Deep Brain Stimulation of the Subthalamic Nucleus Improves Intrinsic Alertness in Parkinson's Disease
Identifieur interne : 000F19 ( PascalFrancis/Checkpoint ); précédent : 000F18; suivant : 000F20Deep Brain Stimulation of the Subthalamic Nucleus Improves Intrinsic Alertness in Parkinson's Disease
Auteurs : Bruno Fimm [Allemagne] ; Ines A. Heber [Allemagne] ; Volker A. Coenen [Allemagne] ; Christoph Fromm [Allemagne] ; Johannes Noth [Allemagne] ; Martin Kronenbuerger [Allemagne]Source :
- Movement disorders [ 0885-3185 ] ; 2009.
Descripteurs français
- Pascal (Inist)
English descriptors
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Abstract
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a treatment option for patients with Parkinson's disease (PD) in the advanced stage. Besides motor improvement, DBS of the STN may also modulate cognitive and attentional functions of the basal ganglia. In our study, 13 patients with PD and bilateral DBS of the STN were assessed with DBS switched on and off by the use of a wide range of neuropsychological tasks. This included reasoning, cognitive flexibility, phonemic and semantic word fluency, verbal and nonverbal short-term memory, learning, delayed verbal memory recall, and stimulus-response incompatibility. Special emphasis was put on basic attentional functions, in particular intrinsic and phasic alertness as well as visual search. DBS significantly improved intrinsic alertness, whereas phasic alertness and other neuropsychological domains were not affected. Additionally, the effects on intrinsic alertness were independent of motor improvements by DBS. The findings suggest that DBS modulates the fronto-parietal network of alertness.
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Heber</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Section of Neuropsychology, University Hospital RWTH Aachen</s1><s2>Aachen</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Coenen, Volker A" sort="Coenen, Volker A" uniqKey="Coenen V" first="Volker A." last="Coenen">Volker A. Coenen</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Neurosurgery, University Hospital RWTH Aachen</s1><s2>Aachen</s2><s3>DEU</s3><sZ>3 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Fromm, Christoph" sort="Fromm, Christoph" uniqKey="Fromm C" first="Christoph" last="Fromm">Christoph Fromm</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, University Hospital RWTH Aachen</s1><s2>Aachen</s2><s3>DEU</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Noth, Johannes" sort="Noth, Johannes" uniqKey="Noth J" first="Johannes" last="Noth">Johannes Noth</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, University Hospital RWTH Aachen</s1><s2>Aachen</s2><s3>DEU</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Kronenbuerger, Martin" sort="Kronenbuerger, Martin" uniqKey="Kronenbuerger M" first="Martin" last="Kronenbuerger">Martin Kronenbuerger</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, University Hospital RWTH Aachen</s1><s2>Aachen</s2><s3>DEU</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Attention</term><term>Basal ganglion</term><term>Cognition</term><term>Deep brain stimulation</term><term>Nervous system diseases</term><term>Parietal</term><term>Parkinson disease</term><term>Subthalamic nucleus</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Noyau sousthalamique</term><term>Pariétal</term><term>Attention</term><term>Cognition</term><term>Noyau gris central</term><term>Stimulation cérébrale profonde</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a treatment option for patients with Parkinson's disease (PD) in the advanced stage. Besides motor improvement, DBS of the STN may also modulate cognitive and attentional functions of the basal ganglia. In our study, 13 patients with PD and bilateral DBS of the STN were assessed with DBS switched on and off by the use of a wide range of neuropsychological tasks. This included reasoning, cognitive flexibility, phonemic and semantic word fluency, verbal and nonverbal short-term memory, learning, delayed verbal memory recall, and stimulus-response incompatibility. Special emphasis was put on basic attentional functions, in particular intrinsic and phasic alertness as well as visual search. DBS significantly improved intrinsic alertness, whereas phasic alertness and other neuropsychological domains were not affected. Additionally, the effects on intrinsic alertness were independent of motor improvements by DBS. The findings suggest that DBS modulates the fronto-parietal network of alertness.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>24</s2></fA05><fA06><s2>11</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Deep Brain Stimulation of the Subthalamic Nucleus Improves Intrinsic Alertness in Parkinson's Disease</s1></fA08><fA11 i1="01" i2="1"><s1>FIMM (Bruno)</s1></fA11><fA11 i1="02" i2="1"><s1>HEBER (Ines A.)</s1></fA11><fA11 i1="03" i2="1"><s1>COENEN (Volker A.)</s1></fA11><fA11 i1="04" i2="1"><s1>FROMM (Christoph)</s1></fA11><fA11 i1="05" i2="1"><s1>NOTH (Johannes)</s1></fA11><fA11 i1="06" i2="1"><s1>KRONENBUERGER (Martin)</s1></fA11><fA14 i1="01"><s1>Department of Neurology, Section of Neuropsychology, University Hospital RWTH Aachen</s1><s2>Aachen</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Neurosurgery, University Hospital RWTH Aachen</s1><s2>Aachen</s2><s3>DEU</s3><sZ>3 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Neurology, University Hospital RWTH Aachen</s1><s2>Aachen</s2><s3>DEU</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></fA14><fA20><s1>1613-1620</s1></fA20><fA21><s1>2009</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000171892190080</s5></fA43><fA44><s0>0000</s0><s1>© 2009 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>47 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>09-0386504</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a treatment option for patients with Parkinson's disease (PD) in the advanced stage. Besides motor improvement, DBS of the STN may also modulate cognitive and attentional functions of the basal ganglia. In our study, 13 patients with PD and bilateral DBS of the STN were assessed with DBS switched on and off by the use of a wide range of neuropsychological tasks. This included reasoning, cognitive flexibility, phonemic and semantic word fluency, verbal and nonverbal short-term memory, learning, delayed verbal memory recall, and stimulus-response incompatibility. Special emphasis was put on basic attentional functions, in particular intrinsic and phasic alertness as well as visual search. DBS significantly improved intrinsic alertness, whereas phasic alertness and other neuropsychological domains were not affected. Additionally, the effects on intrinsic alertness were independent of motor improvements by DBS. 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Coenen</name><name sortKey="Fromm, Christoph" sort="Fromm, Christoph" uniqKey="Fromm C" first="Christoph" last="Fromm">Christoph Fromm</name><name sortKey="Heber, Ines A" sort="Heber, Ines A" uniqKey="Heber I" first="Ines A." last="Heber">Ines A. Heber</name><name sortKey="Kronenbuerger, Martin" sort="Kronenbuerger, Martin" uniqKey="Kronenbuerger M" first="Martin" last="Kronenbuerger">Martin Kronenbuerger</name><name sortKey="Noth, Johannes" sort="Noth, Johannes" uniqKey="Noth J" first="Johannes" last="Noth">Johannes Noth</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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