Exploring the Electrocardiogram as a Potential Tool to Screen for Premotor Parkinson's Disease
Identifieur interne : 000846 ( PascalFrancis/Corpus ); précédent : 000845; suivant : 000847Exploring the Electrocardiogram as a Potential Tool to Screen for Premotor Parkinson's Disease
Auteurs : RUKSANA AZHU VALAPPIL ; Jed E. Black ; Meredith J. Broderick ; Oscar Carrillo ; Eric Frenette ; Shannon S. Sullivan ; Samuel M. Goldman ; Caroline M. Tanner ; James W. LangstonSource :
- Movement disorders [ 0885-3185 ] ; 2010.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
The aim of this study was to test the hypothesis that patients with REM sleep behavior disorder, many of whom will develop Parkinson's disease (PD) or a related synucleinopathy, will demonstrate decreased heart rate variability (HRV) compared with a group of age-matched controls as measured by an electrocardiogram during wakefulness. We compared HRV in 11 untreated idiopathic REM sleep behavior disorder patients (9 men and 2 women; mean age, 63.3 years; SD, 7.5 years) and 11 control subjects with idiopathic insomnia without REM sleep behavior disorder (7 men and 4 women; mean age, 59.5 years; SD, 8.7 years). Subjects with other causes of reduced HRV were excluded. HRV was determined from 5-minute presleep segments of a single channel electrocardiogram recorded during polysomnographic evaluations, using R-R intervals during wakefulness. Time domain, geometric measures, and spectral analysis of the R-R intervals were significantly different between cases and controls. A discriminant function analysis correctly classified 95.5% of subjects (overall model fit, P = 0.016). Leave-one-out cross-validation correctly classified 77.3% of subjects. HRV during wakefulness is significantly decreased in patients with idiopathic REM sleep behavior disorder compared with control subjects, suggesting abnormalities of both sympathetic and parasympathetic function. Patients with RBD may later develop motor and cognitive features of a Lewy body disorder, such as PD. Cardiac autonomic dysfunction is also impaired in PD, suggesting that impaired HRV may be an early sign of PD. HRV measured by routine electrocardiograms could be used to screen for Lewy body disorders such as PD.
Notice en format standard (ISO 2709)
Pour connaître la documentation sur le format Inist Standard.
pA |
|
---|
Format Inist (serveur)
NO : | PASCAL 10-0491583 INIST |
---|---|
ET : | Exploring the Electrocardiogram as a Potential Tool to Screen for Premotor Parkinson's Disease |
AU : | RUKSANA AZHU VALAPPIL; BLACK (Jed E.); BRODERICK (Meredith J.); CARRILLO (Oscar); FRENETTE (Eric); SULLIVAN (Shannon S.); GOLDMAN (Samuel M.); TANNER (Caroline M.); LANGSTON (James W.) |
AF : | Clinical Research Department, The Parkinson's Institute and Clinical Center/Sunnyvale, California/Etats-Unis (1 aut., 7 aut., 8 aut., 9 aut.); Department of Psychiatry and Behavioral Sciences, Stanford University/Redwood City, California/Etats-Unis (2 aut., 4 aut., 6 aut.); Sleep Medicine, Minor & James Medical/Seattle, Washington/Etats-Unis (3 aut.); Department of Neurology, University of Sherbrooke/Sherbrooke, Quebec/Canada (5 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 14; Pp. 2296-2303; Bibl. 36 ref. |
LA : | Anglais |
EA : | The aim of this study was to test the hypothesis that patients with REM sleep behavior disorder, many of whom will develop Parkinson's disease (PD) or a related synucleinopathy, will demonstrate decreased heart rate variability (HRV) compared with a group of age-matched controls as measured by an electrocardiogram during wakefulness. We compared HRV in 11 untreated idiopathic REM sleep behavior disorder patients (9 men and 2 women; mean age, 63.3 years; SD, 7.5 years) and 11 control subjects with idiopathic insomnia without REM sleep behavior disorder (7 men and 4 women; mean age, 59.5 years; SD, 8.7 years). Subjects with other causes of reduced HRV were excluded. HRV was determined from 5-minute presleep segments of a single channel electrocardiogram recorded during polysomnographic evaluations, using R-R intervals during wakefulness. Time domain, geometric measures, and spectral analysis of the R-R intervals were significantly different between cases and controls. A discriminant function analysis correctly classified 95.5% of subjects (overall model fit, P = 0.016). Leave-one-out cross-validation correctly classified 77.3% of subjects. HRV during wakefulness is significantly decreased in patients with idiopathic REM sleep behavior disorder compared with control subjects, suggesting abnormalities of both sympathetic and parasympathetic function. Patients with RBD may later develop motor and cognitive features of a Lewy body disorder, such as PD. Cardiac autonomic dysfunction is also impaired in PD, suggesting that impaired HRV may be an early sign of PD. HRV measured by routine electrocardiograms could be used to screen for Lewy body disorders such as PD. |
CC : | 002B17; 002B17G |
FD : | Maladie de Parkinson; Pathologie du système nerveux; Electrocardiographie; Dépistage; Rythme cardiaque; Variabilité; Trouble fonctionnel |
FG : | Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central |
ED : | Parkinson disease; Nervous system diseases; Electrocardiography; Medical screening; Heart rate; Variability; Dysfunction |
EG : | Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease |
SD : | Parkinson enfermedad; Sistema nervioso patología; Electrocardiografía; Descubrimiento; Ritmo cardíaco; Variabilidad; Trastorno funcional |
LO : | INIST-20953.354000192780100060 |
ID : | 10-0491583 |
Links to Exploration step
Pascal:10-0491583Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Exploring the Electrocardiogram as a Potential Tool to Screen for Premotor Parkinson's Disease</title>
<author><name sortKey="Ruksana Azhu Valappil" sort="Ruksana Azhu Valappil" uniqKey="Ruksana Azhu Valappil" last="Ruksana Azhu Valappil">RUKSANA AZHU VALAPPIL</name>
<affiliation><inist:fA14 i1="01"><s1>Clinical Research Department, The Parkinson's Institute and Clinical Center</s1>
<s2>Sunnyvale, California</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Black, Jed E" sort="Black, Jed E" uniqKey="Black J" first="Jed E." last="Black">Jed E. Black</name>
<affiliation><inist:fA14 i1="02"><s1>Department of Psychiatry and Behavioral Sciences, Stanford University</s1>
<s2>Redwood City, California</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Broderick, Meredith J" sort="Broderick, Meredith J" uniqKey="Broderick M" first="Meredith J." last="Broderick">Meredith J. Broderick</name>
<affiliation><inist:fA14 i1="03"><s1>Sleep Medicine, Minor & James Medical</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Carrillo, Oscar" sort="Carrillo, Oscar" uniqKey="Carrillo O" first="Oscar" last="Carrillo">Oscar Carrillo</name>
<affiliation><inist:fA14 i1="02"><s1>Department of Psychiatry and Behavioral Sciences, Stanford University</s1>
<s2>Redwood City, California</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Frenette, Eric" sort="Frenette, Eric" uniqKey="Frenette E" first="Eric" last="Frenette">Eric Frenette</name>
<affiliation><inist:fA14 i1="04"><s1>Department of Neurology, University of Sherbrooke</s1>
<s2>Sherbrooke, Quebec</s2>
<s3>CAN</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Sullivan, Shannon S" sort="Sullivan, Shannon S" uniqKey="Sullivan S" first="Shannon S." last="Sullivan">Shannon S. Sullivan</name>
<affiliation><inist:fA14 i1="02"><s1>Department of Psychiatry and Behavioral Sciences, Stanford University</s1>
<s2>Redwood City, California</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Goldman, Samuel M" sort="Goldman, Samuel M" uniqKey="Goldman S" first="Samuel M." last="Goldman">Samuel M. Goldman</name>
<affiliation><inist:fA14 i1="01"><s1>Clinical Research Department, The Parkinson's Institute and Clinical Center</s1>
<s2>Sunnyvale, California</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M." last="Tanner">Caroline M. Tanner</name>
<affiliation><inist:fA14 i1="01"><s1>Clinical Research Department, The Parkinson's Institute and Clinical Center</s1>
<s2>Sunnyvale, California</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Langston, James W" sort="Langston, James W" uniqKey="Langston J" first="James W." last="Langston">James W. Langston</name>
<affiliation><inist:fA14 i1="01"><s1>Clinical Research Department, The Parkinson's Institute and Clinical Center</s1>
<s2>Sunnyvale, California</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">10-0491583</idno>
<date when="2010">2010</date>
<idno type="stanalyst">PASCAL 10-0491583 INIST</idno>
<idno type="RBID">Pascal:10-0491583</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000846</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Exploring the Electrocardiogram as a Potential Tool to Screen for Premotor Parkinson's Disease</title>
<author><name sortKey="Ruksana Azhu Valappil" sort="Ruksana Azhu Valappil" uniqKey="Ruksana Azhu Valappil" last="Ruksana Azhu Valappil">RUKSANA AZHU VALAPPIL</name>
<affiliation><inist:fA14 i1="01"><s1>Clinical Research Department, The Parkinson's Institute and Clinical Center</s1>
<s2>Sunnyvale, California</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Black, Jed E" sort="Black, Jed E" uniqKey="Black J" first="Jed E." last="Black">Jed E. Black</name>
<affiliation><inist:fA14 i1="02"><s1>Department of Psychiatry and Behavioral Sciences, Stanford University</s1>
<s2>Redwood City, California</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Broderick, Meredith J" sort="Broderick, Meredith J" uniqKey="Broderick M" first="Meredith J." last="Broderick">Meredith J. Broderick</name>
<affiliation><inist:fA14 i1="03"><s1>Sleep Medicine, Minor & James Medical</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Carrillo, Oscar" sort="Carrillo, Oscar" uniqKey="Carrillo O" first="Oscar" last="Carrillo">Oscar Carrillo</name>
<affiliation><inist:fA14 i1="02"><s1>Department of Psychiatry and Behavioral Sciences, Stanford University</s1>
<s2>Redwood City, California</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Frenette, Eric" sort="Frenette, Eric" uniqKey="Frenette E" first="Eric" last="Frenette">Eric Frenette</name>
<affiliation><inist:fA14 i1="04"><s1>Department of Neurology, University of Sherbrooke</s1>
<s2>Sherbrooke, Quebec</s2>
<s3>CAN</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Sullivan, Shannon S" sort="Sullivan, Shannon S" uniqKey="Sullivan S" first="Shannon S." last="Sullivan">Shannon S. Sullivan</name>
<affiliation><inist:fA14 i1="02"><s1>Department of Psychiatry and Behavioral Sciences, Stanford University</s1>
<s2>Redwood City, California</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Goldman, Samuel M" sort="Goldman, Samuel M" uniqKey="Goldman S" first="Samuel M." last="Goldman">Samuel M. Goldman</name>
<affiliation><inist:fA14 i1="01"><s1>Clinical Research Department, The Parkinson's Institute and Clinical Center</s1>
<s2>Sunnyvale, California</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M." last="Tanner">Caroline M. Tanner</name>
<affiliation><inist:fA14 i1="01"><s1>Clinical Research Department, The Parkinson's Institute and Clinical Center</s1>
<s2>Sunnyvale, California</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Langston, James W" sort="Langston, James W" uniqKey="Langston J" first="James W." last="Langston">James W. Langston</name>
<affiliation><inist:fA14 i1="01"><s1>Clinical Research Department, The Parkinson's Institute and Clinical Center</s1>
<s2>Sunnyvale, California</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dysfunction</term>
<term>Electrocardiography</term>
<term>Heart rate</term>
<term>Medical screening</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Variability</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Pathologie du système nerveux</term>
<term>Electrocardiographie</term>
<term>Dépistage</term>
<term>Rythme cardiaque</term>
<term>Variabilité</term>
<term>Trouble fonctionnel</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The aim of this study was to test the hypothesis that patients with REM sleep behavior disorder, many of whom will develop Parkinson's disease (PD) or a related synucleinopathy, will demonstrate decreased heart rate variability (HRV) compared with a group of age-matched controls as measured by an electrocardiogram during wakefulness. We compared HRV in 11 untreated idiopathic REM sleep behavior disorder patients (9 men and 2 women; mean age, 63.3 years; SD, 7.5 years) and 11 control subjects with idiopathic insomnia without REM sleep behavior disorder (7 men and 4 women; mean age, 59.5 years; SD, 8.7 years). Subjects with other causes of reduced HRV were excluded. HRV was determined from 5-minute presleep segments of a single channel electrocardiogram recorded during polysomnographic evaluations, using R-R intervals during wakefulness. Time domain, geometric measures, and spectral analysis of the R-R intervals were significantly different between cases and controls. A discriminant function analysis correctly classified 95.5% of subjects (overall model fit, P = 0.016). Leave-one-out cross-validation correctly classified 77.3% of subjects. HRV during wakefulness is significantly decreased in patients with idiopathic REM sleep behavior disorder compared with control subjects, suggesting abnormalities of both sympathetic and parasympathetic function. Patients with RBD may later develop motor and cognitive features of a Lewy body disorder, such as PD. Cardiac autonomic dysfunction is also impaired in PD, suggesting that impaired HRV may be an early sign of PD. HRV measured by routine electrocardiograms could be used to screen for Lewy body disorders such as PD.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0>
</fA01>
<fA03 i2="1"><s0>Mov. disord.</s0>
</fA03>
<fA05><s2>25</s2>
</fA05>
<fA06><s2>14</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Exploring the Electrocardiogram as a Potential Tool to Screen for Premotor Parkinson's Disease</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>RUKSANA AZHU VALAPPIL</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>BLACK (Jed E.)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>BRODERICK (Meredith J.)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>CARRILLO (Oscar)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>FRENETTE (Eric)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>SULLIVAN (Shannon S.)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>GOLDMAN (Samuel M.)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>TANNER (Caroline M.)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>LANGSTON (James W.)</s1>
</fA11>
<fA14 i1="01"><s1>Clinical Research Department, The Parkinson's Institute and Clinical Center</s1>
<s2>Sunnyvale, California</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Department of Psychiatry and Behavioral Sciences, Stanford University</s1>
<s2>Redwood City, California</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Sleep Medicine, Minor & James Medical</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Department of Neurology, University of Sherbrooke</s1>
<s2>Sherbrooke, Quebec</s2>
<s3>CAN</s3>
<sZ>5 aut.</sZ>
</fA14>
<fA20><s1>2296-2303</s1>
</fA20>
<fA21><s1>2010</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>20953</s2>
<s5>354000192780100060</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2010 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>36 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>10-0491583</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Movement disorders</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>The aim of this study was to test the hypothesis that patients with REM sleep behavior disorder, many of whom will develop Parkinson's disease (PD) or a related synucleinopathy, will demonstrate decreased heart rate variability (HRV) compared with a group of age-matched controls as measured by an electrocardiogram during wakefulness. We compared HRV in 11 untreated idiopathic REM sleep behavior disorder patients (9 men and 2 women; mean age, 63.3 years; SD, 7.5 years) and 11 control subjects with idiopathic insomnia without REM sleep behavior disorder (7 men and 4 women; mean age, 59.5 years; SD, 8.7 years). Subjects with other causes of reduced HRV were excluded. HRV was determined from 5-minute presleep segments of a single channel electrocardiogram recorded during polysomnographic evaluations, using R-R intervals during wakefulness. Time domain, geometric measures, and spectral analysis of the R-R intervals were significantly different between cases and controls. A discriminant function analysis correctly classified 95.5% of subjects (overall model fit, P = 0.016). Leave-one-out cross-validation correctly classified 77.3% of subjects. HRV during wakefulness is significantly decreased in patients with idiopathic REM sleep behavior disorder compared with control subjects, suggesting abnormalities of both sympathetic and parasympathetic function. Patients with RBD may later develop motor and cognitive features of a Lewy body disorder, such as PD. Cardiac autonomic dysfunction is also impaired in PD, suggesting that impaired HRV may be an early sign of PD. HRV measured by routine electrocardiograms could be used to screen for Lewy body disorders such as PD.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B17</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B17G</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Maladie de Parkinson</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Electrocardiographie</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Electrocardiography</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Electrocardiografía</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Dépistage</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Medical screening</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Descubrimiento</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Rythme cardiaque</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Heart rate</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Ritmo cardíaco</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Variabilité</s0>
<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Variability</s0>
<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Variabilidad</s0>
<s5>12</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Trouble fonctionnel</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Dysfunction</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Trastorno funcional</s0>
<s5>13</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>40</s5>
</fC07>
<fN21><s1>326</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 10-0491583 INIST</NO>
<ET>Exploring the Electrocardiogram as a Potential Tool to Screen for Premotor Parkinson's Disease</ET>
<AU>RUKSANA AZHU VALAPPIL; BLACK (Jed E.); BRODERICK (Meredith J.); CARRILLO (Oscar); FRENETTE (Eric); SULLIVAN (Shannon S.); GOLDMAN (Samuel M.); TANNER (Caroline M.); LANGSTON (James W.)</AU>
<AF>Clinical Research Department, The Parkinson's Institute and Clinical Center/Sunnyvale, California/Etats-Unis (1 aut., 7 aut., 8 aut., 9 aut.); Department of Psychiatry and Behavioral Sciences, Stanford University/Redwood City, California/Etats-Unis (2 aut., 4 aut., 6 aut.); Sleep Medicine, Minor & James Medical/Seattle, Washington/Etats-Unis (3 aut.); Department of Neurology, University of Sherbrooke/Sherbrooke, Quebec/Canada (5 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 14; Pp. 2296-2303; Bibl. 36 ref.</SO>
<LA>Anglais</LA>
<EA>The aim of this study was to test the hypothesis that patients with REM sleep behavior disorder, many of whom will develop Parkinson's disease (PD) or a related synucleinopathy, will demonstrate decreased heart rate variability (HRV) compared with a group of age-matched controls as measured by an electrocardiogram during wakefulness. We compared HRV in 11 untreated idiopathic REM sleep behavior disorder patients (9 men and 2 women; mean age, 63.3 years; SD, 7.5 years) and 11 control subjects with idiopathic insomnia without REM sleep behavior disorder (7 men and 4 women; mean age, 59.5 years; SD, 8.7 years). Subjects with other causes of reduced HRV were excluded. HRV was determined from 5-minute presleep segments of a single channel electrocardiogram recorded during polysomnographic evaluations, using R-R intervals during wakefulness. Time domain, geometric measures, and spectral analysis of the R-R intervals were significantly different between cases and controls. A discriminant function analysis correctly classified 95.5% of subjects (overall model fit, P = 0.016). Leave-one-out cross-validation correctly classified 77.3% of subjects. HRV during wakefulness is significantly decreased in patients with idiopathic REM sleep behavior disorder compared with control subjects, suggesting abnormalities of both sympathetic and parasympathetic function. Patients with RBD may later develop motor and cognitive features of a Lewy body disorder, such as PD. Cardiac autonomic dysfunction is also impaired in PD, suggesting that impaired HRV may be an early sign of PD. HRV measured by routine electrocardiograms could be used to screen for Lewy body disorders such as PD.</EA>
<CC>002B17; 002B17G</CC>
<FD>Maladie de Parkinson; Pathologie du système nerveux; Electrocardiographie; Dépistage; Rythme cardiaque; Variabilité; Trouble fonctionnel</FD>
<FG>Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central</FG>
<ED>Parkinson disease; Nervous system diseases; Electrocardiography; Medical screening; Heart rate; Variability; Dysfunction</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Parkinson enfermedad; Sistema nervioso patología; Electrocardiografía; Descubrimiento; Ritmo cardíaco; Variabilidad; Trastorno funcional</SD>
<LO>INIST-20953.354000192780100060</LO>
<ID>10-0491583</ID>
</server>
</inist>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/PascalFrancis/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000846 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Corpus/biblio.hfd -nk 000846 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= PascalFrancis |étape= Corpus |type= RBID |clé= Pascal:10-0491583 |texte= Exploring the Electrocardiogram as a Potential Tool to Screen for Premotor Parkinson's Disease }}
![]() | This area was generated with Dilib version V0.6.23. | ![]() |