MovDisordV3, PascalFrancis, Corpus, bibRecord, 001431

The Role of Iron in Restless Legs Syndrome

Identifieur interne : 001431 ( PascalFrancis/Corpus ); précédent : 001430; suivant : 001432

The Role of Iron in Restless Legs Syndrome

Auteurs : Richard P. Allen ; Christopher J. Earley

Source :

Movement disorders [ 0885-3185 ] ; 2007.

RBID : Pascal:08-0096822

Descripteurs français

Pascal (Inist)
- Syndrome des jambes sans repos, Pathologie du système nerveux, Fer, Voie intraveineuse.

English descriptors

KwdEn :
- Intravenous administration, Iron, Nervous system diseases, Restless legs syndrome.

Abstract

The impressive relief from restless legs syndrome (RLS) symptoms provided by levodopa treatment indicates RLS is caused by a dopaminergic abnormality. But similar and more lasting relief also occurs for iron treatment in some patients. Thus there are two major putative causes for RLS: CNS dopaminergic abnormality and CNS iron insufficiency. This article presents the data documenting that both peripheral and CNS iron insufficiency occur with RLS symptoms. Brain iron insufficiency is supported by independently replicated cerebrospinal fluid and brain imaging studies for patients without iron deficiency (ID) anemia. Autopsy studies and intravenous iron treatment further link brain iron insufficiency to RLS. The brain iron insufficiency in patients with RLS is now well established. In this article the data are reviewed that support the following postulates combining dopaminergic and iron causes of RLS: (1) All conditions that compromise iron availability will increase the risk of RLS leading to a higher than expected prevalence of RLS in these conditions. (2) Some patients with RLS have marginal CNS iron status that can become insufficient when deprived of normal access to adequate peripheral iron or may be insufficient even with normal access to adequate peripheral iron. (3) The change or reduced CNS iron status produces RLS symptoms largely through its effects on the dopaminergic system and the corollary to 3. (4) Dopaminergic system abnormalities producing RLS symptoms will be included in those produced by brain ID. Study of the iron model of RLS offers hope for developing new treatment approaches and perhaps methods to prevent or cure the disorder.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 0885-3185`
A03		`1`		`@0 Mov. disord.`
A05				`@2 22`
A06				`@3 SUP18`
A08	`01`	`1`	`ENG`	`@1 The Role of Iron in Restless Legs Syndrome`
A09	`01`	`1`	`ENG`	`@1 Update on restless legs syndrome`
A11	`01`	`1`		`@1 ALLEN (Richard P.)`
A11	`02`	`1`		`@1 EARLEY (Christopher J.)`
A12	`01`	`1`		`@1 TRENKWALDER (Claudia) @9 ed.`
A12	`02`	`1`		`@1 OERTEL (Wolfgang H.) @9 ed.`
A12	`03`	`1`		`@1 ALLEN (Richard) @9 ed.`
A12	`04`	`1`		`@1 GARCIA-BORREGUERO (Diego) @9 ed.`
A14	`01`			`@1 Department of Neurology, Johns Hopkins University @2 Baltimore, Maryland @3 USA @Z 1 aut. @Z 2 aut.`
A15	`01`			`@1 Paracelsus-Elena Hospital @2 Kassel @3 DEU @Z 1 aut.`
A15	`02`			`@1 University of Goettingen @3 DEU @Z 1 aut.`
A15	`03`			`@1 Department of Neurology, University of Marburg @3 DEU @Z 2 aut.`
A15	`04`			`@1 Department of Neurology, Johns Hopkins University @2 Baltimore, Maryland @3 USA @Z 3 aut.`
A15	`05`			`@1 Sleep Research Institute @2 Madrid @3 ESP @Z 4 aut.`
A20				`@2 S440-S448`
A21				`@1 2007`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 20953 @5 354000162671150080`
A44				`@0 0000 @1 © 2008 INIST-CNRS. All rights reserved.`
A45				`@0 59 ref.`
A47	`01`	`1`		`@0 08-0096822`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Movement disorders`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 The impressive relief from restless legs syndrome (RLS) symptoms provided by levodopa treatment indicates RLS is caused by a dopaminergic abnormality. But similar and more lasting relief also occurs for iron treatment in some patients. Thus there are two major putative causes for RLS: CNS dopaminergic abnormality and CNS iron insufficiency. This article presents the data documenting that both peripheral and CNS iron insufficiency occur with RLS symptoms. Brain iron insufficiency is supported by independently replicated cerebrospinal fluid and brain imaging studies for patients without iron deficiency (ID) anemia. Autopsy studies and intravenous iron treatment further link brain iron insufficiency to RLS. The brain iron insufficiency in patients with RLS is now well established. In this article the data are reviewed that support the following postulates combining dopaminergic and iron causes of RLS: (1) All conditions that compromise iron availability will increase the risk of RLS leading to a higher than expected prevalence of RLS in these conditions. (2) Some patients with RLS have marginal CNS iron status that can become insufficient when deprived of normal access to adequate peripheral iron or may be insufficient even with normal access to adequate peripheral iron. (3) The change or reduced CNS iron status produces RLS symptoms largely through its effects on the dopaminergic system and the corollary to 3. (4) Dopaminergic system abnormalities producing RLS symptoms will be included in those produced by brain ID. Study of the iron model of RLS offers hope for developing new treatment approaches and perhaps methods to prevent or cure the disorder.
C02	`01`	`X`		`@0 002B17`
C02	`02`	`X`		`@0 002B17D`
C03	`01`	`X`	`FRE`	`@0 Syndrome des jambes sans repos @5 01`
C03	`01`	`X`	`ENG`	`@0 Restless legs syndrome @5 01`
C03	`01`	`X`	`SPA`	`@0 Acroparestesia nocturna @5 01`
C03	`02`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 02`
C03	`02`	`X`	`ENG`	`@0 Nervous system diseases @5 02`
C03	`02`	`X`	`SPA`	`@0 Sistema nervioso patología @5 02`
C03	`03`	`X`	`FRE`	`@0 Fer @2 NC @5 09`
C03	`03`	`X`	`ENG`	`@0 Iron @2 NC @5 09`
C03	`03`	`X`	`SPA`	`@0 Hierro @2 NC @5 09`
C03	`04`	`X`	`FRE`	`@0 Voie intraveineuse @5 10`
C03	`04`	`X`	`ENG`	`@0 Intravenous administration @5 10`
C03	`04`	`X`	`SPA`	`@0 Vía intravenosa @5 10`
C07	`01`	`X`	`FRE`	`@0 Trouble neurologique @5 38`
C07	`01`	`X`	`ENG`	`@0 Neurological disorder @5 38`
C07	`01`	`X`	`SPA`	`@0 Trastorno neurológico @5 38`
C07	`02`	`X`	`FRE`	`@0 Trouble de la sensibilité @5 39`
C07	`02`	`X`	`ENG`	`@0 Sensitivity disorder @5 39`
C07	`02`	`X`	`SPA`	`@0 Trastorno sensibilidad @5 39`
N21				`@1 052`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 08-0096822 INIST
ET :	The Role of Iron in Restless Legs Syndrome
AU :	ALLEN (Richard P.); EARLEY (Christopher J.); TRENKWALDER (Claudia); OERTEL (Wolfgang H.); ALLEN (Richard); GARCIA-BORREGUERO (Diego)
AF :	Department of Neurology, Johns Hopkins University/Baltimore, Maryland/Etats-Unis (1 aut., 2 aut.); Paracelsus-Elena Hospital/Kassel/Allemagne (1 aut.); University of Goettingen/Allemagne (1 aut.); Department of Neurology, University of Marburg/Allemagne (2 aut.); Department of Neurology, Johns Hopkins University/Baltimore, Maryland/Etats-Unis (3 aut.); Sleep Research Institute/Madrid/Espagne (4 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. SUP18; S440-S448; Bibl. 59 ref.
LA :	Anglais
EA :	The impressive relief from restless legs syndrome (RLS) symptoms provided by levodopa treatment indicates RLS is caused by a dopaminergic abnormality. But similar and more lasting relief also occurs for iron treatment in some patients. Thus there are two major putative causes for RLS: CNS dopaminergic abnormality and CNS iron insufficiency. This article presents the data documenting that both peripheral and CNS iron insufficiency occur with RLS symptoms. Brain iron insufficiency is supported by independently replicated cerebrospinal fluid and brain imaging studies for patients without iron deficiency (ID) anemia. Autopsy studies and intravenous iron treatment further link brain iron insufficiency to RLS. The brain iron insufficiency in patients with RLS is now well established. In this article the data are reviewed that support the following postulates combining dopaminergic and iron causes of RLS: (1) All conditions that compromise iron availability will increase the risk of RLS leading to a higher than expected prevalence of RLS in these conditions. (2) Some patients with RLS have marginal CNS iron status that can become insufficient when deprived of normal access to adequate peripheral iron or may be insufficient even with normal access to adequate peripheral iron. (3) The change or reduced CNS iron status produces RLS symptoms largely through its effects on the dopaminergic system and the corollary to 3. (4) Dopaminergic system abnormalities producing RLS symptoms will be included in those produced by brain ID. Study of the iron model of RLS offers hope for developing new treatment approaches and perhaps methods to prevent or cure the disorder.
CC :	002B17; 002B17D
FD :	Syndrome des jambes sans repos; Pathologie du système nerveux; Fer; Voie intraveineuse
FG :	Trouble neurologique; Trouble de la sensibilité
ED :	Restless legs syndrome; Nervous system diseases; Iron; Intravenous administration
EG :	Neurological disorder; Sensitivity disorder
SD :	Acroparestesia nocturna; Sistema nervioso patología; Hierro; Vía intravenosa
LO :	INIST-20953.354000162671150080
ID :	08-0096822

Links to Exploration step

Pascal:08-0096822

Le document en format XML

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<front><div type="abstract" xml:lang="en">The impressive relief from restless legs syndrome (RLS) symptoms provided by levodopa treatment indicates RLS is caused by a dopaminergic abnormality. But similar and more lasting relief also occurs for iron treatment in some patients. Thus there are two major putative causes for RLS: CNS dopaminergic abnormality and CNS iron insufficiency. This article presents the data documenting that both peripheral and CNS iron insufficiency occur with RLS symptoms. Brain iron insufficiency is supported by independently replicated cerebrospinal fluid and brain imaging studies for patients without iron deficiency (ID) anemia. Autopsy studies and intravenous iron treatment further link brain iron insufficiency to RLS. The brain iron insufficiency in patients with RLS is now well established. In this article the data are reviewed that support the following postulates combining dopaminergic and iron causes of RLS: (1) All conditions that compromise iron availability will increase the risk of RLS leading to a higher than expected prevalence of RLS in these conditions. (2) Some patients with RLS have marginal CNS iron status that can become insufficient when deprived of normal access to adequate peripheral iron or may be insufficient even with normal access to adequate peripheral iron. (3) The change or reduced CNS iron status produces RLS symptoms largely through its effects on the dopaminergic system and the corollary to 3. (4) Dopaminergic system abnormalities producing RLS symptoms will be included in those produced by brain ID. Study of the iron model of RLS offers hope for developing new treatment approaches and perhaps methods to prevent or cure the disorder.</div>
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<ET>The Role of Iron in Restless Legs Syndrome</ET>
<AU>ALLEN (Richard P.); EARLEY (Christopher J.); TRENKWALDER (Claudia); OERTEL (Wolfgang H.); ALLEN (Richard); GARCIA-BORREGUERO (Diego)</AU>
<AF>Department of Neurology, Johns Hopkins University/Baltimore, Maryland/Etats-Unis (1 aut., 2 aut.); Paracelsus-Elena Hospital/Kassel/Allemagne (1 aut.); University of Goettingen/Allemagne (1 aut.); Department of Neurology, University of Marburg/Allemagne (2 aut.); Department of Neurology, Johns Hopkins University/Baltimore, Maryland/Etats-Unis (3 aut.); Sleep Research Institute/Madrid/Espagne (4 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
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<LA>Anglais</LA>
<EA>The impressive relief from restless legs syndrome (RLS) symptoms provided by levodopa treatment indicates RLS is caused by a dopaminergic abnormality. But similar and more lasting relief also occurs for iron treatment in some patients. Thus there are two major putative causes for RLS: CNS dopaminergic abnormality and CNS iron insufficiency. This article presents the data documenting that both peripheral and CNS iron insufficiency occur with RLS symptoms. Brain iron insufficiency is supported by independently replicated cerebrospinal fluid and brain imaging studies for patients without iron deficiency (ID) anemia. Autopsy studies and intravenous iron treatment further link brain iron insufficiency to RLS. The brain iron insufficiency in patients with RLS is now well established. In this article the data are reviewed that support the following postulates combining dopaminergic and iron causes of RLS: (1) All conditions that compromise iron availability will increase the risk of RLS leading to a higher than expected prevalence of RLS in these conditions. (2) Some patients with RLS have marginal CNS iron status that can become insufficient when deprived of normal access to adequate peripheral iron or may be insufficient even with normal access to adequate peripheral iron. (3) The change or reduced CNS iron status produces RLS symptoms largely through its effects on the dopaminergic system and the corollary to 3. (4) Dopaminergic system abnormalities producing RLS symptoms will be included in those produced by brain ID. Study of the iron model of RLS offers hope for developing new treatment approaches and perhaps methods to prevent or cure the disorder.</EA>
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	Movement Disorders (revue)
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Movement Disorders (revue)

The Role of Iron in Restless Legs Syndrome

The Role of Iron in Restless Legs Syndrome

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