Development and validation of the Unified Multiple System Atrophy Rating Scale (UMSARS)
Identifieur interne : 002184 ( PascalFrancis/Checkpoint ); précédent : 002183; suivant : 002185Development and validation of the Unified Multiple System Atrophy Rating Scale (UMSARS)
Auteurs : Gregor K. Wenning [Autriche] ; Francois Tison [France] ; Klaus Seppi [Autriche] ; Cristina Sampaio [Portugal] ; Anja Diem [Autriche] ; Farid Yekhlef [France] ; Imad Ghorayeb [France] ; Fabienne Ory [France] ; Monique Galitzky [France] ; Tommaso Scaravilli [Royaume-Uni] ; Maria Bozi [Royaume-Uni] ; Carlo Colosimo [Italie] ; Sid Gilman [États-Unis] ; Clifford W. Shults [États-Unis] ; Niall P. Quinn [Royaume-Uni] ; Olivier Rascol [France] ; Werner Poewe [Autriche]Source :
- Movement disorders [ 0885-3185 ] ; 2004.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
We aimed to develop and validate a novel rating scale for multiple system atrophy (Unified Multiple System Atrophy Rating Scale - UMSARS). The scale comprises the following components: Part I, historical, 12 items; Part II, motor examination, 14 items; Part III, autonomic examination; and Part IV, global disability scale. For validation purposes, 40 MSA patients were assessed in four centers by 4 raters per center (2 senior and 2 junior raters). The raters applied the UMSARS, as well as a range of other scales, including the Unified Parkinson's Disease Rating Scale (UPDRS) and the International Cooperative Ataxia Rating Scale (ICARS). Internal consistency was high for both UMSARS-I (Crohnbach's alpha = 0.84) and UMSARS-II (Crohnbach's alpha = 0.90) sections. The interrater reliability of most of the UMSARS-I and -II items as well as of total UMSARS-I and -II subscores was substantial (k (w) = 0.6-0.8) to excellent (k (w) > 0.8). UMSARS-II correlated well with UPDRS-III and ICARS (rs > 0.8). Depending on the degree of the patient's disability, completion of the entire UMSARS took 30 to 45 minutes. Based on our findings, the UMSARS appears to be a multidimensional, reliable, and valid scale for semiquantitative clinical assessments of MSA patients.
Affiliations:
- Autriche, France, Italie, Portugal, Royaume-Uni, États-Unis
- Angleterre, Californie, Grand Londres, Latium, Michigan, Midi-Pyrénées, Tyrol (Land)
- Innsbruck, Londres, Rome, Toulouse
- Université Toulouse III - Paul Sabatier, Université de Rome « La Sapienza », Université de Toulouse, Université de médecine d'Innsbruck
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Wenning</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University of Innsbruck</s1><s2>Innsbruck</s2><s3>AUT</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Tison, Francois" sort="Tison, Francois" uniqKey="Tison F" first="Francois" last="Tison">Francois Tison</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Service de Neurologie, Hopital du Haut-Leveque</s1><s2>Pessac</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pessac</wicri:noRegion><wicri:noRegion>Hopital du Haut-Leveque</wicri:noRegion><wicri:noRegion>Pessac</wicri:noRegion></affiliation></author><author><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name><affiliation wicri:level="1"><inist:fA14 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aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pessac</wicri:noRegion><wicri:noRegion>Hopital du Haut-Leveque</wicri:noRegion><wicri:noRegion>Pessac</wicri:noRegion></affiliation></author><author><name sortKey="Ory, Fabienne" sort="Ory, Fabienne" uniqKey="Ory F" first="Fabienne" last="Ory">Fabienne Ory</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Toulouse III University, Laboratoire de Phannacologie, Faculte de Medecine</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Galitzky, Monique" sort="Galitzky, Monique" uniqKey="Galitzky M" first="Monique" last="Galitzky">Monique Galitzky</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Toulouse III University, Laboratoire de Phannacologie, Faculte de Medecine</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Scaravilli, Tommaso" sort="Scaravilli, Tommaso" uniqKey="Scaravilli T" first="Tommaso" last="Scaravilli">Tommaso Scaravilli</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>University College London, Institute of Neurology, Queen Square</s1><s2>London</s2><s3>GBR</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Bozi, Maria" sort="Bozi, Maria" uniqKey="Bozi M" first="Maria" last="Bozi">Maria Bozi</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>University College London, Institute of Neurology, Queen Square</s1><s2>London</s2><s3>GBR</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Colosimo, Carlo" sort="Colosimo, Carlo" uniqKey="Colosimo C" first="Carlo" last="Colosimo">Carlo Colosimo</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Dipartimento di Scienze Neurologiche, Universita'La Sapienza</s1><s2>Rome</s2><s3>ITA</s3><sZ>12 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName><orgName type="university">Université de Rome « La Sapienza »</orgName></affiliation></author><author><name sortKey="Gilman, Sid" sort="Gilman, Sid" uniqKey="Gilman S" first="Sid" last="Gilman">Sid Gilman</name><affiliation wicri:level="2"><inist:fA14 i1="07"><s1>Department of Neurology, University of Michigan</s1><s2>Ann Arbor, Michigan</s2><s3>USA</s3><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Shults, Clifford W" sort="Shults, Clifford W" uniqKey="Shults C" first="Clifford W." last="Shults">Clifford W. Shults</name><affiliation wicri:level="2"><inist:fA14 i1="08"><s1>Department of Neurosciences, University of California San Diego School of Medicine, La Jolla</s1><s2>California</s2><s3>USA</s3><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P." last="Quinn">Niall P. Quinn</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>University College London, Institute of Neurology, Queen Square</s1><s2>London</s2><s3>GBR</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Toulouse III University, Laboratoire de Phannacologie, Faculte de Medecine</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Toulouse</settlement></placeName><placeName><settlement type="city">Toulouse</settlement><region type="region" nuts="2">Midi-Pyrénées</region></placeName><orgName type="university" n="3">Université Toulouse III - Paul Sabatier</orgName><orgName type="institution" wicri:auto="newGroup">Université de Toulouse</orgName></affiliation></author><author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University of Innsbruck</s1><s2>Innsbruck</s2><s3>AUT</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Innsbruck</wicri:noRegion><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName><orgName type="university">Université de médecine d'Innsbruck</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">05-0069706</idno><date when="2004">2004</date><idno type="stanalyst">PASCAL 05-0069706 INIST</idno><idno type="RBID">Pascal:05-0069706</idno><idno type="wicri:Area/PascalFrancis/Corpus">002005</idno><idno type="wicri:Area/PascalFrancis/Curation">000D16</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">002184</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Development and validation of the Unified Multiple System Atrophy Rating Scale (UMSARS)</title><author><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K." last="Wenning">Gregor K. Wenning</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University of Innsbruck</s1><s2>Innsbruck</s2><s3>AUT</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Tison, Francois" sort="Tison, Francois" uniqKey="Tison F" first="Francois" last="Tison">Francois Tison</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Service de Neurologie, Hopital du Haut-Leveque</s1><s2>Pessac</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pessac</wicri:noRegion><wicri:noRegion>Hopital du Haut-Leveque</wicri:noRegion><wicri:noRegion>Pessac</wicri:noRegion></affiliation></author><author><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University of Innsbruck</s1><s2>Innsbruck</s2><s3>AUT</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Sampaio, Cristina" sort="Sampaio, Cristina" uniqKey="Sampaio C" first="Cristina" last="Sampaio">Cristina Sampaio</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Faculdade de Medicine de Lisboa, Hospital Santa Maria, Centro de Neurosciencas</s1><s2>Lisboa</s2><s3>PRT</s3><sZ>4 aut.</sZ></inist:fA14><country>Portugal</country><wicri:noRegion>Lisboa</wicri:noRegion></affiliation></author><author><name sortKey="Diem, Anja" sort="Diem, Anja" uniqKey="Diem A" first="Anja" last="Diem">Anja Diem</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University of Innsbruck</s1><s2>Innsbruck</s2><s3>AUT</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Yekhlef, Farid" sort="Yekhlef, Farid" uniqKey="Yekhlef F" first="Farid" last="Yekhlef">Farid Yekhlef</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Service de Neurologie, Hopital du Haut-Leveque</s1><s2>Pessac</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pessac</wicri:noRegion><wicri:noRegion>Hopital du Haut-Leveque</wicri:noRegion><wicri:noRegion>Pessac</wicri:noRegion></affiliation></author><author><name sortKey="Ghorayeb, Imad" sort="Ghorayeb, Imad" uniqKey="Ghorayeb I" first="Imad" last="Ghorayeb">Imad Ghorayeb</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Service de Neurologie, Hopital du Haut-Leveque</s1><s2>Pessac</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pessac</wicri:noRegion><wicri:noRegion>Hopital du Haut-Leveque</wicri:noRegion><wicri:noRegion>Pessac</wicri:noRegion></affiliation></author><author><name sortKey="Ory, Fabienne" sort="Ory, Fabienne" uniqKey="Ory F" first="Fabienne" last="Ory">Fabienne Ory</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Toulouse III University, Laboratoire de Phannacologie, Faculte de Medecine</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Galitzky, Monique" sort="Galitzky, Monique" uniqKey="Galitzky M" first="Monique" last="Galitzky">Monique Galitzky</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Toulouse III University, Laboratoire de Phannacologie, Faculte de Medecine</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Scaravilli, Tommaso" sort="Scaravilli, Tommaso" uniqKey="Scaravilli T" first="Tommaso" last="Scaravilli">Tommaso Scaravilli</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>University College London, Institute of Neurology, Queen Square</s1><s2>London</s2><s3>GBR</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Bozi, Maria" sort="Bozi, Maria" uniqKey="Bozi M" first="Maria" last="Bozi">Maria Bozi</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>University College London, Institute of Neurology, Queen Square</s1><s2>London</s2><s3>GBR</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Colosimo, Carlo" sort="Colosimo, Carlo" uniqKey="Colosimo C" first="Carlo" last="Colosimo">Carlo Colosimo</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Dipartimento di Scienze Neurologiche, Universita'La Sapienza</s1><s2>Rome</s2><s3>ITA</s3><sZ>12 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName><orgName type="university">Université de Rome « La Sapienza »</orgName></affiliation></author><author><name sortKey="Gilman, Sid" sort="Gilman, Sid" uniqKey="Gilman S" first="Sid" last="Gilman">Sid Gilman</name><affiliation wicri:level="2"><inist:fA14 i1="07"><s1>Department of Neurology, University of Michigan</s1><s2>Ann Arbor, Michigan</s2><s3>USA</s3><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Shults, Clifford W" sort="Shults, Clifford W" uniqKey="Shults C" first="Clifford W." last="Shults">Clifford W. Shults</name><affiliation wicri:level="2"><inist:fA14 i1="08"><s1>Department of Neurosciences, University of California San Diego School of Medicine, La Jolla</s1><s2>California</s2><s3>USA</s3><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P." last="Quinn">Niall P. Quinn</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>University College London, Institute of Neurology, Queen Square</s1><s2>London</s2><s3>GBR</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Toulouse III University, Laboratoire de Phannacologie, Faculte de Medecine</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Toulouse</settlement></placeName><placeName><settlement type="city">Toulouse</settlement><region type="region" nuts="2">Midi-Pyrénées</region></placeName><orgName type="university" n="3">Université Toulouse III - Paul Sabatier</orgName><orgName type="institution" wicri:auto="newGroup">Université de Toulouse</orgName></affiliation></author><author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University of Innsbruck</s1><s2>Innsbruck</s2><s3>AUT</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Innsbruck</wicri:noRegion><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName><orgName type="university">Université de médecine d'Innsbruck</orgName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Evaluation scale</term><term>Multiple system atrophy</term><term>Nervous system diseases</term><term>Validation</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Validation</term><term>Echelle d'évaluation</term><term>Atrophie multisystématisée</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We aimed to develop and validate a novel rating scale for multiple system atrophy (Unified Multiple System Atrophy Rating Scale - UMSARS). The scale comprises the following components: Part I, historical, 12 items; Part II, motor examination, 14 items; Part III, autonomic examination; and Part IV, global disability scale. For validation purposes, 40 MSA patients were assessed in four centers by 4 raters per center (2 senior and 2 junior raters). The raters applied the UMSARS, as well as a range of other scales, including the Unified Parkinson's Disease Rating Scale (UPDRS) and the International Cooperative Ataxia Rating Scale (ICARS). Internal consistency was high for both UMSARS-I (Crohnbach's alpha = 0.84) and UMSARS-II (Crohnbach's alpha = 0.90) sections. The interrater reliability of most of the UMSARS-I and -II items as well as of total UMSARS-I and -II subscores was substantial (k (w) = 0.6-0.8) to excellent (k (w) > 0.8). UMSARS-II correlated well with UPDRS-III and ICARS (r<sub>s</sub> > 0.8). Depending on the degree of the patient's disability, completion of the entire UMSARS took 30 to 45 minutes. Based on our findings, the UMSARS appears to be a multidimensional, reliable, and valid scale for semiquantitative clinical assessments of MSA patients.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>19</s2></fA05><fA06><s2>12</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Development and validation of the Unified Multiple System Atrophy Rating Scale (UMSARS)</s1></fA08><fA11 i1="01" i2="1"><s1>WENNING (Gregor K.)</s1></fA11><fA11 i1="02" i2="1"><s1>TISON (Francois)</s1></fA11><fA11 i1="03" i2="1"><s1>SEPPI (Klaus)</s1></fA11><fA11 i1="04" i2="1"><s1>SAMPAIO (Cristina)</s1></fA11><fA11 i1="05" i2="1"><s1>DIEM (Anja)</s1></fA11><fA11 i1="06" i2="1"><s1>YEKHLEF (Farid)</s1></fA11><fA11 i1="07" i2="1"><s1>GHORAYEB (Imad)</s1></fA11><fA11 i1="08" i2="1"><s1>ORY (Fabienne)</s1></fA11><fA11 i1="09" i2="1"><s1>GALITZKY (Monique)</s1></fA11><fA11 i1="10" i2="1"><s1>SCARAVILLI (Tommaso)</s1></fA11><fA11 i1="11" i2="1"><s1>BOZI (Maria)</s1></fA11><fA11 i1="12" i2="1"><s1>COLOSIMO (Carlo)</s1></fA11><fA11 i1="13" i2="1"><s1>GILMAN (Sid)</s1></fA11><fA11 i1="14" i2="1"><s1>SHULTS (Clifford W.)</s1></fA11><fA11 i1="15" i2="1"><s1>QUINN (Niall P.)</s1></fA11><fA11 i1="16" i2="1"><s1>RASCOL (Olivier)</s1></fA11><fA11 i1="17" i2="1"><s1>POEWE (Werner)</s1></fA11><fA14 i1="01"><s1>Department of Neurology, University of Innsbruck</s1><s2>Innsbruck</s2><s3>AUT</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>17 aut.</sZ></fA14><fA14 i1="02"><s1>Service de Neurologie, Hopital du Haut-Leveque</s1><s2>Pessac</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></fA14><fA14 i1="03"><s1>Faculdade de Medicine de Lisboa, Hospital Santa Maria, Centro de Neurosciencas</s1><s2>Lisboa</s2><s3>PRT</s3><sZ>4 aut.</sZ></fA14><fA14 i1="04"><s1>Toulouse III University, Laboratoire de Phannacologie, Faculte de Medecine</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>16 aut.</sZ></fA14><fA14 i1="05"><s1>University College London, Institute of Neurology, Queen Square</s1><s2>London</s2><s3>GBR</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ></fA14><fA14 i1="06"><s1>Dipartimento di Scienze Neurologiche, Universita'La Sapienza</s1><s2>Rome</s2><s3>ITA</s3><sZ>12 aut.</sZ></fA14><fA14 i1="07"><s1>Department of Neurology, University of Michigan</s1><s2>Ann Arbor, Michigan</s2><s3>USA</s3><sZ>13 aut.</sZ></fA14><fA14 i1="08"><s1>Department of Neurosciences, University of California San Diego School of Medicine, La Jolla</s1><s2>California</s2><s3>USA</s3><sZ>14 aut.</sZ></fA14><fA17 i1="01" i2="1"><s1>Multiple System Atrophy Study Group</s1><s3>INC</s3></fA17><fA20><s1>1391-1402</s1></fA20><fA21><s1>2004</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000125735400010</s5></fA43><fA44><s0>0000</s0><s1>© 2005 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>31 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>05-0069706</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>We aimed to develop and validate a novel rating scale for multiple system atrophy (Unified Multiple System Atrophy Rating Scale - UMSARS). The scale comprises the following components: Part I, historical, 12 items; Part II, motor examination, 14 items; Part III, autonomic examination; and Part IV, global disability scale. For validation purposes, 40 MSA patients were assessed in four centers by 4 raters per center (2 senior and 2 junior raters). The raters applied the UMSARS, as well as a range of other scales, including the Unified Parkinson's Disease Rating Scale (UPDRS) and the International Cooperative Ataxia Rating Scale (ICARS). Internal consistency was high for both UMSARS-I (Crohnbach's alpha = 0.84) and UMSARS-II (Crohnbach's alpha = 0.90) sections. The interrater reliability of most of the UMSARS-I and -II items as well as of total UMSARS-I and -II subscores was substantial (k (w) = 0.6-0.8) to excellent (k (w) > 0.8). UMSARS-II correlated well with UPDRS-III and ICARS (r<sub>s</sub> > 0.8). Depending on the degree of the patient's disability, completion of the entire UMSARS took 30 to 45 minutes. Based on our findings, the UMSARS appears to be a multidimensional, reliable, and valid scale for semiquantitative clinical assessments of MSA patients.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17F</s0></fC02><fC02 i1="03" i2="X"><s0>002B17G</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Validation</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Validation</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Validación</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Echelle d'évaluation</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Evaluation scale</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Escala evaluación</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Atrophie multisystématisée</s0><s2>NM</s2><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Multiple system atrophy</s0><s2>NM</s2><s5>04</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Atrofia multisistematizada</s0><s2>NM</s2><s5>04</s5></fC03><fN21><s1>038</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Autriche</li><li>France</li><li>Italie</li><li>Portugal</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Californie</li><li>Grand Londres</li><li>Latium</li><li>Michigan</li><li>Midi-Pyrénées</li><li>Tyrol (Land)</li></region><settlement><li>Innsbruck</li><li>Londres</li><li>Rome</li><li>Toulouse</li></settlement><orgName><li>Université Toulouse III - Paul Sabatier</li><li>Université de Rome « La Sapienza »</li><li>Université de Toulouse</li><li>Université de médecine d'Innsbruck</li></orgName></list><tree><country name="Autriche"><noRegion><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K." last="Wenning">Gregor K. Wenning</name></noRegion><name sortKey="Diem, Anja" sort="Diem, Anja" uniqKey="Diem A" first="Anja" last="Diem">Anja Diem</name><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name></country><country name="France"><noRegion><name sortKey="Tison, Francois" sort="Tison, Francois" uniqKey="Tison F" first="Francois" last="Tison">Francois Tison</name></noRegion><name sortKey="Galitzky, Monique" sort="Galitzky, Monique" uniqKey="Galitzky M" first="Monique" last="Galitzky">Monique Galitzky</name><name sortKey="Ghorayeb, Imad" sort="Ghorayeb, Imad" uniqKey="Ghorayeb I" first="Imad" last="Ghorayeb">Imad Ghorayeb</name><name sortKey="Ory, Fabienne" sort="Ory, Fabienne" uniqKey="Ory F" first="Fabienne" last="Ory">Fabienne Ory</name><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name><name sortKey="Yekhlef, Farid" sort="Yekhlef, Farid" uniqKey="Yekhlef F" first="Farid" last="Yekhlef">Farid Yekhlef</name></country><country name="Portugal"><noRegion><name sortKey="Sampaio, Cristina" sort="Sampaio, Cristina" uniqKey="Sampaio C" first="Cristina" last="Sampaio">Cristina Sampaio</name></noRegion></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Scaravilli, Tommaso" sort="Scaravilli, Tommaso" uniqKey="Scaravilli T" first="Tommaso" last="Scaravilli">Tommaso Scaravilli</name></region><name sortKey="Bozi, Maria" sort="Bozi, Maria" uniqKey="Bozi M" first="Maria" last="Bozi">Maria Bozi</name><name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P." last="Quinn">Niall P. Quinn</name></country><country name="Italie"><region name="Latium"><name sortKey="Colosimo, Carlo" sort="Colosimo, Carlo" uniqKey="Colosimo C" first="Carlo" last="Colosimo">Carlo Colosimo</name></region></country><country name="États-Unis"><region name="Michigan"><name sortKey="Gilman, Sid" sort="Gilman, Sid" uniqKey="Gilman S" first="Sid" last="Gilman">Sid Gilman</name></region><name sortKey="Shults, Clifford W" sort="Shults, Clifford W" uniqKey="Shults C" first="Clifford W." last="Shults">Clifford W. Shults</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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