MovDisordV3, PascalFrancis, Corpus, bibRecord, 000A46

Cognitive and Functional Decline in Huntington's Disease: Dementia Criteria Revisited

Identifieur interne : 000A46 ( PascalFrancis/Corpus ); précédent : 000A45; suivant : 000A47

Cognitive and Functional Decline in Huntington's Disease: Dementia Criteria Revisited

Auteurs : Guerry M. Peavy ; Mark W. Jacobson ; Jody L. Goldstein ; Joanne M. Hamilton ; Amy Kane ; Anthony C. Gamst ; Stephanie L. Lessig ; J. C. Lee ; Jody Corey-Bloom

Source :

Movement disorders [ 0885-3185 ] ; 2010.

RBID : Pascal:10-0376005

Descripteurs français

Pascal (Inist)
- Trouble cognitif, Chorée de Huntington, Démence, Pathologie du système nerveux, Vitesse déplacement, Attention.

English descriptors

KwdEn :
- Attention, Cognitive disorder, Dementia, Huntington disease, Nervous system diseases, Speed.

Abstract

The importance of designating criteria for diagnosing dementia lies in its implications for clinical treatment, research, caregiving, and decision-making. Dementia diagnosis in Huntington's disease (HD) is often based on criteria developed for Alzheimer's disease requiring memory loss. However, it is likely that other cognitive deficits contribute to functional impairment in HD before memory declines. The goal is to identify cognitive deficits that contribute to functional impairment to support dementia criteria that reflect HD neuropathology. Eighty-four HD mutation-positive subjects completed neuropsychological tests and the Unified Huntington's Disease Rating Scale Functional Independence Scale (FIS). Functional impairment was defined as 80 or below on the FIS. Speed of processing, initiation, and attention measures accounted for 70.0% of the variance in FIS ratings (linear regression) and correctly classified 91.7% of subjects as functionally impaired or intact (logistic regression). Measures of memory, motor impairment except dysarthria, neuroleptic use, and depressed mood did not improve prediction. A definition of HD dementia that includes cognitive impairment in at least two areas of cognition but does not require a memory deficit, in the context of impaired functional abilities and a deteriorating course, more accurately reflects HD neuropathology and could lead to improved research methods and patient care.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A06				`@2 9`
A08	`01`	`1`	`ENG`	`@1 Cognitive and Functional Decline in Huntington's Disease: Dementia Criteria Revisited`
A11	`01`	`1`		`@1 PEAVY (Guerry M.)`
A11	`02`	`1`		`@1 JACOBSON (Mark W.)`
A11	`03`	`1`		`@1 GOLDSTEIN (Jody L.)`
A11	`04`	`1`		`@1 HAMILTON (Joanne M.)`
A11	`05`	`1`		`@1 KANE (Amy)`
A11	`06`	`1`		`@1 GAMST (Anthony C.)`
A11	`07`	`1`		`@1 LESSIG (Stephanie L.)`
A11	`08`	`1`		`@1 LEE (J. C.)`
A11	`09`	`1`		`@1 COREY-BLOOM (Jody)`
A14	`01`			`@1 Department of Neurosciences, University of California @2 San Diego, California @3 USA @Z 1 aut. @Z 3 aut. @Z 4 aut. @Z 6 aut. @Z 7 aut. @Z 9 aut.`
A14	`02`			`@1 Department of Psychology, Veterans Administration Medical Center @2 San Diego, California @3 USA @Z 2 aut.`
A14	`03`			`@1 Department of Psychiatry, University of California @2 San Diego, California @3 USA @Z 2 aut. @Z 8 aut.`
A14	`04`			`@1 Joint Doctoral Program in Clinical Psychiatry, San Diego State University/University of California @2 San Diego, California @3 USA @Z 5 aut.`
A14	`05`			`@1 Department of Family and Preventive Medicine, University of California @2 San Diego, California @3 USA @Z 6 aut.`
A14	`06`			`@1 Department of Neurology, Veterans Administration Medical Center @2 San Diego, California @3 USA @Z 7 aut. @Z 9 aut.`
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A21				`@1 2010`
A23	`01`			`@0 ENG`
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A44				`@0 0000 @1 © 2010 INIST-CNRS. All rights reserved.`
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A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Movement disorders`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 The importance of designating criteria for diagnosing dementia lies in its implications for clinical treatment, research, caregiving, and decision-making. Dementia diagnosis in Huntington's disease (HD) is often based on criteria developed for Alzheimer's disease requiring memory loss. However, it is likely that other cognitive deficits contribute to functional impairment in HD before memory declines. The goal is to identify cognitive deficits that contribute to functional impairment to support dementia criteria that reflect HD neuropathology. Eighty-four HD mutation-positive subjects completed neuropsychological tests and the Unified Huntington's Disease Rating Scale Functional Independence Scale (FIS). Functional impairment was defined as 80 or below on the FIS. Speed of processing, initiation, and attention measures accounted for 70.0% of the variance in FIS ratings (linear regression) and correctly classified 91.7% of subjects as functionally impaired or intact (logistic regression). Measures of memory, motor impairment except dysarthria, neuroleptic use, and depressed mood did not improve prediction. A definition of HD dementia that includes cognitive impairment in at least two areas of cognition but does not require a memory deficit, in the context of impaired functional abilities and a deteriorating course, more accurately reflects HD neuropathology and could lead to improved research methods and patient care.
C02	`01`	`X`		`@0 002B17`
C02	`02`	`X`		`@0 002B17G`
C03	`01`	`X`	`FRE`	`@0 Trouble cognitif @5 01`
C03	`01`	`X`	`ENG`	`@0 Cognitive disorder @5 01`
C03	`01`	`X`	`SPA`	`@0 Trastorno cognitivo @5 01`
C03	`02`	`X`	`FRE`	`@0 Chorée de Huntington @5 02`
C03	`02`	`X`	`ENG`	`@0 Huntington disease @5 02`
C03	`02`	`X`	`SPA`	`@0 Corea Huntington @5 02`
C03	`03`	`X`	`FRE`	`@0 Démence @5 03`
C03	`03`	`X`	`ENG`	`@0 Dementia @5 03`
C03	`03`	`X`	`SPA`	`@0 Demencia @5 03`
C03	`04`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 04`
C03	`04`	`X`	`ENG`	`@0 Nervous system diseases @5 04`
C03	`04`	`X`	`SPA`	`@0 Sistema nervioso patología @5 04`
C03	`05`	`X`	`FRE`	`@0 Vitesse déplacement @5 09`
C03	`05`	`X`	`ENG`	`@0 Speed @5 09`
C03	`05`	`X`	`SPA`	`@0 Velocidad desplazamiento @5 09`
C03	`06`	`X`	`FRE`	`@0 Attention @5 10`
C03	`06`	`X`	`ENG`	`@0 Attention @5 10`
C03	`06`	`X`	`SPA`	`@0 Atención @5 10`
C07	`01`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 37`
C07	`01`	`X`	`ENG`	`@0 Cerebral disorder @5 37`
C07	`01`	`X`	`SPA`	`@0 Encéfalo patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 38`
C07	`02`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 38`
C07	`02`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 38`
C07	`03`	`X`	`FRE`	`@0 Maladie dégénérative @5 39`
C07	`03`	`X`	`ENG`	`@0 Degenerative disease @5 39`
C07	`03`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 39`
C07	`04`	`X`	`FRE`	`@0 Maladie héréditaire @5 40`
C07	`04`	`X`	`ENG`	`@0 Genetic disease @5 40`
C07	`04`	`X`	`SPA`	`@0 Enfermedad hereditaria @5 40`
C07	`05`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 41`
C07	`05`	`X`	`ENG`	`@0 Central nervous system disease @5 41`
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N21				`@1 242`
N44	`01`			`@1 OTO`
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Format Inist (serveur)

NO :	PASCAL 10-0376005 INIST
ET :	Cognitive and Functional Decline in Huntington's Disease: Dementia Criteria Revisited
AU :	PEAVY (Guerry M.); JACOBSON (Mark W.); GOLDSTEIN (Jody L.); HAMILTON (Joanne M.); KANE (Amy); GAMST (Anthony C.); LESSIG (Stephanie L.); LEE (J. C.); COREY-BLOOM (Jody)
AF :	Department of Neurosciences, University of California/San Diego, California/Etats-Unis (1 aut., 3 aut., 4 aut., 6 aut., 7 aut., 9 aut.); Department of Psychology, Veterans Administration Medical Center/San Diego, California/Etats-Unis (2 aut.); Department of Psychiatry, University of California/San Diego, California/Etats-Unis (2 aut., 8 aut.); Joint Doctoral Program in Clinical Psychiatry, San Diego State University/University of California/San Diego, California/Etats-Unis (5 aut.); Department of Family and Preventive Medicine, University of California/San Diego, California/Etats-Unis (6 aut.); Department of Neurology, Veterans Administration Medical Center/San Diego, California/Etats-Unis (7 aut., 9 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 9; Pp. 1163-1169; Bibl. 35 ref.
LA :	Anglais
EA :	The importance of designating criteria for diagnosing dementia lies in its implications for clinical treatment, research, caregiving, and decision-making. Dementia diagnosis in Huntington's disease (HD) is often based on criteria developed for Alzheimer's disease requiring memory loss. However, it is likely that other cognitive deficits contribute to functional impairment in HD before memory declines. The goal is to identify cognitive deficits that contribute to functional impairment to support dementia criteria that reflect HD neuropathology. Eighty-four HD mutation-positive subjects completed neuropsychological tests and the Unified Huntington's Disease Rating Scale Functional Independence Scale (FIS). Functional impairment was defined as 80 or below on the FIS. Speed of processing, initiation, and attention measures accounted for 70.0% of the variance in FIS ratings (linear regression) and correctly classified 91.7% of subjects as functionally impaired or intact (logistic regression). Measures of memory, motor impairment except dysarthria, neuroleptic use, and depressed mood did not improve prediction. A definition of HD dementia that includes cognitive impairment in at least two areas of cognition but does not require a memory deficit, in the context of impaired functional abilities and a deteriorating course, more accurately reflects HD neuropathology and could lead to improved research methods and patient care.
CC :	002B17; 002B17G
FD :	Trouble cognitif; Chorée de Huntington; Démence; Pathologie du système nerveux; Vitesse déplacement; Attention
FG :	Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Maladie héréditaire; Pathologie du système nerveux central
ED :	Cognitive disorder; Huntington disease; Dementia; Nervous system diseases; Speed; Attention
EG :	Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Genetic disease; Central nervous system disease
SD :	Trastorno cognitivo; Corea Huntington; Demencia; Sistema nervioso patología; Velocidad desplazamiento; Atención
LO :	INIST-20953.354000191760240080
ID :	10-0376005

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Pascal:10-0376005

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Cognitive and Functional Decline in Huntington's Disease: Dementia Criteria Revisited</title>
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<author><name sortKey="Lessig, Stephanie L" sort="Lessig, Stephanie L" uniqKey="Lessig S" first="Stephanie L." last="Lessig">Stephanie L. Lessig</name>
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<author><name sortKey="Lee, J C" sort="Lee, J C" uniqKey="Lee J" first="J. C." last="Lee">J. C. Lee</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Attention</term>
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<front><div type="abstract" xml:lang="en">The importance of designating criteria for diagnosing dementia lies in its implications for clinical treatment, research, caregiving, and decision-making. Dementia diagnosis in Huntington's disease (HD) is often based on criteria developed for Alzheimer's disease requiring memory loss. However, it is likely that other cognitive deficits contribute to functional impairment in HD before memory declines. The goal is to identify cognitive deficits that contribute to functional impairment to support dementia criteria that reflect HD neuropathology. Eighty-four HD mutation-positive subjects completed neuropsychological tests and the Unified Huntington's Disease Rating Scale Functional Independence Scale (FIS). Functional impairment was defined as 80 or below on the FIS. Speed of processing, initiation, and attention measures accounted for 70.0% of the variance in FIS ratings (linear regression) and correctly classified 91.7% of subjects as functionally impaired or intact (logistic regression). Measures of memory, motor impairment except dysarthria, neuroleptic use, and depressed mood did not improve prediction. A definition of HD dementia that includes cognitive impairment in at least two areas of cognition but does not require a memory deficit, in the context of impaired functional abilities and a deteriorating course, more accurately reflects HD neuropathology and could lead to improved research methods and patient care.</div>
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<ET>Cognitive and Functional Decline in Huntington's Disease: Dementia Criteria Revisited</ET>
<AU>PEAVY (Guerry M.); JACOBSON (Mark W.); GOLDSTEIN (Jody L.); HAMILTON (Joanne M.); KANE (Amy); GAMST (Anthony C.); LESSIG (Stephanie L.); LEE (J. C.); COREY-BLOOM (Jody)</AU>
<AF>Department of Neurosciences, University of California/San Diego, California/Etats-Unis (1 aut., 3 aut., 4 aut., 6 aut., 7 aut., 9 aut.); Department of Psychology, Veterans Administration Medical Center/San Diego, California/Etats-Unis (2 aut.); Department of Psychiatry, University of California/San Diego, California/Etats-Unis (2 aut., 8 aut.); Joint Doctoral Program in Clinical Psychiatry, San Diego State University/University of California/San Diego, California/Etats-Unis (5 aut.); Department of Family and Preventive Medicine, University of California/San Diego, California/Etats-Unis (6 aut.); Department of Neurology, Veterans Administration Medical Center/San Diego, California/Etats-Unis (7 aut., 9 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
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<EA>The importance of designating criteria for diagnosing dementia lies in its implications for clinical treatment, research, caregiving, and decision-making. Dementia diagnosis in Huntington's disease (HD) is often based on criteria developed for Alzheimer's disease requiring memory loss. However, it is likely that other cognitive deficits contribute to functional impairment in HD before memory declines. The goal is to identify cognitive deficits that contribute to functional impairment to support dementia criteria that reflect HD neuropathology. Eighty-four HD mutation-positive subjects completed neuropsychological tests and the Unified Huntington's Disease Rating Scale Functional Independence Scale (FIS). Functional impairment was defined as 80 or below on the FIS. Speed of processing, initiation, and attention measures accounted for 70.0% of the variance in FIS ratings (linear regression) and correctly classified 91.7% of subjects as functionally impaired or intact (logistic regression). Measures of memory, motor impairment except dysarthria, neuroleptic use, and depressed mood did not improve prediction. A definition of HD dementia that includes cognitive impairment in at least two areas of cognition but does not require a memory deficit, in the context of impaired functional abilities and a deteriorating course, more accurately reflects HD neuropathology and could lead to improved research methods and patient care.</EA>
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Movement Disorders (revue)

Cognitive and Functional Decline in Huntington's Disease: Dementia Criteria Revisited

Cognitive and Functional Decline in Huntington's Disease: Dementia Criteria Revisited

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