MovDisordV3, PascalFrancis, Corpus, bibRecord, 001430

Genetics of Restless Legs Syndrome (RLS) : State-of-the-Art and Future Directions

Identifieur interne : 001430 ( PascalFrancis/Corpus ); précédent : 001429; suivant : 001431

Genetics of Restless Legs Syndrome (RLS) : State-of-the-Art and Future Directions

Auteurs : Juliane Winkelmann ; Oli Polo ; Federica Provini ; Sonja Nevsimalova ; David Kemlink ; Karel Sonka ; Birgit Högl ; Werner Poewe ; Karin Stiasny-Kolster ; Wolfgang Oertel ; Al De Weerd ; Luigi Ferini Strambi ; Marco Zucconi ; Peter P. Pramstaller ; Isabelle Arnulf ; Claudia Trenkwalder ; Christine Klein ; Georgios M. Hadjigeorgiou ; Svenja Happe ; David Rye ; Pasquale Montagna

Source :

Movement disorders [ 0885-3185 ] ; 2007.

RBID : Pascal:08-0096823

Descripteurs français

Pascal (Inist)
- Syndrome des jambes sans repos, Pathologie du système nerveux, Etat actuel, Article synthèse, Sommeil.

English descriptors

KwdEn :
- Nervous system diseases, Restless legs syndrome, Review, Sleep, State of the art.

Abstract

Several studies demonstrated that 60% of restless legs syndrome (RLS) patients have a positive family history and it has been suggested that RLS is a highly hereditary trait. To date, several loci have been mapped but no gene has been identified yet. Phenocopies and possible nonpenetrants made it difficult to detect a common segregating haplotype within the families. Defining the exact candidate region is hampered by possible intrafamilial, allelic, and nonallelic heterogeneity. One important prerequisite for future successful genetic studies in RLS is the availability of large and thoroughly phenotyped patients and family samples for linkage as well as association studies.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`10`	`1`		`@1 OERTEL (Wolfgang)`
A11	`11`	`1`		`@1 DE WEERD (Al)`
A11	`12`	`1`		`@1 FERINI STRAMBI (Luigi)`
A11	`13`	`1`		`@1 ZUCCONI (Marco)`
A11	`14`	`1`		`@1 PRAMSTALLER (Peter P.)`
A11	`15`	`1`		`@1 ARNULF (Isabelle)`
A11	`16`	`1`		`@1 TRENKWALDER (Claudia)`
A11	`17`	`1`		`@1 KLEIN (Christine)`
A11	`18`	`1`		`@1 HADJIGEORGIOU (Georgios M.)`
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A11	`20`	`1`		`@1 RYE (David)`
A11	`21`	`1`		`@1 MONTAGNA (Pasquale)`
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A14	`05`			`@1 Department of Neurological Sciences, University of Bologna @2 Bologna @3 ITA @Z 3 aut. @Z 21 aut.`
A14	`06`			`@1 Department of Neurology, 1st Medical Faculty, Charles University @2 Prag @3 CZE @Z 4 aut. @Z 5 aut. @Z 6 aut.`
A14	`07`			`@1 Department of Neurology, University Clinic Innsbruck @2 Innsbruck @3 AUT @Z 7 aut. @Z 8 aut.`
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A14	`09`			`@1 EEG Department and Sleepcenter SEIN Zwolle @3 NLD @Z 11 aut.`
A14	`10`			`@1 Sleep Disorders Center, Università Vita-Salute H San Raffaele @2 Milan @3 ITA @Z 12 aut. @Z 13 aut.`
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A14	`12`			`@1 Federation des Pathologies du Sommeil, Groupe Hospitalier Pitie-Salpetriere @2 Paris @3 FRA @Z 15 aut.`
A14	`13`			`@1 Paracelsius-Elena Klinik @2 Kassel @3 DEU @Z 16 aut.`
A14	`14`			`@1 Department of Neurology, University of Luebeck @2 Luebeck @3 DEU @Z 17 aut.`
A14	`15`			`@1 Department of Neurology, University of Thessaly, Medical School, Neurogenetics Unit @2 Larissa @3 GRC @Z 18 aut.`
A14	`16`			`@1 Department of Clinical Neurophysiology, Georg-August-University @2 Goettingen @3 DEU @Z 19 aut.`
A14	`17`			`@1 Department of Neurology, Emory University School of Medicine @2 Atlanta, Georgia @3 USA @Z 20 aut.`
A15	`01`			`@1 Paracelsus-Elena Hospital @2 Kassel @3 DEU @Z 1 aut.`
A15	`02`			`@1 University of Goettingen @3 DEU @Z 1 aut.`
A15	`03`			`@1 Department of Neurology, University of Marburg @3 DEU @Z 2 aut.`
A15	`04`			`@1 Department of Neurology, Johns Hopkins University @2 Baltimore, Maryland @3 USA @Z 3 aut.`
A15	`05`			`@1 Sleep Research Institute @2 Madrid @3 ESP @Z 4 aut.`
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C01	`01`		`ENG`	@0 Several studies demonstrated that 60% of restless legs syndrome (RLS) patients have a positive family history and it has been suggested that RLS is a highly hereditary trait. To date, several loci have been mapped but no gene has been identified yet. Phenocopies and possible nonpenetrants made it difficult to detect a common segregating haplotype within the families. Defining the exact candidate region is hampered by possible intrafamilial, allelic, and nonallelic heterogeneity. One important prerequisite for future successful genetic studies in RLS is the availability of large and thoroughly phenotyped patients and family samples for linkage as well as association studies.
C02	`01`	`X`		`@0 002B17`
C02	`02`	`X`		`@0 002B17D`
C03	`01`	`X`	`FRE`	`@0 Syndrome des jambes sans repos @5 01`
C03	`01`	`X`	`ENG`	`@0 Restless legs syndrome @5 01`
C03	`01`	`X`	`SPA`	`@0 Acroparestesia nocturna @5 01`
C03	`02`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 02`
C03	`02`	`X`	`ENG`	`@0 Nervous system diseases @5 02`
C03	`02`	`X`	`SPA`	`@0 Sistema nervioso patología @5 02`
C03	`03`	`X`	`FRE`	`@0 Etat actuel @5 09`
C03	`03`	`X`	`ENG`	`@0 State of the art @5 09`
C03	`03`	`X`	`SPA`	`@0 Estado actual @5 09`
C03	`04`	`X`	`FRE`	`@0 Article synthèse @5 10`
C03	`04`	`X`	`ENG`	`@0 Review @5 10`
C03	`04`	`X`	`SPA`	`@0 Artículo síntesis @5 10`
C03	`05`	`X`	`FRE`	`@0 Sommeil @5 11`
C03	`05`	`X`	`ENG`	`@0 Sleep @5 11`
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C07	`01`	`X`	`ENG`	`@0 Neurological disorder @5 38`
C07	`01`	`X`	`SPA`	`@0 Trastorno neurológico @5 38`
C07	`02`	`X`	`FRE`	`@0 Trouble de la sensibilité @5 39`
C07	`02`	`X`	`ENG`	`@0 Sensitivity disorder @5 39`
C07	`02`	`X`	`SPA`	`@0 Trastorno sensibilidad @5 39`
C07	`03`	`X`	`FRE`	`@0 Cycle veille sommeil @5 40`
C07	`03`	`X`	`ENG`	`@0 Sleep wake cycle @5 40`
C07	`03`	`X`	`SPA`	`@0 Ciclo sueño vigilia @5 40`
N21				`@1 052`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 08-0096823 INIST
ET :	Genetics of Restless Legs Syndrome (RLS) : State-of-the-Art and Future Directions
AU :	WINKELMANN (Juliane); POLO (Oli); PROVINI (Federica); NEVSIMALOVA (Sonja); KEMLINK (David); SONKA (Karel); HÖGL (Birgit); POEWE (Werner); STIASNY-KOLSTER (Karin); OERTEL (Wolfgang); DE WEERD (Al); FERINI STRAMBI (Luigi); ZUCCONI (Marco); PRAMSTALLER (Peter P.); ARNULF (Isabelle); TRENKWALDER (Claudia); KLEIN (Christine); HADJIGEORGIOU (Georgios M.); HAPPE (Svenja); RYE (David); MONTAGNA (Pasquale); TRENKWALDER (Claudia); OERTEL (Wolfgang H.); ALLEN (Richard); GARCIA-BORREGUERO (Diego)
AF :	Institute of Human Genetics, GSF-National Research Center for Environment and Health/Munich/Allemagne (1 aut.); Max Planck Institute of Psychiatry/Munich/Allemagne (1 aut.); Technical University, Institute of Human Genetics/Munich/Allemagne (1 aut.); Sleep Research Unit, University of Turku/Turku/Finlande (2 aut.); Department of Neurological Sciences, University of Bologna/Bologna/Italie (3 aut., 21 aut.); Department of Neurology, 1st Medical Faculty, Charles University/Prag/Tchèque, République (4 aut., 5 aut., 6 aut.); Department of Neurology, University Clinic Innsbruck/Innsbruck/Autriche (7 aut., 8 aut.); Department of Neurology, Philipps University Marburg/Marburg/Allemagne (9 aut., 10 aut.); EEG Department and Sleepcenter SEIN Zwolle/Pays-Bas (11 aut.); Sleep Disorders Center, Università Vita-Salute H San Raffaele/Milan/Italie (12 aut., 13 aut.); GenNovaEurac-Research/Bolzano/Italie (14 aut.); Federation des Pathologies du Sommeil, Groupe Hospitalier Pitie-Salpetriere/Paris/France (15 aut.); Paracelsius-Elena Klinik/Kassel/Allemagne (16 aut.); Department of Neurology, University of Luebeck/Luebeck/Allemagne (17 aut.); Department of Neurology, University of Thessaly, Medical School, Neurogenetics Unit/Larissa/Grèce (18 aut.); Department of Clinical Neurophysiology, Georg-August-University/Goettingen/Allemagne (19 aut.); Department of Neurology, Emory University School of Medicine/Atlanta, Georgia/Etats-Unis (20 aut.); Paracelsus-Elena Hospital/Kassel/Allemagne (1 aut.); University of Goettingen/Allemagne (1 aut.); Department of Neurology, University of Marburg/Allemagne (2 aut.); Department of Neurology, Johns Hopkins University/Baltimore, Maryland/Etats-Unis (3 aut.); Sleep Research Institute/Madrid/Espagne (4 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. SUP18; S449-S458; Bibl. 69 ref.
LA :	Anglais
EA :	Several studies demonstrated that 60% of restless legs syndrome (RLS) patients have a positive family history and it has been suggested that RLS is a highly hereditary trait. To date, several loci have been mapped but no gene has been identified yet. Phenocopies and possible nonpenetrants made it difficult to detect a common segregating haplotype within the families. Defining the exact candidate region is hampered by possible intrafamilial, allelic, and nonallelic heterogeneity. One important prerequisite for future successful genetic studies in RLS is the availability of large and thoroughly phenotyped patients and family samples for linkage as well as association studies.
CC :	002B17; 002B17D
FD :	Syndrome des jambes sans repos; Pathologie du système nerveux; Etat actuel; Article synthèse; Sommeil
FG :	Trouble neurologique; Trouble de la sensibilité; Cycle veille sommeil
ED :	Restless legs syndrome; Nervous system diseases; State of the art; Review; Sleep
EG :	Neurological disorder; Sensitivity disorder; Sleep wake cycle
SD :	Acroparestesia nocturna; Sistema nervioso patología; Estado actual; Artículo síntesis; Sueño
LO :	INIST-20953.354000162671150090
ID :	08-0096823

Links to Exploration step

Pascal:08-0096823

Le document en format XML

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<author><name sortKey="Stiasny Kolster, Karin" sort="Stiasny Kolster, Karin" uniqKey="Stiasny Kolster K" first="Karin" last="Stiasny-Kolster">Karin Stiasny-Kolster</name>
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<author><name sortKey="Oertel, Wolfgang" sort="Oertel, Wolfgang" uniqKey="Oertel W" first="Wolfgang" last="Oertel">Wolfgang Oertel</name>
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<author><name sortKey="De Weerd, Al" sort="De Weerd, Al" uniqKey="De Weerd A" first="Al" last="De Weerd">Al De Weerd</name>
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<author><name sortKey="Ferini Strambi, Luigi" sort="Ferini Strambi, Luigi" uniqKey="Ferini Strambi L" first="Luigi" last="Ferini Strambi">Luigi Ferini Strambi</name>
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<author><name sortKey="Zucconi, Marco" sort="Zucconi, Marco" uniqKey="Zucconi M" first="Marco" last="Zucconi">Marco Zucconi</name>
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<s3>ITA</s3>
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<author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name>
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<author><name sortKey="Arnulf, Isabelle" sort="Arnulf, Isabelle" uniqKey="Arnulf I" first="Isabelle" last="Arnulf">Isabelle Arnulf</name>
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<author><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name>
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<author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name>
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<author><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M." last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name>
<affiliation><inist:fA14 i1="15"><s1>Department of Neurology, University of Thessaly, Medical School, Neurogenetics Unit</s1>
<s2>Larissa</s2>
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<author><name sortKey="Happe, Svenja" sort="Happe, Svenja" uniqKey="Happe S" first="Svenja" last="Happe">Svenja Happe</name>
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<author><name sortKey="Rye, David" sort="Rye, David" uniqKey="Rye D" first="David" last="Rye">David Rye</name>
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<author><name sortKey="Montagna, Pasquale" sort="Montagna, Pasquale" uniqKey="Montagna P" first="Pasquale" last="Montagna">Pasquale Montagna</name>
<affiliation><inist:fA14 i1="05"><s1>Department of Neurological Sciences, University of Bologna</s1>
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<s3>DEU</s3>
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<affiliation><inist:fA14 i1="03"><s1>Technical University, Institute of Human Genetics</s1>
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<s3>DEU</s3>
<sZ>1 aut.</sZ>
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<s3>FIN</s3>
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<s3>ITA</s3>
<sZ>3 aut.</sZ>
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<author><name sortKey="Nevsimalova, Sonja" sort="Nevsimalova, Sonja" uniqKey="Nevsimalova S" first="Sonja" last="Nevsimalova">Sonja Nevsimalova</name>
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<s3>CZE</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
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<s3>CZE</s3>
<sZ>4 aut.</sZ>
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<s3>CZE</s3>
<sZ>4 aut.</sZ>
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<author><name sortKey="Hogl, Birgit" sort="Hogl, Birgit" uniqKey="Hogl B" first="Birgit" last="Högl">Birgit Högl</name>
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<s3>AUT</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
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<s3>AUT</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
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<author><name sortKey="Stiasny Kolster, Karin" sort="Stiasny Kolster, Karin" uniqKey="Stiasny Kolster K" first="Karin" last="Stiasny-Kolster">Karin Stiasny-Kolster</name>
<affiliation><inist:fA14 i1="08"><s1>Department of Neurology, Philipps University Marburg</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
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<affiliation><inist:fA14 i1="08"><s1>Department of Neurology, Philipps University Marburg</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
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<author><name sortKey="De Weerd, Al" sort="De Weerd, Al" uniqKey="De Weerd A" first="Al" last="De Weerd">Al De Weerd</name>
<affiliation><inist:fA14 i1="09"><s1>EEG Department and Sleepcenter SEIN Zwolle</s1>
<s3>NLD</s3>
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<author><name sortKey="Ferini Strambi, Luigi" sort="Ferini Strambi, Luigi" uniqKey="Ferini Strambi L" first="Luigi" last="Ferini Strambi">Luigi Ferini Strambi</name>
<affiliation><inist:fA14 i1="10"><s1>Sleep Disorders Center, Università Vita-Salute H San Raffaele</s1>
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<affiliation><inist:fA14 i1="10"><s1>Sleep Disorders Center, Università Vita-Salute H San Raffaele</s1>
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<s3>ITA</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
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<author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name>
<affiliation><inist:fA14 i1="11"><s1>GenNovaEurac-Research</s1>
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<author><name sortKey="Arnulf, Isabelle" sort="Arnulf, Isabelle" uniqKey="Arnulf I" first="Isabelle" last="Arnulf">Isabelle Arnulf</name>
<affiliation><inist:fA14 i1="12"><s1>Federation des Pathologies du Sommeil, Groupe Hospitalier Pitie-Salpetriere</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>15 aut.</sZ>
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<author><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name>
<affiliation><inist:fA14 i1="13"><s1>Paracelsius-Elena Klinik</s1>
<s2>Kassel</s2>
<s3>DEU</s3>
<sZ>16 aut.</sZ>
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<author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name>
<affiliation><inist:fA14 i1="14"><s1>Department of Neurology, University of Luebeck</s1>
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<s3>DEU</s3>
<sZ>17 aut.</sZ>
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<affiliation><inist:fA14 i1="15"><s1>Department of Neurology, University of Thessaly, Medical School, Neurogenetics Unit</s1>
<s2>Larissa</s2>
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<author><name sortKey="Happe, Svenja" sort="Happe, Svenja" uniqKey="Happe S" first="Svenja" last="Happe">Svenja Happe</name>
<affiliation><inist:fA14 i1="16"><s1>Department of Clinical Neurophysiology, Georg-August-University</s1>
<s2>Goettingen</s2>
<s3>DEU</s3>
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<author><name sortKey="Rye, David" sort="Rye, David" uniqKey="Rye D" first="David" last="Rye">David Rye</name>
<affiliation><inist:fA14 i1="17"><s1>Department of Neurology, Emory University School of Medicine</s1>
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<sZ>20 aut.</sZ>
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<author><name sortKey="Montagna, Pasquale" sort="Montagna, Pasquale" uniqKey="Montagna P" first="Pasquale" last="Montagna">Pasquale Montagna</name>
<affiliation><inist:fA14 i1="05"><s1>Department of Neurological Sciences, University of Bologna</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>3 aut.</sZ>
<sZ>21 aut.</sZ>
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<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2007">2007</date>
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<seriesStmt><title level="j" type="main">Movement disorders</title>
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<idno type="ISSN">0885-3185</idno>
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</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Nervous system diseases</term>
<term>Restless legs syndrome</term>
<term>Review</term>
<term>Sleep</term>
<term>State of the art</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Syndrome des jambes sans repos</term>
<term>Pathologie du   système nerveux</term>
<term>Etat actuel</term>
<term>Article synthèse</term>
<term>Sommeil</term>
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<front><div type="abstract" xml:lang="en">Several studies demonstrated that 60% of restless legs syndrome (RLS) patients have a positive family history and it has been suggested that RLS is a highly hereditary trait. To date, several loci have been mapped but no gene has been identified yet. Phenocopies and possible nonpenetrants made it difficult to detect a common segregating haplotype within the families. Defining the exact candidate region is hampered by possible intrafamilial, allelic, and nonallelic heterogeneity. One important prerequisite for future successful genetic studies in RLS is the availability of large and thoroughly phenotyped patients and family samples for linkage as well as association studies.</div>
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<fA08 i1="01" i2="1" l="ENG"><s1>Genetics of Restless Legs Syndrome (RLS) : State-of-the-Art and Future Directions</s1>
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<fA09 i1="01" i2="1" l="ENG"><s1>Update on restless legs syndrome</s1>
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<fA14 i1="05"><s1>Department of Neurological Sciences, University of Bologna</s1>
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<sZ>21 aut.</sZ>
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<fA14 i1="06"><s1>Department of Neurology, 1st Medical Faculty, Charles University</s1>
<s2>Prag</s2>
<s3>CZE</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
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<fA14 i1="07"><s1>Department of Neurology, University Clinic Innsbruck</s1>
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<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
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<fA14 i1="08"><s1>Department of Neurology, Philipps University Marburg</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
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<fA14 i1="09"><s1>EEG Department and Sleepcenter SEIN Zwolle</s1>
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<fA14 i1="10"><s1>Sleep Disorders Center, Università Vita-Salute H San Raffaele</s1>
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<sZ>13 aut.</sZ>
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<fA14 i1="11"><s1>GenNovaEurac-Research</s1>
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<fA14 i1="13"><s1>Paracelsius-Elena Klinik</s1>
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<fA14 i1="14"><s1>Department of Neurology, University of Luebeck</s1>
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<sZ>17 aut.</sZ>
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<fA14 i1="15"><s1>Department of Neurology, University of Thessaly, Medical School, Neurogenetics Unit</s1>
<s2>Larissa</s2>
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<sZ>18 aut.</sZ>
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<fA14 i1="16"><s1>Department of Clinical Neurophysiology, Georg-August-University</s1>
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<fA14 i1="17"><s1>Department of Neurology, Emory University School of Medicine</s1>
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<fA15 i1="01"><s1>Paracelsus-Elena Hospital</s1>
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<fA15 i1="03"><s1>Department of Neurology, University of Marburg</s1>
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<fA15 i1="05"><s1>Sleep Research Institute</s1>
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<s5>38</s5>
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<fC07 i1="01" i2="X" l="SPA"><s0>Trastorno neurológico</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Trouble de la sensibilité</s0>
<s5>39</s5>
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<fC07 i1="02" i2="X" l="ENG"><s0>Sensitivity disorder</s0>
<s5>39</s5>
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<fC07 i1="02" i2="X" l="SPA"><s0>Trastorno sensibilidad</s0>
<s5>39</s5>
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<s5>40</s5>
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<fC07 i1="03" i2="X" l="SPA"><s0>Ciclo sueño vigilia</s0>
<s5>40</s5>
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<ET>Genetics of Restless Legs Syndrome (RLS) : State-of-the-Art and Future Directions</ET>
<AU>WINKELMANN (Juliane); POLO (Oli); PROVINI (Federica); NEVSIMALOVA (Sonja); KEMLINK (David); SONKA (Karel); HÖGL (Birgit); POEWE (Werner); STIASNY-KOLSTER (Karin); OERTEL (Wolfgang); DE WEERD (Al); FERINI STRAMBI (Luigi); ZUCCONI (Marco); PRAMSTALLER (Peter P.); ARNULF (Isabelle); TRENKWALDER (Claudia); KLEIN (Christine); HADJIGEORGIOU (Georgios M.); HAPPE (Svenja); RYE (David); MONTAGNA (Pasquale); TRENKWALDER (Claudia); OERTEL (Wolfgang H.); ALLEN (Richard); GARCIA-BORREGUERO (Diego)</AU>
<AF>Institute of Human Genetics, GSF-National Research Center for Environment and Health/Munich/Allemagne (1 aut.); Max Planck Institute of Psychiatry/Munich/Allemagne (1 aut.); Technical University, Institute of Human Genetics/Munich/Allemagne (1 aut.); Sleep Research Unit, University of Turku/Turku/Finlande (2 aut.); Department of Neurological Sciences, University of Bologna/Bologna/Italie (3 aut., 21 aut.); Department of Neurology, 1st Medical Faculty, Charles University/Prag/Tchèque, République (4 aut., 5 aut., 6 aut.); Department of Neurology, University Clinic Innsbruck/Innsbruck/Autriche (7 aut., 8 aut.); Department of Neurology, Philipps University Marburg/Marburg/Allemagne (9 aut., 10 aut.); EEG Department and Sleepcenter SEIN Zwolle/Pays-Bas (11 aut.); Sleep Disorders Center, Università Vita-Salute H San Raffaele/Milan/Italie (12 aut., 13 aut.); GenNovaEurac-Research/Bolzano/Italie (14 aut.); Federation des Pathologies du Sommeil, Groupe Hospitalier Pitie-Salpetriere/Paris/France (15 aut.); Paracelsius-Elena Klinik/Kassel/Allemagne (16 aut.); Department of Neurology, University of Luebeck/Luebeck/Allemagne (17 aut.); Department of Neurology, University of Thessaly, Medical School, Neurogenetics Unit/Larissa/Grèce (18 aut.); Department of Clinical Neurophysiology, Georg-August-University/Goettingen/Allemagne (19 aut.); Department of Neurology, Emory University School of Medicine/Atlanta, Georgia/Etats-Unis (20 aut.); Paracelsus-Elena Hospital/Kassel/Allemagne (1 aut.); University of Goettingen/Allemagne (1 aut.); Department of Neurology, University of Marburg/Allemagne (2 aut.); Department of Neurology, Johns Hopkins University/Baltimore, Maryland/Etats-Unis (3 aut.); Sleep Research Institute/Madrid/Espagne (4 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. SUP18; S449-S458; Bibl. 69 ref.</SO>
<LA>Anglais</LA>
<EA>Several studies demonstrated that 60% of restless legs syndrome (RLS) patients have a positive family history and it has been suggested that RLS is a highly hereditary trait. To date, several loci have been mapped but no gene has been identified yet. Phenocopies and possible nonpenetrants made it difficult to detect a common segregating haplotype within the families. Defining the exact candidate region is hampered by possible intrafamilial, allelic, and nonallelic heterogeneity. One important prerequisite for future successful genetic studies in RLS is the availability of large and thoroughly phenotyped patients and family samples for linkage as well as association studies.</EA>
<CC>002B17; 002B17D</CC>
<FD>Syndrome des jambes sans repos; Pathologie du   système nerveux; Etat actuel; Article synthèse; Sommeil</FD>
<FG>Trouble neurologique; Trouble de la sensibilité; Cycle veille sommeil</FG>
<ED>Restless legs syndrome; Nervous system diseases; State of the art; Review; Sleep</ED>
<EG>Neurological disorder; Sensitivity disorder; Sleep wake cycle</EG>
<SD>Acroparestesia nocturna; Sistema nervioso patología; Estado actual; Artículo síntesis; Sueño</SD>
<LO>INIST-20953.354000162671150090</LO>
<ID>08-0096823</ID>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Genetics of Restless Legs Syndrome (RLS) : State-of-the-Art and Future Directions

Genetics of Restless Legs Syndrome (RLS) : State-of-the-Art and Future Directions

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