Serum Cholesterol Levels and the Risk of Multiple System Atrophy : A Case-Control Study
Identifieur interne : 000F14 ( PascalFrancis/Corpus ); précédent : 000F13; suivant : 000F15Serum Cholesterol Levels and the Risk of Multiple System Atrophy : A Case-Control Study
Auteurs : PHIL HYU LEE ; TAE SUNG LIM ; Hae-Won Shin ; SEOK WOO YONG ; HYO SUK NAM ; Young H. SohnSource :
- Movement disorders [ 0885-3185 ] ; 2009.
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English descriptors
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Abstract
Cholesterol in brain membranes may modulate the conformational state and accumulation of α-synuclein in α-synucleinopathies. We examined the association between serum cholesterol and the risk of multiple system atrophy (MSA), one of the α-synucleinopathies. We enrolled 142 patients with probable MSA from two tertiary referral hospitals and 155 age- and gender-matched healthy people with no neurological disease. The levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were significantly lower in MSA patients than in controls (total cholesterol: 172.7 vs. 196.3 mg/dL, P < 0.001; LDL-C: 104.0 vs. 115.3 mg/dL, P = 0.001; HDL-C: 47.3 vs. 54.2 mg/dL, P < 0.001). After adjusting for age, gender, use of cholesterol-lowering drugs, and histories of hypertension, diabetes mellitus, and smoking, the odds ratios was 5.9 (95% CI = 2.3-11.5, P < 0.001) for MSA patients in the lowest quartile of total cholesterol and 2.6 (95% CI = 1.2-5.5, P = 0.016) for those in the lowest quartile of HDL-C, compared with the highest quartiles. Levels of serum cholesterol did not significantly correlate with disease duration or severity. Our data suggest that lower levels of total cholesterol and HDL may be associated with an increased risk of MSA.
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Format Inist (serveur)
NO : | PASCAL 09-0218148 INIST |
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ET : | Serum Cholesterol Levels and the Risk of Multiple System Atrophy : A Case-Control Study |
AU : | PHIL HYU LEE; TAE SUNG LIM; SHIN (Hae-Won); SEOK WOO YONG; HYO SUK NAM; SOHN (Young H.) |
AF : | Department of Neurology, Yonsei University College of Medicine/Seoul/Corée, République de (1 aut., 5 aut., 6 aut.); Department of Neurology, Ajou University School of Medicine/Suwon/Corée, République de (2 aut., 4 aut.); Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine/Seoul/Corée, République de (3 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2009; Vol. 24; No. 5; Pp. 752-758; Bibl. 37 ref. |
LA : | Anglais |
EA : | Cholesterol in brain membranes may modulate the conformational state and accumulation of α-synuclein in α-synucleinopathies. We examined the association between serum cholesterol and the risk of multiple system atrophy (MSA), one of the α-synucleinopathies. We enrolled 142 patients with probable MSA from two tertiary referral hospitals and 155 age- and gender-matched healthy people with no neurological disease. The levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were significantly lower in MSA patients than in controls (total cholesterol: 172.7 vs. 196.3 mg/dL, P < 0.001; LDL-C: 104.0 vs. 115.3 mg/dL, P = 0.001; HDL-C: 47.3 vs. 54.2 mg/dL, P < 0.001). After adjusting for age, gender, use of cholesterol-lowering drugs, and histories of hypertension, diabetes mellitus, and smoking, the odds ratios was 5.9 (95% CI = 2.3-11.5, P < 0.001) for MSA patients in the lowest quartile of total cholesterol and 2.6 (95% CI = 1.2-5.5, P = 0.016) for those in the lowest quartile of HDL-C, compared with the highest quartiles. Levels of serum cholesterol did not significantly correlate with disease duration or severity. Our data suggest that lower levels of total cholesterol and HDL may be associated with an increased risk of MSA. |
CC : | 002B17; 002B17F |
FD : | Atrophie multisystématisée; Pathologie du système nerveux; Cholestérol; Facteur risque; Etude cas témoin |
FG : | Lipide |
ED : | Multiple system atrophy; Nervous system diseases; Cholesterol; Risk factor; Case control study |
EG : | Lipids |
SD : | Atrofia multisistematizada; Sistema nervioso patología; Colesterol; Factor riesgo; Estudio caso control |
LO : | INIST-20953.354000186090170180 |
ID : | 09-0218148 |
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Pascal:09-0218148Le document en format XML
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<front><div type="abstract" xml:lang="en">Cholesterol in brain membranes may modulate the conformational state and accumulation of α-synuclein in α-synucleinopathies. We examined the association between serum cholesterol and the risk of multiple system atrophy (MSA), one of the α-synucleinopathies. We enrolled 142 patients with probable MSA from two tertiary referral hospitals and 155 age- and gender-matched healthy people with no neurological disease. The levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were significantly lower in MSA patients than in controls (total cholesterol: 172.7 vs. 196.3 mg/dL, P < 0.001; LDL-C: 104.0 vs. 115.3 mg/dL, P = 0.001; HDL-C: 47.3 vs. 54.2 mg/dL, P < 0.001). After adjusting for age, gender, use of cholesterol-lowering drugs, and histories of hypertension, diabetes mellitus, and smoking, the odds ratios was 5.9 (95% CI = 2.3-11.5, P < 0.001) for MSA patients in the lowest quartile of total cholesterol and 2.6 (95% CI = 1.2-5.5, P = 0.016) for those in the lowest quartile of HDL-C, compared with the highest quartiles. Levels of serum cholesterol did not significantly correlate with disease duration or severity. Our data suggest that lower levels of total cholesterol and HDL may be associated with an increased risk of MSA.</div>
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<ET>Serum Cholesterol Levels and the Risk of Multiple System Atrophy : A Case-Control Study</ET>
<AU>PHIL HYU LEE; TAE SUNG LIM; SHIN (Hae-Won); SEOK WOO YONG; HYO SUK NAM; SOHN (Young H.)</AU>
<AF>Department of Neurology, Yonsei University College of Medicine/Seoul/Corée, République de (1 aut., 5 aut., 6 aut.); Department of Neurology, Ajou University School of Medicine/Suwon/Corée, République de (2 aut., 4 aut.); Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine/Seoul/Corée, République de (3 aut.)</AF>
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<EA>Cholesterol in brain membranes may modulate the conformational state and accumulation of α-synuclein in α-synucleinopathies. We examined the association between serum cholesterol and the risk of multiple system atrophy (MSA), one of the α-synucleinopathies. We enrolled 142 patients with probable MSA from two tertiary referral hospitals and 155 age- and gender-matched healthy people with no neurological disease. The levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were significantly lower in MSA patients than in controls (total cholesterol: 172.7 vs. 196.3 mg/dL, P < 0.001; LDL-C: 104.0 vs. 115.3 mg/dL, P = 0.001; HDL-C: 47.3 vs. 54.2 mg/dL, P < 0.001). After adjusting for age, gender, use of cholesterol-lowering drugs, and histories of hypertension, diabetes mellitus, and smoking, the odds ratios was 5.9 (95% CI = 2.3-11.5, P < 0.001) for MSA patients in the lowest quartile of total cholesterol and 2.6 (95% CI = 1.2-5.5, P = 0.016) for those in the lowest quartile of HDL-C, compared with the highest quartiles. Levels of serum cholesterol did not significantly correlate with disease duration or severity. Our data suggest that lower levels of total cholesterol and HDL may be associated with an increased risk of MSA.</EA>
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