MovDisordV3, PascalFrancis, Corpus, bibRecord, 000A45

Timed Motor Tests Can Detect Subtle Motor Dysfunction in Early Parkinson's Disease

Identifieur interne : 000A45 ( PascalFrancis/Corpus ); précédent : 000A44; suivant : 000A46

Timed Motor Tests Can Detect Subtle Motor Dysfunction in Early Parkinson's Disease

Auteurs : Charlotte A. Haaxma ; Bastiaan R. Bloem ; Sebastiaan Overeem ; George F. Borm ; Martin W. I. M. Horstink

Source :

Movement disorders [ 0885-3185 ] ; 2010.

RBID : Pascal:10-0376006

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Trouble fonctionnel, Diagnostic, Asymptomatique.

English descriptors

KwdEn :
- Asymptomatic, Diagnosis, Dysfunction, Nervous system diseases, Parkinson disease.

Abstract

Early diagnosis of Parkinson's disease (PD) is important for putative neuroprotective therapies to be initiated in the earliest stage of the disease. We investigated whether a previously validated timed motor test (TMT) battery could detect subtle motor dysfunction in early PD patients and even in clinically unaffected limbs of strictly hemiparkinsonian patients. We assessed 107 PD patients (symptom duration <2 years; dopa-naive) and 100 healthy, age-matched controls with eight simple TMTs based on aspects of (a) walking, (b) writing, (c) single and double-handed pegboard performance, (d) finger tapping, and (e) diadochokinesis. We evaluated the ability of individual and combined TMTs to discriminate patients from controls using ROC curves. Second, we investigated whether these TMTs could identify motor dysfunction of the clinically unaffected limb in 42 strictly hemiparkinsonian patients. The pegboard dexterity test had the best ROC curve (AUC 0.97; 95% sensitivity, 89% specificity) for patients versus controls. It retained reasonable accuracy when testing the clinically unaffected limb of hemiparkinsonian patients versus the mean of right and left-hand scores in controls (AUC 0.73). The pegboard dexterity test is a sensitive and inexpensive instrument to detect motor dysfunction in early PD. Therefore, it may be worth evaluating as a diagnostic tool in everyday clinical practice to assess patients with early symptomatic PD, or as part of a more elaborate screening battery in a defined population at risk.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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Format Inist (serveur)

NO :	PASCAL 10-0376006 INIST
ET :	Timed Motor Tests Can Detect Subtle Motor Dysfunction in Early Parkinson's Disease
AU :	HAAXMA (Charlotte A.); BLOEM (Bastiaan R.); OVEREEM (Sebastiaan); BORM (George F.); HORSTINK (Martin W. I. M.)
AF :	Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre/Nijmegen/Pays-Bas (1 aut., 2 aut., 3 aut., 5 aut.); Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre/Nijmegen/Pays-Bas (4 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 9; Pp. 1150-1156; Bibl. 33 ref.
LA :	Anglais
EA :	Early diagnosis of Parkinson's disease (PD) is important for putative neuroprotective therapies to be initiated in the earliest stage of the disease. We investigated whether a previously validated timed motor test (TMT) battery could detect subtle motor dysfunction in early PD patients and even in clinically unaffected limbs of strictly hemiparkinsonian patients. We assessed 107 PD patients (symptom duration <2 years; dopa-naive) and 100 healthy, age-matched controls with eight simple TMTs based on aspects of (a) walking, (b) writing, (c) single and double-handed pegboard performance, (d) finger tapping, and (e) diadochokinesis. We evaluated the ability of individual and combined TMTs to discriminate patients from controls using ROC curves. Second, we investigated whether these TMTs could identify motor dysfunction of the clinically unaffected limb in 42 strictly hemiparkinsonian patients. The pegboard dexterity test had the best ROC curve (AUC 0.97; 95% sensitivity, 89% specificity) for patients versus controls. It retained reasonable accuracy when testing the clinically unaffected limb of hemiparkinsonian patients versus the mean of right and left-hand scores in controls (AUC 0.73). The pegboard dexterity test is a sensitive and inexpensive instrument to detect motor dysfunction in early PD. Therefore, it may be worth evaluating as a diagnostic tool in everyday clinical practice to assess patients with early symptomatic PD, or as part of a more elaborate screening battery in a defined population at risk.
CC :	002B17; 002B17G
FD :	Maladie de Parkinson; Pathologie du système nerveux; Trouble fonctionnel; Diagnostic; Asymptomatique
FG :	Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central
ED :	Parkinson disease; Nervous system diseases; Dysfunction; Diagnosis; Asymptomatic
EG :	Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD :	Parkinson enfermedad; Sistema nervioso patología; Trastorno funcional; Diagnóstico; Asintomático
LO :	INIST-20953.354000191760240060
ID :	10-0376006

Links to Exploration step

Pascal:10-0376006

Le document en format XML

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<front><div type="abstract" xml:lang="en">Early diagnosis of Parkinson's disease (PD) is important for putative neuroprotective therapies to be initiated in the earliest stage of the disease. We investigated whether a previously validated timed motor test (TMT) battery could detect subtle motor dysfunction in early PD patients and even in clinically unaffected limbs of strictly hemiparkinsonian patients. We assessed 107 PD patients (symptom duration <2 years; dopa-naive) and 100 healthy, age-matched controls with eight simple TMTs based on aspects of (a) walking, (b) writing, (c) single and double-handed pegboard performance, (d) finger tapping, and (e) diadochokinesis. We evaluated the ability of individual and combined TMTs to discriminate patients from controls using ROC curves. Second, we investigated whether these TMTs could identify motor dysfunction of the clinically unaffected limb in 42 strictly hemiparkinsonian patients. The pegboard dexterity test had the best ROC curve (AUC 0.97; 95% sensitivity, 89% specificity) for patients versus controls. It retained reasonable accuracy when testing the clinically unaffected limb of hemiparkinsonian patients versus the mean of right and left-hand scores in controls (AUC 0.73). The pegboard dexterity test is a sensitive and inexpensive instrument to detect motor dysfunction in early PD. Therefore, it may be worth evaluating as a diagnostic tool in everyday clinical practice to assess patients with early symptomatic PD, or as part of a more elaborate screening battery in a defined population at risk.</div>
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<server><NO>PASCAL 10-0376006 INIST</NO>
<ET>Timed Motor Tests Can Detect Subtle Motor Dysfunction in Early Parkinson's Disease</ET>
<AU>HAAXMA (Charlotte A.); BLOEM (Bastiaan R.); OVEREEM (Sebastiaan); BORM (George F.); HORSTINK (Martin W. I. M.)</AU>
<AF>Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre/Nijmegen/Pays-Bas (1 aut., 2 aut., 3 aut., 5 aut.); Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre/Nijmegen/Pays-Bas (4 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 9; Pp. 1150-1156; Bibl. 33 ref.</SO>
<LA>Anglais</LA>
<EA>Early diagnosis of Parkinson's disease (PD) is important for putative neuroprotective therapies to be initiated in the earliest stage of the disease. We investigated whether a previously validated timed motor test (TMT) battery could detect subtle motor dysfunction in early PD patients and even in clinically unaffected limbs of strictly hemiparkinsonian patients. We assessed 107 PD patients (symptom duration <2 years; dopa-naive) and 100 healthy, age-matched controls with eight simple TMTs based on aspects of (a) walking, (b) writing, (c) single and double-handed pegboard performance, (d) finger tapping, and (e) diadochokinesis. We evaluated the ability of individual and combined TMTs to discriminate patients from controls using ROC curves. Second, we investigated whether these TMTs could identify motor dysfunction of the clinically unaffected limb in 42 strictly hemiparkinsonian patients. The pegboard dexterity test had the best ROC curve (AUC 0.97; 95% sensitivity, 89% specificity) for patients versus controls. It retained reasonable accuracy when testing the clinically unaffected limb of hemiparkinsonian patients versus the mean of right and left-hand scores in controls (AUC 0.73). The pegboard dexterity test is a sensitive and inexpensive instrument to detect motor dysfunction in early PD. Therefore, it may be worth evaluating as a diagnostic tool in everyday clinical practice to assess patients with early symptomatic PD, or as part of a more elaborate screening battery in a defined population at risk.</EA>
<CC>002B17; 002B17G</CC>
<FD>Maladie de Parkinson; Pathologie du   système nerveux; Trouble fonctionnel; Diagnostic; Asymptomatique</FD>
<FG>Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du   système nerveux central</FG>
<ED>Parkinson disease; Nervous system diseases; Dysfunction; Diagnosis; Asymptomatic</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Parkinson enfermedad; Sistema nervioso patología; Trastorno funcional; Diagnóstico; Asintomático</SD>
<LO>INIST-20953.354000191760240060</LO>
<ID>10-0376006</ID>
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Movement Disorders (revue)

Timed Motor Tests Can Detect Subtle Motor Dysfunction in Early Parkinson's Disease

Timed Motor Tests Can Detect Subtle Motor Dysfunction in Early Parkinson's Disease

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