The Duration of the Motor Response to Apomorphine Boluses Is Conditioned by the Length of a Prior Infusion in Parkinson's Disease
Identifieur interne : 000F13 ( PascalFrancis/Corpus ); précédent : 000F12; suivant : 000F14The Duration of the Motor Response to Apomorphine Boluses Is Conditioned by the Length of a Prior Infusion in Parkinson's Disease
Auteurs : Julia Vaamonde ; José M. Flores ; Roberto Weisser ; Ramon Ibanez ; José A. ObesoSource :
- Movement disorders [ 0885-3185 ] ; 2009.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
"Pulsatile" administration of levodopa has been invocated a relevant factor for motor fluctuations in Parkinson's disease (PD). We studied dopaminergic sensitivity to apomorphine in 10 parkinsonian patients with motor fluctuations. Patients were tested as follows: the minimal effective dose of apomorphine (MED-1) was administered in the morning to induce an on response. Fifteen minutes after this motor response had disappeared, an apomorphine infusion was initiated and maintained to ensure on periods of three different durations on different days. Infusion lasted for '30, 60 and 90 minutes. Subsequently, the infusion was stopped, and after 15 minutes in the off state, a second bolus of apomorphine (MED-2) was given. The mean infusion doses were 49.2 ± 5.4, 108.4 ± 10.3, and 150 ± 8.2 mg. These elicited on periods of 48.2 ± 4.1, 110 ± 4.5, and 195 ± 3.8 minutes. The MED-2 elicited on responses with a duration of 30 ± 4.5, 18.4 ± 3.2, and 11.2 ± 4.1 minutes. The duration of the on response induced by the apomorphine infusions correlated inversely (P < 0.01) with the on induced by the MED-2 of apomorphine. Our findings indicate that a continuous dopaminergic stimulus may induce pharmacodynamic changes associated with tolerance in PD patients.
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Format Inist (serveur)
NO : | PASCAL 09-0218150 INIST |
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ET : | The Duration of the Motor Response to Apomorphine Boluses Is Conditioned by the Length of a Prior Infusion in Parkinson's Disease |
AU : | VAAMONDE (Julia); FLORES (José M.); WEISSER (Roberto); IBANEZ (Ramon); OBESO (José A.) |
AF : | Department of Neurology, Hospital General/Ciudad Real/Espagne (1 aut., 2 aut., 3 aut., 4 aut., 5 aut.); Department of Neurology, Clinica Universitaria and Medical School, CIMA, University of Navarra/Pamplona/Espagne |
DT : | Publication en série; Courte communication, note brève; Niveau analytique |
SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2009; Vol. 24; No. 5; Pp. 762-765; Bibl. 37 ref. |
LA : | Anglais |
EA : | "Pulsatile" administration of levodopa has been invocated a relevant factor for motor fluctuations in Parkinson's disease (PD). We studied dopaminergic sensitivity to apomorphine in 10 parkinsonian patients with motor fluctuations. Patients were tested as follows: the minimal effective dose of apomorphine (MED-1) was administered in the morning to induce an on response. Fifteen minutes after this motor response had disappeared, an apomorphine infusion was initiated and maintained to ensure on periods of three different durations on different days. Infusion lasted for '30, 60 and 90 minutes. Subsequently, the infusion was stopped, and after 15 minutes in the off state, a second bolus of apomorphine (MED-2) was given. The mean infusion doses were 49.2 ± 5.4, 108.4 ± 10.3, and 150 ± 8.2 mg. These elicited on periods of 48.2 ± 4.1, 110 ± 4.5, and 195 ± 3.8 minutes. The MED-2 elicited on responses with a duration of 30 ± 4.5, 18.4 ± 3.2, and 11.2 ± 4.1 minutes. The duration of the on response induced by the apomorphine infusions correlated inversely (P < 0.01) with the on induced by the MED-2 of apomorphine. Our findings indicate that a continuous dopaminergic stimulus may induce pharmacodynamic changes associated with tolerance in PD patients. |
CC : | 002B17; 002B17G |
FD : | Maladie de Parkinson; Pathologie du système nerveux; Apomorphine; Complication; Tolérance |
FG : | Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central |
ED : | Parkinson disease; Nervous system diseases; Complication; Tolerance |
EG : | Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease |
SD : | Parkinson enfermedad; Sistema nervioso patología; Complicación; Tolerancia |
LO : | INIST-20953.354000186090170200 |
ID : | 09-0218150 |
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Pascal:09-0218150Le document en format XML
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<ET>The Duration of the Motor Response to Apomorphine Boluses Is Conditioned by the Length of a Prior Infusion in Parkinson's Disease</ET>
<AU>VAAMONDE (Julia); FLORES (José M.); WEISSER (Roberto); IBANEZ (Ramon); OBESO (José A.)</AU>
<AF>Department of Neurology, Hospital General/Ciudad Real/Espagne (1 aut., 2 aut., 3 aut., 4 aut., 5 aut.); Department of Neurology, Clinica Universitaria and Medical School, CIMA, University of Navarra/Pamplona/Espagne</AF>
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