Cognitive and Functional Decline in Huntington's Disease: Dementia Criteria Revisited
Identifieur interne : 000A46 ( PascalFrancis/Corpus ); précédent : 000A45; suivant : 000A47Cognitive and Functional Decline in Huntington's Disease: Dementia Criteria Revisited
Auteurs : Guerry M. Peavy ; Mark W. Jacobson ; Jody L. Goldstein ; Joanne M. Hamilton ; Amy Kane ; Anthony C. Gamst ; Stephanie L. Lessig ; J. C. Lee ; Jody Corey-BloomSource :
- Movement disorders [ 0885-3185 ] ; 2010.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
The importance of designating criteria for diagnosing dementia lies in its implications for clinical treatment, research, caregiving, and decision-making. Dementia diagnosis in Huntington's disease (HD) is often based on criteria developed for Alzheimer's disease requiring memory loss. However, it is likely that other cognitive deficits contribute to functional impairment in HD before memory declines. The goal is to identify cognitive deficits that contribute to functional impairment to support dementia criteria that reflect HD neuropathology. Eighty-four HD mutation-positive subjects completed neuropsychological tests and the Unified Huntington's Disease Rating Scale Functional Independence Scale (FIS). Functional impairment was defined as 80 or below on the FIS. Speed of processing, initiation, and attention measures accounted for 70.0% of the variance in FIS ratings (linear regression) and correctly classified 91.7% of subjects as functionally impaired or intact (logistic regression). Measures of memory, motor impairment except dysarthria, neuroleptic use, and depressed mood did not improve prediction. A definition of HD dementia that includes cognitive impairment in at least two areas of cognition but does not require a memory deficit, in the context of impaired functional abilities and a deteriorating course, more accurately reflects HD neuropathology and could lead to improved research methods and patient care.
Notice en format standard (ISO 2709)
Pour connaître la documentation sur le format Inist Standard.
pA |
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Format Inist (serveur)
NO : | PASCAL 10-0376005 INIST |
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ET : | Cognitive and Functional Decline in Huntington's Disease: Dementia Criteria Revisited |
AU : | PEAVY (Guerry M.); JACOBSON (Mark W.); GOLDSTEIN (Jody L.); HAMILTON (Joanne M.); KANE (Amy); GAMST (Anthony C.); LESSIG (Stephanie L.); LEE (J. C.); COREY-BLOOM (Jody) |
AF : | Department of Neurosciences, University of California/San Diego, California/Etats-Unis (1 aut., 3 aut., 4 aut., 6 aut., 7 aut., 9 aut.); Department of Psychology, Veterans Administration Medical Center/San Diego, California/Etats-Unis (2 aut.); Department of Psychiatry, University of California/San Diego, California/Etats-Unis (2 aut., 8 aut.); Joint Doctoral Program in Clinical Psychiatry, San Diego State University/University of California/San Diego, California/Etats-Unis (5 aut.); Department of Family and Preventive Medicine, University of California/San Diego, California/Etats-Unis (6 aut.); Department of Neurology, Veterans Administration Medical Center/San Diego, California/Etats-Unis (7 aut., 9 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 9; Pp. 1163-1169; Bibl. 35 ref. |
LA : | Anglais |
EA : | The importance of designating criteria for diagnosing dementia lies in its implications for clinical treatment, research, caregiving, and decision-making. Dementia diagnosis in Huntington's disease (HD) is often based on criteria developed for Alzheimer's disease requiring memory loss. However, it is likely that other cognitive deficits contribute to functional impairment in HD before memory declines. The goal is to identify cognitive deficits that contribute to functional impairment to support dementia criteria that reflect HD neuropathology. Eighty-four HD mutation-positive subjects completed neuropsychological tests and the Unified Huntington's Disease Rating Scale Functional Independence Scale (FIS). Functional impairment was defined as 80 or below on the FIS. Speed of processing, initiation, and attention measures accounted for 70.0% of the variance in FIS ratings (linear regression) and correctly classified 91.7% of subjects as functionally impaired or intact (logistic regression). Measures of memory, motor impairment except dysarthria, neuroleptic use, and depressed mood did not improve prediction. A definition of HD dementia that includes cognitive impairment in at least two areas of cognition but does not require a memory deficit, in the context of impaired functional abilities and a deteriorating course, more accurately reflects HD neuropathology and could lead to improved research methods and patient care. |
CC : | 002B17; 002B17G |
FD : | Trouble cognitif; Chorée de Huntington; Démence; Pathologie du système nerveux; Vitesse déplacement; Attention |
FG : | Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Maladie héréditaire; Pathologie du système nerveux central |
ED : | Cognitive disorder; Huntington disease; Dementia; Nervous system diseases; Speed; Attention |
EG : | Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Genetic disease; Central nervous system disease |
SD : | Trastorno cognitivo; Corea Huntington; Demencia; Sistema nervioso patología; Velocidad desplazamiento; Atención |
LO : | INIST-20953.354000191760240080 |
ID : | 10-0376005 |
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Pascal:10-0376005Le document en format XML
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<front><div type="abstract" xml:lang="en">The importance of designating criteria for diagnosing dementia lies in its implications for clinical treatment, research, caregiving, and decision-making. Dementia diagnosis in Huntington's disease (HD) is often based on criteria developed for Alzheimer's disease requiring memory loss. However, it is likely that other cognitive deficits contribute to functional impairment in HD before memory declines. The goal is to identify cognitive deficits that contribute to functional impairment to support dementia criteria that reflect HD neuropathology. Eighty-four HD mutation-positive subjects completed neuropsychological tests and the Unified Huntington's Disease Rating Scale Functional Independence Scale (FIS). Functional impairment was defined as 80 or below on the FIS. Speed of processing, initiation, and attention measures accounted for 70.0% of the variance in FIS ratings (linear regression) and correctly classified 91.7% of subjects as functionally impaired or intact (logistic regression). Measures of memory, motor impairment except dysarthria, neuroleptic use, and depressed mood did not improve prediction. A definition of HD dementia that includes cognitive impairment in at least two areas of cognition but does not require a memory deficit, in the context of impaired functional abilities and a deteriorating course, more accurately reflects HD neuropathology and could lead to improved research methods and patient care.</div>
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<fC03 i1="01" i2="X" l="SPA"><s0>Trastorno cognitivo</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Chorée de Huntington</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Huntington disease</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Corea Huntington</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Démence</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Dementia</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Demencia</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Vitesse déplacement</s0>
<s5>09</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Speed</s0>
<s5>09</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Velocidad desplazamiento</s0>
<s5>09</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Attention</s0>
<s5>10</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Attention</s0>
<s5>10</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Atención</s0>
<s5>10</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Maladie héréditaire</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Genetic disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Enfermedad hereditaria</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>41</s5>
</fC07>
<fN21><s1>242</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 10-0376005 INIST</NO>
<ET>Cognitive and Functional Decline in Huntington's Disease: Dementia Criteria Revisited</ET>
<AU>PEAVY (Guerry M.); JACOBSON (Mark W.); GOLDSTEIN (Jody L.); HAMILTON (Joanne M.); KANE (Amy); GAMST (Anthony C.); LESSIG (Stephanie L.); LEE (J. C.); COREY-BLOOM (Jody)</AU>
<AF>Department of Neurosciences, University of California/San Diego, California/Etats-Unis (1 aut., 3 aut., 4 aut., 6 aut., 7 aut., 9 aut.); Department of Psychology, Veterans Administration Medical Center/San Diego, California/Etats-Unis (2 aut.); Department of Psychiatry, University of California/San Diego, California/Etats-Unis (2 aut., 8 aut.); Joint Doctoral Program in Clinical Psychiatry, San Diego State University/University of California/San Diego, California/Etats-Unis (5 aut.); Department of Family and Preventive Medicine, University of California/San Diego, California/Etats-Unis (6 aut.); Department of Neurology, Veterans Administration Medical Center/San Diego, California/Etats-Unis (7 aut., 9 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 9; Pp. 1163-1169; Bibl. 35 ref.</SO>
<LA>Anglais</LA>
<EA>The importance of designating criteria for diagnosing dementia lies in its implications for clinical treatment, research, caregiving, and decision-making. Dementia diagnosis in Huntington's disease (HD) is often based on criteria developed for Alzheimer's disease requiring memory loss. However, it is likely that other cognitive deficits contribute to functional impairment in HD before memory declines. The goal is to identify cognitive deficits that contribute to functional impairment to support dementia criteria that reflect HD neuropathology. Eighty-four HD mutation-positive subjects completed neuropsychological tests and the Unified Huntington's Disease Rating Scale Functional Independence Scale (FIS). Functional impairment was defined as 80 or below on the FIS. Speed of processing, initiation, and attention measures accounted for 70.0% of the variance in FIS ratings (linear regression) and correctly classified 91.7% of subjects as functionally impaired or intact (logistic regression). Measures of memory, motor impairment except dysarthria, neuroleptic use, and depressed mood did not improve prediction. A definition of HD dementia that includes cognitive impairment in at least two areas of cognition but does not require a memory deficit, in the context of impaired functional abilities and a deteriorating course, more accurately reflects HD neuropathology and could lead to improved research methods and patient care.</EA>
<CC>002B17; 002B17G</CC>
<FD>Trouble cognitif; Chorée de Huntington; Démence; Pathologie du système nerveux; Vitesse déplacement; Attention</FD>
<FG>Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Maladie héréditaire; Pathologie du système nerveux central</FG>
<ED>Cognitive disorder; Huntington disease; Dementia; Nervous system diseases; Speed; Attention</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Genetic disease; Central nervous system disease</EG>
<SD>Trastorno cognitivo; Corea Huntington; Demencia; Sistema nervioso patología; Velocidad desplazamiento; Atención</SD>
<LO>INIST-20953.354000191760240080</LO>
<ID>10-0376005</ID>
</server>
</inist>
</record>
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