MovDisordV3, PascalFrancis, Corpus, bibRecord, 000F14

Serum Cholesterol Levels and the Risk of Multiple System Atrophy : A Case-Control Study

Identifieur interne : 000F14 ( PascalFrancis/Corpus ); précédent : 000F13; suivant : 000F15

Serum Cholesterol Levels and the Risk of Multiple System Atrophy : A Case-Control Study

Auteurs : PHIL HYU LEE ; TAE SUNG LIM ; Hae-Won Shin ; SEOK WOO YONG ; HYO SUK NAM ; Young H. Sohn

Source :

Movement disorders [ 0885-3185 ] ; 2009.

RBID : Pascal:09-0218148

Descripteurs français

Pascal (Inist)
- Atrophie multisystématisée, Pathologie du système nerveux, Cholestérol, Facteur risque, Etude cas témoin.

English descriptors

KwdEn :
- Case control study, Cholesterol, Multiple system atrophy, Nervous system diseases, Risk factor.

Abstract

Cholesterol in brain membranes may modulate the conformational state and accumulation of α-synuclein in α-synucleinopathies. We examined the association between serum cholesterol and the risk of multiple system atrophy (MSA), one of the α-synucleinopathies. We enrolled 142 patients with probable MSA from two tertiary referral hospitals and 155 age- and gender-matched healthy people with no neurological disease. The levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were significantly lower in MSA patients than in controls (total cholesterol: 172.7 vs. 196.3 mg/dL, P < 0.001; LDL-C: 104.0 vs. 115.3 mg/dL, P = 0.001; HDL-C: 47.3 vs. 54.2 mg/dL, P < 0.001). After adjusting for age, gender, use of cholesterol-lowering drugs, and histories of hypertension, diabetes mellitus, and smoking, the odds ratios was 5.9 (95% CI = 2.3-11.5, P < 0.001) for MSA patients in the lowest quartile of total cholesterol and 2.6 (95% CI = 1.2-5.5, P = 0.016) for those in the lowest quartile of HDL-C, compared with the highest quartiles. Levels of serum cholesterol did not significantly correlate with disease duration or severity. Our data suggest that lower levels of total cholesterol and HDL may be associated with an increased risk of MSA.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A03		`1`		`@0 Mov. disord.`
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A08	`01`	`1`	`ENG`	`@1 Serum Cholesterol Levels and the Risk of Multiple System Atrophy : A Case-Control Study`
A11	`01`	`1`		`@1 PHIL HYU LEE`
A11	`02`	`1`		`@1 TAE SUNG LIM`
A11	`03`	`1`		`@1 SHIN (Hae-Won)`
A11	`04`	`1`		`@1 SEOK WOO YONG`
A11	`05`	`1`		`@1 HYO SUK NAM`
A11	`06`	`1`		`@1 SOHN (Young H.)`
A14	`01`			`@1 Department of Neurology, Yonsei University College of Medicine @2 Seoul @3 KOR @Z 1 aut. @Z 5 aut. @Z 6 aut.`
A14	`02`			`@1 Department of Neurology, Ajou University School of Medicine @2 Suwon @3 KOR @Z 2 aut. @Z 4 aut.`
A14	`03`			`@1 Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine @2 Seoul @3 KOR @Z 3 aut.`
A20				`@1 752-758`
A21				`@1 2009`
A23	`01`			`@0 ENG`
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A44				`@0 0000 @1 © 2009 INIST-CNRS. All rights reserved.`
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A47	`01`	`1`		`@0 09-0218148`
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A61				`@0 A`
A64	`01`	`1`		`@0 Movement disorders`
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C01	`01`		`ENG`	@0 Cholesterol in brain membranes may modulate the conformational state and accumulation of α-synuclein in α-synucleinopathies. We examined the association between serum cholesterol and the risk of multiple system atrophy (MSA), one of the α-synucleinopathies. We enrolled 142 patients with probable MSA from two tertiary referral hospitals and 155 age- and gender-matched healthy people with no neurological disease. The levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were significantly lower in MSA patients than in controls (total cholesterol: 172.7 vs. 196.3 mg/dL, P < 0.001; LDL-C: 104.0 vs. 115.3 mg/dL, P = 0.001; HDL-C: 47.3 vs. 54.2 mg/dL, P < 0.001). After adjusting for age, gender, use of cholesterol-lowering drugs, and histories of hypertension, diabetes mellitus, and smoking, the odds ratios was 5.9 (95% CI = 2.3-11.5, P < 0.001) for MSA patients in the lowest quartile of total cholesterol and 2.6 (95% CI = 1.2-5.5, P = 0.016) for those in the lowest quartile of HDL-C, compared with the highest quartiles. Levels of serum cholesterol did not significantly correlate with disease duration or severity. Our data suggest that lower levels of total cholesterol and HDL may be associated with an increased risk of MSA.
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C03	`01`	`X`	`FRE`	`@0 Atrophie multisystématisée @2 NM @5 01`
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C03	`04`	`X`	`ENG`	`@0 Risk factor @5 10`
C03	`04`	`X`	`SPA`	`@0 Factor riesgo @5 10`
C03	`05`	`X`	`FRE`	`@0 Etude cas témoin @5 11`
C03	`05`	`X`	`ENG`	`@0 Case control study @5 11`
C03	`05`	`X`	`SPA`	`@0 Estudio caso control @5 11`
C07	`01`	`X`	`FRE`	`@0 Lipide @5 37`
C07	`01`	`X`	`ENG`	`@0 Lipids @5 37`
C07	`01`	`X`	`SPA`	`@0 Lípido @5 37`
N21				`@1 159`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 09-0218148 INIST
ET :	Serum Cholesterol Levels and the Risk of Multiple System Atrophy : A Case-Control Study
AU :	PHIL HYU LEE; TAE SUNG LIM; SHIN (Hae-Won); SEOK WOO YONG; HYO SUK NAM; SOHN (Young H.)
AF :	Department of Neurology, Yonsei University College of Medicine/Seoul/Corée, République de (1 aut., 5 aut., 6 aut.); Department of Neurology, Ajou University School of Medicine/Suwon/Corée, République de (2 aut., 4 aut.); Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine/Seoul/Corée, République de (3 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2009; Vol. 24; No. 5; Pp. 752-758; Bibl. 37 ref.
LA :	Anglais
EA :	Cholesterol in brain membranes may modulate the conformational state and accumulation of α-synuclein in α-synucleinopathies. We examined the association between serum cholesterol and the risk of multiple system atrophy (MSA), one of the α-synucleinopathies. We enrolled 142 patients with probable MSA from two tertiary referral hospitals and 155 age- and gender-matched healthy people with no neurological disease. The levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were significantly lower in MSA patients than in controls (total cholesterol: 172.7 vs. 196.3 mg/dL, P < 0.001; LDL-C: 104.0 vs. 115.3 mg/dL, P = 0.001; HDL-C: 47.3 vs. 54.2 mg/dL, P < 0.001). After adjusting for age, gender, use of cholesterol-lowering drugs, and histories of hypertension, diabetes mellitus, and smoking, the odds ratios was 5.9 (95% CI = 2.3-11.5, P < 0.001) for MSA patients in the lowest quartile of total cholesterol and 2.6 (95% CI = 1.2-5.5, P = 0.016) for those in the lowest quartile of HDL-C, compared with the highest quartiles. Levels of serum cholesterol did not significantly correlate with disease duration or severity. Our data suggest that lower levels of total cholesterol and HDL may be associated with an increased risk of MSA.
CC :	002B17; 002B17F
FD :	Atrophie multisystématisée; Pathologie du système nerveux; Cholestérol; Facteur risque; Etude cas témoin
FG :	Lipide
ED :	Multiple system atrophy; Nervous system diseases; Cholesterol; Risk factor; Case control study
EG :	Lipids
SD :	Atrofia multisistematizada; Sistema nervioso patología; Colesterol; Factor riesgo; Estudio caso control
LO :	INIST-20953.354000186090170180
ID :	09-0218148

Links to Exploration step

Pascal:09-0218148

Le document en format XML

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<front><div type="abstract" xml:lang="en">Cholesterol in brain membranes may modulate the conformational state and accumulation of α-synuclein in α-synucleinopathies. We examined the association between serum cholesterol and the risk of multiple system atrophy (MSA), one of the α-synucleinopathies. We enrolled 142 patients with probable MSA from two tertiary referral hospitals and 155 age- and gender-matched healthy people with no neurological disease. The levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were significantly lower in MSA patients than in controls (total cholesterol: 172.7 vs. 196.3 mg/dL, P < 0.001; LDL-C: 104.0 vs. 115.3 mg/dL, P = 0.001; HDL-C: 47.3 vs. 54.2 mg/dL, P < 0.001). After adjusting for age, gender, use of cholesterol-lowering drugs, and histories of hypertension, diabetes mellitus, and smoking, the odds ratios was 5.9 (95% CI = 2.3-11.5, P < 0.001) for MSA patients in the lowest quartile of total cholesterol and 2.6 (95% CI = 1.2-5.5, P = 0.016) for those in the lowest quartile of HDL-C, compared with the highest quartiles. Levels of serum cholesterol did not significantly correlate with disease duration or severity. Our data suggest that lower levels of total cholesterol and HDL may be associated with an increased risk of MSA.</div>
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<server><NO>PASCAL 09-0218148 INIST</NO>
<ET>Serum Cholesterol Levels and the Risk of Multiple System Atrophy : A Case-Control Study</ET>
<AU>PHIL HYU LEE; TAE SUNG LIM; SHIN (Hae-Won); SEOK WOO YONG; HYO SUK NAM; SOHN (Young H.)</AU>
<AF>Department of Neurology, Yonsei University College of Medicine/Seoul/Corée, République de (1 aut., 5 aut., 6 aut.); Department of Neurology, Ajou University School of Medicine/Suwon/Corée, République de (2 aut., 4 aut.); Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine/Seoul/Corée, République de (3 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2009; Vol. 24; No. 5; Pp. 752-758; Bibl. 37 ref.</SO>
<LA>Anglais</LA>
<EA>Cholesterol in brain membranes may modulate the conformational state and accumulation of α-synuclein in α-synucleinopathies. We examined the association between serum cholesterol and the risk of multiple system atrophy (MSA), one of the α-synucleinopathies. We enrolled 142 patients with probable MSA from two tertiary referral hospitals and 155 age- and gender-matched healthy people with no neurological disease. The levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were significantly lower in MSA patients than in controls (total cholesterol: 172.7 vs. 196.3 mg/dL, P < 0.001; LDL-C: 104.0 vs. 115.3 mg/dL, P = 0.001; HDL-C: 47.3 vs. 54.2 mg/dL, P < 0.001). After adjusting for age, gender, use of cholesterol-lowering drugs, and histories of hypertension, diabetes mellitus, and smoking, the odds ratios was 5.9 (95% CI = 2.3-11.5, P < 0.001) for MSA patients in the lowest quartile of total cholesterol and 2.6 (95% CI = 1.2-5.5, P = 0.016) for those in the lowest quartile of HDL-C, compared with the highest quartiles. Levels of serum cholesterol did not significantly correlate with disease duration or severity. Our data suggest that lower levels of total cholesterol and HDL may be associated with an increased risk of MSA.</EA>
<CC>002B17; 002B17F</CC>
<FD>Atrophie multisystématisée; Pathologie du système nerveux; Cholestérol; Facteur risque; Etude cas témoin</FD>
<FG>Lipide</FG>
<ED>Multiple system atrophy; Nervous system diseases; Cholesterol; Risk factor; Case control study</ED>
<EG>Lipids</EG>
<SD>Atrofia multisistematizada; Sistema nervioso patología; Colesterol; Factor riesgo; Estudio caso control</SD>
<LO>INIST-20953.354000186090170180</LO>
<ID>09-0218148</ID>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Serum Cholesterol Levels and the Risk of Multiple System Atrophy : A Case-Control Study

Serum Cholesterol Levels and the Risk of Multiple System Atrophy : A Case-Control Study

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