MovDisordV3, PascalFrancis, Checkpoint, bibRecord, 000B63

Characterization of Lewy Body Pathology in 12- and 16-Year-Old Intrastriatal Mesencephalic Grafts Surviving in a Patient With Parkinson's Disease

Identifieur interne : 000B63 ( PascalFrancis/Checkpoint ); précédent : 000B62; suivant : 000B64

Characterization of Lewy Body Pathology in 12- and 16-Year-Old Intrastriatal Mesencephalic Grafts Surviving in a Patient With Parkinson's Disease

Auteurs : Jia-Yi Li [Suède] ; Elisabet Englund [Suède] ; Hakan Widner [Suède] ; Stig Rehncrona [Suède] ; Anders Björklund [Suède] ; Olle Lindvall [Suède] ; Patrik Brundin [Suède]

Source :

Movement disorders [ 0885-3185 ] ; 2010.

RBID : Pascal:10-0315071

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Corps Lewy, Anatomopathologie, Greffe, Homme, Transplantation, Protéine, Agrégation.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Aggregation, Anatomic pathology, Graft, Human, Lewy body, Nervous system diseases, Parkinson disease, Protein, Transplantation.

Abstract

We previously reported the occurrence of Lewy bodies in grafted human fetal mesencephalic neurons in two patients with Parkinson's disease. Here, we have used immunohistochemistry and electron microscopy to characterize the development of Lewy bodies in one of these cases. This patient was operated in putamen on both sides at 12 or 16 years before death, respectively. We demonstrate that 2% of the 12-year-old and 5% of the 16-year-old grafted, presumed dopaminergic neurons contained Lewy bodies immunoreactive for α-synuclein. Based on morphological analysis, two forms of α-synuclein-positive aggregates were distinguished in the grafts, the first a classical and compact Lewy body, the other a loose mesh-work aggregate. Lewy bodies in the grafts stained positively for ubiquitin and thioflavin-S, and contained characteristic α-synuclein immunoreactive electron dense fibrillar structures on electron microscopy. Our data indicate that Lewy bodies develop gradually in transplanted dopaminergic neurons in a fashion similar to that in dopaminergic neurons in the host substantia nigra.

Affiliations:

Suède

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<front><div type="abstract" xml:lang="en">We previously reported the occurrence of Lewy bodies in grafted human fetal mesencephalic neurons in two patients with Parkinson's disease. Here, we have used immunohistochemistry and electron microscopy to characterize the development of Lewy bodies in one of these cases. This patient was operated in putamen on both sides at 12 or 16 years before death, respectively. We demonstrate that 2% of the 12-year-old and 5% of the 16-year-old grafted, presumed dopaminergic neurons contained Lewy bodies immunoreactive for α-synuclein. Based on morphological analysis, two forms of α-synuclein-positive aggregates were distinguished in the grafts, the first a classical and compact Lewy body, the other a loose mesh-work aggregate. Lewy bodies in the grafts stained positively for ubiquitin and thioflavin-S, and contained characteristic α-synuclein immunoreactive electron dense fibrillar structures on electron microscopy. Our data indicate that Lewy bodies develop gradually in transplanted dopaminergic neurons in a fashion similar to that in dopaminergic neurons in the host substantia nigra.</div>
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<fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>40</s5>
</fC07>
<fN21><s1>200</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
<affiliations><list><country><li>Suède</li>
</country>
</list>
<tree><country name="Suède"><noRegion><name sortKey="Li, Jia Yi" sort="Li, Jia Yi" uniqKey="Li J" first="Jia-Yi" last="Li">Jia-Yi Li</name>
</noRegion>
<name sortKey="Bjorklund, Anders" sort="Bjorklund, Anders" uniqKey="Bjorklund A" first="Anders" last="Björklund">Anders Björklund</name>
<name sortKey="Brundin, Patrik" sort="Brundin, Patrik" uniqKey="Brundin P" first="Patrik" last="Brundin">Patrik Brundin</name>
<name sortKey="Englund, Elisabet" sort="Englund, Elisabet" uniqKey="Englund E" first="Elisabet" last="Englund">Elisabet Englund</name>
<name sortKey="Lindvall, Olle" sort="Lindvall, Olle" uniqKey="Lindvall O" first="Olle" last="Lindvall">Olle Lindvall</name>
<name sortKey="Lindvall, Olle" sort="Lindvall, Olle" uniqKey="Lindvall O" first="Olle" last="Lindvall">Olle Lindvall</name>
<name sortKey="Rehncrona, Stig" sort="Rehncrona, Stig" uniqKey="Rehncrona S" first="Stig" last="Rehncrona">Stig Rehncrona</name>
<name sortKey="Widner, Hakan" sort="Widner, Hakan" uniqKey="Widner H" first="Hakan" last="Widner">Hakan Widner</name>
</country>
</tree>
</affiliations>
</record>

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   |texte=   Characterization of Lewy Body Pathology in 12- and 16-Year-Old Intrastriatal Mesencephalic Grafts Surviving in a Patient With Parkinson's Disease
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	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Movement Disorders (revue)

Characterization of Lewy Body Pathology in 12- and 16-Year-Old Intrastriatal Mesencephalic Grafts Surviving in a Patient With Parkinson's Disease

Characterization of Lewy Body Pathology in 12- and 16-Year-Old Intrastriatal Mesencephalic Grafts Surviving in a Patient With Parkinson's Disease

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