MovDisordV3, PascalFrancis, Corpus, bibRecord, 001591

Inhibitory control and spatial working memory in Parkinson's disease

Identifieur interne : 001591 ( PascalFrancis/Corpus ); précédent : 001590; suivant : 001592

Inhibitory control and spatial working memory in Parkinson's disease

Auteurs : Caroline Gurvich ; Nellie Georgiou Karistianis ; Paul B. Fitzgerald ; Lyn Millist ; Owen B. White

Source :

Movement disorders [ 0885-3185 ] ; 2007.

RBID : Pascal:07-0393265

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Parkinson maladie, Mémoire spatiale, Mémoire travail.

English descriptors

KwdEn :
- Nervous system diseases, Parkinson disease, Spatial memory, Working memory.

Abstract

Patients with Parkinson's disease (PD) have difficulty performing tasks relying on inhibitory control and working memory, functions of the prefrontal cortex. Eye movement paradigms can be used to investigate basic sensorimotor functions and higher order cognitive aspects of motor control. This study investigated inhibitory control and spatial working memory in the saccadic system of 13 individuals with mild-moderate PD and 13 age-matched controls. Tasks explored suppression of reflexive saccades during qualitatively different tasks, generation of express and anticipatory saccades, and the ability to respond to occasional, unpredictable ("oddball") targets that occurred during a sequence of well-learned, reciprocating saccades between horizontal targets. Spatial working memory was assessed using single and two-step (involving a visually guided saccade during the delay period) memory-guided tasks. Results for the PD group indicated an increased percentage of response selection errors during an oddball task, reduced suppression of inappropriate reflexive saccades during memory-guided tasks (but not during fixation or saccade-engagement tasks), and an increased percentage of express and anticipatory saccades. Spatial working memory was preserved in the PD group during single and two-step memory-guided tasks. These findings are consistent with dysfunction within fronto-striatal and prefrontal-collicular pathways influencing suppression and selection of eye movements.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A08	`01`	`1`	`ENG`	`@1 Inhibitory control and spatial working memory in Parkinson's disease`
A11	`01`	`1`		`@1 GURVICH (Caroline)`
A11	`02`	`1`		`@1 GEORGIOU -KARISTIANIS (Nellie)`
A11	`03`	`1`		`@1 FITZGERALD (Paul B.)`
A11	`04`	`1`		`@1 MILLIST (Lyn)`
A11	`05`	`1`		`@1 WHITE (Owen B.)`
A14	`01`			`@1 Experimental Neuropsychology Research Unit, School of Psychology, Psychiatry and Psychological Medicine, Monash University @2 Clayton, Victoria @3 AUS @Z 1 aut. @Z 2 aut. @Z 5 aut.`
A14	`02`			`@1 Brain Systems Research Laboratory, The Mental Health Research Institute @2 Parkville, Victoria @3 AUS @Z 1 aut. @Z 4 aut. @Z 5 aut.`
A14	`03`			`@1 Alfred Psychiatry Research Centre, The Alfred Hospital and Monash University School of Psychology, Psychiatry and Psychological Medicine @2 Prahran, Victoria @3 AUS @Z 1 aut. @Z 3 aut.`
A14	`04`			`@1 Royal Melbourne Neurosciences, Royal Melbourne Hospital @2 Parkville, Victoria @3 AUS @Z 4 aut. @Z 5 aut.`
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A23	`01`			`@0 ENG`
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A44				`@0 0000 @1 © 2007 INIST-CNRS. All rights reserved.`
A45				`@0 40 ref.`
A47	`01`	`1`		`@0 07-0393265`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Movement disorders`
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C01	`01`		`ENG`	@0 Patients with Parkinson's disease (PD) have difficulty performing tasks relying on inhibitory control and working memory, functions of the prefrontal cortex. Eye movement paradigms can be used to investigate basic sensorimotor functions and higher order cognitive aspects of motor control. This study investigated inhibitory control and spatial working memory in the saccadic system of 13 individuals with mild-moderate PD and 13 age-matched controls. Tasks explored suppression of reflexive saccades during qualitatively different tasks, generation of express and anticipatory saccades, and the ability to respond to occasional, unpredictable ("oddball") targets that occurred during a sequence of well-learned, reciprocating saccades between horizontal targets. Spatial working memory was assessed using single and two-step (involving a visually guided saccade during the delay period) memory-guided tasks. Results for the PD group indicated an increased percentage of response selection errors during an oddball task, reduced suppression of inappropriate reflexive saccades during memory-guided tasks (but not during fixation or saccade-engagement tasks), and an increased percentage of express and anticipatory saccades. Spatial working memory was preserved in the PD group during single and two-step memory-guided tasks. These findings are consistent with dysfunction within fronto-striatal and prefrontal-collicular pathways influencing suppression and selection of eye movements.
C02	`01`	`X`		`@0 002B17`
C02	`02`	`X`		`@0 002B17G`
C02	`03`	`X`		`@0 002B17A03`
C03	`01`	`X`	`FRE`	`@0 Système nerveux pathologie @5 01`
C03	`01`	`X`	`ENG`	`@0 Nervous system diseases @5 01`
C03	`01`	`X`	`SPA`	`@0 Sistema nervioso patología @5 01`
C03	`02`	`X`	`FRE`	`@0 Parkinson maladie @5 02`
C03	`02`	`X`	`ENG`	`@0 Parkinson disease @5 02`
C03	`02`	`X`	`SPA`	`@0 Parkinson enfermedad @5 02`
C03	`03`	`X`	`FRE`	`@0 Mémoire spatiale @5 09`
C03	`03`	`X`	`ENG`	`@0 Spatial memory @5 09`
C03	`03`	`X`	`SPA`	`@0 Memoria espacial @5 09`
C03	`04`	`X`	`FRE`	`@0 Mémoire travail @5 10`
C03	`04`	`X`	`ENG`	`@0 Working memory @5 10`
C03	`04`	`X`	`SPA`	`@0 Memoria trabajo @5 10`
C07	`01`	`X`	`FRE`	`@0 Encéphale pathologie @5 37`
C07	`01`	`X`	`ENG`	`@0 Cerebral disorder @5 37`
C07	`01`	`X`	`SPA`	`@0 Encéfalo patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Extrapyramidal syndrome @5 38`
C07	`02`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 38`
C07	`02`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 38`
C07	`03`	`X`	`FRE`	`@0 Maladie dégénérative @5 39`
C07	`03`	`X`	`ENG`	`@0 Degenerative disease @5 39`
C07	`03`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 39`
C07	`04`	`X`	`FRE`	`@0 Système nerveux central pathologie @5 40`
C07	`04`	`X`	`ENG`	`@0 Central nervous system disease @5 40`
C07	`04`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 40`
N21				`@1 253`
N44	`01`			`@1 OTO`
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Format Inist (serveur)

NO :	PASCAL 07-0393265 INIST
ET :	Inhibitory control and spatial working memory in Parkinson's disease
AU :	GURVICH (Caroline); GEORGIOU -KARISTIANIS (Nellie); FITZGERALD (Paul B.); MILLIST (Lyn); WHITE (Owen B.)
AF :	Experimental Neuropsychology Research Unit, School of Psychology, Psychiatry and Psychological Medicine, Monash University/Clayton, Victoria/Australie (1 aut., 2 aut., 5 aut.); Brain Systems Research Laboratory, The Mental Health Research Institute/Parkville, Victoria/Australie (1 aut., 4 aut., 5 aut.); Alfred Psychiatry Research Centre, The Alfred Hospital and Monash University School of Psychology, Psychiatry and Psychological Medicine/Prahran, Victoria/Australie (1 aut., 3 aut.); Royal Melbourne Neurosciences, Royal Melbourne Hospital/Parkville, Victoria/Australie (4 aut., 5 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 10; Pp. 1444-1450; Bibl. 40 ref.
LA :	Anglais
EA :	Patients with Parkinson's disease (PD) have difficulty performing tasks relying on inhibitory control and working memory, functions of the prefrontal cortex. Eye movement paradigms can be used to investigate basic sensorimotor functions and higher order cognitive aspects of motor control. This study investigated inhibitory control and spatial working memory in the saccadic system of 13 individuals with mild-moderate PD and 13 age-matched controls. Tasks explored suppression of reflexive saccades during qualitatively different tasks, generation of express and anticipatory saccades, and the ability to respond to occasional, unpredictable ("oddball") targets that occurred during a sequence of well-learned, reciprocating saccades between horizontal targets. Spatial working memory was assessed using single and two-step (involving a visually guided saccade during the delay period) memory-guided tasks. Results for the PD group indicated an increased percentage of response selection errors during an oddball task, reduced suppression of inappropriate reflexive saccades during memory-guided tasks (but not during fixation or saccade-engagement tasks), and an increased percentage of express and anticipatory saccades. Spatial working memory was preserved in the PD group during single and two-step memory-guided tasks. These findings are consistent with dysfunction within fronto-striatal and prefrontal-collicular pathways influencing suppression and selection of eye movements.
CC :	002B17; 002B17G; 002B17A03
FD :	Système nerveux pathologie; Parkinson maladie; Mémoire spatiale; Mémoire travail
FG :	Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie
ED :	Nervous system diseases; Parkinson disease; Spatial memory; Working memory
EG :	Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD :	Sistema nervioso patología; Parkinson enfermedad; Memoria espacial; Memoria trabajo
LO :	INIST-20953.354000161473330110
ID :	07-0393265

Links to Exploration step

Pascal:07-0393265

Le document en format XML

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<front><div type="abstract" xml:lang="en">Patients with Parkinson's disease (PD) have difficulty performing tasks relying on inhibitory control and working memory, functions of the prefrontal cortex. Eye movement paradigms can be used to investigate basic sensorimotor functions and higher order cognitive aspects of motor control. This study investigated inhibitory control and spatial working memory in the saccadic system of 13 individuals with mild-moderate PD and 13 age-matched controls. Tasks explored suppression of reflexive saccades during qualitatively different tasks, generation of express and anticipatory saccades, and the ability to respond to occasional, unpredictable ("oddball") targets that occurred during a sequence of well-learned, reciprocating saccades between horizontal targets. Spatial working memory was assessed using single and two-step (involving a visually guided saccade during the delay period) memory-guided tasks. Results for the PD group indicated an increased percentage of response selection errors during an oddball task, reduced suppression of inappropriate reflexive saccades during memory-guided tasks (but not during fixation or saccade-engagement tasks), and an increased percentage of express and anticipatory saccades. Spatial working memory was preserved in the PD group during single and two-step memory-guided tasks. These findings are consistent with dysfunction within fronto-striatal and prefrontal-collicular pathways influencing suppression and selection of eye movements.</div>
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<server><NO>PASCAL 07-0393265 INIST</NO>
<ET>Inhibitory control and spatial working memory in Parkinson's disease</ET>
<AU>GURVICH (Caroline); GEORGIOU -KARISTIANIS (Nellie); FITZGERALD (Paul B.); MILLIST (Lyn); WHITE (Owen B.)</AU>
<AF>Experimental Neuropsychology Research Unit, School of Psychology, Psychiatry and Psychological Medicine, Monash University/Clayton, Victoria/Australie (1 aut., 2 aut., 5 aut.); Brain Systems Research Laboratory, The Mental Health Research Institute/Parkville, Victoria/Australie (1 aut., 4 aut., 5 aut.); Alfred Psychiatry Research Centre, The Alfred Hospital and Monash University School of Psychology, Psychiatry and Psychological Medicine/Prahran, Victoria/Australie (1 aut., 3 aut.); Royal Melbourne Neurosciences, Royal Melbourne Hospital/Parkville, Victoria/Australie (4 aut., 5 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 10; Pp. 1444-1450; Bibl. 40 ref.</SO>
<LA>Anglais</LA>
<EA>Patients with Parkinson's disease (PD) have difficulty performing tasks relying on inhibitory control and working memory, functions of the prefrontal cortex. Eye movement paradigms can be used to investigate basic sensorimotor functions and higher order cognitive aspects of motor control. This study investigated inhibitory control and spatial working memory in the saccadic system of 13 individuals with mild-moderate PD and 13 age-matched controls. Tasks explored suppression of reflexive saccades during qualitatively different tasks, generation of express and anticipatory saccades, and the ability to respond to occasional, unpredictable ("oddball") targets that occurred during a sequence of well-learned, reciprocating saccades between horizontal targets. Spatial working memory was assessed using single and two-step (involving a visually guided saccade during the delay period) memory-guided tasks. Results for the PD group indicated an increased percentage of response selection errors during an oddball task, reduced suppression of inappropriate reflexive saccades during memory-guided tasks (but not during fixation or saccade-engagement tasks), and an increased percentage of express and anticipatory saccades. Spatial working memory was preserved in the PD group during single and two-step memory-guided tasks. These findings are consistent with dysfunction within fronto-striatal and prefrontal-collicular pathways influencing suppression and selection of eye movements.</EA>
<CC>002B17; 002B17G; 002B17A03</CC>
<FD>Système nerveux pathologie; Parkinson maladie; Mémoire spatiale; Mémoire travail</FD>
<FG>Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie</FG>
<ED>Nervous system diseases; Parkinson disease; Spatial memory; Working memory</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Sistema nervioso patología; Parkinson enfermedad; Memoria espacial; Memoria trabajo</SD>
<LO>INIST-20953.354000161473330110</LO>
<ID>07-0393265</ID>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Inhibitory control and spatial working memory in Parkinson's disease

Inhibitory control and spatial working memory in Parkinson's disease

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