MovDisordV3, PascalFrancis, Corpus, bibRecord, 001297

Cortical Excitability is Abnormal in Patients with the "Fixed Dystonia" Syndrome

Identifieur interne : 001297 ( PascalFrancis/Corpus ); précédent : 001296; suivant : 001298

Cortical Excitability is Abnormal in Patients with the "Fixed Dystonia" Syndrome

Auteurs : Laura Avanzino ; Davide Martino ; Bart P. C. Van De Warrenburg ; Susanne A. Schneider ; Giovanni Abbruzzese ; Giovanni Defazio ; Anette Schrag ; Kailash P. Bhatia ; John C. Rothwell

Source :

Movement disorders [ 0885-3185 ] ; 2008.

RBID : Pascal:08-0247710

Descripteurs français

Pascal (Inist)
- Dystonie, Pathologie du système nerveux, Excitabilité, Homme, Cortex moteur.

English descriptors

KwdEn :
- Dystonia, Excitability, Human, Motor cortex, Nervous system diseases.

Abstract

A form of fixed dystonia (FD) without evidence of basal ganglia lesions or neurodegeneration has been recently characterized (Schrag et al., Brain 2004; 127:2360-2372), which may overlap the clinical spectrum of either complex regional pain syndrome or psychogenic dystonia. Transcranial magnetic stimulation studies in typically mobile dystonia revealed abnormal motor cortical excitability and sensori-motor integration. We compared 12 patients with limb FD to 10 patients with primary adult-onset typically mobile dystonia and 11 age-matched healthy volunteers. Measurements at the first digital interosseus representation area on both hemispheres included: short intracortical inhibition (SICI), contralateral silent period (cSP), and short and long afferent inhibition (SAI and LAI). Repeated measure ANOVA and post-hoc t-tests were used for statistical analysis. SICI was significantly reduced in both hemispheres of patients with "typical" and FD, compared to healthy subjects. For both hemispheres, cSP duration was shorter in both fixed and "typical" dystonia patients. SAI and LAI did not significantly differ between the three groups. The abnormal cortical excitability observed in FD might represent an underlying trait predisposing to different clinical forms of dystonia.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A08	`01`	`1`	`ENG`	`@1 Cortical Excitability is Abnormal in Patients with the "Fixed Dystonia" Syndrome`
A11	`01`	`1`		`@1 AVANZINO (Laura)`
A11	`02`	`1`		`@1 MARTINO (Davide)`
A11	`03`	`1`		`@1 VAN DE WARRENBURG (Bart P. C.)`
A11	`04`	`1`		`@1 SCHNEIDER (Susanne A.)`
A11	`05`	`1`		`@1 ABBRUZZESE (Giovanni)`
A11	`06`	`1`		`@1 DEFAZIO (Giovanni)`
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A11	`08`	`1`		`@1 BHATIA (Kailash P.)`
A11	`09`	`1`		`@1 ROTHWELL (John C.)`
A14	`01`			`@1 Sobell Department of Motor Neuroscience, Institute of Neurology, University College London @2 London @3 GBR @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 8 aut. @Z 9 aut.`
A14	`02`			`@1 Department of Neurosciences, Ophthalmology and Genetics, University of Genoa @3 ITA @Z 1 aut. @Z 5 aut.`
A14	`03`			`@1 Department of Neurologic and Psychiatric Sciences, University of Bari @3 ITA @Z 2 aut. @Z 6 aut.`
A14	`04`			`@1 Department of Neurology, Radboud University Nijmegen Medical Centre @2 Nijmegen @3 NLD @Z 3 aut.`
A14	`05`			`@1 Royal Free and University College Medical School, University College London @2 London @3 GBR @Z 7 aut.`
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A21				`@1 2008`
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A43	`01`			`@1 INIST @2 20953 @5 354000173776990030`
A44				`@0 0000 @1 © 2008 INIST-CNRS. All rights reserved.`
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A64	`01`	`1`		`@0 Movement disorders`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 A form of fixed dystonia (FD) without evidence of basal ganglia lesions or neurodegeneration has been recently characterized (Schrag et al., Brain 2004; 127:2360-2372), which may overlap the clinical spectrum of either complex regional pain syndrome or psychogenic dystonia. Transcranial magnetic stimulation studies in typically mobile dystonia revealed abnormal motor cortical excitability and sensori-motor integration. We compared 12 patients with limb FD to 10 patients with primary adult-onset typically mobile dystonia and 11 age-matched healthy volunteers. Measurements at the first digital interosseus representation area on both hemispheres included: short intracortical inhibition (SICI), contralateral silent period (cSP), and short and long afferent inhibition (SAI and LAI). Repeated measure ANOVA and post-hoc t-tests were used for statistical analysis. SICI was significantly reduced in both hemispheres of patients with "typical" and FD, compared to healthy subjects. For both hemispheres, cSP duration was shorter in both fixed and "typical" dystonia patients. SAI and LAI did not significantly differ between the three groups. The abnormal cortical excitability observed in FD might represent an underlying trait predisposing to different clinical forms of dystonia.
C02	`01`	`X`		`@0 002B17`
C02	`02`	`X`		`@0 002B17H`
C03	`01`	`X`	`FRE`	`@0 Dystonie @5 01`
C03	`01`	`X`	`ENG`	`@0 Dystonia @5 01`
C03	`01`	`X`	`SPA`	`@0 Distonía @5 01`
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C03	`03`	`X`	`FRE`	`@0 Excitabilité @5 09`
C03	`03`	`X`	`ENG`	`@0 Excitability @5 09`
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C03	`05`	`X`	`FRE`	`@0 Cortex moteur @5 11`
C03	`05`	`X`	`ENG`	`@0 Motor cortex @5 11`
C03	`05`	`X`	`SPA`	`@0 Corteza motora @5 11`
C07	`01`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 37`
C07	`01`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 37`
C07	`01`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 37`
C07	`02`	`X`	`FRE`	`@0 Mouvement involontaire @5 38`
C07	`02`	`X`	`ENG`	`@0 Involuntary movement @5 38`
C07	`02`	`X`	`SPA`	`@0 Movimiento involuntario @5 38`
C07	`03`	`X`	`FRE`	`@0 Pathologie du muscle strié @5 39`
C07	`03`	`X`	`ENG`	`@0 Striated muscle disease @5 39`
C07	`03`	`X`	`SPA`	`@0 Músculo estriado patología @5 39`
C07	`04`	`X`	`FRE`	`@0 Trouble neurologique @5 41`
C07	`04`	`X`	`ENG`	`@0 Neurological disorder @5 41`
C07	`04`	`X`	`SPA`	`@0 Trastorno neurológico @5 41`
C07	`05`	`X`	`FRE`	`@0 Encéphale @5 42`
C07	`05`	`X`	`ENG`	`@0 Encephalon @5 42`
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C07	`06`	`X`	`FRE`	`@0 Système nerveux central @5 43`
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C07	`06`	`X`	`SPA`	`@0 Sistema nervioso central @5 43`
C07	`07`	`X`	`FRE`	`@0 Voie motrice @5 44`
C07	`07`	`X`	`ENG`	`@0 Motor pathway @5 44`
C07	`07`	`X`	`SPA`	`@0 Vía motora @5 44`
C07	`08`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 45`
C07	`08`	`X`	`ENG`	`@0 Cerebral disorder @5 45`
C07	`08`	`X`	`SPA`	`@0 Encéfalo patología @5 45`
C07	`09`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 46`
C07	`09`	`X`	`ENG`	`@0 Central nervous system disease @5 46`
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N21				`@1 162`
N44	`01`			`@1 OTO`
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Format Inist (serveur)

NO :	PASCAL 08-0247710 INIST
ET :	Cortical Excitability is Abnormal in Patients with the "Fixed Dystonia" Syndrome
AU :	AVANZINO (Laura); MARTINO (Davide); VAN DE WARRENBURG (Bart P. C.); SCHNEIDER (Susanne A.); ABBRUZZESE (Giovanni); DEFAZIO (Giovanni); SCHRAG (Anette); BHATIA (Kailash P.); ROTHWELL (John C.)
AF :	Sobell Department of Motor Neuroscience, Institute of Neurology, University College London/London/Royaume-Uni (1 aut., 2 aut., 3 aut., 4 aut., 8 aut., 9 aut.); Department of Neurosciences, Ophthalmology and Genetics, University of Genoa/Italie (1 aut., 5 aut.); Department of Neurologic and Psychiatric Sciences, University of Bari/Italie (2 aut., 6 aut.); Department of Neurology, Radboud University Nijmegen Medical Centre/Nijmegen/Pays-Bas (3 aut.); Royal Free and University College Medical School, University College London/London/Royaume-Uni (7 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. 5; Pp. 646-652; Bibl. 31 ref.
LA :	Anglais
EA :	A form of fixed dystonia (FD) without evidence of basal ganglia lesions or neurodegeneration has been recently characterized (Schrag et al., Brain 2004; 127:2360-2372), which may overlap the clinical spectrum of either complex regional pain syndrome or psychogenic dystonia. Transcranial magnetic stimulation studies in typically mobile dystonia revealed abnormal motor cortical excitability and sensori-motor integration. We compared 12 patients with limb FD to 10 patients with primary adult-onset typically mobile dystonia and 11 age-matched healthy volunteers. Measurements at the first digital interosseus representation area on both hemispheres included: short intracortical inhibition (SICI), contralateral silent period (cSP), and short and long afferent inhibition (SAI and LAI). Repeated measure ANOVA and post-hoc t-tests were used for statistical analysis. SICI was significantly reduced in both hemispheres of patients with "typical" and FD, compared to healthy subjects. For both hemispheres, cSP duration was shorter in both fixed and "typical" dystonia patients. SAI and LAI did not significantly differ between the three groups. The abnormal cortical excitability observed in FD might represent an underlying trait predisposing to different clinical forms of dystonia.
CC :	002B17; 002B17H
FD :	Dystonie; Pathologie du système nerveux; Excitabilité; Homme; Cortex moteur
FG :	Syndrome extrapyramidal; Mouvement involontaire; Pathologie du muscle strié; Trouble neurologique; Encéphale; Système nerveux central; Voie motrice; Pathologie de l'encéphale; Pathologie du système nerveux central
ED :	Dystonia; Nervous system diseases; Excitability; Human; Motor cortex
EG :	Extrapyramidal syndrome; Involuntary movement; Striated muscle disease; Neurological disorder; Encephalon; Central nervous system; Motor pathway; Cerebral disorder; Central nervous system disease
SD :	Distonía; Sistema nervioso patología; Excitabilidad; Hombre; Corteza motora
LO :	INIST-20953.354000173776990030
ID :	08-0247710

Links to Exploration step

Pascal:08-0247710

Le document en format XML

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<author><name sortKey="Van De Warrenburg, Bart P C" sort="Van De Warrenburg, Bart P C" uniqKey="Van De Warrenburg B" first="Bart P. C." last="Van De Warrenburg">Bart P. C. Van De Warrenburg</name>
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<author><name sortKey="Schrag, Anette" sort="Schrag, Anette" uniqKey="Schrag A" first="Anette" last="Schrag">Anette Schrag</name>
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<author><name sortKey="Bhatia, Kailash P" sort="Bhatia, Kailash P" uniqKey="Bhatia K" first="Kailash P." last="Bhatia">Kailash P. Bhatia</name>
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<author><name sortKey="Rothwell, John C" sort="Rothwell, John C" uniqKey="Rothwell J" first="John C." last="Rothwell">John C. Rothwell</name>
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<series><title level="j" type="main">Movement disorders</title>
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<seriesStmt><title level="j" type="main">Movement disorders</title>
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<term>Excitability</term>
<term>Human</term>
<term>Motor cortex</term>
<term>Nervous system diseases</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Dystonie</term>
<term>Pathologie du   système nerveux</term>
<term>Excitabilité</term>
<term>Homme</term>
<term>Cortex moteur</term>
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<front><div type="abstract" xml:lang="en">A form of fixed dystonia (FD) without evidence of basal ganglia lesions or neurodegeneration has been recently characterized (Schrag et al., Brain 2004; 127:2360-2372), which may overlap the clinical spectrum of either complex regional pain syndrome or psychogenic dystonia. Transcranial magnetic stimulation studies in typically mobile dystonia revealed abnormal motor cortical excitability and sensori-motor integration. We compared 12 patients with limb FD to 10 patients with primary adult-onset typically mobile dystonia and 11 age-matched healthy volunteers. Measurements at the first digital interosseus representation area on both hemispheres included: short intracortical inhibition (SICI), contralateral silent period (cSP), and short and long afferent inhibition (SAI and LAI). Repeated measure ANOVA and post-hoc t-tests were used for statistical analysis. SICI was significantly reduced in both hemispheres of patients with "typical" and FD, compared to healthy subjects. For both hemispheres, cSP duration was shorter in both fixed and "typical" dystonia patients. SAI and LAI did not significantly differ between the three groups. The abnormal cortical excitability observed in FD might represent an underlying trait predisposing to different clinical forms of dystonia.</div>
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<fA11 i1="08" i2="1"><s1>BHATIA (Kailash P.)</s1>
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<fA11 i1="09" i2="1"><s1>ROTHWELL (John C.)</s1>
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<fA14 i1="01"><s1>Sobell Department of Motor Neuroscience, Institute of Neurology, University College London</s1>
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<sZ>1 aut.</sZ>
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<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
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<fA14 i1="03"><s1>Department of Neurologic and Psychiatric Sciences, University of Bari</s1>
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<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Department of Neurology, Radboud University Nijmegen Medical Centre</s1>
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<s3>NLD</s3>
<sZ>3 aut.</sZ>
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<fA14 i1="05"><s1>Royal Free and University College Medical School, University College London</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>7 aut.</sZ>
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<s5>10</s5>
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<s5>10</s5>
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<fC03 i1="05" i2="X" l="FRE"><s0>Cortex moteur</s0>
<s5>11</s5>
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<s5>43</s5>
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<fC07 i1="07" i2="X" l="FRE"><s0>Voie motrice</s0>
<s5>44</s5>
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<fC07 i1="07" i2="X" l="ENG"><s0>Motor pathway</s0>
<s5>44</s5>
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<fC07 i1="07" i2="X" l="SPA"><s0>Vía motora</s0>
<s5>44</s5>
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<fC07 i1="08" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0>
<s5>45</s5>
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<fC07 i1="08" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>45</s5>
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<fC07 i1="08" i2="X" l="SPA"><s0>Encéfalo patología</s0>
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<server><NO>PASCAL 08-0247710 INIST</NO>
<ET>Cortical Excitability is Abnormal in Patients with the "Fixed Dystonia" Syndrome</ET>
<AU>AVANZINO (Laura); MARTINO (Davide); VAN DE WARRENBURG (Bart P. C.); SCHNEIDER (Susanne A.); ABBRUZZESE (Giovanni); DEFAZIO (Giovanni); SCHRAG (Anette); BHATIA (Kailash P.); ROTHWELL (John C.)</AU>
<AF>Sobell Department of Motor Neuroscience, Institute of Neurology, University College London/London/Royaume-Uni (1 aut., 2 aut., 3 aut., 4 aut., 8 aut., 9 aut.); Department of Neurosciences, Ophthalmology and Genetics, University of Genoa/Italie (1 aut., 5 aut.); Department of Neurologic and Psychiatric Sciences, University of Bari/Italie (2 aut., 6 aut.); Department of Neurology, Radboud University Nijmegen Medical Centre/Nijmegen/Pays-Bas (3 aut.); Royal Free and University College Medical School, University College London/London/Royaume-Uni (7 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. 5; Pp. 646-652; Bibl. 31 ref.</SO>
<LA>Anglais</LA>
<EA>A form of fixed dystonia (FD) without evidence of basal ganglia lesions or neurodegeneration has been recently characterized (Schrag et al., Brain 2004; 127:2360-2372), which may overlap the clinical spectrum of either complex regional pain syndrome or psychogenic dystonia. Transcranial magnetic stimulation studies in typically mobile dystonia revealed abnormal motor cortical excitability and sensori-motor integration. We compared 12 patients with limb FD to 10 patients with primary adult-onset typically mobile dystonia and 11 age-matched healthy volunteers. Measurements at the first digital interosseus representation area on both hemispheres included: short intracortical inhibition (SICI), contralateral silent period (cSP), and short and long afferent inhibition (SAI and LAI). Repeated measure ANOVA and post-hoc t-tests were used for statistical analysis. SICI was significantly reduced in both hemispheres of patients with "typical" and FD, compared to healthy subjects. For both hemispheres, cSP duration was shorter in both fixed and "typical" dystonia patients. SAI and LAI did not significantly differ between the three groups. The abnormal cortical excitability observed in FD might represent an underlying trait predisposing to different clinical forms of dystonia.</EA>
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<FD>Dystonie; Pathologie du   système nerveux; Excitabilité; Homme; Cortex moteur</FD>
<FG>Syndrome extrapyramidal; Mouvement involontaire; Pathologie du muscle strié; Trouble neurologique; Encéphale; Système nerveux central; Voie motrice; Pathologie de l'encéphale; Pathologie du   système nerveux central</FG>
<ED>Dystonia; Nervous system diseases; Excitability; Human; Motor cortex</ED>
<EG>Extrapyramidal syndrome; Involuntary movement; Striated muscle disease; Neurological disorder; Encephalon; Central nervous system; Motor pathway; Cerebral disorder; Central nervous system disease</EG>
<SD>Distonía; Sistema nervioso patología; Excitabilidad; Hombre; Corteza motora</SD>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Cortical Excitability is Abnormal in Patients with the "Fixed Dystonia" Syndrome

Cortical Excitability is Abnormal in Patients with the "Fixed Dystonia" Syndrome

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