MovDisordV3, PascalFrancis, Corpus, bibRecord, 000541

Pupillary Unrest Correlates With Arousal Symptoms and Motor Signs in Parkinson Disease

Identifieur interne : 000541 ( PascalFrancis/Corpus ); précédent : 000540; suivant : 000542

Pupillary Unrest Correlates With Arousal Symptoms and Motor Signs in Parkinson Disease

Auteurs : Samay Jain ; Greg J. Siegle ; CHEN GU ; Charity G. Moore ; Larry S. Ivanco ; Stephanie Studenski ; J. Timothy Greenamyre ; Stuart R. Steinhauer

Source :

Movement disorders [ 0885-3185 ] ; 2011.

RBID : Pascal:11-0321226

Descripteurs français

Pascal (Inist)
- Trouble moteur, Maladie de Parkinson, Trouble du sommeil, Pathologie du système nerveux, Eveil, Signe, Pupille, Trouble fonctionnel.

English descriptors

KwdEn :
- Arousal, Dysfunction, Motor system disorder, Nervous system diseases, Parkinson disease, Pupil, Sign, Sleep disorder.

Abstract

Background: Arousal symptoms (e.g., sleepiness) are common in Parkinson's disease, and pupillary unrest (spontaneous changes in pupil diameter) is positively associated with sleepiness. We explored pupillary unrest in Parkinson's disease. Methods: Arousal symptoms (Epworth sleepiness scale and sleep/fatigue domain of the nonmotor symptoms scale for Parkinson's disease) and pupillary unrest were assessed in 31 participants (14 patients with Parkinson's disease, 17 controls). Effect sizes and t tests compared patients with Parkinson's disease with control participants. Correlation coefficients were calculated among arousal symptoms, pupillary unrest, and Unified Parkinson Disease Rating Scale Part III. Linear regression was performed with arousal symptoms or pupillary unrest as outcome. Results: Participants with Parkinson's disease reported more arousal symptoms than controls. Pupillary unrest, arousal symptoms, and Unified Parkinson Disease Rating Scale Part III were positively correlated. The association between nonmotor symptoms scale-sleep score and pupillary unrest was higher in participants with Parkinson's disease than controls and higher in those with more Parkinsonian motor signs. Unified Parkinson Disease Rating Scale Part III was positively associated with pupillary unrest. Conclusions: Pupillary unrest correlates with motor and nonmotor features associated with Lewy-related pathology, suggesting it may be a nonmotor marker of progression in Parkinson's disease.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A08	`01`	`1`	`ENG`	`@1 Pupillary Unrest Correlates With Arousal Symptoms and Motor Signs in Parkinson Disease`
A11	`01`	`1`		`@1 JAIN (Samay)`
A11	`02`	`1`		`@1 SIEGLE (Greg J.)`
A11	`03`	`1`		`@1 CHEN GU`
A11	`04`	`1`		`@1 MOORE (Charity G.)`
A11	`05`	`1`		`@1 IVANCO (Larry S.)`
A11	`06`	`1`		`@1 STUDENSKI (Stephanie)`
A11	`07`	`1`		`@1 GREENAMYRE (J. Timothy)`
A11	`08`	`1`		`@1 STEINHAUER (Stuart R.)`
A14	`01`			`@1 University of Pittsburgh School of Medicine @2 Pittsburgh, Pennsylvania @3 USA @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut. @Z 7 aut. @Z 8 aut.`
A14	`02`			`@1 Pittsburgh Institute for Neurodegenerative Diseases @2 Pittsburgh, Pennsylvania @3 USA @Z 1 aut. @Z 7 aut.`
A14	`03`			`@1 VA Pittsburgh Healthcare System @2 Pittsburgh, Pennsylvania @3 USA @Z 7 aut. @Z 8 aut.`
A20				`@1 1344-1347`
A21				`@1 2011`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 20953 @5 354000190480410230`
A44				`@0 0000 @1 © 2011 INIST-CNRS. All rights reserved.`
A45				`@0 10 ref.`
A47	`01`	`1`		`@0 11-0321226`
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A61				`@0 A`
A64	`01`	`1`		`@0 Movement disorders`
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C01	`01`		`ENG`	@0 Background: Arousal symptoms (e.g., sleepiness) are common in Parkinson's disease, and pupillary unrest (spontaneous changes in pupil diameter) is positively associated with sleepiness. We explored pupillary unrest in Parkinson's disease. Methods: Arousal symptoms (Epworth sleepiness scale and sleep/fatigue domain of the nonmotor symptoms scale for Parkinson's disease) and pupillary unrest were assessed in 31 participants (14 patients with Parkinson's disease, 17 controls). Effect sizes and t tests compared patients with Parkinson's disease with control participants. Correlation coefficients were calculated among arousal symptoms, pupillary unrest, and Unified Parkinson Disease Rating Scale Part III. Linear regression was performed with arousal symptoms or pupillary unrest as outcome. Results: Participants with Parkinson's disease reported more arousal symptoms than controls. Pupillary unrest, arousal symptoms, and Unified Parkinson Disease Rating Scale Part III were positively correlated. The association between nonmotor symptoms scale-sleep score and pupillary unrest was higher in participants with Parkinson's disease than controls and higher in those with more Parkinsonian motor signs. Unified Parkinson Disease Rating Scale Part III was positively associated with pupillary unrest. Conclusions: Pupillary unrest correlates with motor and nonmotor features associated with Lewy-related pathology, suggesting it may be a nonmotor marker of progression in Parkinson's disease.
C02	`01`	`X`		`@0 002B17`
C02	`02`	`X`		`@0 002B17G`
C03	`01`	`X`	`FRE`	`@0 Trouble moteur @5 01`
C03	`01`	`X`	`ENG`	`@0 Motor system disorder @5 01`
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C03	`04`	`X`	`SPA`	`@0 Sistema nervioso patología @5 04`
C03	`05`	`X`	`FRE`	`@0 Eveil @5 09`
C03	`05`	`X`	`ENG`	`@0 Arousal @5 09`
C03	`05`	`X`	`SPA`	`@0 Despertar @5 09`
C03	`06`	`X`	`FRE`	`@0 Signe @5 10`
C03	`06`	`X`	`ENG`	`@0 Sign @5 10`
C03	`06`	`X`	`SPA`	`@0 Signo @5 10`
C03	`07`	`X`	`FRE`	`@0 Pupille @5 11`
C03	`07`	`X`	`ENG`	`@0 Pupil @5 11`
C03	`07`	`X`	`SPA`	`@0 Pupila @5 11`
C03	`08`	`X`	`FRE`	`@0 Trouble fonctionnel @5 12`
C03	`08`	`X`	`ENG`	`@0 Dysfunction @5 12`
C03	`08`	`X`	`SPA`	`@0 Trastorno funcional @5 12`
C07	`01`	`X`	`FRE`	`@0 Trouble neurologique @5 38`
C07	`01`	`X`	`ENG`	`@0 Neurological disorder @5 38`
C07	`01`	`X`	`SPA`	`@0 Trastorno neurológico @5 38`
C07	`02`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 39`
C07	`02`	`X`	`ENG`	`@0 Cerebral disorder @5 39`
C07	`02`	`X`	`SPA`	`@0 Encéfalo patología @5 39`
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C07	`03`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 40`
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N21				`@1 220`
N44	`01`			`@1 OTO`
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Format Inist (serveur)

NO :	PASCAL 11-0321226 INIST
ET :	Pupillary Unrest Correlates With Arousal Symptoms and Motor Signs in Parkinson Disease
AU :	JAIN (Samay); SIEGLE (Greg J.); CHEN GU; MOORE (Charity G.); IVANCO (Larry S.); STUDENSKI (Stephanie); GREENAMYRE (J. Timothy); STEINHAUER (Stuart R.)
AF :	University of Pittsburgh School of Medicine/Pittsburgh, Pennsylvania/Etats-Unis (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut., 8 aut.); Pittsburgh Institute for Neurodegenerative Diseases/Pittsburgh, Pennsylvania/Etats-Unis (1 aut., 7 aut.); VA Pittsburgh Healthcare System/Pittsburgh, Pennsylvania/Etats-Unis (7 aut., 8 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2011; Vol. 26; No. 7; Pp. 1344-1347; Bibl. 10 ref.
LA :	Anglais
EA :	Background: Arousal symptoms (e.g., sleepiness) are common in Parkinson's disease, and pupillary unrest (spontaneous changes in pupil diameter) is positively associated with sleepiness. We explored pupillary unrest in Parkinson's disease. Methods: Arousal symptoms (Epworth sleepiness scale and sleep/fatigue domain of the nonmotor symptoms scale for Parkinson's disease) and pupillary unrest were assessed in 31 participants (14 patients with Parkinson's disease, 17 controls). Effect sizes and t tests compared patients with Parkinson's disease with control participants. Correlation coefficients were calculated among arousal symptoms, pupillary unrest, and Unified Parkinson Disease Rating Scale Part III. Linear regression was performed with arousal symptoms or pupillary unrest as outcome. Results: Participants with Parkinson's disease reported more arousal symptoms than controls. Pupillary unrest, arousal symptoms, and Unified Parkinson Disease Rating Scale Part III were positively correlated. The association between nonmotor symptoms scale-sleep score and pupillary unrest was higher in participants with Parkinson's disease than controls and higher in those with more Parkinsonian motor signs. Unified Parkinson Disease Rating Scale Part III was positively associated with pupillary unrest. Conclusions: Pupillary unrest correlates with motor and nonmotor features associated with Lewy-related pathology, suggesting it may be a nonmotor marker of progression in Parkinson's disease.
CC :	002B17; 002B17G
FD :	Trouble moteur; Maladie de Parkinson; Trouble du sommeil; Pathologie du système nerveux; Eveil; Signe; Pupille; Trouble fonctionnel
FG :	Trouble neurologique; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central
ED :	Motor system disorder; Parkinson disease; Sleep disorder; Nervous system diseases; Arousal; Sign; Pupil; Dysfunction
EG :	Neurological disorder; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD :	Trastorno motor; Parkinson enfermedad; Trastorno sueño; Sistema nervioso patología; Despertar; Signo; Pupila; Trastorno funcional
LO :	INIST-20953.354000190480410230
ID :	11-0321226

Links to Exploration step

Pascal:11-0321226

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Pupillary Unrest Correlates With Arousal Symptoms and Motor Signs in Parkinson Disease</title>
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<sZ>8 aut.</sZ>
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</affiliation>
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<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2011">2011</date>
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<seriesStmt><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Arousal</term>
<term>Dysfunction</term>
<term>Motor system disorder</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Pupil</term>
<term>Sign</term>
<term>Sleep disorder</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Trouble moteur</term>
<term>Maladie de Parkinson</term>
<term>Trouble du sommeil</term>
<term>Pathologie du   système nerveux</term>
<term>Eveil</term>
<term>Signe</term>
<term>Pupille</term>
<term>Trouble fonctionnel</term>
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<front><div type="abstract" xml:lang="en">Background: Arousal symptoms (e.g., sleepiness) are common in Parkinson's disease, and pupillary unrest (spontaneous changes in pupil diameter) is positively associated with sleepiness. We explored pupillary unrest in Parkinson's disease. Methods: Arousal symptoms (Epworth sleepiness scale and sleep/fatigue domain of the nonmotor symptoms scale for Parkinson's disease) and pupillary unrest were assessed in 31 participants (14 patients with Parkinson's disease, 17 controls). Effect sizes and t tests compared patients with Parkinson's disease with control participants. Correlation coefficients were calculated among arousal symptoms, pupillary unrest, and Unified Parkinson Disease Rating Scale Part III. Linear regression was performed with arousal symptoms or pupillary unrest as outcome. Results: Participants with Parkinson's disease reported more arousal symptoms than controls. Pupillary unrest, arousal symptoms, and Unified Parkinson Disease Rating Scale Part III were positively correlated. The association between nonmotor symptoms scale-sleep score and pupillary unrest was higher in participants with Parkinson's disease than controls and higher in those with more Parkinsonian motor signs. Unified Parkinson Disease Rating Scale Part III was positively associated with pupillary unrest. Conclusions: Pupillary unrest correlates with motor and nonmotor features associated with Lewy-related pathology, suggesting it may be a nonmotor marker of progression in Parkinson's disease.</div>
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<fA11 i1="01" i2="1"><s1>JAIN (Samay)</s1>
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<fA11 i1="02" i2="1"><s1>SIEGLE (Greg J.)</s1>
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<fA11 i1="03" i2="1"><s1>CHEN GU</s1>
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<fA11 i1="07" i2="1"><s1>GREENAMYRE (J. Timothy)</s1>
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<fA11 i1="08" i2="1"><s1>STEINHAUER (Stuart R.)</s1>
</fA11>
<fA14 i1="01"><s1>University of Pittsburgh School of Medicine</s1>
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<sZ>7 aut.</sZ>
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<s2>Pittsburgh, Pennsylvania</s2>
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<fC01 i1="01" l="ENG"><s0>Background: Arousal symptoms (e.g., sleepiness) are common in Parkinson's disease, and pupillary unrest (spontaneous changes in pupil diameter) is positively associated with sleepiness. We explored pupillary unrest in Parkinson's disease. Methods: Arousal symptoms (Epworth sleepiness scale and sleep/fatigue domain of the nonmotor symptoms scale for Parkinson's disease) and pupillary unrest were assessed in 31 participants (14 patients with Parkinson's disease, 17 controls). Effect sizes and t tests compared patients with Parkinson's disease with control participants. Correlation coefficients were calculated among arousal symptoms, pupillary unrest, and Unified Parkinson Disease Rating Scale Part III. Linear regression was performed with arousal symptoms or pupillary unrest as outcome. Results: Participants with Parkinson's disease reported more arousal symptoms than controls. Pupillary unrest, arousal symptoms, and Unified Parkinson Disease Rating Scale Part III were positively correlated. The association between nonmotor symptoms scale-sleep score and pupillary unrest was higher in participants with Parkinson's disease than controls and higher in those with more Parkinsonian motor signs. Unified Parkinson Disease Rating Scale Part III was positively associated with pupillary unrest. Conclusions: Pupillary unrest correlates with motor and nonmotor features associated with Lewy-related pathology, suggesting it may be a nonmotor marker of progression in Parkinson's disease.</s0>
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<server><NO>PASCAL 11-0321226 INIST</NO>
<ET>Pupillary Unrest Correlates With Arousal Symptoms and Motor Signs in Parkinson Disease</ET>
<AU>JAIN (Samay); SIEGLE (Greg J.); CHEN GU; MOORE (Charity G.); IVANCO (Larry S.); STUDENSKI (Stephanie); GREENAMYRE (J. Timothy); STEINHAUER (Stuart R.)</AU>
<AF>University of Pittsburgh School of Medicine/Pittsburgh, Pennsylvania/Etats-Unis (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut., 8 aut.); Pittsburgh Institute for Neurodegenerative Diseases/Pittsburgh, Pennsylvania/Etats-Unis (1 aut., 7 aut.); VA Pittsburgh Healthcare System/Pittsburgh, Pennsylvania/Etats-Unis (7 aut., 8 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2011; Vol. 26; No. 7; Pp. 1344-1347; Bibl. 10 ref.</SO>
<LA>Anglais</LA>
<EA>Background: Arousal symptoms (e.g., sleepiness) are common in Parkinson's disease, and pupillary unrest (spontaneous changes in pupil diameter) is positively associated with sleepiness. We explored pupillary unrest in Parkinson's disease. Methods: Arousal symptoms (Epworth sleepiness scale and sleep/fatigue domain of the nonmotor symptoms scale for Parkinson's disease) and pupillary unrest were assessed in 31 participants (14 patients with Parkinson's disease, 17 controls). Effect sizes and t tests compared patients with Parkinson's disease with control participants. Correlation coefficients were calculated among arousal symptoms, pupillary unrest, and Unified Parkinson Disease Rating Scale Part III. Linear regression was performed with arousal symptoms or pupillary unrest as outcome. Results: Participants with Parkinson's disease reported more arousal symptoms than controls. Pupillary unrest, arousal symptoms, and Unified Parkinson Disease Rating Scale Part III were positively correlated. The association between nonmotor symptoms scale-sleep score and pupillary unrest was higher in participants with Parkinson's disease than controls and higher in those with more Parkinsonian motor signs. Unified Parkinson Disease Rating Scale Part III was positively associated with pupillary unrest. Conclusions: Pupillary unrest correlates with motor and nonmotor features associated with Lewy-related pathology, suggesting it may be a nonmotor marker of progression in Parkinson's disease.</EA>
<CC>002B17; 002B17G</CC>
<FD>Trouble moteur; Maladie de Parkinson; Trouble du sommeil; Pathologie du   système nerveux; Eveil; Signe; Pupille; Trouble fonctionnel</FD>
<FG>Trouble neurologique; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du   système nerveux central</FG>
<ED>Motor system disorder; Parkinson disease; Sleep disorder; Nervous system diseases; Arousal; Sign; Pupil; Dysfunction</ED>
<EG>Neurological disorder; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Trastorno motor; Parkinson enfermedad; Trastorno sueño; Sistema nervioso patología; Despertar; Signo; Pupila; Trastorno funcional</SD>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Pupillary Unrest Correlates With Arousal Symptoms and Motor Signs in Parkinson Disease

Pupillary Unrest Correlates With Arousal Symptoms and Motor Signs in Parkinson Disease

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