of motor-evoked potential (MEP) amplitude that outlasts the end of stimulation. This phenomenon is related to a short-term enhancement of cortical excitatory interneurones. In this study, we investigated whether 5 Hz-rTMS elicits similar MEP facilitation during stimulation and similar facilitatory after-effects in patients with upper limb dystonia and healthy subjects. Trains of 5, 10, and 20 stimuli were delivered at 120% RMT over the primary motor cortex with the subjects at rest. rTMS-trains were followed by single test stimuli delivered at various interstimulus intervals (0.5-10 s) at 120% RMT using a conditioning-test paradigm. Single conditioning stimuli were also delivered. The effects of suprathreshold 1 Hz-rTMS were also tested. The MEP amplitude during the course of the trains and of the test stimuli was measured. In control experiments, we investigated the role of the afferent inputs elicited by muscle twitches after ulnar nerve stimulation on the MEP amplitude. In patients and healthy subjects, MEP amplitude increased significantly during the course of 5 Hz-trains. In both groups the MEP facilitation outlasted the end of 5 Hz-rTMS, however the facilitatory after-effects were more pronounced and lasted longer in patients than in healthy subjects. MEP amplitudes during and after 1 Hz-rTMS remained unchanged. Ulnar nerve stimulation did not change the test MEP amplitude. We conclude that in patients with upper limb dystonia there is an abnormal recovery from MEP facilitation after suprathreshold 5 Hz-rTMS suggesting an abnormal pattern of short-term cortical plasticity.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B17</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B17H</s0>
</fC02>
<fC02 i1="03" i2="X"><s0>002B17F</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Dystonie</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Dystonia</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Distonía</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Court terme</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Short term</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Corto plazo</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Plasticité</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Plasticity</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Plasticidad</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Homme</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Human</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Hombre</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Stimulus répétitif</s0>
<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Repetitive stimulus</s0>
<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Estímulo repetitivo</s0>
<s5>12</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Potentiel évoqué moteur</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Motor evoked potential</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Potencial evocado motor</s0>
<s5>13</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Stimulation magnétique transcrânienne</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Transcranial magnetic stimulation</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Mouvement involontaire</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Involuntary movement</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Movimiento involuntario</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Muscle strié pathologie</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Striated muscle disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Músculo estriado patología</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Trouble neurologique</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Neurological disorder</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Trastorno neurológico</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Electrophysiologie</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Electrophysiology</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Electrofisiología</s0>
<s5>41</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>42</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>43</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>43</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>43</s5>
</fC07>
<fN21><s1>253</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 07-0393264 INIST</NO>
<ET>Short-term cortical plasticity in patients with dystonia : A study with repetitive transcranial magnetic stimulation</ET>
<AU>GILIO (Francesca); SUPPA (Antonio); BOLOGNA (Matteo); LORENZANO (Cinzia); FABBRINI (Giovanni); BERARDELLI (Alfredo)</AU>
<AF>Department of Neurological Sciences and Neuromed Institute (IRCCS), University of Rome "La Sapienza"/Rome/Italie (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 10; Pp. 1436-1443; Bibl. 33 ref.</SO>
<LA>Anglais</LA>
<EA>Repetitive transcranial magnetic stimulation (rTMS) delivered at 5 Hz frequency and suprathreshold (RMT) intensity produces a progressive facilitation of motor-evoked potential (MEP) amplitude that outlasts the end of stimulation. This phenomenon is related to a short-term enhancement of cortical excitatory interneurones. In this study, we investigated whether 5 Hz-rTMS elicits similar MEP facilitation during stimulation and similar facilitatory after-effects in patients with upper limb dystonia and healthy subjects. Trains of 5, 10, and 20 stimuli were delivered at 120% RMT over the primary motor cortex with the subjects at rest. rTMS-trains were followed by single test stimuli delivered at various interstimulus intervals (0.5-10 s) at 120% RMT using a conditioning-test paradigm. Single conditioning stimuli were also delivered. The effects of suprathreshold 1 Hz-rTMS were also tested. The MEP amplitude during the course of the trains and of the test stimuli was measured. In control experiments, we investigated the role of the afferent inputs elicited by muscle twitches after ulnar nerve stimulation on the MEP amplitude. In patients and healthy subjects, MEP amplitude increased significantly during the course of 5 Hz-trains. In both groups the MEP facilitation outlasted the end of 5 Hz-rTMS, however the facilitatory after-effects were more pronounced and lasted longer in patients than in healthy subjects. MEP amplitudes during and after 1 Hz-rTMS remained unchanged. Ulnar nerve stimulation did not change the test MEP amplitude. We conclude that in patients with upper limb dystonia there is an abnormal recovery from MEP facilitation after suprathreshold 5 Hz-rTMS suggesting an abnormal pattern of short-term cortical plasticity.</EA>
<CC>002B17; 002B17H; 002B17F</CC>
<FD>Système nerveux pathologie; Dystonie; Court terme; Plasticité; Homme; Stimulus répétitif; Potentiel évoqué moteur; Stimulation magnétique transcrânienne</FD>
<FG>Extrapyramidal syndrome; Mouvement involontaire; Muscle strié pathologie; Trouble neurologique; Electrophysiologie; Encéphale pathologie; Système nerveux central pathologie</FG>
<ED>Nervous system diseases; Dystonia; Short term; Plasticity; Human; Repetitive stimulus; Motor evoked potential; Transcranial magnetic stimulation</ED>
<EG>Extrapyramidal syndrome; Involuntary movement; Striated muscle disease; Neurological disorder; Electrophysiology; Cerebral disorder; Central nervous system disease</EG>
<SD>Sistema nervioso patología; Distonía; Corto plazo; Plasticidad; Hombre; Estímulo repetitivo; Potencial evocado motor</SD>
<LO>INIST-20953.354000161473330100</LO>
<ID>07-0393264</ID>
</server>
</inist>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/PascalFrancis/Corpus

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001592 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Corpus/biblio.hfd -nk 001592 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    PascalFrancis
   |étape=   Corpus
   |type=    RBID
   |clé=     Pascal:07-0393264
   |texte=   Short-term cortical plasticity in patients with dystonia : A study with repetitive transcranial magnetic stimulation
}}

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Movement Disorders (revue)

Short-term cortical plasticity in patients with dystonia : A study with repetitive transcranial magnetic stimulation

Short-term cortical plasticity in patients with dystonia : A study with repetitive transcranial magnetic stimulation

Source :

Descripteurs français

English descriptors

Abstract

Notice en format standard (ISO 2709)

Format Inist (serveur)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri