Brain Atrophy and White Matter Hyperintensities in Early Parkinson's Diseasea
Identifieur interne : 000F62 ( PascalFrancis/Checkpoint ); précédent : 000F61; suivant : 000F63Brain Atrophy and White Matter Hyperintensities in Early Parkinson's Diseasea
Auteurs : Turi O. Dalaker [États-Unis, Norvège] ; Jan P. Larsen [Norvège] ; Niels Bergsland [États-Unis] ; Mona K. Beyer [Norvège] ; Guido Alves [Norvège] ; Michael G. Dwyer [États-Unis] ; Ole-Bjom Tysnes [Norvège] ; Ralph H. B. Benedict [États-Unis] ; Arpad Kelemen [États-Unis] ; Kolbjom Bronnick [Norvège] ; Robert Zivadinov [États-Unis]Source :
- Movement disorders [ 0885-3185 ] ; 2009.
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Abstract
The purpose of this research was to examine the extent of global brain atrophy and white matter hyperintensities (WMH) in early Parkinson's disease (PD) compared to normal controls (NC), to explore the relationship between the MRI variables and cognition in PD. In this multicenter study we included 155 PD patients (age 65.6 ± 9.1 years, disease duration 26.7 ± 19.9 months) and 101 age-matched NC. On 3D-T1-WI, we calculated normalized brain volumes using SIENAX software. WMH volumes were assessed semiautomatically. In PD patients, correlation and regression analyses investigated the association between atrophy and WMH outcomes and global, attention-executive, visuospatial, and memory cognitive functions. Regression analysis was controlled for age, education, depression score, motor severity, cerebrovascular risk, and sex. No significant MRI variable volume group differences were found. The models did not retain any of the imaging variables as significant predictors of cognitive impairment. There was no evidence of brain atrophy or higher WMH volume in PD compared to NC, and MRI volumetric measurements were not significant predictors of cognitive functions in PD patients. We conclude that global structural brain changes are not a major feature in patients with incident PD.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Brain Atrophy and White Matter Hyperintensities in Early Parkinson's Disease<sup>a</sup></title><author><name sortKey="Dalaker, Turi O" sort="Dalaker, Turi O" uniqKey="Dalaker T" first="Turi O." last="Dalaker">Turi O. Dalaker</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo</s1><s2>Buffalo, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Radiology, Stavanger University Hospital</s1><s2>Stavanger</s2><s3>NOR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Stavanger</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>The Norwegian Centre for Movement Disorders, Stavanger University Hospital</s1><s2>Stavanger</s2><s3>NOR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Stavanger</wicri:noRegion></affiliation></author><author><name sortKey="Larsen, Jan P" sort="Larsen, Jan P" uniqKey="Larsen J" first="Jan P." last="Larsen">Jan P. Larsen</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>The Norwegian Centre for Movement Disorders, Stavanger University Hospital</s1><s2>Stavanger</s2><s3>NOR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Stavanger</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurology, Stavanger University Hospital</s1><s2>Stavanger</s2><s3>NOR</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Stavanger</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Institute of Clinical Medicine, University of Bergen</s1><s2>Bergen</s2><s3>NOR</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Bergen</wicri:noRegion></affiliation></author><author><name sortKey="Bergsland, Niels" sort="Bergsland, Niels" uniqKey="Bergsland N" first="Niels" last="Bergsland">Niels Bergsland</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo</s1><s2>Buffalo, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Beyer, Mona K" sort="Beyer, Mona K" uniqKey="Beyer M" first="Mona K." last="Beyer">Mona K. Beyer</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Radiology, Stavanger University Hospital</s1><s2>Stavanger</s2><s3>NOR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Stavanger</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>The Norwegian Centre for Movement Disorders, Stavanger University Hospital</s1><s2>Stavanger</s2><s3>NOR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Stavanger</wicri:noRegion></affiliation></author><author><name sortKey="Alves, Guido" sort="Alves, Guido" uniqKey="Alves G" first="Guido" last="Alves">Guido Alves</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>The Norwegian Centre for Movement Disorders, Stavanger University Hospital</s1><s2>Stavanger</s2><s3>NOR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Stavanger</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurology, Stavanger University Hospital</s1><s2>Stavanger</s2><s3>NOR</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Stavanger</wicri:noRegion></affiliation></author><author><name sortKey="Dwyer, Michael G" sort="Dwyer, Michael G" uniqKey="Dwyer M" first="Michael G." last="Dwyer">Michael G. Dwyer</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo</s1><s2>Buffalo, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Tysnes, Ole Bjom" sort="Tysnes, Ole Bjom" uniqKey="Tysnes O" first="Ole-Bjom" last="Tysnes">Ole-Bjom Tysnes</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Institute of Clinical Medicine, University of Bergen</s1><s2>Bergen</s2><s3>NOR</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Bergen</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurology, Haukeland University Hospital</s1><s2>Bergen</s2><s3>NOR</s3><sZ>7 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Bergen</wicri:noRegion></affiliation></author><author><name sortKey="Benedict, Ralph H B" sort="Benedict, Ralph H B" uniqKey="Benedict R" first="Ralph H. B." last="Benedict">Ralph H. B. Benedict</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo</s1><s2>Buffalo, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="07"><s1>Department of Neurology, The Jacobs Neurological Institute, State University of New York at Buffalo</s1><s2>Buffalo, New York</s2><s3>USA</s3><sZ>8 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Kelemen, Arpad" sort="Kelemen, Arpad" uniqKey="Kelemen A" first="Arpad" last="Kelemen">Arpad Kelemen</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo</s1><s2>Buffalo, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Bronnick, Kolbjom" sort="Bronnick, Kolbjom" uniqKey="Bronnick K" first="Kolbjom" last="Bronnick">Kolbjom Bronnick</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>The Norwegian Centre for Movement Disorders, Stavanger University Hospital</s1><s2>Stavanger</s2><s3>NOR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Stavanger</wicri:noRegion></affiliation></author><author><name sortKey="Zivadinov, Robert" sort="Zivadinov, Robert" uniqKey="Zivadinov R" first="Robert" last="Zivadinov">Robert Zivadinov</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo</s1><s2>Buffalo, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="07"><s1>Department of Neurology, The Jacobs Neurological Institute, State University of New York at Buffalo</s1><s2>Buffalo, New York</s2><s3>USA</s3><sZ>8 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">10-0036262</idno><date when="2009">2009</date><idno type="stanalyst">PASCAL 10-0036262 INIST</idno><idno type="RBID">Pascal:10-0036262</idno><idno type="wicri:Area/PascalFrancis/Corpus">000D15</idno><idno type="wicri:Area/PascalFrancis/Curation">002004</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000F62</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Brain Atrophy and White Matter Hyperintensities in Early Parkinson's Disease<sup>a</sup></title><author><name sortKey="Dalaker, Turi O" sort="Dalaker, Turi O" uniqKey="Dalaker T" first="Turi O." last="Dalaker">Turi O. Dalaker</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo</s1><s2>Buffalo, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Radiology, Stavanger University Hospital</s1><s2>Stavanger</s2><s3>NOR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Stavanger</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>The Norwegian Centre for Movement Disorders, Stavanger University Hospital</s1><s2>Stavanger</s2><s3>NOR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Stavanger</wicri:noRegion></affiliation></author><author><name sortKey="Larsen, Jan P" sort="Larsen, Jan P" uniqKey="Larsen J" first="Jan P." last="Larsen">Jan P. Larsen</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>The Norwegian Centre for Movement Disorders, Stavanger University Hospital</s1><s2>Stavanger</s2><s3>NOR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Stavanger</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurology, Stavanger University Hospital</s1><s2>Stavanger</s2><s3>NOR</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Stavanger</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Institute of Clinical Medicine, University of Bergen</s1><s2>Bergen</s2><s3>NOR</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Bergen</wicri:noRegion></affiliation></author><author><name sortKey="Bergsland, Niels" sort="Bergsland, Niels" uniqKey="Bergsland N" first="Niels" last="Bergsland">Niels Bergsland</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo</s1><s2>Buffalo, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Beyer, Mona K" sort="Beyer, Mona K" uniqKey="Beyer M" first="Mona K." last="Beyer">Mona K. Beyer</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Radiology, Stavanger University Hospital</s1><s2>Stavanger</s2><s3>NOR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Stavanger</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>The Norwegian Centre for Movement Disorders, Stavanger University Hospital</s1><s2>Stavanger</s2><s3>NOR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Stavanger</wicri:noRegion></affiliation></author><author><name sortKey="Alves, Guido" sort="Alves, Guido" uniqKey="Alves G" first="Guido" last="Alves">Guido Alves</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>The Norwegian Centre for Movement Disorders, Stavanger University Hospital</s1><s2>Stavanger</s2><s3>NOR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Stavanger</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurology, Stavanger University Hospital</s1><s2>Stavanger</s2><s3>NOR</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Stavanger</wicri:noRegion></affiliation></author><author><name sortKey="Dwyer, Michael G" sort="Dwyer, Michael G" uniqKey="Dwyer M" first="Michael G." last="Dwyer">Michael G. Dwyer</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo</s1><s2>Buffalo, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Tysnes, Ole Bjom" sort="Tysnes, Ole Bjom" uniqKey="Tysnes O" first="Ole-Bjom" last="Tysnes">Ole-Bjom Tysnes</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Institute of Clinical Medicine, University of Bergen</s1><s2>Bergen</s2><s3>NOR</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Bergen</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurology, Haukeland University Hospital</s1><s2>Bergen</s2><s3>NOR</s3><sZ>7 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Bergen</wicri:noRegion></affiliation></author><author><name sortKey="Benedict, Ralph H B" sort="Benedict, Ralph H B" uniqKey="Benedict R" first="Ralph H. B." last="Benedict">Ralph H. B. Benedict</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo</s1><s2>Buffalo, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="07"><s1>Department of Neurology, The Jacobs Neurological Institute, State University of New York at Buffalo</s1><s2>Buffalo, New York</s2><s3>USA</s3><sZ>8 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Kelemen, Arpad" sort="Kelemen, Arpad" uniqKey="Kelemen A" first="Arpad" last="Kelemen">Arpad Kelemen</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo</s1><s2>Buffalo, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Bronnick, Kolbjom" sort="Bronnick, Kolbjom" uniqKey="Bronnick K" first="Kolbjom" last="Bronnick">Kolbjom Bronnick</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>The Norwegian Centre for Movement Disorders, Stavanger University Hospital</s1><s2>Stavanger</s2><s3>NOR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Stavanger</wicri:noRegion></affiliation></author><author><name sortKey="Zivadinov, Robert" sort="Zivadinov, Robert" uniqKey="Zivadinov R" first="Robert" last="Zivadinov">Robert Zivadinov</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo</s1><s2>Buffalo, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="07"><s1>Department of Neurology, The Jacobs Neurological Institute, State University of New York at Buffalo</s1><s2>Buffalo, New York</s2><s3>USA</s3><sZ>8 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Atrophy</term><term>Cognition</term><term>Encephalon</term><term>Hyperintensity</term><term>Nervous system diseases</term><term>Nuclear magnetic resonance imaging</term><term>Parkinson disease</term><term>White matter</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Atrophie</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Encéphale</term><term>Substance blanche</term><term>Hyperintensité</term><term>Imagerie RMN</term><term>Cognition</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The purpose of this research was to examine the extent of global brain atrophy and white matter hyperintensities (WMH) in early Parkinson's disease (PD) compared to normal controls (NC), to explore the relationship between the MRI variables and cognition in PD. In this multicenter study we included 155 PD patients (age 65.6 ± 9.1 years, disease duration 26.7 ± 19.9 months) and 101 age-matched NC. On 3D-T1-WI, we calculated normalized brain volumes using SIENAX software. WMH volumes were assessed semiautomatically. In PD patients, correlation and regression analyses investigated the association between atrophy and WMH outcomes and global, attention-executive, visuospatial, and memory cognitive functions. Regression analysis was controlled for age, education, depression score, motor severity, cerebrovascular risk, and sex. No significant MRI variable volume group differences were found. The models did not retain any of the imaging variables as significant predictors of cognitive impairment. There was no evidence of brain atrophy or higher WMH volume in PD compared to NC, and MRI volumetric measurements were not significant predictors of cognitive functions in PD patients. We conclude that global structural brain changes are not a major feature in patients with incident PD.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>24</s2></fA05><fA06><s2>15</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Brain Atrophy and White Matter Hyperintensities in Early Parkinson's Disease<sup>a</sup></s1></fA08><fA11 i1="01" i2="1"><s1>DALAKER (Turi O.)</s1></fA11><fA11 i1="02" i2="1"><s1>LARSEN (Jan P.)</s1></fA11><fA11 i1="03" i2="1"><s1>BERGSLAND (Niels)</s1></fA11><fA11 i1="04" i2="1"><s1>BEYER (Mona K.)</s1></fA11><fA11 i1="05" i2="1"><s1>ALVES (Guido)</s1></fA11><fA11 i1="06" i2="1"><s1>DWYER (Michael G.)</s1></fA11><fA11 i1="07" i2="1"><s1>TYSNES (Ole-Bjom)</s1></fA11><fA11 i1="08" i2="1"><s1>BENEDICT (Ralph H. B.)</s1></fA11><fA11 i1="09" i2="1"><s1>KELEMEN (Arpad)</s1></fA11><fA11 i1="10" i2="1"><s1>BRONNICK (Kolbjom)</s1></fA11><fA11 i1="11" i2="1"><s1>ZIVADINOV (Robert)</s1></fA11><fA14 i1="01"><s1>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo</s1><s2>Buffalo, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Radiology, Stavanger University Hospital</s1><s2>Stavanger</s2><s3>NOR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></fA14><fA14 i1="03"><s1>The Norwegian Centre for Movement Disorders, Stavanger University Hospital</s1><s2>Stavanger</s2><s3>NOR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ></fA14><fA14 i1="04"><s1>Department of Neurology, Stavanger University Hospital</s1><s2>Stavanger</s2><s3>NOR</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ></fA14><fA14 i1="05"><s1>Institute of Clinical Medicine, University of Bergen</s1><s2>Bergen</s2><s3>NOR</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ></fA14><fA14 i1="06"><s1>Department of Neurology, Haukeland University Hospital</s1><s2>Bergen</s2><s3>NOR</s3><sZ>7 aut.</sZ></fA14><fA14 i1="07"><s1>Department of Neurology, The Jacobs Neurological Institute, State University of New York at Buffalo</s1><s2>Buffalo, New York</s2><s3>USA</s3><sZ>8 aut.</sZ><sZ>11 aut.</sZ></fA14><fA20><s1>2233-2241</s1></fA20><fA21><s1>2009</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000171746820080</s5></fA43><fA44><s0>0000</s0><s1>© 2010 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>44 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>10-0036262</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>The purpose of this research was to examine the extent of global brain atrophy and white matter hyperintensities (WMH) in early Parkinson's disease (PD) compared to normal controls (NC), to explore the relationship between the MRI variables and cognition in PD. In this multicenter study we included 155 PD patients (age 65.6 ± 9.1 years, disease duration 26.7 ± 19.9 months) and 101 age-matched NC. On 3D-T1-WI, we calculated normalized brain volumes using SIENAX software. WMH volumes were assessed semiautomatically. In PD patients, correlation and regression analyses investigated the association between atrophy and WMH outcomes and global, attention-executive, visuospatial, and memory cognitive functions. Regression analysis was controlled for age, education, depression score, motor severity, cerebrovascular risk, and sex. No significant MRI variable volume group differences were found. The models did not retain any of the imaging variables as significant predictors of cognitive impairment. There was no evidence of brain atrophy or higher WMH volume in PD compared to NC, and MRI volumetric measurements were not significant predictors of cognitive functions in PD patients. We conclude that global structural brain changes are not a major feature in patients with incident PD.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17G</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Atrophie</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Atrophy</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Atrofia</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Maladie de Parkinson</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Parkinson disease</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Encéphale</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Encephalon</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Encéfalo</s0><s5>09</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Substance blanche</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>White matter</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Substancia blanca</s0><s5>10</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Hyperintensité</s0><s5>11</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Hyperintensity</s0><s5>11</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Hyperintensidad</s0><s5>11</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Imagerie RMN</s0><s5>12</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Nuclear magnetic resonance imaging</s0><s5>12</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Imaginería RMN</s0><s5>12</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Cognition</s0><s5>13</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Cognition</s0><s5>13</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Cognición</s0><s5>13</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Système nerveux central</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Central nervous system</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Sistema nervioso central</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>40</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>41</s5></fC07><fN21><s1>025</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Norvège</li><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Dalaker, Turi O" sort="Dalaker, Turi O" uniqKey="Dalaker T" first="Turi O." last="Dalaker">Turi O. Dalaker</name></region><name sortKey="Benedict, Ralph H B" sort="Benedict, Ralph H B" uniqKey="Benedict R" first="Ralph H. B." last="Benedict">Ralph H. B. Benedict</name><name sortKey="Benedict, Ralph H B" sort="Benedict, Ralph H B" uniqKey="Benedict R" first="Ralph H. B." last="Benedict">Ralph H. B. Benedict</name><name sortKey="Bergsland, Niels" sort="Bergsland, Niels" uniqKey="Bergsland N" first="Niels" last="Bergsland">Niels Bergsland</name><name sortKey="Dwyer, Michael G" sort="Dwyer, Michael G" uniqKey="Dwyer M" first="Michael G." last="Dwyer">Michael G. Dwyer</name><name sortKey="Kelemen, Arpad" sort="Kelemen, Arpad" uniqKey="Kelemen A" first="Arpad" last="Kelemen">Arpad Kelemen</name><name sortKey="Zivadinov, Robert" sort="Zivadinov, Robert" uniqKey="Zivadinov R" first="Robert" last="Zivadinov">Robert Zivadinov</name><name sortKey="Zivadinov, Robert" sort="Zivadinov, Robert" uniqKey="Zivadinov R" first="Robert" last="Zivadinov">Robert Zivadinov</name></country><country name="Norvège"><noRegion><name sortKey="Dalaker, Turi O" sort="Dalaker, Turi O" uniqKey="Dalaker T" first="Turi O." last="Dalaker">Turi O. Dalaker</name></noRegion><name sortKey="Alves, Guido" sort="Alves, Guido" uniqKey="Alves G" first="Guido" last="Alves">Guido Alves</name><name sortKey="Alves, Guido" sort="Alves, Guido" uniqKey="Alves G" first="Guido" last="Alves">Guido Alves</name><name sortKey="Beyer, Mona K" sort="Beyer, Mona K" uniqKey="Beyer M" first="Mona K." last="Beyer">Mona K. Beyer</name><name sortKey="Beyer, Mona K" sort="Beyer, Mona K" uniqKey="Beyer M" first="Mona K." last="Beyer">Mona K. Beyer</name><name sortKey="Bronnick, Kolbjom" sort="Bronnick, Kolbjom" uniqKey="Bronnick K" first="Kolbjom" last="Bronnick">Kolbjom Bronnick</name><name sortKey="Dalaker, Turi O" sort="Dalaker, Turi O" uniqKey="Dalaker T" first="Turi O." last="Dalaker">Turi O. Dalaker</name><name sortKey="Larsen, Jan P" sort="Larsen, Jan P" uniqKey="Larsen J" first="Jan P." last="Larsen">Jan P. Larsen</name><name sortKey="Larsen, Jan P" sort="Larsen, Jan P" uniqKey="Larsen J" first="Jan P." last="Larsen">Jan P. Larsen</name><name sortKey="Larsen, Jan P" sort="Larsen, Jan P" uniqKey="Larsen J" first="Jan P." last="Larsen">Jan P. Larsen</name><name sortKey="Tysnes, Ole Bjom" sort="Tysnes, Ole Bjom" uniqKey="Tysnes O" first="Ole-Bjom" last="Tysnes">Ole-Bjom Tysnes</name><name sortKey="Tysnes, Ole Bjom" sort="Tysnes, Ole Bjom" uniqKey="Tysnes O" first="Ole-Bjom" last="Tysnes">Ole-Bjom Tysnes</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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