MovDisordV3, PascalFrancis, Corpus, bibRecord, 000578

A Tale on Animal Models of Parkinson's Disease

Identifieur interne : 000578 ( PascalFrancis/Corpus ); précédent : 000577; suivant : 000579

A Tale on Animal Models of Parkinson's Disease

Auteurs : Erwan Bezard ; Serge Przedborski

Source :

Movement disorders [ 0885-3185 ] ; 2011.

RBID : Pascal:11-0264646

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Modèle animal, Animal, Rat, Souris, Primates.

English descriptors

KwdEn :
- Animal, Animal model, Mouse, Nervous system diseases, Parkinson disease, Primates, Rat.

Abstract

Parkinson's disease is a neurodegenerative disorder whose cardinal manifestations are due primarily to a profound deficit in brain dopamine. Since the 1980s, several therapeutic strategies have been discovered to treat the symptoms of this neurological disorder, but as of yet, none halts or retards the neurodegenerative process. In an attempt to shed light on the neurobiology of Parkinson's disease, a number of experimental models have been developed, especially during the last 25 years. They come essentially in 3 flavors: pharmacological (eg, reserpine), toxic (eg, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), and genetic (eg, transgenic synuclein mice). These models can also be recast as etiologic, pathogenic, and symptomatic/ pathophysiologic, as each may contribute to our understanding of the cause, the mechanisms, and the treatment of Parkinson's disease. In this review, we will discuss the question of Parkinson's disease models, starting from the period when this journal was born to today. During this journey of 25 years, we will discuss both the significant contributions of the Parkinson's disease models and hurdles that remain to be overcome to one day cure this neurological disease.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`02`	`1`		`@1 PRZEDBORSKI (Serge)`
A14	`01`			`@1 Insitute of Neurodegenerative Diseases, Université Victor Ségalen-Bordeaux II, Centre National de la Recherche Scientifique @2 Bordeaux @3 FRA @Z 1 aut.`
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Format Inist (serveur)

NO :	PASCAL 11-0264646 INIST
ET :	A Tale on Animal Models of Parkinson's Disease
AU :	BEZARD (Erwan); PRZEDBORSKI (Serge)
AF :	Insitute of Neurodegenerative Diseases, Université Victor Ségalen-Bordeaux II, Centre National de la Recherche Scientifique/Bordeaux/France (1 aut.); Departments of Neurology, Pathology, and Cell Biology and the Center for Motor Neuron. Biology and Disease, Columbia University/New York, New York/Etats-Unis (2 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2011; Vol. 26; No. 6; Pp. 993-1002; Bibl. 112 ref.
LA :	Anglais
EA :	Parkinson's disease is a neurodegenerative disorder whose cardinal manifestations are due primarily to a profound deficit in brain dopamine. Since the 1980s, several therapeutic strategies have been discovered to treat the symptoms of this neurological disorder, but as of yet, none halts or retards the neurodegenerative process. In an attempt to shed light on the neurobiology of Parkinson's disease, a number of experimental models have been developed, especially during the last 25 years. They come essentially in 3 flavors: pharmacological (eg, reserpine), toxic (eg, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridin e), and genetic (eg, transgenic synuclein mice). These models can also be recast as etiologic, pathogenic, and symptomatic/ pathophysiologic, as each may contribute to our understanding of the cause, the mechanisms, and the treatment of Parkinson's disease. In this review, we will discuss the question of Parkinson's disease models, starting from the period when this journal was born to today. During this journey of 25 years, we will discuss both the significant contributions of the Parkinson's disease models and hurdles that remain to be overcome to one day cure this neurological disease.
CC :	002B17; 002B17G
FD :	Maladie de Parkinson; Pathologie du système nerveux; Modèle animal; Animal; Rat; Souris; Primates
FG :	Rodentia; Mammalia; Vertebrata; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central
ED :	Parkinson disease; Nervous system diseases; Animal model; Animal; Rat; Mouse; Primates
EG :	Rodentia; Mammalia; Vertebrata; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD :	Parkinson enfermedad; Sistema nervioso patología; Modelo animal; Animal; Rata; Ratón; Primates
LO :	INIST-20953.354000191622890060
ID :	11-0264646

Links to Exploration step

Pascal:11-0264646

Le document en format XML

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<ET>A Tale on Animal Models of Parkinson's Disease</ET>
<AU>BEZARD (Erwan); PRZEDBORSKI (Serge)</AU>
<AF>Insitute of Neurodegenerative Diseases, Université Victor Ségalen-Bordeaux II, Centre National de la Recherche Scientifique/Bordeaux/France (1 aut.); Departments of Neurology, Pathology, and Cell Biology and the Center for Motor Neuron. Biology and Disease, Columbia University/New York, New York/Etats-Unis (2 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2011; Vol. 26; No. 6; Pp. 993-1002; Bibl. 112 ref.</SO>
<LA>Anglais</LA>
<EA>Parkinson's disease is a neurodegenerative disorder whose cardinal manifestations are due primarily to a profound deficit in brain dopamine. Since the 1980s, several therapeutic strategies have been discovered to treat the symptoms of this neurological disorder, but as of yet, none halts or retards the neurodegenerative process. In an attempt to shed light on the neurobiology of Parkinson's disease, a number of experimental models have been developed, especially during the last 25 years. They come essentially in 3 flavors: pharmacological (eg, reserpine), toxic (eg, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridin e), and genetic (eg, transgenic synuclein mice). These models can also be recast as etiologic, pathogenic, and symptomatic/ pathophysiologic, as each may contribute to our understanding of the cause, the mechanisms, and the treatment of Parkinson's disease. In this review, we will discuss the question of Parkinson's disease models, starting from the period when this journal was born to today. During this journey of 25 years, we will discuss both the significant contributions of the Parkinson's disease models and hurdles that remain to be overcome to one day cure this neurological disease.</EA>
<CC>002B17; 002B17G</CC>
<FD>Maladie de Parkinson; Pathologie du   système nerveux; Modèle animal; Animal; Rat; Souris; Primates</FD>
<FG>Rodentia; Mammalia; Vertebrata; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du   système nerveux central</FG>
<ED>Parkinson disease; Nervous system diseases; Animal model; Animal; Rat; Mouse; Primates</ED>
<EG>Rodentia; Mammalia; Vertebrata; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Parkinson enfermedad; Sistema nervioso patología; Modelo animal; Animal; Rata; Ratón; Primates</SD>
<LO>INIST-20953.354000191622890060</LO>
<ID>11-0264646</ID>
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	Movement Disorders (revue)
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Movement Disorders (revue)

A Tale on Animal Models of Parkinson's Disease

A Tale on Animal Models of Parkinson's Disease

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