International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson's disease : The NMSQuest study
Identifieur interne : 001A48 ( PascalFrancis/Checkpoint ); précédent : 001A47; suivant : 001A49International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson's disease : The NMSQuest study
Auteurs : Kallol Ray Chaudhuri [Royaume-Uni] ; Pablo Martinez-Martin [Espagne] ; Anthony H. V. Schapira [Royaume-Uni] ; Fabrizio Stocchi [Italie] ; Kapil Sethi [États-Unis] ; Per Odin [Allemagne] ; Richard G. Brown [Royaume-Uni] ; William Koller [États-Unis] ; Paolo Barone [Italie] ; Graeme Macphee [Royaume-Uni] ; Linda Kelly [Royaume-Uni] ; Martin Rabey [Israël] ; Doug Macmahon [Royaume-Uni] ; Sue Thomas [Royaume-Uni] ; William Ondo [États-Unis] ; David Rye [États-Unis] ; Alison Forbes [Royaume-Uni] ; Susanne Tluk [Royaume-Uni] ; Vandana Dhawan [Royaume-Uni] ; Annette Bowron [Royaume-Uni] ; Adrian J. Williams [Royaume-Uni] ; Charles W. Olanow [États-Unis]Source :
- Movement disorders [ 0885-3185 ] ; 2006.
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Abstract
Nonmotor symptoms (NMS) of Parkinson's disease (PD) are not well recognized in clinical practice, either in primary or in secondary care, and are frequently missed during routine consultations. There is no single instrument (questionnaire or scale) that enables a comprehensive assessment of the range of NMS in PD both for the identification of problems and for the measurement of outcome. Against this background, a multidisciplinary group of experts, including patient group representatives, has developed an NMS screening questionnaire comprising 30 items. This instrument does not provide an overall score of disability and is not a graded or rating instrument. Instead, it is a screening tool designed to draw attention to the presence of NMS and initiate further investigation. In this article, we present the results from an international pilot study assessing feasibility, validity, and acceptability of a nonmotor questionnaire (NMSQuest). Data from 123 PD patients and 96 controls were analyzed. NMS were highly significantly more prevalent in PD compared to controls (PD NMS, median = 9.0, mean - 9.5 vs. control NMS, median = 5.5, mean = 4.0; Mann-Whitney, Kruskal-Wallis, and t test, P < 0.0001), with PD patients reporting at least 10 different NMS on average per patient. In PD, NMS were highly significantly more prevalent across all disease stages and the number of symptoms correlated significantly with advancing disease and duration of disease. Furthermore, frequently, problems such as diplopia, dribbling, apathy, blues, taste and smell problems were never previously disclosed to the health professionals.
Affiliations:
- Allemagne, Espagne, Israël, Italie, Royaume-Uni, États-Unis
- Angleterre, Caroline du Nord, Communauté de Madrid, Grand Londres, Géorgie (États-Unis), Texas, État de New York
- Londres, Madrid
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson's disease : The NMSQuest study</title><author><name sortKey="Chaudhuri, Kallol Ray" sort="Chaudhuri, Kallol Ray" uniqKey="Chaudhuri K" first="Kallol Ray" last="Chaudhuri">Kallol Ray Chaudhuri</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Movement Disorders Unit, Kings College Hospital, University Hospital Lewisham, Guy's King's and St. Thomas' School of Medicine</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Martinez Martin, Pablo" sort="Martinez Martin, Pablo" uniqKey="Martinez Martin P" first="Pablo" last="Martinez-Martin">Pablo Martinez-Martin</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Unit of Neuroepidemiology, National Center for Epidemiology, Carlos III Institute of Health</s1><s2>Madrid</s2><s3>ESP</s3><sZ>2 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Schapira, Anthony H V" sort="Schapira, Anthony H V" uniqKey="Schapira A" first="Anthony H. 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Schapira</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, Royal Free Hospital Medical School and National Hospital for Neurology</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Stocchi, Fabrizio" sort="Stocchi, Fabrizio" uniqKey="Stocchi F" first="Fabrizio" last="Stocchi">Fabrizio Stocchi</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Institute of Neurology, IRCCS NEUROMED</s1><s2>Pozzilli</s2><s3>ITA</s3><sZ>4 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Pozzilli</wicri:noRegion></affiliation></author><author><name sortKey="Sethi, Kapil" sort="Sethi, Kapil" uniqKey="Sethi K" first="Kapil" last="Sethi">Kapil Sethi</name><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Department of Neurology, Medical College of Georgia</s1><s2>Augusta, Georgia</s2><s3>USA</s3><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Odin, Per" sort="Odin, Per" uniqKey="Odin P" first="Per" last="Odin">Per Odin</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurology, Klinikum-Bremerhaven Reinkenheide</s1><s2>Bremenhaven</s2><s3>DEU</s3><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Bremenhaven</wicri:noRegion><wicri:noRegion>Klinikum-Bremerhaven Reinkenheide</wicri:noRegion><wicri:noRegion>Bremenhaven</wicri:noRegion></affiliation></author><author><name sortKey="Brown, Richard G" sort="Brown, Richard G" uniqKey="Brown R" first="Richard G." last="Brown">Richard G. Brown</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Psychology, Institute of Psychiatry, King's College London</s1><s2>London</s2><s3>GBR</s3><sZ>7 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Koller, William" sort="Koller, William" uniqKey="Koller W" first="William" last="Koller">William Koller</name><affiliation wicri:level="2"><inist:fA14 i1="08"><s1>Department of Neurology, University of North Carolina</s1><s2>Chapel Hill, North Carolina</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Neurology, University of Napoli</s1><s2>Napoli</s2><s3>ITA</s3><sZ>9 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Napoli</wicri:noRegion></affiliation></author><author><name sortKey="Macphee, Graeme" sort="Macphee, Graeme" uniqKey="Macphee G" first="Graeme" last="Macphee">Graeme Macphee</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Care of the Elderly, Southern General Hospital</s1><s2>Glasgow</s2><s3>GBR</s3><sZ>10 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Glasgow</wicri:noRegion></affiliation></author><author><name sortKey="Kelly, Linda" sort="Kelly, Linda" uniqKey="Kelly L" first="Linda" last="Kelly">Linda Kelly</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>U.K. Parkinson's Disease Society</s1><s2>London</s2><s3>GBR</s3><sZ>11 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Rabey, Martin" sort="Rabey, Martin" uniqKey="Rabey M" first="Martin" last="Rabey">Martin Rabey</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Assaf Harofeh Medical Center, School of Medicine, Tel-Aviv University</s1><s2>Zerifin</s2><s3>ISR</s3><sZ>12 aut.</sZ></inist:fA14><country>Israël</country><wicri:noRegion>Zerifin</wicri:noRegion></affiliation></author><author><name sortKey="Macmahon, Doug" sort="Macmahon, Doug" uniqKey="Macmahon D" first="Doug" last="Macmahon">Doug Macmahon</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Department of Care of the Elderly, Camborne-Redruth Hospital</s1><s2>Cornwall</s2><s3>GBR</s3><sZ>13 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cornwall</wicri:noRegion></affiliation></author><author><name sortKey="Thomas, Sue" sort="Thomas, Sue" uniqKey="Thomas S" first="Sue" last="Thomas">Sue Thomas</name><affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Division of Nursing, Royal College of Nursing</s1><s2>London</s2><s3>GBR</s3><sZ>14 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Ondo, William" sort="Ondo, William" uniqKey="Ondo W" first="William" last="Ondo">William Ondo</name><affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Department of Neurology, Baylor College of Medicine</s1><s2>Houston, Texas</s2><s3>USA</s3><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Rye, David" sort="Rye, David" uniqKey="Rye D" first="David" last="Rye">David Rye</name><affiliation wicri:level="2"><inist:fA14 i1="16"><s1>Department of Neurology, Emory University</s1><s2>Atlanta, Georgia</s2><s3>USA</s3><sZ>16 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Forbes, Alison" sort="Forbes, Alison" uniqKey="Forbes A" first="Alison" last="Forbes">Alison Forbes</name><affiliation wicri:level="3"><inist:fA14 i1="17"><s1>Department of Neurology, University Hospital Lewisham</s1><s2>London</s2><s3>GBR</s3><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Tluk, Susanne" sort="Tluk, Susanne" uniqKey="Tluk S" first="Susanne" last="Tluk">Susanne Tluk</name><affiliation wicri:level="3"><inist:fA14 i1="17"><s1>Department of Neurology, University Hospital Lewisham</s1><s2>London</s2><s3>GBR</s3><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Dhawan, Vandana" sort="Dhawan, Vandana" uniqKey="Dhawan V" first="Vandana" last="Dhawan">Vandana Dhawan</name><affiliation wicri:level="3"><inist:fA14 i1="17"><s1>Department of Neurology, University Hospital Lewisham</s1><s2>London</s2><s3>GBR</s3><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="18"><s1>Movement Disorders Section, Department of Neurology, King's College Hospital</s1><s2>London</s2><s3>GBR</s3><sZ>19 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Bowron, Annette" sort="Bowron, Annette" uniqKey="Bowron A" first="Annette" last="Bowron">Annette Bowron</name><affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Department of Medicine, North Tyneside General Hospital</s1><s2>North Shields</s2><s3>GBR</s3><sZ>20 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>North Shields</wicri:noRegion></affiliation></author><author><name sortKey="Williams, Adrian J" sort="Williams, Adrian J" uniqKey="Williams A" first="Adrian J." last="Williams">Adrian J. Williams</name><affiliation wicri:level="3"><inist:fA14 i1="20"><s1>Lane-Fox Sleep Centre, St. Thomas' Hospital</s1><s2>London</s2><s3>GBR</s3><sZ>21 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Olanow, Charles W" sort="Olanow, Charles W" uniqKey="Olanow C" first="Charles W." last="Olanow">Charles W. Olanow</name><affiliation wicri:level="2"><inist:fA14 i1="21"><s1>Department of Neurology, Mount Sinai School of Medicine</s1><s2>New York, New York</s2><s3>USA</s3><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">06-0393851</idno><date when="2006">2006</date><idno type="stanalyst">PASCAL 06-0393851 INIST</idno><idno type="RBID">Pascal:06-0393851</idno><idno type="wicri:Area/PascalFrancis/Corpus">001A93</idno><idno type="wicri:Area/PascalFrancis/Curation">001228</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001A48</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson's disease : The NMSQuest study</title><author><name sortKey="Chaudhuri, Kallol Ray" sort="Chaudhuri, Kallol Ray" uniqKey="Chaudhuri K" first="Kallol Ray" last="Chaudhuri">Kallol Ray Chaudhuri</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Movement Disorders Unit, Kings College Hospital, University Hospital Lewisham, Guy's King's and St. Thomas' School of Medicine</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Martinez Martin, Pablo" sort="Martinez Martin, Pablo" uniqKey="Martinez Martin P" first="Pablo" last="Martinez-Martin">Pablo Martinez-Martin</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Unit of Neuroepidemiology, National Center for Epidemiology, Carlos III Institute of Health</s1><s2>Madrid</s2><s3>ESP</s3><sZ>2 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Schapira, Anthony H V" sort="Schapira, Anthony H V" uniqKey="Schapira A" first="Anthony H. V." last="Schapira">Anthony H. V. Schapira</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, Royal Free Hospital Medical School and National Hospital for Neurology</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Stocchi, Fabrizio" sort="Stocchi, Fabrizio" uniqKey="Stocchi F" first="Fabrizio" last="Stocchi">Fabrizio Stocchi</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Institute of Neurology, IRCCS NEUROMED</s1><s2>Pozzilli</s2><s3>ITA</s3><sZ>4 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Pozzilli</wicri:noRegion></affiliation></author><author><name sortKey="Sethi, Kapil" sort="Sethi, Kapil" uniqKey="Sethi K" first="Kapil" last="Sethi">Kapil Sethi</name><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Department of Neurology, Medical College of Georgia</s1><s2>Augusta, Georgia</s2><s3>USA</s3><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Odin, Per" sort="Odin, Per" uniqKey="Odin P" first="Per" last="Odin">Per Odin</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurology, Klinikum-Bremerhaven Reinkenheide</s1><s2>Bremenhaven</s2><s3>DEU</s3><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Bremenhaven</wicri:noRegion><wicri:noRegion>Klinikum-Bremerhaven Reinkenheide</wicri:noRegion><wicri:noRegion>Bremenhaven</wicri:noRegion></affiliation></author><author><name sortKey="Brown, Richard G" sort="Brown, Richard G" uniqKey="Brown R" first="Richard G." last="Brown">Richard G. Brown</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Psychology, Institute of Psychiatry, King's College London</s1><s2>London</s2><s3>GBR</s3><sZ>7 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Koller, William" sort="Koller, William" uniqKey="Koller W" first="William" last="Koller">William Koller</name><affiliation wicri:level="2"><inist:fA14 i1="08"><s1>Department of Neurology, University of North Carolina</s1><s2>Chapel Hill, North Carolina</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Neurology, University of Napoli</s1><s2>Napoli</s2><s3>ITA</s3><sZ>9 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Napoli</wicri:noRegion></affiliation></author><author><name sortKey="Macphee, Graeme" sort="Macphee, Graeme" uniqKey="Macphee G" first="Graeme" last="Macphee">Graeme Macphee</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Care of the Elderly, Southern General Hospital</s1><s2>Glasgow</s2><s3>GBR</s3><sZ>10 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Glasgow</wicri:noRegion></affiliation></author><author><name sortKey="Kelly, Linda" sort="Kelly, Linda" uniqKey="Kelly L" first="Linda" last="Kelly">Linda Kelly</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>U.K. Parkinson's Disease Society</s1><s2>London</s2><s3>GBR</s3><sZ>11 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Rabey, Martin" sort="Rabey, Martin" uniqKey="Rabey M" first="Martin" last="Rabey">Martin Rabey</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Assaf Harofeh Medical Center, School of Medicine, Tel-Aviv University</s1><s2>Zerifin</s2><s3>ISR</s3><sZ>12 aut.</sZ></inist:fA14><country>Israël</country><wicri:noRegion>Zerifin</wicri:noRegion></affiliation></author><author><name sortKey="Macmahon, Doug" sort="Macmahon, Doug" uniqKey="Macmahon D" first="Doug" last="Macmahon">Doug Macmahon</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Department of Care of the Elderly, Camborne-Redruth Hospital</s1><s2>Cornwall</s2><s3>GBR</s3><sZ>13 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cornwall</wicri:noRegion></affiliation></author><author><name sortKey="Thomas, Sue" sort="Thomas, Sue" uniqKey="Thomas S" first="Sue" last="Thomas">Sue Thomas</name><affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Division of Nursing, Royal College of Nursing</s1><s2>London</s2><s3>GBR</s3><sZ>14 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Ondo, William" sort="Ondo, William" uniqKey="Ondo W" first="William" last="Ondo">William Ondo</name><affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Department of Neurology, Baylor College of Medicine</s1><s2>Houston, Texas</s2><s3>USA</s3><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Rye, David" sort="Rye, David" uniqKey="Rye D" first="David" last="Rye">David Rye</name><affiliation wicri:level="2"><inist:fA14 i1="16"><s1>Department of Neurology, Emory University</s1><s2>Atlanta, Georgia</s2><s3>USA</s3><sZ>16 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Forbes, Alison" sort="Forbes, Alison" uniqKey="Forbes A" first="Alison" last="Forbes">Alison Forbes</name><affiliation wicri:level="3"><inist:fA14 i1="17"><s1>Department of Neurology, University Hospital Lewisham</s1><s2>London</s2><s3>GBR</s3><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Tluk, Susanne" sort="Tluk, Susanne" uniqKey="Tluk S" first="Susanne" last="Tluk">Susanne Tluk</name><affiliation wicri:level="3"><inist:fA14 i1="17"><s1>Department of Neurology, University Hospital Lewisham</s1><s2>London</s2><s3>GBR</s3><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Dhawan, Vandana" sort="Dhawan, Vandana" uniqKey="Dhawan V" first="Vandana" last="Dhawan">Vandana Dhawan</name><affiliation wicri:level="3"><inist:fA14 i1="17"><s1>Department of Neurology, University Hospital Lewisham</s1><s2>London</s2><s3>GBR</s3><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="18"><s1>Movement Disorders Section, Department of Neurology, King's College Hospital</s1><s2>London</s2><s3>GBR</s3><sZ>19 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Bowron, Annette" sort="Bowron, Annette" uniqKey="Bowron A" first="Annette" last="Bowron">Annette Bowron</name><affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Department of Medicine, North Tyneside General Hospital</s1><s2>North Shields</s2><s3>GBR</s3><sZ>20 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>North Shields</wicri:noRegion></affiliation></author><author><name sortKey="Williams, Adrian J" sort="Williams, Adrian J" uniqKey="Williams A" first="Adrian J." last="Williams">Adrian J. Williams</name><affiliation wicri:level="3"><inist:fA14 i1="20"><s1>Lane-Fox Sleep Centre, St. Thomas' Hospital</s1><s2>London</s2><s3>GBR</s3><sZ>21 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Olanow, Charles W" sort="Olanow, Charles W" uniqKey="Olanow C" first="Charles W." last="Olanow">Charles W. Olanow</name><affiliation wicri:level="2"><inist:fA14 i1="21"><s1>Department of Neurology, Mount Sinai School of Medicine</s1><s2>New York, New York</s2><s3>USA</s3><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Evaluation scale</term><term>Multicenter study</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Quality of life</term><term>Questionnaire</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Parkinson maladie</term><term>Etude multicentrique</term><term>Questionnaire</term><term>Echelle d'évaluation</term><term>Qualité vie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Nonmotor symptoms (NMS) of Parkinson's disease (PD) are not well recognized in clinical practice, either in primary or in secondary care, and are frequently missed during routine consultations. There is no single instrument (questionnaire or scale) that enables a comprehensive assessment of the range of NMS in PD both for the identification of problems and for the measurement of outcome. Against this background, a multidisciplinary group of experts, including patient group representatives, has developed an NMS screening questionnaire comprising 30 items. This instrument does not provide an overall score of disability and is not a graded or rating instrument. Instead, it is a screening tool designed to draw attention to the presence of NMS and initiate further investigation. In this article, we present the results from an international pilot study assessing feasibility, validity, and acceptability of a nonmotor questionnaire (NMSQuest). Data from 123 PD patients and 96 controls were analyzed. NMS were highly significantly more prevalent in PD compared to controls (PD NMS, median = 9.0, mean - 9.5 vs. control NMS, median = 5.5, mean = 4.0; Mann-Whitney, Kruskal-Wallis, and t test, P < 0.0001), with PD patients reporting at least 10 different NMS on average per patient. In PD, NMS were highly significantly more prevalent across all disease stages and the number of symptoms correlated significantly with advancing disease and duration of disease. Furthermore, frequently, problems such as diplopia, dribbling, apathy, blues, taste and smell problems were never previously disclosed to the health professionals.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>21</s2></fA05><fA06><s2>7</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson's disease : The NMSQuest study</s1></fA08><fA11 i1="01" i2="1"><s1>CHAUDHURI (Kallol Ray)</s1></fA11><fA11 i1="02" i2="1"><s1>MARTINEZ-MARTIN (Pablo)</s1></fA11><fA11 i1="03" i2="1"><s1>SCHAPIRA (Anthony H. V.)</s1></fA11><fA11 i1="04" i2="1"><s1>STOCCHI (Fabrizio)</s1></fA11><fA11 i1="05" i2="1"><s1>SETHI (Kapil)</s1></fA11><fA11 i1="06" i2="1"><s1>ODIN (Per)</s1></fA11><fA11 i1="07" i2="1"><s1>BROWN (Richard G.)</s1></fA11><fA11 i1="08" i2="1"><s1>KOLLER (William)</s1></fA11><fA11 i1="09" i2="1"><s1>BARONE (Paolo)</s1></fA11><fA11 i1="10" i2="1"><s1>MACPHEE (Graeme)</s1></fA11><fA11 i1="11" i2="1"><s1>KELLY (Linda)</s1></fA11><fA11 i1="12" i2="1"><s1>RABEY (Martin)</s1></fA11><fA11 i1="13" i2="1"><s1>MACMAHON (Doug)</s1></fA11><fA11 i1="14" i2="1"><s1>THOMAS (Sue)</s1></fA11><fA11 i1="15" i2="1"><s1>ONDO (William)</s1></fA11><fA11 i1="16" i2="1"><s1>RYE (David)</s1></fA11><fA11 i1="17" i2="1"><s1>FORBES (Alison)</s1></fA11><fA11 i1="18" i2="1"><s1>TLUK (Susanne)</s1></fA11><fA11 i1="19" i2="1"><s1>DHAWAN (Vandana)</s1></fA11><fA11 i1="20" i2="1"><s1>BOWRON (Annette)</s1></fA11><fA11 i1="21" i2="1"><s1>WILLIAMS (Adrian J.)</s1></fA11><fA11 i1="22" i2="1"><s1>OLANOW (Charles W.)</s1></fA11><fA14 i1="01"><s1>Movement Disorders Unit, Kings College Hospital, University Hospital Lewisham, Guy's King's and St. Thomas' School of Medicine</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ></fA14><fA14 i1="02"><s1>Unit of Neuroepidemiology, National Center for Epidemiology, Carlos III Institute of Health</s1><s2>Madrid</s2><s3>ESP</s3><sZ>2 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Neurology, Royal Free Hospital Medical School and National Hospital for Neurology</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ></fA14><fA14 i1="04"><s1>Institute of Neurology, IRCCS NEUROMED</s1><s2>Pozzilli</s2><s3>ITA</s3><sZ>4 aut.</sZ></fA14><fA14 i1="05"><s1>Department of Neurology, Medical College of Georgia</s1><s2>Augusta, Georgia</s2><s3>USA</s3><sZ>5 aut.</sZ></fA14><fA14 i1="06"><s1>Department of Neurology, Klinikum-Bremerhaven Reinkenheide</s1><s2>Bremenhaven</s2><s3>DEU</s3><sZ>6 aut.</sZ></fA14><fA14 i1="07"><s1>Department of Psychology, Institute of Psychiatry, King's College London</s1><s2>London</s2><s3>GBR</s3><sZ>7 aut.</sZ></fA14><fA14 i1="08"><s1>Department of Neurology, University of North Carolina</s1><s2>Chapel Hill, North Carolina</s2><s3>USA</s3><sZ>8 aut.</sZ></fA14><fA14 i1="09"><s1>Department of Neurology, University of Napoli</s1><s2>Napoli</s2><s3>ITA</s3><sZ>9 aut.</sZ></fA14><fA14 i1="10"><s1>Department of Care of the Elderly, Southern General Hospital</s1><s2>Glasgow</s2><s3>GBR</s3><sZ>10 aut.</sZ></fA14><fA14 i1="11"><s1>U.K. Parkinson's Disease Society</s1><s2>London</s2><s3>GBR</s3><sZ>11 aut.</sZ></fA14><fA14 i1="12"><s1>Assaf Harofeh Medical Center, School of Medicine, Tel-Aviv University</s1><s2>Zerifin</s2><s3>ISR</s3><sZ>12 aut.</sZ></fA14><fA14 i1="13"><s1>Department of Care of the Elderly, Camborne-Redruth Hospital</s1><s2>Cornwall</s2><s3>GBR</s3><sZ>13 aut.</sZ></fA14><fA14 i1="14"><s1>Division of Nursing, Royal College of Nursing</s1><s2>London</s2><s3>GBR</s3><sZ>14 aut.</sZ></fA14><fA14 i1="15"><s1>Department of Neurology, Baylor College of Medicine</s1><s2>Houston, Texas</s2><s3>USA</s3><sZ>15 aut.</sZ></fA14><fA14 i1="16"><s1>Department of Neurology, Emory University</s1><s2>Atlanta, Georgia</s2><s3>USA</s3><sZ>16 aut.</sZ></fA14><fA14 i1="17"><s1>Department of Neurology, University Hospital Lewisham</s1><s2>London</s2><s3>GBR</s3><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></fA14><fA14 i1="18"><s1>Movement Disorders Section, Department of Neurology, King's College Hospital</s1><s2>London</s2><s3>GBR</s3><sZ>19 aut.</sZ></fA14><fA14 i1="19"><s1>Department of Medicine, North Tyneside General Hospital</s1><s2>North Shields</s2><s3>GBR</s3><sZ>20 aut.</sZ></fA14><fA14 i1="20"><s1>Lane-Fox Sleep Centre, St. Thomas' Hospital</s1><s2>London</s2><s3>GBR</s3><sZ>21 aut.</sZ></fA14><fA14 i1="21"><s1>Department of Neurology, Mount Sinai School of Medicine</s1><s2>New York, New York</s2><s3>USA</s3><sZ>22 aut.</sZ></fA14><fA20><s1>916-923</s1></fA20><fA21><s1>2006</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000133412770060</s5></fA43><fA44><s0>0000</s0><s1>© 2006 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>24 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>06-0393851</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Nonmotor symptoms (NMS) of Parkinson's disease (PD) are not well recognized in clinical practice, either in primary or in secondary care, and are frequently missed during routine consultations. There is no single instrument (questionnaire or scale) that enables a comprehensive assessment of the range of NMS in PD both for the identification of problems and for the measurement of outcome. Against this background, a multidisciplinary group of experts, including patient group representatives, has developed an NMS screening questionnaire comprising 30 items. This instrument does not provide an overall score of disability and is not a graded or rating instrument. Instead, it is a screening tool designed to draw attention to the presence of NMS and initiate further investigation. In this article, we present the results from an international pilot study assessing feasibility, validity, and acceptability of a nonmotor questionnaire (NMSQuest). Data from 123 PD patients and 96 controls were analyzed. NMS were highly significantly more prevalent in PD compared to controls (PD NMS, median = 9.0, mean - 9.5 vs. control NMS, median = 5.5, mean = 4.0; Mann-Whitney, Kruskal-Wallis, and t test, P < 0.0001), with PD patients reporting at least 10 different NMS on average per patient. In PD, NMS were highly significantly more prevalent across all disease stages and the number of symptoms correlated significantly with advancing disease and duration of disease. Furthermore, frequently, problems such as diplopia, dribbling, apathy, blues, taste and smell problems were never previously disclosed to the health professionals.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17G</s0></fC02><fC02 i1="03" i2="X"><s0>002B17A03</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Parkinson maladie</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Parkinson disease</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Etude multicentrique</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Multicenter study</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Estudio multicéntrico</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Questionnaire</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Questionnaire</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Cuestionario</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Echelle d'évaluation</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Evaluation scale</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Escala evaluación</s0><s5>11</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Qualité vie</s0><s5>12</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Quality of life</s0><s5>12</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Calidad vida</s0><s5>12</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Encéphale pathologie</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>40</s5></fC07><fN21><s1>261</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Allemagne</li><li>Espagne</li><li>Israël</li><li>Italie</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Caroline du Nord</li><li>Communauté de Madrid</li><li>Grand Londres</li><li>Géorgie (États-Unis)</li><li>Texas</li><li>État de New York</li></region><settlement><li>Londres</li><li>Madrid</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Chaudhuri, Kallol Ray" sort="Chaudhuri, Kallol Ray" uniqKey="Chaudhuri K" first="Kallol Ray" last="Chaudhuri">Kallol Ray Chaudhuri</name></region><name sortKey="Bowron, Annette" sort="Bowron, Annette" uniqKey="Bowron A" first="Annette" last="Bowron">Annette Bowron</name><name sortKey="Brown, Richard G" sort="Brown, Richard G" uniqKey="Brown R" first="Richard G." last="Brown">Richard G. Brown</name><name sortKey="Dhawan, Vandana" sort="Dhawan, Vandana" uniqKey="Dhawan V" first="Vandana" last="Dhawan">Vandana Dhawan</name><name sortKey="Dhawan, Vandana" sort="Dhawan, Vandana" uniqKey="Dhawan V" first="Vandana" last="Dhawan">Vandana Dhawan</name><name sortKey="Forbes, Alison" sort="Forbes, Alison" uniqKey="Forbes A" first="Alison" last="Forbes">Alison Forbes</name><name sortKey="Kelly, Linda" sort="Kelly, Linda" uniqKey="Kelly L" first="Linda" last="Kelly">Linda Kelly</name><name sortKey="Macmahon, Doug" sort="Macmahon, Doug" uniqKey="Macmahon D" first="Doug" last="Macmahon">Doug Macmahon</name><name sortKey="Macphee, Graeme" sort="Macphee, Graeme" uniqKey="Macphee G" first="Graeme" last="Macphee">Graeme Macphee</name><name sortKey="Schapira, Anthony H V" sort="Schapira, Anthony H V" uniqKey="Schapira A" first="Anthony H. V." last="Schapira">Anthony H. V. Schapira</name><name sortKey="Thomas, Sue" sort="Thomas, Sue" uniqKey="Thomas S" first="Sue" last="Thomas">Sue Thomas</name><name sortKey="Tluk, Susanne" sort="Tluk, Susanne" uniqKey="Tluk S" first="Susanne" last="Tluk">Susanne Tluk</name><name sortKey="Williams, Adrian J" sort="Williams, Adrian J" uniqKey="Williams A" first="Adrian J." last="Williams">Adrian J. Williams</name></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Martinez Martin, Pablo" sort="Martinez Martin, Pablo" uniqKey="Martinez Martin P" first="Pablo" last="Martinez-Martin">Pablo Martinez-Martin</name></region></country><country name="Italie"><noRegion><name sortKey="Stocchi, Fabrizio" sort="Stocchi, Fabrizio" uniqKey="Stocchi F" first="Fabrizio" last="Stocchi">Fabrizio Stocchi</name></noRegion><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name></country><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Sethi, Kapil" sort="Sethi, Kapil" uniqKey="Sethi K" first="Kapil" last="Sethi">Kapil Sethi</name></region><name sortKey="Koller, William" sort="Koller, William" uniqKey="Koller W" first="William" last="Koller">William Koller</name><name sortKey="Olanow, Charles W" sort="Olanow, Charles W" uniqKey="Olanow C" first="Charles W." last="Olanow">Charles W. Olanow</name><name sortKey="Ondo, William" sort="Ondo, William" uniqKey="Ondo W" first="William" last="Ondo">William Ondo</name><name sortKey="Rye, David" sort="Rye, David" uniqKey="Rye D" first="David" last="Rye">David Rye</name></country><country name="Allemagne"><noRegion><name sortKey="Odin, Per" sort="Odin, Per" uniqKey="Odin P" first="Per" last="Odin">Per Odin</name></noRegion></country><country name="Israël"><noRegion><name sortKey="Rabey, Martin" sort="Rabey, Martin" uniqKey="Rabey M" first="Martin" last="Rabey">Martin Rabey</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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