Reliability and validity of the scale for the assessment and rating of ataxia : A study in 64 ataxia patients
Identifieur interne : 001488 ( PascalFrancis/Checkpoint ); précédent : 001487; suivant : 001489Reliability and validity of the scale for the assessment and rating of ataxia : A study in 64 ataxia patients
Auteurs : Anja Weyer [Allemagne] ; Michael Abele [Allemagne] ; Tanja Schmitz-Hübsch [Allemagne] ; Beate Schoch [Allemagne] ; Markus Frings [Allemagne] ; Dagmar Timmann [Allemagne] ; Thomas Klockgether [Allemagne]Source :
- Movement disorders [ 0885-3185 ] ; 2007.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
The objective of this study was to test the reliability and validity of the Scale for the Assessment and Rating of Ataxia (SARA) in ataxia patients not suffering from autosomal dominant spinocerebellar ataxia (SCA). To this end, 64 patients with various ataxia disorders or stable cerebellar lesions were rated independently by two investigators. In addition to SARA, the following assessment instruments were applied: ataxia disease stage, Barthel index and part IV (functional assessment) of the Unified Huntington's Disease Rating scale (UHDRS-IV). Eighteen patients were rated twice. Inter-rater and intrarater reliability were very high with ICCs of 0.98 and 0.99. Internal consistency was high indicated by Cronbach's α of 0.97. Factorial analysis revealed that the rating results were mainly determined by one major factor with an eigenvalue of 6.34 which explained 52.8% of the variance. SARA score increased with disease stage (P < 0.0001) and was closely correlated with Barthel index (r = -0.63, P < 0.0001) and UHDRS-IV (r = -0.62, P < 0.0001), but only weakly correlated with disease duration (r = 0.44, P < 0.001). The results suggest that SARA is a reliable and valid measure of ataxia in non-SCA ataxia patients.
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Bonn</s1><s2>Bonn</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Schmitz Hubsch, Tanja" sort="Schmitz Hubsch, Tanja" uniqKey="Schmitz Hubsch T" first="Tanja" last="Schmitz-Hübsch">Tanja Schmitz-Hübsch</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital of Bonn</s1><s2>Bonn</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Schoch, Beate" sort="Schoch, Beate" uniqKey="Schoch B" first="Beate" last="Schoch">Beate Schoch</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurosurgery, University Hospital Essen</s1><s2>Essen</s2><s3>DEU</s3><sZ>4 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>University Hospital Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Frings, Markus" sort="Frings, Markus" uniqKey="Frings M" first="Markus" last="Frings">Markus Frings</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, University Hospital Essen</s1><s2>Essen</s2><s3>DEU</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>University Hospital Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Timmann, Dagmar" sort="Timmann, Dagmar" uniqKey="Timmann D" first="Dagmar" last="Timmann">Dagmar Timmann</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, University Hospital Essen</s1><s2>Essen</s2><s3>DEU</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>University Hospital Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Klockgether, Thomas" sort="Klockgether, Thomas" uniqKey="Klockgether T" first="Thomas" last="Klockgether">Thomas Klockgether</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital of Bonn</s1><s2>Bonn</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">07-0448801</idno><date when="2007">2007</date><idno type="stanalyst">PASCAL 07-0448801 INIST</idno><idno type="RBID">Pascal:07-0448801</idno><idno type="wicri:Area/PascalFrancis/Corpus">001559</idno><idno type="wicri:Area/PascalFrancis/Curation">001762</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001488</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Reliability and validity of the scale for the assessment and rating of ataxia : A study in 64 ataxia patients</title><author><name sortKey="Weyer, Anja" sort="Weyer, Anja" uniqKey="Weyer A" first="Anja" last="Weyer">Anja Weyer</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital of Bonn</s1><s2>Bonn</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Abele, Michael" sort="Abele, Michael" uniqKey="Abele M" first="Michael" last="Abele">Michael Abele</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital of Bonn</s1><s2>Bonn</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Schmitz Hubsch, Tanja" sort="Schmitz Hubsch, Tanja" uniqKey="Schmitz Hubsch T" first="Tanja" last="Schmitz-Hübsch">Tanja Schmitz-Hübsch</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital of Bonn</s1><s2>Bonn</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Schoch, Beate" sort="Schoch, Beate" uniqKey="Schoch B" first="Beate" last="Schoch">Beate Schoch</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurosurgery, University Hospital Essen</s1><s2>Essen</s2><s3>DEU</s3><sZ>4 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>University Hospital Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Frings, Markus" sort="Frings, Markus" uniqKey="Frings M" first="Markus" last="Frings">Markus Frings</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, University Hospital Essen</s1><s2>Essen</s2><s3>DEU</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>University Hospital Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Timmann, Dagmar" sort="Timmann, Dagmar" uniqKey="Timmann D" first="Dagmar" last="Timmann">Dagmar Timmann</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, University Hospital Essen</s1><s2>Essen</s2><s3>DEU</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>University Hospital Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Klockgether, Thomas" sort="Klockgether, Thomas" uniqKey="Klockgether T" first="Thomas" last="Klockgether">Thomas Klockgether</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital of Bonn</s1><s2>Bonn</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Ataxia</term><term>Evaluation scale</term><term>Human</term><term>Nervous system diseases</term><term>Reliability</term><term>Validity</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Ataxie</term><term>Fiabilité</term><term>Validité</term><term>Echelle d'évaluation</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The objective of this study was to test the reliability and validity of the Scale for the Assessment and Rating of Ataxia (SARA) in ataxia patients not suffering from autosomal dominant spinocerebellar ataxia (SCA). To this end, 64 patients with various ataxia disorders or stable cerebellar lesions were rated independently by two investigators. In addition to SARA, the following assessment instruments were applied: ataxia disease stage, Barthel index and part IV (functional assessment) of the Unified Huntington's Disease Rating scale (UHDRS-IV). Eighteen patients were rated twice. Inter-rater and intrarater reliability were very high with ICCs of 0.98 and 0.99. Internal consistency was high indicated by Cronbach's α of 0.97. Factorial analysis revealed that the rating results were mainly determined by one major factor with an eigenvalue of 6.34 which explained 52.8% of the variance. SARA score increased with disease stage (P < 0.0001) and was closely correlated with Barthel index (r = -0.63, P < 0.0001) and UHDRS-IV (r = -0.62, P < 0.0001), but only weakly correlated with disease duration (r = 0.44, P < 0.001). The results suggest that SARA is a reliable and valid measure of ataxia in non-SCA ataxia patients.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>22</s2></fA05><fA06><s2>11</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Reliability and validity of the scale for the assessment and rating of ataxia : A study in 64 ataxia patients</s1></fA08><fA11 i1="01" i2="1"><s1>WEYER (Anja)</s1></fA11><fA11 i1="02" i2="1"><s1>ABELE (Michael)</s1></fA11><fA11 i1="03" i2="1"><s1>SCHMITZ-HÜBSCH (Tanja)</s1></fA11><fA11 i1="04" i2="1"><s1>SCHOCH (Beate)</s1></fA11><fA11 i1="05" i2="1"><s1>FRINGS (Markus)</s1></fA11><fA11 i1="06" i2="1"><s1>TIMMANN (Dagmar)</s1></fA11><fA11 i1="07" i2="1"><s1>KLOCKGETHER (Thomas)</s1></fA11><fA14 i1="01"><s1>Department of Neurology, University Hospital of Bonn</s1><s2>Bonn</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Neurosurgery, University Hospital Essen</s1><s2>Essen</s2><s3>DEU</s3><sZ>4 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Neurology, University Hospital Essen</s1><s2>Essen</s2><s3>DEU</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ></fA14><fA20><s1>1633-1637</s1></fA20><fA21><s1>2007</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000149744800180</s5></fA43><fA44><s0>0000</s0><s1>© 2007 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>12 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>07-0448801</s0></fA47><fA60><s1>P</s1><s3>CC</s3></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>The objective of this study was to test the reliability and validity of the Scale for the Assessment and Rating of Ataxia (SARA) in ataxia patients not suffering from autosomal dominant spinocerebellar ataxia (SCA). To this end, 64 patients with various ataxia disorders or stable cerebellar lesions were rated independently by two investigators. In addition to SARA, the following assessment instruments were applied: ataxia disease stage, Barthel index and part IV (functional assessment) of the Unified Huntington's Disease Rating scale (UHDRS-IV). Eighteen patients were rated twice. Inter-rater and intrarater reliability were very high with ICCs of 0.98 and 0.99. Internal consistency was high indicated by Cronbach's α of 0.97. Factorial analysis revealed that the rating results were mainly determined by one major factor with an eigenvalue of 6.34 which explained 52.8% of the variance. SARA score increased with disease stage (P < 0.0001) and was closely correlated with Barthel index (r = -0.63, P < 0.0001) and UHDRS-IV (r = -0.62, P < 0.0001), but only weakly correlated with disease duration (r = 0.44, P < 0.001). The results suggest that SARA is a reliable and valid measure of ataxia in non-SCA ataxia patients.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17F</s0></fC02><fC02 i1="03" i2="X"><s0>002B17G</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Ataxie</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Ataxia</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Ataxia</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Fiabilité</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Reliability</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Fiabilidad</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Validité</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Validity</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Validez</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Echelle d'évaluation</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Evaluation scale</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Escala evaluación</s0><s5>11</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Homme</s0><s5>12</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Human</s0><s5>12</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Hombre</s0><s5>12</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Encéphale pathologie</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Trouble neurologique</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Neurological disorder</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Trastorno neurológico</s0><s5>39</s5></fC07><fN21><s1>295</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Allemagne</li></country><region><li>District de Cologne</li><li>Rhénanie-du-Nord-Westphalie</li></region><settlement><li>Bonn</li></settlement></list><tree><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Weyer, Anja" sort="Weyer, Anja" uniqKey="Weyer A" first="Anja" last="Weyer">Anja Weyer</name></region><name sortKey="Abele, Michael" sort="Abele, Michael" uniqKey="Abele M" first="Michael" last="Abele">Michael Abele</name><name sortKey="Frings, Markus" sort="Frings, Markus" uniqKey="Frings M" first="Markus" last="Frings">Markus Frings</name><name sortKey="Klockgether, Thomas" sort="Klockgether, Thomas" uniqKey="Klockgether T" first="Thomas" last="Klockgether">Thomas Klockgether</name><name sortKey="Schmitz Hubsch, Tanja" sort="Schmitz Hubsch, Tanja" uniqKey="Schmitz Hubsch T" first="Tanja" last="Schmitz-Hübsch">Tanja Schmitz-Hübsch</name><name sortKey="Schoch, Beate" sort="Schoch, Beate" uniqKey="Schoch B" first="Beate" last="Schoch">Beate Schoch</name><name sortKey="Timmann, Dagmar" sort="Timmann, Dagmar" uniqKey="Timmann D" first="Dagmar" last="Timmann">Dagmar Timmann</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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