MovDisordV3, PascalFrancis, Corpus, bibRecord, 001197

GPi-DBS in Huntington's Disease : Results on Motor Function and Cognition in a 72-Year-Old Case

Identifieur interne : 001197 ( PascalFrancis/Corpus ); précédent : 001196; suivant : 001198

GPi-DBS in Huntington's Disease : Results on Motor Function and Cognition in a 72-Year-Old Case

Auteurs : Alfonso Fasano ; Paolo Mazzone ; Carla Piano ; Davide Quaranta ; Francesco Soleti ; Anna Rita Bentivoglio

Source :

Movement disorders [ 0885-3185 ] ; 2008.

RBID : Pascal:08-0396186

Descripteurs français

Pascal (Inist)
- Chorée de Huntington, Pathologie du système nerveux, Cognition, Chirurgie, Traitement, Stimulation cérébrale profonde.

English descriptors

KwdEn :
- Cognition, Deep brain stimulation, Huntington disease, Nervous system diseases, Surgery, Treatment.

Abstract

Huntington's disease (HD) produces debilitating motor abnormalities that are poorly responsive to medical therapy. Deep brain stimulation (DBS) of the posteroventral globus pallidus internus (GPi) may offer a treatment option for patients with diskinetic phenotype and minimal cognitive impairment, but its role in the management of HD remains unclear and to date only two cases have been reported. We report the outcome of GPi-DBS in a 72-year-old man with HD. Stimulation at 130 Hz caused a rapid amelioration of chorea producing the worsening of bradykinesia, whereas 40 Hz stimulation (maintaining constant the total electrical energy delivered) improved chorea while preserving the ability to walk. At 1-year follow-up, chorea has completely disappeared; however, the patient was unable to stand and walk. The cognitive profile showed a progressive deterioration, with an extension of deficit from the mainly dysexecutive alterations at baseline to a more diffused cognitive deterioration.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 0885-3185`
A03		`1`		`@0 Mov. disord.`
A05				`@2 23`
A06				`@2 9`
A08	`01`	`1`	`ENG`	`@1 GPi-DBS in Huntington's Disease : Results on Motor Function and Cognition in a 72-Year-Old Case`
A11	`01`	`1`		`@1 FASANO (Alfonso)`
A11	`02`	`1`		`@1 MAZZONE (Paolo)`
A11	`03`	`1`		`@1 PIANO (Carla)`
A11	`04`	`1`		`@1 QUARANTA (Davide)`
A11	`05`	`1`		`@1 SOLETI (Francesco)`
A11	`06`	`1`		`@1 BENTIVOGLIO (Anna Rita)`
A14	`01`			`@1 Istituto di Neurologia, Universitd Cattolica del Sacro Cuore @2 Roma @3 ITA @Z 1 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut.`
A14	`02`			`@1 Neurochirurgia Funzionale e Stereotassica, CTO "Alesini" @2 Roma @3 ITA @Z 2 aut.`
A20				`@1 1289-1293`
A21				`@1 2008`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 20953 @5 354000196264160150`
A44				`@0 0000 @1 © 2008 INIST-CNRS. All rights reserved.`
A45				`@0 15 ref.`
A47	`01`	`1`		`@0 08-0396186`
A60				`@1 P @3 CC`
A61				`@0 A`
A64	`01`	`1`		`@0 Movement disorders`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 Huntington's disease (HD) produces debilitating motor abnormalities that are poorly responsive to medical therapy. Deep brain stimulation (DBS) of the posteroventral globus pallidus internus (GPi) may offer a treatment option for patients with diskinetic phenotype and minimal cognitive impairment, but its role in the management of HD remains unclear and to date only two cases have been reported. We report the outcome of GPi-DBS in a 72-year-old man with HD. Stimulation at 130 Hz caused a rapid amelioration of chorea producing the worsening of bradykinesia, whereas 40 Hz stimulation (maintaining constant the total electrical energy delivered) improved chorea while preserving the ability to walk. At 1-year follow-up, chorea has completely disappeared; however, the patient was unable to stand and walk. The cognitive profile showed a progressive deterioration, with an extension of deficit from the mainly dysexecutive alterations at baseline to a more diffused cognitive deterioration.
C02	`01`	`X`		`@0 002B17`
C02	`02`	`X`		`@0 002B17G`
C03	`01`	`X`	`FRE`	`@0 Chorée de Huntington @5 01`
C03	`01`	`X`	`ENG`	`@0 Huntington disease @5 01`
C03	`01`	`X`	`SPA`	`@0 Corea Huntington @5 01`
C03	`02`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 02`
C03	`02`	`X`	`ENG`	`@0 Nervous system diseases @5 02`
C03	`02`	`X`	`SPA`	`@0 Sistema nervioso patología @5 02`
C03	`03`	`X`	`FRE`	`@0 Cognition @5 09`
C03	`03`	`X`	`ENG`	`@0 Cognition @5 09`
C03	`03`	`X`	`SPA`	`@0 Cognición @5 09`
C03	`04`	`X`	`FRE`	`@0 Chirurgie @5 10`
C03	`04`	`X`	`ENG`	`@0 Surgery @5 10`
C03	`04`	`X`	`SPA`	`@0 Cirugía @5 10`
C03	`05`	`X`	`FRE`	`@0 Traitement @5 11`
C03	`05`	`X`	`ENG`	`@0 Treatment @5 11`
C03	`05`	`X`	`SPA`	`@0 Tratamiento @5 11`
C03	`06`	`X`	`FRE`	`@0 Stimulation cérébrale profonde @4 CD @5 96`
C03	`06`	`X`	`ENG`	`@0 Deep brain stimulation @4 CD @5 96`
C07	`01`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 37`
C07	`01`	`X`	`ENG`	`@0 Cerebral disorder @5 37`
C07	`01`	`X`	`SPA`	`@0 Encéfalo patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 38`
C07	`02`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 38`
C07	`02`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 38`
C07	`03`	`X`	`FRE`	`@0 Maladie dégénérative @5 39`
C07	`03`	`X`	`ENG`	`@0 Degenerative disease @5 39`
C07	`03`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 39`
C07	`04`	`X`	`FRE`	`@0 Maladie héréditaire @5 40`
C07	`04`	`X`	`ENG`	`@0 Genetic disease @5 40`
C07	`04`	`X`	`SPA`	`@0 Enfermedad hereditaria @5 40`
C07	`05`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 41`
C07	`05`	`X`	`ENG`	`@0 Central nervous system disease @5 41`
C07	`05`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 41`
N21				`@1 259`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 08-0396186 INIST
ET :	GPi-DBS in Huntington's Disease : Results on Motor Function and Cognition in a 72-Year-Old Case
AU :	FASANO (Alfonso); MAZZONE (Paolo); PIANO (Carla); QUARANTA (Davide); SOLETI (Francesco); BENTIVOGLIO (Anna Rita)
AF :	Istituto di Neurologia, Universitd Cattolica del Sacro Cuore/Roma/Italie (1 aut., 3 aut., 4 aut., 5 aut., 6 aut.); Neurochirurgia Funzionale e Stereotassica, CTO "Alesini"/Roma/Italie (2 aut.)
DT :	Publication en série; Courte communication, note brève; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. 9; Pp. 1289-1293; Bibl. 15 ref.
LA :	Anglais
EA :	Huntington's disease (HD) produces debilitating motor abnormalities that are poorly responsive to medical therapy. Deep brain stimulation (DBS) of the posteroventral globus pallidus internus (GPi) may offer a treatment option for patients with diskinetic phenotype and minimal cognitive impairment, but its role in the management of HD remains unclear and to date only two cases have been reported. We report the outcome of GPi-DBS in a 72-year-old man with HD. Stimulation at 130 Hz caused a rapid amelioration of chorea producing the worsening of bradykinesia, whereas 40 Hz stimulation (maintaining constant the total electrical energy delivered) improved chorea while preserving the ability to walk. At 1-year follow-up, chorea has completely disappeared; however, the patient was unable to stand and walk. The cognitive profile showed a progressive deterioration, with an extension of deficit from the mainly dysexecutive alterations at baseline to a more diffused cognitive deterioration.
CC :	002B17; 002B17G
FD :	Chorée de Huntington; Pathologie du système nerveux; Cognition; Chirurgie; Traitement; Stimulation cérébrale profonde
FG :	Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Maladie héréditaire; Pathologie du système nerveux central
ED :	Huntington disease; Nervous system diseases; Cognition; Surgery; Treatment; Deep brain stimulation
EG :	Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Genetic disease; Central nervous system disease
SD :	Corea Huntington; Sistema nervioso patología; Cognición; Cirugía; Tratamiento
LO :	INIST-20953.354000196264160150
ID :	08-0396186

Links to Exploration step

Pascal:08-0396186

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">GPi-DBS in Huntington's Disease : Results on Motor Function and Cognition in a 72-Year-Old Case</title>
<author><name sortKey="Fasano, Alfonso" sort="Fasano, Alfonso" uniqKey="Fasano A" first="Alfonso" last="Fasano">Alfonso Fasano</name>
<affiliation><inist:fA14 i1="01"><s1>Istituto di Neurologia, Universitd Cattolica del Sacro Cuore</s1>
<s2>Roma</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Mazzone, Paolo" sort="Mazzone, Paolo" uniqKey="Mazzone P" first="Paolo" last="Mazzone">Paolo Mazzone</name>
<affiliation><inist:fA14 i1="02"><s1>Neurochirurgia Funzionale e Stereotassica, CTO "Alesini"</s1>
<s2>Roma</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Piano, Carla" sort="Piano, Carla" uniqKey="Piano C" first="Carla" last="Piano">Carla Piano</name>
<affiliation><inist:fA14 i1="01"><s1>Istituto di Neurologia, Universitd Cattolica del Sacro Cuore</s1>
<s2>Roma</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Quaranta, Davide" sort="Quaranta, Davide" uniqKey="Quaranta D" first="Davide" last="Quaranta">Davide Quaranta</name>
<affiliation><inist:fA14 i1="01"><s1>Istituto di Neurologia, Universitd Cattolica del Sacro Cuore</s1>
<s2>Roma</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Soleti, Francesco" sort="Soleti, Francesco" uniqKey="Soleti F" first="Francesco" last="Soleti">Francesco Soleti</name>
<affiliation><inist:fA14 i1="01"><s1>Istituto di Neurologia, Universitd Cattolica del Sacro Cuore</s1>
<s2>Roma</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name>
<affiliation><inist:fA14 i1="01"><s1>Istituto di Neurologia, Universitd Cattolica del Sacro Cuore</s1>
<s2>Roma</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">08-0396186</idno>
<date when="2008">2008</date>
<idno type="stanalyst">PASCAL 08-0396186 INIST</idno>
<idno type="RBID">Pascal:08-0396186</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001197</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">GPi-DBS in Huntington's Disease : Results on Motor Function and Cognition in a 72-Year-Old Case</title>
<author><name sortKey="Fasano, Alfonso" sort="Fasano, Alfonso" uniqKey="Fasano A" first="Alfonso" last="Fasano">Alfonso Fasano</name>
<affiliation><inist:fA14 i1="01"><s1>Istituto di Neurologia, Universitd Cattolica del Sacro Cuore</s1>
<s2>Roma</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Mazzone, Paolo" sort="Mazzone, Paolo" uniqKey="Mazzone P" first="Paolo" last="Mazzone">Paolo Mazzone</name>
<affiliation><inist:fA14 i1="02"><s1>Neurochirurgia Funzionale e Stereotassica, CTO "Alesini"</s1>
<s2>Roma</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Piano, Carla" sort="Piano, Carla" uniqKey="Piano C" first="Carla" last="Piano">Carla Piano</name>
<affiliation><inist:fA14 i1="01"><s1>Istituto di Neurologia, Universitd Cattolica del Sacro Cuore</s1>
<s2>Roma</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Quaranta, Davide" sort="Quaranta, Davide" uniqKey="Quaranta D" first="Davide" last="Quaranta">Davide Quaranta</name>
<affiliation><inist:fA14 i1="01"><s1>Istituto di Neurologia, Universitd Cattolica del Sacro Cuore</s1>
<s2>Roma</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Soleti, Francesco" sort="Soleti, Francesco" uniqKey="Soleti F" first="Francesco" last="Soleti">Francesco Soleti</name>
<affiliation><inist:fA14 i1="01"><s1>Istituto di Neurologia, Universitd Cattolica del Sacro Cuore</s1>
<s2>Roma</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name>
<affiliation><inist:fA14 i1="01"><s1>Istituto di Neurologia, Universitd Cattolica del Sacro Cuore</s1>
<s2>Roma</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cognition</term>
<term>Deep brain stimulation</term>
<term>Huntington disease</term>
<term>Nervous system diseases</term>
<term>Surgery</term>
<term>Treatment</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Chorée de Huntington</term>
<term>Pathologie du   système nerveux</term>
<term>Cognition</term>
<term>Chirurgie</term>
<term>Traitement</term>
<term>Stimulation cérébrale profonde</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Huntington's disease (HD) produces debilitating motor abnormalities that are poorly responsive to medical therapy. Deep brain stimulation (DBS) of the posteroventral globus pallidus internus (GPi) may offer a treatment option for patients with diskinetic phenotype and minimal cognitive impairment, but its role in the management of HD remains unclear and to date only two cases have been reported. We report the outcome of GPi-DBS in a 72-year-old man with HD. Stimulation at 130 Hz caused a rapid amelioration of chorea producing the worsening of bradykinesia, whereas 40 Hz stimulation (maintaining constant the total electrical energy delivered) improved chorea while preserving the ability to walk. At 1-year follow-up, chorea has completely disappeared; however, the patient was unable to stand and walk. The cognitive profile showed a progressive deterioration, with an extension of deficit from the mainly dysexecutive alterations at baseline to a more diffused cognitive deterioration.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0>
</fA01>
<fA03 i2="1"><s0>Mov. disord.</s0>
</fA03>
<fA05><s2>23</s2>
</fA05>
<fA06><s2>9</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>GPi-DBS in Huntington's Disease : Results on Motor Function and Cognition in a 72-Year-Old Case</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>FASANO (Alfonso)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>MAZZONE (Paolo)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>PIANO (Carla)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>QUARANTA (Davide)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>SOLETI (Francesco)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>BENTIVOGLIO (Anna Rita)</s1>
</fA11>
<fA14 i1="01"><s1>Istituto di Neurologia, Universitd Cattolica del Sacro Cuore</s1>
<s2>Roma</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Neurochirurgia Funzionale e Stereotassica, CTO "Alesini"</s1>
<s2>Roma</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
</fA14>
<fA20><s1>1289-1293</s1>
</fA20>
<fA21><s1>2008</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>20953</s2>
<s5>354000196264160150</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2008 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>15 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>08-0396186</s0>
</fA47>
<fA60><s1>P</s1>
<s3>CC</s3>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Movement disorders</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Huntington's disease (HD) produces debilitating motor abnormalities that are poorly responsive to medical therapy. Deep brain stimulation (DBS) of the posteroventral globus pallidus internus (GPi) may offer a treatment option for patients with diskinetic phenotype and minimal cognitive impairment, but its role in the management of HD remains unclear and to date only two cases have been reported. We report the outcome of GPi-DBS in a 72-year-old man with HD. Stimulation at 130 Hz caused a rapid amelioration of chorea producing the worsening of bradykinesia, whereas 40 Hz stimulation (maintaining constant the total electrical energy delivered) improved chorea while preserving the ability to walk. At 1-year follow-up, chorea has completely disappeared; however, the patient was unable to stand and walk. The cognitive profile showed a progressive deterioration, with an extension of deficit from the mainly dysexecutive alterations at baseline to a more diffused cognitive deterioration.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B17</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B17G</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Chorée de Huntington</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Huntington disease</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Corea Huntington</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Pathologie du   système nerveux</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Cognition</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Cognition</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Cognición</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Chirurgie</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Surgery</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Cirugía</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Traitement</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Treatment</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Tratamiento</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Stimulation cérébrale profonde</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Deep brain stimulation</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Maladie héréditaire</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Genetic disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Enfermedad hereditaria</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Pathologie du   système nerveux central</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>41</s5>
</fC07>
<fN21><s1>259</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 08-0396186 INIST</NO>
<ET>GPi-DBS in Huntington's Disease : Results on Motor Function and Cognition in a 72-Year-Old Case</ET>
<AU>FASANO (Alfonso); MAZZONE (Paolo); PIANO (Carla); QUARANTA (Davide); SOLETI (Francesco); BENTIVOGLIO (Anna Rita)</AU>
<AF>Istituto di Neurologia, Universitd Cattolica del Sacro Cuore/Roma/Italie (1 aut., 3 aut., 4 aut., 5 aut., 6 aut.); Neurochirurgia Funzionale e Stereotassica, CTO "Alesini"/Roma/Italie (2 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. 9; Pp. 1289-1293; Bibl. 15 ref.</SO>
<LA>Anglais</LA>
<EA>Huntington's disease (HD) produces debilitating motor abnormalities that are poorly responsive to medical therapy. Deep brain stimulation (DBS) of the posteroventral globus pallidus internus (GPi) may offer a treatment option for patients with diskinetic phenotype and minimal cognitive impairment, but its role in the management of HD remains unclear and to date only two cases have been reported. We report the outcome of GPi-DBS in a 72-year-old man with HD. Stimulation at 130 Hz caused a rapid amelioration of chorea producing the worsening of bradykinesia, whereas 40 Hz stimulation (maintaining constant the total electrical energy delivered) improved chorea while preserving the ability to walk. At 1-year follow-up, chorea has completely disappeared; however, the patient was unable to stand and walk. The cognitive profile showed a progressive deterioration, with an extension of deficit from the mainly dysexecutive alterations at baseline to a more diffused cognitive deterioration.</EA>
<CC>002B17; 002B17G</CC>
<FD>Chorée de Huntington; Pathologie du   système nerveux; Cognition; Chirurgie; Traitement; Stimulation cérébrale profonde</FD>
<FG>Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Maladie héréditaire; Pathologie du   système nerveux central</FG>
<ED>Huntington disease; Nervous system diseases; Cognition; Surgery; Treatment; Deep brain stimulation</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Genetic disease; Central nervous system disease</EG>
<SD>Corea Huntington; Sistema nervioso patología; Cognición; Cirugía; Tratamiento</SD>
<LO>INIST-20953.354000196264160150</LO>
<ID>08-0396186</ID>
</server>
</inist>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/PascalFrancis/Corpus

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001197 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Corpus/biblio.hfd -nk 001197 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    PascalFrancis
   |étape=   Corpus
   |type=    RBID
   |clé=     Pascal:08-0396186
   |texte=   GPi-DBS in Huntington's Disease : Results on Motor Function and Cognition in a 72-Year-Old Case
}}

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Movement Disorders (revue)

GPi-DBS in Huntington's Disease : Results on Motor Function and Cognition in a 72-Year-Old Case

GPi-DBS in Huntington's Disease : Results on Motor Function and Cognition in a 72-Year-Old Case

Source :

Descripteurs français

English descriptors

Abstract

Notice en format standard (ISO 2709)

Format Inist (serveur)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri