MovDisordV3, PascalFrancis, Corpus, bibRecord, 001A93

International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson's disease : The NMSQuest study

Identifieur interne : 001A93 ( PascalFrancis/Corpus ); précédent : 001A92; suivant : 001A94

International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson's disease : The NMSQuest study

Auteurs : Kallol Ray Chaudhuri ; Pablo Martinez-Martin ; Anthony H. V. Schapira ; Fabrizio Stocchi ; Kapil Sethi ; Per Odin ; Richard G. Brown ; William Koller ; Paolo Barone ; Graeme Macphee ; Linda Kelly ; Martin Rabey ; Doug Macmahon ; Sue Thomas ; William Ondo ; David Rye ; Alison Forbes ; Susanne Tluk ; Vandana Dhawan ; Annette Bowron ; Adrian J. Williams ; Charles W. Olanow

Source :

Movement disorders [ 0885-3185 ] ; 2006.

RBID : Pascal:06-0393851

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Parkinson maladie, Etude multicentrique, Questionnaire, Echelle d'évaluation, Qualité vie.

English descriptors

KwdEn :
- Evaluation scale, Multicenter study, Nervous system diseases, Parkinson disease, Quality of life, Questionnaire.

Abstract

Nonmotor symptoms (NMS) of Parkinson's disease (PD) are not well recognized in clinical practice, either in primary or in secondary care, and are frequently missed during routine consultations. There is no single instrument (questionnaire or scale) that enables a comprehensive assessment of the range of NMS in PD both for the identification of problems and for the measurement of outcome. Against this background, a multidisciplinary group of experts, including patient group representatives, has developed an NMS screening questionnaire comprising 30 items. This instrument does not provide an overall score of disability and is not a graded or rating instrument. Instead, it is a screening tool designed to draw attention to the presence of NMS and initiate further investigation. In this article, we present the results from an international pilot study assessing feasibility, validity, and acceptability of a nonmotor questionnaire (NMSQuest). Data from 123 PD patients and 96 controls were analyzed. NMS were highly significantly more prevalent in PD compared to controls (PD NMS, median = 9.0, mean - 9.5 vs. control NMS, median = 5.5, mean = 4.0; Mann-Whitney, Kruskal-Wallis, and t test, P < 0.0001), with PD patients reporting at least 10 different NMS on average per patient. In PD, NMS were highly significantly more prevalent across all disease stages and the number of symptoms correlated significantly with advancing disease and duration of disease. Furthermore, frequently, problems such as diplopia, dribbling, apathy, blues, taste and smell problems were never previously disclosed to the health professionals.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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C01	`01`		`ENG`	@0 Nonmotor symptoms (NMS) of Parkinson's disease (PD) are not well recognized in clinical practice, either in primary or in secondary care, and are frequently missed during routine consultations. There is no single instrument (questionnaire or scale) that enables a comprehensive assessment of the range of NMS in PD both for the identification of problems and for the measurement of outcome. Against this background, a multidisciplinary group of experts, including patient group representatives, has developed an NMS screening questionnaire comprising 30 items. This instrument does not provide an overall score of disability and is not a graded or rating instrument. Instead, it is a screening tool designed to draw attention to the presence of NMS and initiate further investigation. In this article, we present the results from an international pilot study assessing feasibility, validity, and acceptability of a nonmotor questionnaire (NMSQuest). Data from 123 PD patients and 96 controls were analyzed. NMS were highly significantly more prevalent in PD compared to controls (PD NMS, median = 9.0, mean - 9.5 vs. control NMS, median = 5.5, mean = 4.0; Mann-Whitney, Kruskal-Wallis, and t test, P < 0.0001), with PD patients reporting at least 10 different NMS on average per patient. In PD, NMS were highly significantly more prevalent across all disease stages and the number of symptoms correlated significantly with advancing disease and duration of disease. Furthermore, frequently, problems such as diplopia, dribbling, apathy, blues, taste and smell problems were never previously disclosed to the health professionals.
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Format Inist (serveur)

NO :	PASCAL 06-0393851 INIST
ET :	International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson's disease : The NMSQuest study
AU :	CHAUDHURI (Kallol Ray); MARTINEZ-MARTIN (Pablo); SCHAPIRA (Anthony H. V.); STOCCHI (Fabrizio); SETHI (Kapil); ODIN (Per); BROWN (Richard G.); KOLLER (William); BARONE (Paolo); MACPHEE (Graeme); KELLY (Linda); RABEY (Martin); MACMAHON (Doug); THOMAS (Sue); ONDO (William); RYE (David); FORBES (Alison); TLUK (Susanne); DHAWAN (Vandana); BOWRON (Annette); WILLIAMS (Adrian J.); OLANOW (Charles W.)
AF :	Movement Disorders Unit, Kings College Hospital, University Hospital Lewisham, Guy's King's and St. Thomas' School of Medicine/London/Royaume-Uni (1 aut.); Unit of Neuroepidemiology, National Center for Epidemiology, Carlos III Institute of Health/Madrid/Espagne (2 aut.); Department of Neurology, Royal Free Hospital Medical School and National Hospital for Neurology/London/Royaume-Uni (3 aut.); Institute of Neurology, IRCCS NEUROMED/Pozzilli/Italie (4 aut.); Department of Neurology, Medical College of Georgia/Augusta, Georgia/Etats-Unis (5 aut.); Department of Neurology, Klinikum-Bremerhaven Reinkenheide/Bremenhaven/Allemagne (6 aut.); Department of Psychology, Institute of Psychiatry, King's College London/London/Royaume-Uni (7 aut.); Department of Neurology, University of North Carolina/Chapel Hill, North Carolina/Etats-Unis (8 aut.); Department of Neurology, University of Napoli/Napoli/Italie (9 aut.); Department of Care of the Elderly, Southern General Hospital/Glasgow/Royaume-Uni (10 aut.); U.K. Parkinson's Disease Society/London/Royaume-Uni (11 aut.); Assaf Harofeh Medical Center, School of Medicine, Tel-Aviv University/Zerifin/Israël (12 aut.); Department of Care of the Elderly, Camborne-Redruth Hospital/Cornwall/Royaume-Uni (13 aut.); Division of Nursing, Royal College of Nursing/London/Royaume-Uni (14 aut.); Department of Neurology, Baylor College of Medicine/Houston, Texas/Etats-Unis (15 aut.); Department of Neurology, Emory University/Atlanta, Georgia/Etats-Unis (16 aut.); Department of Neurology, University Hospital Lewisham/London/Royaume-Uni (17 aut., 18 aut., 19 aut.); Movement Disorders Section, Department of Neurology, King's College Hospital/London/Royaume-Uni (19 aut.); Department of Medicine, North Tyneside General Hospital/North Shields/Royaume-Uni (20 aut.); Lane-Fox Sleep Centre, St. Thomas' Hospital/London/Royaume-Uni (21 aut.); Department of Neurology, Mount Sinai School of Medicine/New York, New York/Etats-Unis (22 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2006; Vol. 21; No. 7; Pp. 916-923; Bibl. 24 ref.
LA :	Anglais
EA :	Nonmotor symptoms (NMS) of Parkinson's disease (PD) are not well recognized in clinical practice, either in primary or in secondary care, and are frequently missed during routine consultations. There is no single instrument (questionnaire or scale) that enables a comprehensive assessment of the range of NMS in PD both for the identification of problems and for the measurement of outcome. Against this background, a multidisciplinary group of experts, including patient group representatives, has developed an NMS screening questionnaire comprising 30 items. This instrument does not provide an overall score of disability and is not a graded or rating instrument. Instead, it is a screening tool designed to draw attention to the presence of NMS and initiate further investigation. In this article, we present the results from an international pilot study assessing feasibility, validity, and acceptability of a nonmotor questionnaire (NMSQuest). Data from 123 PD patients and 96 controls were analyzed. NMS were highly significantly more prevalent in PD compared to controls (PD NMS, median = 9.0, mean - 9.5 vs. control NMS, median = 5.5, mean = 4.0; Mann-Whitney, Kruskal-Wallis, and t test, P < 0.0001), with PD patients reporting at least 10 different NMS on average per patient. In PD, NMS were highly significantly more prevalent across all disease stages and the number of symptoms correlated significantly with advancing disease and duration of disease. Furthermore, frequently, problems such as diplopia, dribbling, apathy, blues, taste and smell problems were never previously disclosed to the health professionals.
CC :	002B17; 002B17G; 002B17A03
FD :	Système nerveux pathologie; Parkinson maladie; Etude multicentrique; Questionnaire; Echelle d'évaluation; Qualité vie
FG :	Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie
ED :	Nervous system diseases; Parkinson disease; Multicenter study; Questionnaire; Evaluation scale; Quality of life
EG :	Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD :	Sistema nervioso patología; Parkinson enfermedad; Estudio multicéntrico; Cuestionario; Escala evaluación; Calidad vida
LO :	INIST-20953.354000133412770060
ID :	06-0393851

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Pascal:06-0393851

Le document en format XML

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<author><name sortKey="Kelly, Linda" sort="Kelly, Linda" uniqKey="Kelly L" first="Linda" last="Kelly">Linda Kelly</name>
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<author><name sortKey="Rabey, Martin" sort="Rabey, Martin" uniqKey="Rabey M" first="Martin" last="Rabey">Martin Rabey</name>
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<author><name sortKey="Macmahon, Doug" sort="Macmahon, Doug" uniqKey="Macmahon D" first="Doug" last="Macmahon">Doug Macmahon</name>
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<author><name sortKey="Thomas, Sue" sort="Thomas, Sue" uniqKey="Thomas S" first="Sue" last="Thomas">Sue Thomas</name>
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<author><name sortKey="Ondo, William" sort="Ondo, William" uniqKey="Ondo W" first="William" last="Ondo">William Ondo</name>
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<author><name sortKey="Rye, David" sort="Rye, David" uniqKey="Rye D" first="David" last="Rye">David Rye</name>
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<author><name sortKey="Forbes, Alison" sort="Forbes, Alison" uniqKey="Forbes A" first="Alison" last="Forbes">Alison Forbes</name>
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<author><name sortKey="Tluk, Susanne" sort="Tluk, Susanne" uniqKey="Tluk S" first="Susanne" last="Tluk">Susanne Tluk</name>
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<author><name sortKey="Dhawan, Vandana" sort="Dhawan, Vandana" uniqKey="Dhawan V" first="Vandana" last="Dhawan">Vandana Dhawan</name>
<affiliation><inist:fA14 i1="17"><s1>Department of Neurology, University Hospital Lewisham</s1>
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<affiliation><inist:fA14 i1="19"><s1>Department of Medicine, North Tyneside General Hospital</s1>
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<s2>London</s2>
<s3>GBR</s3>
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<affiliation><inist:fA14 i1="02"><s1>Unit of Neuroepidemiology, National Center for Epidemiology, Carlos III Institute of Health</s1>
<s2>Madrid</s2>
<s3>ESP</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
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<s2>London</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
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<s2>Pozzilli</s2>
<s3>ITA</s3>
<sZ>4 aut.</sZ>
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</affiliation>
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<s3>USA</s3>
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<s2>Bremenhaven</s2>
<s3>DEU</s3>
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</inist:fA14>
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<author><name sortKey="Koller, William" sort="Koller, William" uniqKey="Koller W" first="William" last="Koller">William Koller</name>
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<s3>ITA</s3>
<sZ>9 aut.</sZ>
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<author><name sortKey="Macphee, Graeme" sort="Macphee, Graeme" uniqKey="Macphee G" first="Graeme" last="Macphee">Graeme Macphee</name>
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<author><name sortKey="Kelly, Linda" sort="Kelly, Linda" uniqKey="Kelly L" first="Linda" last="Kelly">Linda Kelly</name>
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<s3>ISR</s3>
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<author><name sortKey="Macmahon, Doug" sort="Macmahon, Doug" uniqKey="Macmahon D" first="Doug" last="Macmahon">Doug Macmahon</name>
<affiliation><inist:fA14 i1="13"><s1>Department of Care of the Elderly, Camborne-Redruth Hospital</s1>
<s2>Cornwall</s2>
<s3>GBR</s3>
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<author><name sortKey="Thomas, Sue" sort="Thomas, Sue" uniqKey="Thomas S" first="Sue" last="Thomas">Sue Thomas</name>
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<author><name sortKey="Ondo, William" sort="Ondo, William" uniqKey="Ondo W" first="William" last="Ondo">William Ondo</name>
<affiliation><inist:fA14 i1="15"><s1>Department of Neurology, Baylor College of Medicine</s1>
<s2>Houston, Texas</s2>
<s3>USA</s3>
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<author><name sortKey="Rye, David" sort="Rye, David" uniqKey="Rye D" first="David" last="Rye">David Rye</name>
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<s3>USA</s3>
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<author><name sortKey="Forbes, Alison" sort="Forbes, Alison" uniqKey="Forbes A" first="Alison" last="Forbes">Alison Forbes</name>
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<s2>London</s2>
<s3>GBR</s3>
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<affiliation><inist:fA14 i1="17"><s1>Department of Neurology, University Hospital Lewisham</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
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<s2>London</s2>
<s3>GBR</s3>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
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<affiliation><inist:fA14 i1="18"><s1>Movement Disorders Section, Department of Neurology, King's College Hospital</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>19 aut.</sZ>
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</affiliation>
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<author><name sortKey="Bowron, Annette" sort="Bowron, Annette" uniqKey="Bowron A" first="Annette" last="Bowron">Annette Bowron</name>
<affiliation><inist:fA14 i1="19"><s1>Department of Medicine, North Tyneside General Hospital</s1>
<s2>North Shields</s2>
<s3>GBR</s3>
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<author><name sortKey="Williams, Adrian J" sort="Williams, Adrian J" uniqKey="Williams A" first="Adrian J." last="Williams">Adrian J. Williams</name>
<affiliation><inist:fA14 i1="20"><s1>Lane-Fox Sleep Centre, St. Thomas' Hospital</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>21 aut.</sZ>
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</affiliation>
</author>
<author><name sortKey="Olanow, Charles W" sort="Olanow, Charles W" uniqKey="Olanow C" first="Charles W." last="Olanow">Charles W. Olanow</name>
<affiliation><inist:fA14 i1="21"><s1>Department of Neurology, Mount Sinai School of Medicine</s1>
<s2>New York, New York</s2>
<s3>USA</s3>
<sZ>22 aut.</sZ>
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<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2006">2006</date>
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<seriesStmt><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Evaluation scale</term>
<term>Multicenter study</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Quality of life</term>
<term>Questionnaire</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
<term>Parkinson maladie</term>
<term>Etude multicentrique</term>
<term>Questionnaire</term>
<term>Echelle d'évaluation</term>
<term>Qualité vie</term>
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<front><div type="abstract" xml:lang="en">Nonmotor symptoms (NMS) of Parkinson's disease (PD) are not well recognized in clinical practice, either in primary or in secondary care, and are frequently missed during routine consultations. There is no single instrument (questionnaire or scale) that enables a comprehensive assessment of the range of NMS in PD both for the identification of problems and for the measurement of outcome. Against this background, a multidisciplinary group of experts, including patient group representatives, has developed an NMS screening questionnaire comprising 30 items. This instrument does not provide an overall score of disability and is not a graded or rating instrument. Instead, it is a screening tool designed to draw attention to the presence of NMS and initiate further investigation. In this article, we present the results from an international pilot study assessing feasibility, validity, and acceptability of a nonmotor questionnaire (NMSQuest). Data from 123 PD patients and 96 controls were analyzed. NMS were highly significantly more prevalent in PD compared to controls (PD NMS, median = 9.0, mean - 9.5 vs. control NMS, median = 5.5, mean = 4.0; Mann-Whitney, Kruskal-Wallis, and t test, P < 0.0001), with PD patients reporting at least 10 different NMS on average per patient. In PD, NMS were highly significantly more prevalent across all disease stages and the number of symptoms correlated significantly with advancing disease and duration of disease. Furthermore, frequently, problems such as diplopia, dribbling, apathy, blues, taste and smell problems were never previously disclosed to the health professionals.</div>
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<s2>London</s2>
<s3>GBR</s3>
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<fA14 i1="02"><s1>Unit of Neuroepidemiology, National Center for Epidemiology, Carlos III Institute of Health</s1>
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<s3>ESP</s3>
<sZ>2 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Department of Neurology, Royal Free Hospital Medical School and National Hospital for Neurology</s1>
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<fA14 i1="04"><s1>Institute of Neurology, IRCCS NEUROMED</s1>
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<fA14 i1="06"><s1>Department of Neurology, Klinikum-Bremerhaven Reinkenheide</s1>
<s2>Bremenhaven</s2>
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<s2>London</s2>
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<fA14 i1="08"><s1>Department of Neurology, University of North Carolina</s1>
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<s3>USA</s3>
<sZ>8 aut.</sZ>
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<fA14 i1="09"><s1>Department of Neurology, University of Napoli</s1>
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<s3>ITA</s3>
<sZ>9 aut.</sZ>
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<fA14 i1="16"><s1>Department of Neurology, Emory University</s1>
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<sZ>16 aut.</sZ>
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<fA14 i1="17"><s1>Department of Neurology, University Hospital Lewisham</s1>
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<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
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<fA14 i1="18"><s1>Movement Disorders Section, Department of Neurology, King's College Hospital</s1>
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<s3>GBR</s3>
<sZ>21 aut.</sZ>
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<fA14 i1="21"><s1>Department of Neurology, Mount Sinai School of Medicine</s1>
<s2>New York, New York</s2>
<s3>USA</s3>
<sZ>22 aut.</sZ>
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<fC01 i1="01" l="ENG"><s0>Nonmotor symptoms (NMS) of Parkinson's disease (PD) are not well recognized in clinical practice, either in primary or in secondary care, and are frequently missed during routine consultations. There is no single instrument (questionnaire or scale) that enables a comprehensive assessment of the range of NMS in PD both for the identification of problems and for the measurement of outcome. Against this background, a multidisciplinary group of experts, including patient group representatives, has developed an NMS screening questionnaire comprising 30 items. This instrument does not provide an overall score of disability and is not a graded or rating instrument. Instead, it is a screening tool designed to draw attention to the presence of NMS and initiate further investigation. In this article, we present the results from an international pilot study assessing feasibility, validity, and acceptability of a nonmotor questionnaire (NMSQuest). Data from 123 PD patients and 96 controls were analyzed. NMS were highly significantly more prevalent in PD compared to controls (PD NMS, median = 9.0, mean - 9.5 vs. control NMS, median = 5.5, mean = 4.0; Mann-Whitney, Kruskal-Wallis, and t test, P < 0.0001), with PD patients reporting at least 10 different NMS on average per patient. In PD, NMS were highly significantly more prevalent across all disease stages and the number of symptoms correlated significantly with advancing disease and duration of disease. Furthermore, frequently, problems such as diplopia, dribbling, apathy, blues, taste and smell problems were never previously disclosed to the health professionals.</s0>
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<s5>01</s5>
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<s5>02</s5>
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<s5>02</s5>
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</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Estudio multicéntrico</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Questionnaire</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Questionnaire</s0>
<s5>10</s5>
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<s5>10</s5>
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<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Evaluation scale</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Escala evaluación</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Qualité vie</s0>
<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Quality of life</s0>
<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Calidad vida</s0>
<s5>12</s5>
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<fC07 i1="01" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>37</s5>
</fC07>
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<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>40</s5>
</fC07>
<fN21><s1>261</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
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<server><NO>PASCAL 06-0393851 INIST</NO>
<ET>International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson's disease : The NMSQuest study</ET>
<AU>CHAUDHURI (Kallol Ray); MARTINEZ-MARTIN (Pablo); SCHAPIRA (Anthony H. V.); STOCCHI (Fabrizio); SETHI (Kapil); ODIN (Per); BROWN (Richard G.); KOLLER (William); BARONE (Paolo); MACPHEE (Graeme); KELLY (Linda); RABEY (Martin); MACMAHON (Doug); THOMAS (Sue); ONDO (William); RYE (David); FORBES (Alison); TLUK (Susanne); DHAWAN (Vandana); BOWRON (Annette); WILLIAMS (Adrian J.); OLANOW (Charles W.)</AU>
<AF>Movement Disorders Unit, Kings College Hospital, University Hospital Lewisham, Guy's King's and St. Thomas' School of Medicine/London/Royaume-Uni (1 aut.); Unit of Neuroepidemiology, National Center for Epidemiology, Carlos III Institute of Health/Madrid/Espagne (2 aut.); Department of Neurology, Royal Free Hospital Medical School and National Hospital for Neurology/London/Royaume-Uni (3 aut.); Institute of Neurology, IRCCS NEUROMED/Pozzilli/Italie (4 aut.); Department of Neurology, Medical College of Georgia/Augusta, Georgia/Etats-Unis (5 aut.); Department of Neurology, Klinikum-Bremerhaven Reinkenheide/Bremenhaven/Allemagne (6 aut.); Department of Psychology, Institute of Psychiatry, King's College London/London/Royaume-Uni (7 aut.); Department of Neurology, University of North Carolina/Chapel Hill, North Carolina/Etats-Unis (8 aut.); Department of Neurology, University of Napoli/Napoli/Italie (9 aut.); Department of Care of the Elderly, Southern General Hospital/Glasgow/Royaume-Uni (10 aut.); U.K. Parkinson's Disease Society/London/Royaume-Uni (11 aut.); Assaf Harofeh Medical Center, School of Medicine, Tel-Aviv University/Zerifin/Israël (12 aut.); Department of Care of the Elderly, Camborne-Redruth Hospital/Cornwall/Royaume-Uni (13 aut.); Division of Nursing, Royal College of Nursing/London/Royaume-Uni (14 aut.); Department of Neurology, Baylor College of Medicine/Houston, Texas/Etats-Unis (15 aut.); Department of Neurology, Emory University/Atlanta, Georgia/Etats-Unis (16 aut.); Department of Neurology, University Hospital Lewisham/London/Royaume-Uni (17 aut., 18 aut., 19 aut.); Movement Disorders Section, Department of Neurology, King's College Hospital/London/Royaume-Uni (19 aut.); Department of Medicine, North Tyneside General Hospital/North Shields/Royaume-Uni (20 aut.); Lane-Fox Sleep Centre, St. Thomas' Hospital/London/Royaume-Uni (21 aut.); Department of Neurology, Mount Sinai School of Medicine/New York, New York/Etats-Unis (22 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2006; Vol. 21; No. 7; Pp. 916-923; Bibl. 24 ref.</SO>
<LA>Anglais</LA>
<EA>Nonmotor symptoms (NMS) of Parkinson's disease (PD) are not well recognized in clinical practice, either in primary or in secondary care, and are frequently missed during routine consultations. There is no single instrument (questionnaire or scale) that enables a comprehensive assessment of the range of NMS in PD both for the identification of problems and for the measurement of outcome. Against this background, a multidisciplinary group of experts, including patient group representatives, has developed an NMS screening questionnaire comprising 30 items. This instrument does not provide an overall score of disability and is not a graded or rating instrument. Instead, it is a screening tool designed to draw attention to the presence of NMS and initiate further investigation. In this article, we present the results from an international pilot study assessing feasibility, validity, and acceptability of a nonmotor questionnaire (NMSQuest). Data from 123 PD patients and 96 controls were analyzed. NMS were highly significantly more prevalent in PD compared to controls (PD NMS, median = 9.0, mean - 9.5 vs. control NMS, median = 5.5, mean = 4.0; Mann-Whitney, Kruskal-Wallis, and t test, P < 0.0001), with PD patients reporting at least 10 different NMS on average per patient. In PD, NMS were highly significantly more prevalent across all disease stages and the number of symptoms correlated significantly with advancing disease and duration of disease. Furthermore, frequently, problems such as diplopia, dribbling, apathy, blues, taste and smell problems were never previously disclosed to the health professionals.</EA>
<CC>002B17; 002B17G; 002B17A03</CC>
<FD>Système nerveux pathologie; Parkinson maladie; Etude multicentrique; Questionnaire; Echelle d'évaluation; Qualité vie</FD>
<FG>Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie</FG>
<ED>Nervous system diseases; Parkinson disease; Multicenter study; Questionnaire; Evaluation scale; Quality of life</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Sistema nervioso patología; Parkinson enfermedad; Estudio multicéntrico; Cuestionario; Escala evaluación; Calidad vida</SD>
<LO>INIST-20953.354000133412770060</LO>
<ID>06-0393851</ID>
</server>
</inist>
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	Movement Disorders (revue)
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Movement Disorders (revue)

International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson's disease : The NMSQuest study

International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson's disease : The NMSQuest study

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