MovDisordV3, PascalFrancis, Corpus, bibRecord, 001365

A Neuropsychological Longitudinal Study in Parkinson's Patients With and Without Hallucinations

Identifieur interne : 001365 ( PascalFrancis/Corpus ); précédent : 001364; suivant : 001366

A Neuropsychological Longitudinal Study in Parkinson's Patients With and Without Hallucinations

Auteurs : Gabriella Santangelo ; Luigi Trojano ; Carmine Vitale ; Marta Ianniciello ; Marianna Amboni ; Dario Grossi ; Paolo Barone

Source :

Movement disorders [ 0885-3185 ] ; 2007.

RBID : Pascal:08-0146971

Descripteurs français

Pascal (Inist)
- Hallucination, Maladie de Parkinson, Démence, Pathologie du système nerveux, Homme, Frontal, Trouble fonctionnel.

English descriptors

KwdEn :
- Dementia, Dysfunction, Frontal, Hallucination, Human, Nervous system diseases, Parkinson disease.

Abstract

The aim of this work was to determine the progression of cognitive impairment in Parkinson's disease (PD) patients with or without hallucinations. Two years after the first assessment, 36 PD patients were re-evaluated on standardized neuropsychological tests, including the Frontal Assessment Battery (FAB), and on rating scales for overall cognitive functioning, functional autonomy, behavioral disorders. Nine patients had hallucinations at baseline and endpoint assessments; 12 patients developed hallucinations during the follow-up; and 15 patients were hallucination-free throughout the study. Cognitive performance significantly declined in all three groups, but at endpoint assessment PD hallucinators scored significantly lower than nonhallucinators on phonological and semantic fluency tasks, immediate free recall and the go/no-go FAB subtest; moreover, they showed more severe apathy than nonhallucinators. Reduced phonological fluency at baseline (odds ratio [OR], 13.5; 95% CI: 1.34-135.98, P = 0.027) was the only independent predictor of onset of hallucinations after 2 years, whereas hallucinations (OR, 10.1; 95% CI: 1.94-51.54, P = 0.006) and poor phonological fluency (OR, 6.1; 95% CI: 1.04-35.03, P = 0.045) independently predicted development of diffuse cognitive impairment. We concluded that reduced verbal fluency scores may predict the onset of hallucinations, while hallucinations and poor phonological fluency may predict development of dementia in PD patients.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`04`	`1`		`@1 IANNICIELLO (Marta)`
A11	`05`	`1`		`@1 AMBONI (Marianna)`
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A14	`01`			`@1 Dipartimento di Science Neurologiche, Università di Napoli Federico II @2 Naples @3 ITA @Z 1 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 7 aut.`
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A14	`03`			`@1 Istituto di Diagnostica e Cura "Hermitage Capodimonte," @2 Naples @3 ITA @Z 3 aut. @Z 5 aut.`
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A44				`@0 0000 @1 © 2008 INIST-CNRS. All rights reserved.`
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C01	`01`		`ENG`	@0 The aim of this work was to determine the progression of cognitive impairment in Parkinson's disease (PD) patients with or without hallucinations. Two years after the first assessment, 36 PD patients were re-evaluated on standardized neuropsychological tests, including the Frontal Assessment Battery (FAB), and on rating scales for overall cognitive functioning, functional autonomy, behavioral disorders. Nine patients had hallucinations at baseline and endpoint assessments; 12 patients developed hallucinations during the follow-up; and 15 patients were hallucination-free throughout the study. Cognitive performance significantly declined in all three groups, but at endpoint assessment PD hallucinators scored significantly lower than nonhallucinators on phonological and semantic fluency tasks, immediate free recall and the go/no-go FAB subtest; moreover, they showed more severe apathy than nonhallucinators. Reduced phonological fluency at baseline (odds ratio [OR], 13.5; 95% CI: 1.34-135.98, P = 0.027) was the only independent predictor of onset of hallucinations after 2 years, whereas hallucinations (OR, 10.1; 95% CI: 1.94-51.54, P = 0.006) and poor phonological fluency (OR, 6.1; 95% CI: 1.04-35.03, P = 0.045) independently predicted development of diffuse cognitive impairment. We concluded that reduced verbal fluency scores may predict the onset of hallucinations, while hallucinations and poor phonological fluency may predict development of dementia in PD patients.
C02	`01`	`X`		`@0 002B17`
C03	`01`	`X`	`FRE`	`@0 Hallucination @5 01`
C03	`01`	`X`	`ENG`	`@0 Hallucination @5 01`
C03	`01`	`X`	`SPA`	`@0 Alucinación @5 01`
C03	`02`	`X`	`FRE`	`@0 Maladie de Parkinson @2 NM @5 02`
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C03	`04`	`X`	`ENG`	`@0 Nervous system diseases @5 04`
C03	`04`	`X`	`SPA`	`@0 Sistema nervioso patología @5 04`
C03	`05`	`X`	`FRE`	`@0 Homme @5 09`
C03	`05`	`X`	`ENG`	`@0 Human @5 09`
C03	`05`	`X`	`SPA`	`@0 Hombre @5 09`
C03	`06`	`X`	`FRE`	`@0 Frontal @5 10`
C03	`06`	`X`	`ENG`	`@0 Frontal @5 10`
C03	`06`	`X`	`SPA`	`@0 Frontal @5 10`
C03	`07`	`X`	`FRE`	`@0 Trouble fonctionnel @5 11`
C03	`07`	`X`	`ENG`	`@0 Dysfunction @5 11`
C03	`07`	`X`	`SPA`	`@0 Trastorno funcional @5 11`
C07	`01`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 37`
C07	`01`	`X`	`ENG`	`@0 Cerebral disorder @5 37`
C07	`01`	`X`	`SPA`	`@0 Encéfalo patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 38`
C07	`02`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 38`
C07	`02`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 38`
C07	`03`	`X`	`FRE`	`@0 Maladie dégénérative @5 39`
C07	`03`	`X`	`ENG`	`@0 Degenerative disease @5 39`
C07	`03`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 39`
C07	`04`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 40`
C07	`04`	`X`	`ENG`	`@0 Central nervous system disease @5 40`
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Format Inist (serveur)

NO :	PASCAL 08-0146971 INIST
ET :	A Neuropsychological Longitudinal Study in Parkinson's Patients With and Without Hallucinations
AU :	SANTANGELO (Gabriella); TROJANO (Luigi); VITALE (Carmine); IANNICIELLO (Marta); AMBONI (Marianna); GROSSI (Dario); BARONE (Paolo)
AF :	Dipartimento di Science Neurologiche, Università di Napoli Federico II/Naples/Italie (1 aut., 3 aut., 4 aut., 5 aut., 7 aut.); Laboratorio di Neuropsicologia, Dipartimento di Psicologia, Seconda Università Studi di Napoli/Naples/Italie (1 aut., 2 aut., 6 aut.); Istituto di Diagnostica e Cura "Hermitage Capodimonte,"/Naples/Italie (3 aut., 5 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 16; Pp. 2418-2425; Bibl. 61 ref.
LA :	Anglais
EA :	The aim of this work was to determine the progression of cognitive impairment in Parkinson's disease (PD) patients with or without hallucinations. Two years after the first assessment, 36 PD patients were re-evaluated on standardized neuropsychological tests, including the Frontal Assessment Battery (FAB), and on rating scales for overall cognitive functioning, functional autonomy, behavioral disorders. Nine patients had hallucinations at baseline and endpoint assessments; 12 patients developed hallucinations during the follow-up; and 15 patients were hallucination-free throughout the study. Cognitive performance significantly declined in all three groups, but at endpoint assessment PD hallucinators scored significantly lower than nonhallucinators on phonological and semantic fluency tasks, immediate free recall and the go/no-go FAB subtest; moreover, they showed more severe apathy than nonhallucinators. Reduced phonological fluency at baseline (odds ratio [OR], 13.5; 95% CI: 1.34-135.98, P = 0.027) was the only independent predictor of onset of hallucinations after 2 years, whereas hallucinations (OR, 10.1; 95% CI: 1.94-51.54, P = 0.006) and poor phonological fluency (OR, 6.1; 95% CI: 1.04-35.03, P = 0.045) independently predicted development of diffuse cognitive impairment. We concluded that reduced verbal fluency scores may predict the onset of hallucinations, while hallucinations and poor phonological fluency may predict development of dementia in PD patients.
CC :	002B17
FD :	Hallucination; Maladie de Parkinson; Démence; Pathologie du système nerveux; Homme; Frontal; Trouble fonctionnel
FG :	Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central
ED :	Hallucination; Parkinson disease; Dementia; Nervous system diseases; Human; Frontal; Dysfunction
EG :	Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD :	Alucinación; Parkinson enfermedad; Demencia; Sistema nervioso patología; Hombre; Frontal; Trastorno funcional
LO :	INIST-20953.354000162715700180
ID :	08-0146971

Links to Exploration step

Pascal:08-0146971

Le document en format XML

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<front><div type="abstract" xml:lang="en">The aim of this work was to determine the progression of cognitive impairment in Parkinson's disease (PD) patients with or without hallucinations. Two years after the first assessment, 36 PD patients were re-evaluated on standardized neuropsychological tests, including the Frontal Assessment Battery (FAB), and on rating scales for overall cognitive functioning, functional autonomy, behavioral disorders. Nine patients had hallucinations at baseline and endpoint assessments; 12 patients developed hallucinations during the follow-up; and 15 patients were hallucination-free throughout the study. Cognitive performance significantly declined in all three groups, but at endpoint assessment PD hallucinators scored significantly lower than nonhallucinators on phonological and semantic fluency tasks, immediate free recall and the go/no-go FAB subtest; moreover, they showed more severe apathy than nonhallucinators. Reduced phonological fluency at baseline (odds ratio [OR], 13.5; 95% CI: 1.34-135.98, P = 0.027) was the only independent predictor of onset of hallucinations after 2 years, whereas hallucinations (OR, 10.1; 95% CI: 1.94-51.54, P = 0.006) and poor phonological fluency (OR, 6.1; 95% CI: 1.04-35.03, P = 0.045) independently predicted development of diffuse cognitive impairment. We concluded that reduced verbal fluency scores may predict the onset of hallucinations, while hallucinations and poor phonological fluency may predict development of dementia in PD patients.</div>
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<fA11 i1="04" i2="1"><s1>IANNICIELLO (Marta)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>AMBONI (Marianna)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>GROSSI (Dario)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>BARONE (Paolo)</s1>
</fA11>
<fA14 i1="01"><s1>Dipartimento di Science Neurologiche, Università di Napoli Federico II</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Laboratorio di Neuropsicologia, Dipartimento di Psicologia, Seconda Università Studi di Napoli</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Istituto di Diagnostica e Cura "Hermitage Capodimonte,"</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</fA14>
<fA20><s1>2418-2425</s1>
</fA20>
<fA21><s1>2007</s1>
</fA21>
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</fA23>
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<s5>354000162715700180</s5>
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<fA44><s0>0000</s0>
<s1>© 2008 INIST-CNRS. All rights reserved.</s1>
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</fA45>
<fA47 i1="01" i2="1"><s0>08-0146971</s0>
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<fA60><s1>P</s1>
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<fC01 i1="01" l="ENG"><s0>The aim of this work was to determine the progression of cognitive impairment in Parkinson's disease (PD) patients with or without hallucinations. Two years after the first assessment, 36 PD patients were re-evaluated on standardized neuropsychological tests, including the Frontal Assessment Battery (FAB), and on rating scales for overall cognitive functioning, functional autonomy, behavioral disorders. Nine patients had hallucinations at baseline and endpoint assessments; 12 patients developed hallucinations during the follow-up; and 15 patients were hallucination-free throughout the study. Cognitive performance significantly declined in all three groups, but at endpoint assessment PD hallucinators scored significantly lower than nonhallucinators on phonological and semantic fluency tasks, immediate free recall and the go/no-go FAB subtest; moreover, they showed more severe apathy than nonhallucinators. Reduced phonological fluency at baseline (odds ratio [OR], 13.5; 95% CI: 1.34-135.98, P = 0.027) was the only independent predictor of onset of hallucinations after 2 years, whereas hallucinations (OR, 10.1; 95% CI: 1.94-51.54, P = 0.006) and poor phonological fluency (OR, 6.1; 95% CI: 1.04-35.03, P = 0.045) independently predicted development of diffuse cognitive impairment. We concluded that reduced verbal fluency scores may predict the onset of hallucinations, while hallucinations and poor phonological fluency may predict development of dementia in PD patients.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B17</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Hallucination</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Hallucination</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Alucinación</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Maladie de Parkinson</s0>
<s2>NM</s2>
<s5>02</s5>
</fC03>
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<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
<s2>NM</s2>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Démence</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Dementia</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Demencia</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Pathologie du   système nerveux</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Homme</s0>
<s5>09</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Human</s0>
<s5>09</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Hombre</s0>
<s5>09</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Frontal</s0>
<s5>10</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Frontal</s0>
<s5>10</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Frontal</s0>
<s5>10</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Trouble fonctionnel</s0>
<s5>11</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Dysfunction</s0>
<s5>11</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Trastorno funcional</s0>
<s5>11</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Pathologie du   système nerveux central</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>40</s5>
</fC07>
<fN21><s1>091</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
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<fN82><s1>OTO</s1>
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<server><NO>PASCAL 08-0146971 INIST</NO>
<ET>A Neuropsychological Longitudinal Study in Parkinson's Patients With and Without Hallucinations</ET>
<AU>SANTANGELO (Gabriella); TROJANO (Luigi); VITALE (Carmine); IANNICIELLO (Marta); AMBONI (Marianna); GROSSI (Dario); BARONE (Paolo)</AU>
<AF>Dipartimento di Science Neurologiche, Università di Napoli Federico II/Naples/Italie (1 aut., 3 aut., 4 aut., 5 aut., 7 aut.); Laboratorio di Neuropsicologia, Dipartimento di Psicologia, Seconda Università Studi di Napoli/Naples/Italie (1 aut., 2 aut., 6 aut.); Istituto di Diagnostica e Cura "Hermitage Capodimonte,"/Naples/Italie (3 aut., 5 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 16; Pp. 2418-2425; Bibl. 61 ref.</SO>
<LA>Anglais</LA>
<EA>The aim of this work was to determine the progression of cognitive impairment in Parkinson's disease (PD) patients with or without hallucinations. Two years after the first assessment, 36 PD patients were re-evaluated on standardized neuropsychological tests, including the Frontal Assessment Battery (FAB), and on rating scales for overall cognitive functioning, functional autonomy, behavioral disorders. Nine patients had hallucinations at baseline and endpoint assessments; 12 patients developed hallucinations during the follow-up; and 15 patients were hallucination-free throughout the study. Cognitive performance significantly declined in all three groups, but at endpoint assessment PD hallucinators scored significantly lower than nonhallucinators on phonological and semantic fluency tasks, immediate free recall and the go/no-go FAB subtest; moreover, they showed more severe apathy than nonhallucinators. Reduced phonological fluency at baseline (odds ratio [OR], 13.5; 95% CI: 1.34-135.98, P = 0.027) was the only independent predictor of onset of hallucinations after 2 years, whereas hallucinations (OR, 10.1; 95% CI: 1.94-51.54, P = 0.006) and poor phonological fluency (OR, 6.1; 95% CI: 1.04-35.03, P = 0.045) independently predicted development of diffuse cognitive impairment. We concluded that reduced verbal fluency scores may predict the onset of hallucinations, while hallucinations and poor phonological fluency may predict development of dementia in PD patients.</EA>
<CC>002B17</CC>
<FD>Hallucination; Maladie de Parkinson; Démence; Pathologie du système nerveux; Homme; Frontal; Trouble fonctionnel</FD>
<FG>Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du   système nerveux central</FG>
<ED>Hallucination; Parkinson disease; Dementia; Nervous system diseases; Human; Frontal; Dysfunction</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Alucinación; Parkinson enfermedad; Demencia; Sistema nervioso patología; Hombre; Frontal; Trastorno funcional</SD>
<LO>INIST-20953.354000162715700180</LO>
<ID>08-0146971</ID>
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	Movement Disorders (revue)
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Movement Disorders (revue)

A Neuropsychological Longitudinal Study in Parkinson's Patients With and Without Hallucinations

A Neuropsychological Longitudinal Study in Parkinson's Patients With and Without Hallucinations

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