MovDisordV3, PascalFrancis, Corpus, bibRecord, 001196

Deep Brain Stimulation in Parkinson's Disease Following Fetal Nigral Transplantation

Identifieur interne : 001196 ( PascalFrancis/Corpus ); précédent : 001195; suivant : 001197

Deep Brain Stimulation in Parkinson's Disease Following Fetal Nigral Transplantation

Auteurs : Jan Herzog ; Oliver Pogarell ; Marcus O. Pinsker ; Andreas Kupsch ; Wolfgang H. Oertel ; Olle Lindvall ; Günther Deuschl ; Jens Volkmann

Source :

Movement disorders [ 0885-3185 ] ; 2008.

RBID : Pascal:08-0396188

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Dyskinésie, Pathologie du système nerveux, Transplantation, Stimulation cérébrale profonde.

English descriptors

KwdEn :
- Deep brain stimulation, Dyskinesia, Nervous system diseases, Parkinson disease, Transplantation.

Abstract

OFF-period dyskinesias have been reported as a consequence of fetal nigral transplantation for Parkinson disease. This type of dyskinesias may appear in patients even in the prolonged absence of antiparkinson medication and be aggravated by levodopa. Therefore, pharmacological therapeutic approaches in these patients are limited. Here we report two patients with bilateral fetal nigral grafts in the caudate and putamen subjected to deep brain stimulation (DBS) of the globus pallidus internus (GPi) or subthalamic nucleus (STN). Clinical assessment was performed according to UPDRS and the clinical dyskinesia rating scale. In both patients, we found significant improvement in OFF-period symptoms as well as levodopa-induced dyskinesias. However, only GPi-DBS led to a significant reduction of OFF-period dyskinesias whereas STN-DBS did not influence dyskinesias unrelated to external dopaminergic application. These findings, based on two case reports, highlight the pivotal role of the GPi in mediating dyskinesia-related neural activity within the basal ganglia loop.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A03		`1`		`@0 Mov. disord.`
A05				`@2 23`
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A08	`01`	`1`	`ENG`	`@1 Deep Brain Stimulation in Parkinson's Disease Following Fetal Nigral Transplantation`
A11	`01`	`1`		`@1 HERZOG (Jan)`
A11	`02`	`1`		`@1 POGARELL (Oliver)`
A11	`03`	`1`		`@1 PINSKER (Marcus O.)`
A11	`04`	`1`		`@1 KUPSCH (Andreas)`
A11	`05`	`1`		`@1 OERTEL (Wolfgang H.)`
A11	`06`	`1`		`@1 LINDVALL (Olle)`
A11	`07`	`1`		`@1 DEUSCHL (Günther)`
A11	`08`	`1`		`@1 VOLKMANN (Jens)`
A14	`01`			`@1 Department of Neurology, Christian-Albrechts-University @2 Kiel @3 DEU @Z 1 aut. @Z 7 aut. @Z 8 aut.`
A14	`02`			`@1 Department of Psychiatry, Ludwig-Maximilians-University @2 Munich @3 DEU @Z 2 aut.`
A14	`03`			`@1 Department of Neurosurgery, Christian-Albrechts-University @2 Kiel @3 DEU @Z 3 aut.`
A14	`04`			`@1 Department of Neurology, Charité Humboldt University @2 Berlin @3 DEU @Z 4 aut.`
A14	`05`			`@1 Department of Neurology, Philipps-University @2 Marburg @3 DEU @Z 5 aut.`
A14	`06`			`@1 Section of Restorative Neurology, Wallenberg Neuroscience Centre @2 Lund @3 SWE @Z 6 aut.`
A20				`@1 1293-1296`
A21				`@1 2008`
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A44				`@0 0000 @1 © 2008 INIST-CNRS. All rights reserved.`
A45				`@0 15 ref.`
A47	`01`	`1`		`@0 08-0396188`
A60				`@1 P @3 CC`
A61				`@0 A`
A64	`01`	`1`		`@0 Movement disorders`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 OFF-period dyskinesias have been reported as a consequence of fetal nigral transplantation for Parkinson disease. This type of dyskinesias may appear in patients even in the prolonged absence of antiparkinson medication and be aggravated by levodopa. Therefore, pharmacological therapeutic approaches in these patients are limited. Here we report two patients with bilateral fetal nigral grafts in the caudate and putamen subjected to deep brain stimulation (DBS) of the globus pallidus internus (GPi) or subthalamic nucleus (STN). Clinical assessment was performed according to UPDRS and the clinical dyskinesia rating scale. In both patients, we found significant improvement in OFF-period symptoms as well as levodopa-induced dyskinesias. However, only GPi-DBS led to a significant reduction of OFF-period dyskinesias whereas STN-DBS did not influence dyskinesias unrelated to external dopaminergic application. These findings, based on two case reports, highlight the pivotal role of the GPi in mediating dyskinesia-related neural activity within the basal ganglia loop.
C02	`01`	`X`		`@0 002B17`
C02	`02`	`X`		`@0 002B17G`
C03	`01`	`X`	`FRE`	`@0 Maladie de Parkinson @2 NM @5 01`
C03	`01`	`X`	`ENG`	`@0 Parkinson disease @2 NM @5 01`
C03	`01`	`X`	`SPA`	`@0 Parkinson enfermedad @2 NM @5 01`
C03	`02`	`X`	`FRE`	`@0 Dyskinésie @5 02`
C03	`02`	`X`	`ENG`	`@0 Dyskinesia @5 02`
C03	`02`	`X`	`SPA`	`@0 Disquinesia @5 02`
C03	`03`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 03`
C03	`03`	`X`	`ENG`	`@0 Nervous system diseases @5 03`
C03	`03`	`X`	`SPA`	`@0 Sistema nervioso patología @5 03`
C03	`04`	`X`	`FRE`	`@0 Transplantation @5 09`
C03	`04`	`X`	`ENG`	`@0 Transplantation @5 09`
C03	`04`	`X`	`SPA`	`@0 Trasplantación @5 09`
C03	`05`	`X`	`FRE`	`@0 Stimulation cérébrale profonde @4 CD @5 96`
C03	`05`	`X`	`ENG`	`@0 Deep brain stimulation @4 CD @5 96`
C07	`01`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 37`
C07	`01`	`X`	`ENG`	`@0 Cerebral disorder @5 37`
C07	`01`	`X`	`SPA`	`@0 Encéfalo patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 38`
C07	`02`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 38`
C07	`02`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 38`
C07	`03`	`X`	`FRE`	`@0 Maladie dégénérative @5 39`
C07	`03`	`X`	`ENG`	`@0 Degenerative disease @5 39`
C07	`03`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 39`
C07	`04`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 40`
C07	`04`	`X`	`ENG`	`@0 Central nervous system disease @5 40`
C07	`04`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 40`
C07	`05`	`X`	`FRE`	`@0 Mouvement involontaire @5 42`
C07	`05`	`X`	`ENG`	`@0 Involuntary movement @5 42`
C07	`05`	`X`	`SPA`	`@0 Movimiento involuntario @5 42`
C07	`06`	`X`	`FRE`	`@0 Trouble neurologique @5 43`
C07	`06`	`X`	`ENG`	`@0 Neurological disorder @5 43`
C07	`06`	`X`	`SPA`	`@0 Trastorno neurológico @5 43`
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N44	`01`			`@1 OTO`
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Format Inist (serveur)

NO :	PASCAL 08-0396188 INIST
ET :	Deep Brain Stimulation in Parkinson's Disease Following Fetal Nigral Transplantation
AU :	HERZOG (Jan); POGARELL (Oliver); PINSKER (Marcus O.); KUPSCH (Andreas); OERTEL (Wolfgang H.); LINDVALL (Olle); DEUSCHL (Günther); VOLKMANN (Jens)
AF :	Department of Neurology, Christian-Albrechts-University/Kiel/Allemagne (1 aut., 7 aut., 8 aut.); Department of Psychiatry, Ludwig-Maximilians-University/Munich/Allemagne (2 aut.); Department of Neurosurgery, Christian-Albrechts-University/Kiel/Allemagne (3 aut.); Department of Neurology, Charité Humboldt University/Berlin/Allemagne (4 aut.); Department of Neurology, Philipps-University/Marburg/Allemagne (5 aut.); Section of Restorative Neurology, Wallenberg Neuroscience Centre/Lund/Suède (6 aut.)
DT :	Publication en série; Courte communication, note brève; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. 9; Pp. 1293-1296; Bibl. 15 ref.
LA :	Anglais
EA :	OFF-period dyskinesias have been reported as a consequence of fetal nigral transplantation for Parkinson disease. This type of dyskinesias may appear in patients even in the prolonged absence of antiparkinson medication and be aggravated by levodopa. Therefore, pharmacological therapeutic approaches in these patients are limited. Here we report two patients with bilateral fetal nigral grafts in the caudate and putamen subjected to deep brain stimulation (DBS) of the globus pallidus internus (GPi) or subthalamic nucleus (STN). Clinical assessment was performed according to UPDRS and the clinical dyskinesia rating scale. In both patients, we found significant improvement in OFF-period symptoms as well as levodopa-induced dyskinesias. However, only GPi-DBS led to a significant reduction of OFF-period dyskinesias whereas STN-DBS did not influence dyskinesias unrelated to external dopaminergic application. These findings, based on two case reports, highlight the pivotal role of the GPi in mediating dyskinesia-related neural activity within the basal ganglia loop.
CC :	002B17; 002B17G
FD :	Maladie de Parkinson; Dyskinésie; Pathologie du système nerveux; Transplantation; Stimulation cérébrale profonde
FG :	Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central; Mouvement involontaire; Trouble neurologique
ED :	Parkinson disease; Dyskinesia; Nervous system diseases; Transplantation; Deep brain stimulation
EG :	Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Involuntary movement; Neurological disorder
SD :	Parkinson enfermedad; Disquinesia; Sistema nervioso patología; Trasplantación
LO :	INIST-20953.354000196264160160
ID :	08-0396188

Links to Exploration step

Pascal:08-0396188

Le document en format XML

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<front><div type="abstract" xml:lang="en">OFF-period dyskinesias have been reported as a consequence of fetal nigral transplantation for Parkinson disease. This type of dyskinesias may appear in patients even in the prolonged absence of antiparkinson medication and be aggravated by levodopa. Therefore, pharmacological therapeutic approaches in these patients are limited. Here we report two patients with bilateral fetal nigral grafts in the caudate and putamen subjected to deep brain stimulation (DBS) of the globus pallidus internus (GPi) or subthalamic nucleus (STN). Clinical assessment was performed according to UPDRS and the clinical dyskinesia rating scale. In both patients, we found significant improvement in OFF-period symptoms as well as levodopa-induced dyskinesias. However, only GPi-DBS led to a significant reduction of OFF-period dyskinesias whereas STN-DBS did not influence dyskinesias unrelated to external dopaminergic application. These findings, based on two case reports, highlight the pivotal role of the GPi in mediating dyskinesia-related neural activity within the basal ganglia loop.</div>
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<server><NO>PASCAL 08-0396188 INIST</NO>
<ET>Deep Brain Stimulation in Parkinson's Disease Following Fetal Nigral Transplantation</ET>
<AU>HERZOG (Jan); POGARELL (Oliver); PINSKER (Marcus O.); KUPSCH (Andreas); OERTEL (Wolfgang H.); LINDVALL (Olle); DEUSCHL (Günther); VOLKMANN (Jens)</AU>
<AF>Department of Neurology, Christian-Albrechts-University/Kiel/Allemagne (1 aut., 7 aut., 8 aut.); Department of Psychiatry, Ludwig-Maximilians-University/Munich/Allemagne (2 aut.); Department of Neurosurgery, Christian-Albrechts-University/Kiel/Allemagne (3 aut.); Department of Neurology, Charité Humboldt University/Berlin/Allemagne (4 aut.); Department of Neurology, Philipps-University/Marburg/Allemagne (5 aut.); Section of Restorative Neurology, Wallenberg Neuroscience Centre/Lund/Suède (6 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. 9; Pp. 1293-1296; Bibl. 15 ref.</SO>
<LA>Anglais</LA>
<EA>OFF-period dyskinesias have been reported as a consequence of fetal nigral transplantation for Parkinson disease. This type of dyskinesias may appear in patients even in the prolonged absence of antiparkinson medication and be aggravated by levodopa. Therefore, pharmacological therapeutic approaches in these patients are limited. Here we report two patients with bilateral fetal nigral grafts in the caudate and putamen subjected to deep brain stimulation (DBS) of the globus pallidus internus (GPi) or subthalamic nucleus (STN). Clinical assessment was performed according to UPDRS and the clinical dyskinesia rating scale. In both patients, we found significant improvement in OFF-period symptoms as well as levodopa-induced dyskinesias. However, only GPi-DBS led to a significant reduction of OFF-period dyskinesias whereas STN-DBS did not influence dyskinesias unrelated to external dopaminergic application. These findings, based on two case reports, highlight the pivotal role of the GPi in mediating dyskinesia-related neural activity within the basal ganglia loop.</EA>
<CC>002B17; 002B17G</CC>
<FD>Maladie de Parkinson; Dyskinésie; Pathologie du   système nerveux; Transplantation; Stimulation cérébrale profonde</FD>
<FG>Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du   système nerveux central; Mouvement involontaire; Trouble neurologique</FG>
<ED>Parkinson disease; Dyskinesia; Nervous system diseases; Transplantation; Deep brain stimulation</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Involuntary movement; Neurological disorder</EG>
<SD>Parkinson enfermedad; Disquinesia; Sistema nervioso patología; Trasplantación</SD>
<LO>INIST-20953.354000196264160160</LO>
<ID>08-0396188</ID>
</server>
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Movement Disorders (revue)

Deep Brain Stimulation in Parkinson's Disease Following Fetal Nigral Transplantation

Deep Brain Stimulation in Parkinson's Disease Following Fetal Nigral Transplantation

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