Long-Term Results of a Multicenter Study on Subthalamic and Pallidal Stimulation in Parkinson's Disease
Identifieur interne : 000979 ( PascalFrancis/Checkpoint ); précédent : 000978; suivant : 000980Long-Term Results of a Multicenter Study on Subthalamic and Pallidal Stimulation in Parkinson's Disease
Auteurs : Elena Moro [Canada] ; Andres M. Lozano [Canada] ; Pierre Pollak [France] ; Yves Agid [France] ; Stig Rehncrona [Suède] ; Jens Volkmann [Allemagne] ; Jaime Kulisevsky [Espagne] ; Jose A. Obeso [Espagne] ; Alberto Albanese [Italie] ; Marwan I. Hariz [Royaume-Uni, Suède] ; Niall P. Quinn [Canada] ; Jans D. Speelman [Pays-Bas] ; Alim-Louis Benabid [France] ; Valerie Fraix [France] ; Alexandre Mendes [France] ; Marie-Laure Welter [France] ; Jean-Luc Houeto [France] ; Philippe Cornu [France] ; Didier Dormont [France] ; Annalena L. Tornqvist [Suède] ; Ron Ekberg [Suède] ; Alfons Schnitzler [Allemagne] ; Lars Timmermann [Allemagne] ; Lars Wojtecki [Allemagne] ; Andres Gironell [Espagne] ; Maria C. Rodriguez-Oroz [Espagne] ; Jorge Guridi [Espagne] ; Anna R. Bentivoglio [Italie] ; Maria F. Contarino [Italie, Pays-Bas] ; Luigi Romito [Italie] ; Massimo Scerrati [Italie] ; Marc Janssens [Pays-Bas] ; Anthony E. Lang [Canada]Source :
- Movement disorders [ 0885-3185 ] ; 2010.
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- Pascal (Inist)
English descriptors
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Abstract
We report the 5 to 6 year follow-up of a multicenter study of bilateral subthalamic nucleus (STN) and globus pallidus intemus (GPi) deep brain stimulation (DBS) in advanced Parkinson's disease (PD) patients. Thirty-five STN patients and 16 GPi patients were assessed at 5 to 6 years after DBS surgery. Primary outcome measure was the stimulation effect on the motor Unified Parkinson's Disease Rating Scale (UPDRS) assessed with a prospective cross-over double-blind assessment without medications (stimulation was randomly switched on or off). Secondary outcomes were motor UPDRS changes with unblinded assessments in off-and on-medication states with and without stimulation, activities of daily living (ADL), anti-PD medications, and dyskinesias. In double-blind assessment, both STN and GPi DBS were significantly effective in improving the motor UPDRS scores (STN, P < 0.0001, 45.4%; GPi, P = 0.008, 20.0%) compared with off-stimulation, regardless of the sequence of stimulation. In open assessment, both STN- and GPi-DBS significantly improved the off-medication motor UPDRS when compared with before surgery (STN, P < 0.001, 50.5%; GPi, P = 0.002, 35.6%). Dyskinesias and ADL were significantly improved in both groups. Anti-PD medications were significantly reduced only in the STN group. Adverse events were more frequent in the STN group. These results confirm the long-term efficacy of STN and GPi DBS in advanced PD. Although the surgical targets were not randomized, there was a trend to a better outcome of motor signs in the STN-DBS patients and fewer adverse events in the GPi-DBS group.
Affiliations:
- Allemagne, Canada, Espagne, France, Italie, Pays-Bas, Royaume-Uni, Suède
- Angleterre, Auvergne-Rhône-Alpes, Catalogne, Grand Londres, Hollande-Septentrionale, Latium, Rhône-Alpes, Schleswig-Holstein, Île-de-France
- Amsterdam, Barcelone, Grenoble, Kiel, Londres, Paris, Poitiers, Rome
- Centre hospitalier universitaire Grenoble Alpes, Hôpital de la Salpêtrière
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Lozano</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Neurosurgery, University of Toronto and University Health Network</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Service de Neurologie, CHU de Grenoble</s1><s2>Grenoble</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Hôpital de la Salpêtrière, Fédération de Neurologie</s1><s2>Paris</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Paris</settlement></placeName><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author><author><name sortKey="Rehncrona, Stig" sort="Rehncrona, Stig" uniqKey="Rehncrona S" first="Stig" last="Rehncrona">Stig Rehncrona</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Neurosurgery Service, Lund University Hospital</s1><s2>Lund</s2><s3>SWE</s3><sZ>5 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Neurologische Klinik der Christian-Albrect-Universitat</s1><s2>Kiel</s2><s3>DEU</s3><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Kulisevsky, Jaime" sort="Kulisevsky, Jaime" uniqKey="Kulisevsky J" first="Jaime" last="Kulisevsky">Jaime Kulisevsky</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Neurology, Sant Pau Hospital, Autonomous University of Barcelona, CIBERNED</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>7 aut.</sZ><sZ>25 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="Jose A." last="Obeso">Jose A. Obeso</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED</s1><s2>Pamplona</s2><s3>ESP</s3><sZ>8 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Albanese, Alberto" sort="Albanese, Alberto" uniqKey="Albanese A" first="Alberto" last="Albanese">Alberto Albanese</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Istituto Nazionale Neurologico C. Besta and Università Cattolica</s1><s2>Milano</s2><s3>ITA</s3><sZ>9 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Istituto Nazionale Neurologico C. Besta and Università Cattolica</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore</s1><s2>Roma</s2><s3>ITA</s3><sZ>9 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Hariz, Marwan I" sort="Hariz, Marwan I" uniqKey="Hariz M" first="Marwan I." last="Hariz">Marwan I. Hariz</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Institute of Neurology, Queen Square</s1><s2>London</s2><s3>GBR</s3><sZ>10 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Neurosurgery, University Hospital of Northern Sweden</s1><s2>Umeå</s2><s3>SWE</s3><sZ>10 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P." last="Quinn">Niall P. Quinn</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Hospital, Movement Disorders Center, University of Toronto and University Health Network</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>11 aut.</sZ><sZ>33 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Speelman, Jans D" sort="Speelman, Jans D" uniqKey="Speelman J" first="Jans D." last="Speelman">Jans D. Speelman</name><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Department of Neurology, Academic Medical Center</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>12 aut.</sZ><sZ>29 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Benabid, Alim L" sort="Benabid, Alim L" uniqKey="Benabid A" first="Alim L." last="Benabid">Alim-Louis Benabid</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Service de Neurologie, CHU de Grenoble</s1><s2>Grenoble</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Grenoble</settlement></placeName><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="hospital" n="4">Centre hospitalier universitaire Grenoble Alpes</orgName></affiliation></author><author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valerie" last="Fraix">Valerie Fraix</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Service de Neurologie, CHU de Grenoble</s1><s2>Grenoble</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Mendes, Alexandre" sort="Mendes, Alexandre" uniqKey="Mendes A" first="Alexandre" last="Mendes">Alexandre Mendes</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Service de Neurologie, CHU de Grenoble</s1><s2>Grenoble</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Welter, Marie Laure" sort="Welter, Marie Laure" uniqKey="Welter M" first="Marie-Laure" last="Welter">Marie-Laure Welter</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Hôpital de la Salpêtrière, Fédération de Neurologie</s1><s2>Paris</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Houeto, Jean Luc" sort="Houeto, Jean Luc" uniqKey="Houeto J" first="Jean-Luc" last="Houeto">Jean-Luc Houeto</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Hôpital de la Salpêtrière, Fédération de Neurologie</s1><s2>Paris</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Service de Neurologie, CHU de Poitiers, University of Poitiers</s1><s2>Poitiers</s2><s3>FRA</s3><sZ>17 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Poitiers</settlement></placeName></affiliation></author><author><name sortKey="Cornu, Philippe" sort="Cornu, Philippe" uniqKey="Cornu P" first="Philippe" last="Cornu">Philippe Cornu</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Hôpital de la Salpêtrière, Fédération de Neurologie</s1><s2>Paris</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Dormont, Didier" sort="Dormont, Didier" uniqKey="Dormont D" first="Didier" last="Dormont">Didier Dormont</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Hôpital de la Salpêtrière, Fédération de Neurologie</s1><s2>Paris</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Tornqvist, Annalena L" sort="Tornqvist, Annalena L" uniqKey="Tornqvist A" first="Annalena L." last="Tornqvist">Annalena L. Tornqvist</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Neurosurgery Service, Lund University Hospital</s1><s2>Lund</s2><s3>SWE</s3><sZ>5 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Ekberg, Ron" sort="Ekberg, Ron" uniqKey="Ekberg R" first="Ron" last="Ekberg">Ron Ekberg</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Neurosurgery Service, Lund University Hospital</s1><s2>Lund</s2><s3>SWE</s3><sZ>5 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Department of Neurology and Institute of Clinical Neurosciences, Heinrich-Heine-Universitat Duesseldorf</s1><s2>Duesseldorf</s2><s3>DEU</s3><sZ>22 aut.</sZ><sZ>23 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Duesseldorf</wicri:noRegion><wicri:noRegion>Heinrich-Heine-Universitat Duesseldorf</wicri:noRegion><wicri:noRegion>Duesseldorf</wicri:noRegion></affiliation></author><author><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Department of Neurology and Institute of Clinical Neurosciences, Heinrich-Heine-Universitat Duesseldorf</s1><s2>Duesseldorf</s2><s3>DEU</s3><sZ>22 aut.</sZ><sZ>23 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Duesseldorf</wicri:noRegion><wicri:noRegion>Heinrich-Heine-Universitat Duesseldorf</wicri:noRegion><wicri:noRegion>Duesseldorf</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Department of Neurology, University Hospital</s1><s2>Cologne</s2><s3>DEU</s3><sZ>23 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>University Hospital</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Wojtecki, Lars" sort="Wojtecki, Lars" uniqKey="Wojtecki L" first="Lars" last="Wojtecki">Lars Wojtecki</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Department of Neurology and Institute of Clinical Neurosciences, Heinrich-Heine-Universitat Duesseldorf</s1><s2>Duesseldorf</s2><s3>DEU</s3><sZ>22 aut.</sZ><sZ>23 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Duesseldorf</wicri:noRegion><wicri:noRegion>Heinrich-Heine-Universitat Duesseldorf</wicri:noRegion><wicri:noRegion>Duesseldorf</wicri:noRegion></affiliation></author><author><name sortKey="Gironell, Andres" sort="Gironell, Andres" uniqKey="Gironell A" first="Andres" last="Gironell">Andres Gironell</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Neurology, Sant Pau Hospital, Autonomous University of Barcelona, CIBERNED</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>7 aut.</sZ><sZ>25 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Rodriguez Oroz, Maria C" sort="Rodriguez Oroz, Maria C" uniqKey="Rodriguez Oroz M" first="Maria C." last="Rodriguez-Oroz">Maria C. Rodriguez-Oroz</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED</s1><s2>Pamplona</s2><s3>ESP</s3><sZ>8 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Guridi, Jorge" sort="Guridi, Jorge" uniqKey="Guridi J" first="Jorge" last="Guridi">Jorge Guridi</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED</s1><s2>Pamplona</s2><s3>ESP</s3><sZ>8 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Bentivoglio, Anna R" sort="Bentivoglio, Anna R" uniqKey="Bentivoglio A" first="Anna R." last="Bentivoglio">Anna R. Bentivoglio</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore</s1><s2>Roma</s2><s3>ITA</s3><sZ>9 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Contarino, Maria F" sort="Contarino, Maria F" uniqKey="Contarino M" first="Maria F." last="Contarino">Maria F. Contarino</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore</s1><s2>Roma</s2><s3>ITA</s3><sZ>9 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Department of Neurology, Academic Medical Center</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>12 aut.</sZ><sZ>29 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Romito, Luigi" sort="Romito, Luigi" uniqKey="Romito L" first="Luigi" last="Romito">Luigi Romito</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Istituto Nazionale Neurologico C. Besta and Università Cattolica</s1><s2>Milano</s2><s3>ITA</s3><sZ>9 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Istituto Nazionale Neurologico C. Besta and Università Cattolica</wicri:noRegion></affiliation></author><author><name sortKey="Scerrati, Massimo" sort="Scerrati, Massimo" uniqKey="Scerrati M" first="Massimo" last="Scerrati">Massimo Scerrati</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore</s1><s2>Roma</s2><s3>ITA</s3><sZ>9 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Dipartimento di Neuroscienze, Sezione di Neurochirurgia, Universitd Politecnica delle Marche</s1><s2>Ancona</s2><s3>ITA</s3><sZ>31 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Ancona</wicri:noRegion></affiliation></author><author><name sortKey="Janssens, Marc" sort="Janssens, Marc" uniqKey="Janssens M" first="Marc" last="Janssens">Marc Janssens</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Bakken Research Center</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>32 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Bakken Research Center</wicri:noRegion></affiliation></author><author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Hospital, Movement Disorders Center, University of Toronto and University Health Network</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>11 aut.</sZ><sZ>33 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, Ontario</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">10-0233216</idno><date when="2010">2010</date><idno type="stanalyst">PASCAL 10-0233216 INIST</idno><idno type="RBID">Pascal:10-0233216</idno><idno type="wicri:Area/PascalFrancis/Corpus">000B40</idno><idno type="wicri:Area/PascalFrancis/Curation">002179</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000979</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Long-Term Results of a Multicenter Study on Subthalamic and Pallidal Stimulation in Parkinson's Disease</title><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Hospital, Movement Disorders Center, University of Toronto and University Health Network</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>11 aut.</sZ><sZ>33 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Neurosurgery, University of Toronto and University Health Network</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Service de Neurologie, CHU de Grenoble</s1><s2>Grenoble</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Hôpital de la Salpêtrière, Fédération de Neurologie</s1><s2>Paris</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Paris</settlement></placeName><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author><author><name sortKey="Rehncrona, Stig" sort="Rehncrona, Stig" uniqKey="Rehncrona S" first="Stig" last="Rehncrona">Stig Rehncrona</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Neurosurgery Service, Lund University Hospital</s1><s2>Lund</s2><s3>SWE</s3><sZ>5 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Neurologische Klinik der Christian-Albrect-Universitat</s1><s2>Kiel</s2><s3>DEU</s3><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Kulisevsky, Jaime" sort="Kulisevsky, Jaime" uniqKey="Kulisevsky J" first="Jaime" last="Kulisevsky">Jaime Kulisevsky</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Neurology, Sant Pau Hospital, Autonomous University of Barcelona, CIBERNED</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>7 aut.</sZ><sZ>25 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="Jose A." last="Obeso">Jose A. Obeso</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED</s1><s2>Pamplona</s2><s3>ESP</s3><sZ>8 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Albanese, Alberto" sort="Albanese, Alberto" uniqKey="Albanese A" first="Alberto" last="Albanese">Alberto Albanese</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Istituto Nazionale Neurologico C. Besta and Università Cattolica</s1><s2>Milano</s2><s3>ITA</s3><sZ>9 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Istituto Nazionale Neurologico C. Besta and Università Cattolica</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore</s1><s2>Roma</s2><s3>ITA</s3><sZ>9 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Hariz, Marwan I" sort="Hariz, Marwan I" uniqKey="Hariz M" first="Marwan I." last="Hariz">Marwan I. Hariz</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Institute of Neurology, Queen Square</s1><s2>London</s2><s3>GBR</s3><sZ>10 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Neurosurgery, University Hospital of Northern Sweden</s1><s2>Umeå</s2><s3>SWE</s3><sZ>10 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P." last="Quinn">Niall P. Quinn</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Hospital, Movement Disorders Center, University of Toronto and University Health Network</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>11 aut.</sZ><sZ>33 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Speelman, Jans D" sort="Speelman, Jans D" uniqKey="Speelman J" first="Jans D." last="Speelman">Jans D. Speelman</name><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Department of Neurology, Academic Medical Center</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>12 aut.</sZ><sZ>29 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Benabid, Alim L" sort="Benabid, Alim L" uniqKey="Benabid A" first="Alim L." last="Benabid">Alim-Louis Benabid</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Service de Neurologie, CHU de Grenoble</s1><s2>Grenoble</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Grenoble</settlement></placeName><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="hospital" n="4">Centre hospitalier universitaire Grenoble Alpes</orgName></affiliation></author><author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valerie" last="Fraix">Valerie Fraix</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Service de Neurologie, CHU de Grenoble</s1><s2>Grenoble</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Mendes, Alexandre" sort="Mendes, Alexandre" uniqKey="Mendes A" first="Alexandre" last="Mendes">Alexandre Mendes</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Service de Neurologie, CHU de Grenoble</s1><s2>Grenoble</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Welter, Marie Laure" sort="Welter, Marie Laure" uniqKey="Welter M" first="Marie-Laure" last="Welter">Marie-Laure Welter</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Hôpital de la Salpêtrière, Fédération de Neurologie</s1><s2>Paris</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Houeto, Jean Luc" sort="Houeto, Jean Luc" uniqKey="Houeto J" first="Jean-Luc" last="Houeto">Jean-Luc Houeto</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Hôpital de la Salpêtrière, Fédération de Neurologie</s1><s2>Paris</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Service de Neurologie, CHU de Poitiers, University of Poitiers</s1><s2>Poitiers</s2><s3>FRA</s3><sZ>17 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Poitiers</settlement></placeName></affiliation></author><author><name sortKey="Cornu, Philippe" sort="Cornu, Philippe" uniqKey="Cornu P" first="Philippe" last="Cornu">Philippe Cornu</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Hôpital de la Salpêtrière, Fédération de Neurologie</s1><s2>Paris</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Dormont, Didier" sort="Dormont, Didier" uniqKey="Dormont D" first="Didier" last="Dormont">Didier Dormont</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Hôpital de la Salpêtrière, Fédération de Neurologie</s1><s2>Paris</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Tornqvist, Annalena L" sort="Tornqvist, Annalena L" uniqKey="Tornqvist A" first="Annalena L." last="Tornqvist">Annalena L. Tornqvist</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Neurosurgery Service, Lund University Hospital</s1><s2>Lund</s2><s3>SWE</s3><sZ>5 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Ekberg, Ron" sort="Ekberg, Ron" uniqKey="Ekberg R" first="Ron" last="Ekberg">Ron Ekberg</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Neurosurgery Service, Lund University Hospital</s1><s2>Lund</s2><s3>SWE</s3><sZ>5 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Department of Neurology and Institute of Clinical Neurosciences, Heinrich-Heine-Universitat Duesseldorf</s1><s2>Duesseldorf</s2><s3>DEU</s3><sZ>22 aut.</sZ><sZ>23 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Duesseldorf</wicri:noRegion><wicri:noRegion>Heinrich-Heine-Universitat Duesseldorf</wicri:noRegion><wicri:noRegion>Duesseldorf</wicri:noRegion></affiliation></author><author><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Department of Neurology and Institute of Clinical Neurosciences, Heinrich-Heine-Universitat Duesseldorf</s1><s2>Duesseldorf</s2><s3>DEU</s3><sZ>22 aut.</sZ><sZ>23 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Duesseldorf</wicri:noRegion><wicri:noRegion>Heinrich-Heine-Universitat Duesseldorf</wicri:noRegion><wicri:noRegion>Duesseldorf</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Department of Neurology, University Hospital</s1><s2>Cologne</s2><s3>DEU</s3><sZ>23 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>University Hospital</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Wojtecki, Lars" sort="Wojtecki, Lars" uniqKey="Wojtecki L" first="Lars" last="Wojtecki">Lars Wojtecki</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Department of Neurology and Institute of Clinical Neurosciences, Heinrich-Heine-Universitat Duesseldorf</s1><s2>Duesseldorf</s2><s3>DEU</s3><sZ>22 aut.</sZ><sZ>23 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Duesseldorf</wicri:noRegion><wicri:noRegion>Heinrich-Heine-Universitat Duesseldorf</wicri:noRegion><wicri:noRegion>Duesseldorf</wicri:noRegion></affiliation></author><author><name sortKey="Gironell, Andres" sort="Gironell, Andres" uniqKey="Gironell A" first="Andres" last="Gironell">Andres Gironell</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Neurology, Sant Pau Hospital, Autonomous University of Barcelona, CIBERNED</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>7 aut.</sZ><sZ>25 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Rodriguez Oroz, Maria C" sort="Rodriguez Oroz, Maria C" uniqKey="Rodriguez Oroz M" first="Maria C." last="Rodriguez-Oroz">Maria C. Rodriguez-Oroz</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED</s1><s2>Pamplona</s2><s3>ESP</s3><sZ>8 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Guridi, Jorge" sort="Guridi, Jorge" uniqKey="Guridi J" first="Jorge" last="Guridi">Jorge Guridi</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED</s1><s2>Pamplona</s2><s3>ESP</s3><sZ>8 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Bentivoglio, Anna R" sort="Bentivoglio, Anna R" uniqKey="Bentivoglio A" first="Anna R." last="Bentivoglio">Anna R. Bentivoglio</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore</s1><s2>Roma</s2><s3>ITA</s3><sZ>9 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Contarino, Maria F" sort="Contarino, Maria F" uniqKey="Contarino M" first="Maria F." last="Contarino">Maria F. Contarino</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore</s1><s2>Roma</s2><s3>ITA</s3><sZ>9 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Department of Neurology, Academic Medical Center</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>12 aut.</sZ><sZ>29 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Romito, Luigi" sort="Romito, Luigi" uniqKey="Romito L" first="Luigi" last="Romito">Luigi Romito</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Istituto Nazionale Neurologico C. Besta and Università Cattolica</s1><s2>Milano</s2><s3>ITA</s3><sZ>9 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Istituto Nazionale Neurologico C. Besta and Università Cattolica</wicri:noRegion></affiliation></author><author><name sortKey="Scerrati, Massimo" sort="Scerrati, Massimo" uniqKey="Scerrati M" first="Massimo" last="Scerrati">Massimo Scerrati</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore</s1><s2>Roma</s2><s3>ITA</s3><sZ>9 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Dipartimento di Neuroscienze, Sezione di Neurochirurgia, Universitd Politecnica delle Marche</s1><s2>Ancona</s2><s3>ITA</s3><sZ>31 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Ancona</wicri:noRegion></affiliation></author><author><name sortKey="Janssens, Marc" sort="Janssens, Marc" uniqKey="Janssens M" first="Marc" last="Janssens">Marc Janssens</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Bakken Research Center</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>32 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Bakken Research Center</wicri:noRegion></affiliation></author><author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Hospital, Movement Disorders Center, University of Toronto and University Health Network</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>11 aut.</sZ><sZ>33 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, Ontario</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Deep brain stimulation</term><term>Long term</term><term>Multicenter study</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Subthalamic nucleus</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Long terme</term><term>Etude multicentrique</term><term>Noyau sousthalamique</term><term>Stimulation cérébrale profonde</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We report the 5 to 6 year follow-up of a multicenter study of bilateral subthalamic nucleus (STN) and globus pallidus intemus (GPi) deep brain stimulation (DBS) in advanced Parkinson's disease (PD) patients. Thirty-five STN patients and 16 GPi patients were assessed at 5 to 6 years after DBS surgery. Primary outcome measure was the stimulation effect on the motor Unified Parkinson's Disease Rating Scale (UPDRS) assessed with a prospective cross-over double-blind assessment without medications (stimulation was randomly switched on or off). Secondary outcomes were motor UPDRS changes with unblinded assessments in off-and on-medication states with and without stimulation, activities of daily living (ADL), anti-PD medications, and dyskinesias. In double-blind assessment, both STN and GPi DBS were significantly effective in improving the motor UPDRS scores (STN, P < 0.0001, 45.4%; GPi, P = 0.008, 20.0%) compared with off-stimulation, regardless of the sequence of stimulation. In open assessment, both STN- and GPi-DBS significantly improved the off-medication motor UPDRS when compared with before surgery (STN, P < 0.001, 50.5%; GPi, P = 0.002, 35.6%). Dyskinesias and ADL were significantly improved in both groups. Anti-PD medications were significantly reduced only in the STN group. Adverse events were more frequent in the STN group. These results confirm the long-term efficacy of STN and GPi DBS in advanced PD. Although the surgical targets were not randomized, there was a trend to a better outcome of motor signs in the STN-DBS patients and fewer adverse events in the GPi-DBS group.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>25</s2></fA05><fA06><s2>5</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Long-Term Results of a Multicenter Study on Subthalamic and Pallidal Stimulation in Parkinson's Disease</s1></fA08><fA11 i1="01" i2="1"><s1>MORO (Elena)</s1></fA11><fA11 i1="02" i2="1"><s1>LOZANO (Andres M.)</s1></fA11><fA11 i1="03" i2="1"><s1>POLLAK (Pierre)</s1></fA11><fA11 i1="04" i2="1"><s1>AGID (Yves)</s1></fA11><fA11 i1="05" i2="1"><s1>REHNCRONA (Stig)</s1></fA11><fA11 i1="06" i2="1"><s1>VOLKMANN (Jens)</s1></fA11><fA11 i1="07" i2="1"><s1>KULISEVSKY (Jaime)</s1></fA11><fA11 i1="08" i2="1"><s1>OBESO (Jose A.)</s1></fA11><fA11 i1="09" i2="1"><s1>ALBANESE (Alberto)</s1></fA11><fA11 i1="10" i2="1"><s1>HARIZ (Marwan I.)</s1></fA11><fA11 i1="11" i2="1"><s1>QUINN (Niall P.)</s1></fA11><fA11 i1="12" i2="1"><s1>SPEELMAN (Jans D.)</s1></fA11><fA11 i1="13" i2="1"><s1>BENABID (Alim L.)</s1></fA11><fA11 i1="14" i2="1"><s1>FRAIX (Valerie)</s1></fA11><fA11 i1="15" i2="1"><s1>MENDES (Alexandre)</s1></fA11><fA11 i1="16" i2="1"><s1>WELTER (Marie-Laure)</s1></fA11><fA11 i1="17" i2="1"><s1>HOUETO (Jean-Luc)</s1></fA11><fA11 i1="18" i2="1"><s1>CORNU (Philippe)</s1></fA11><fA11 i1="19" i2="1"><s1>DORMONT (Didier)</s1></fA11><fA11 i1="20" i2="1"><s1>TORNQVIST (Annalena L.)</s1></fA11><fA11 i1="21" i2="1"><s1>EKBERG (Ron)</s1></fA11><fA11 i1="22" i2="1"><s1>SCHNITZLER (Alfons)</s1></fA11><fA11 i1="23" i2="1"><s1>TIMMERMANN (Lars)</s1></fA11><fA11 i1="24" i2="1"><s1>WOJTECKI (Lars)</s1></fA11><fA11 i1="25" i2="1"><s1>GIRONELL (Andres)</s1></fA11><fA11 i1="26" i2="1"><s1>RODRIGUEZ-OROZ (Maria C.)</s1></fA11><fA11 i1="27" i2="1"><s1>GURIDI (Jorge)</s1></fA11><fA11 i1="28" i2="1"><s1>BENTIVOGLIO (Anna R.)</s1></fA11><fA11 i1="29" i2="1"><s1>CONTARINO (Maria F.)</s1></fA11><fA11 i1="30" i2="1"><s1>ROMITO (Luigi)</s1></fA11><fA11 i1="31" i2="1"><s1>SCERRATI (Massimo)</s1></fA11><fA11 i1="32" i2="1"><s1>JANSSENS (Marc)</s1></fA11><fA11 i1="33" i2="1"><s1>LANG (Anthony E.)</s1></fA11><fA14 i1="01"><s1>Toronto Western Hospital, Movement Disorders Center, University of Toronto and University Health Network</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>11 aut.</sZ><sZ>33 aut.</sZ></fA14><fA14 i1="02"><s1>Division of Neurosurgery, University of Toronto and University Health Network</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>2 aut.</sZ></fA14><fA14 i1="03"><s1>Service de Neurologie, CHU de Grenoble</s1><s2>Grenoble</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></fA14><fA14 i1="04"><s1>Hôpital de la Salpêtrière, Fédération de Neurologie</s1><s2>Paris</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></fA14><fA14 i1="05"><s1>Neurosurgery Service, Lund University Hospital</s1><s2>Lund</s2><s3>SWE</s3><sZ>5 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ></fA14><fA14 i1="06"><s1>Neurologische Klinik der Christian-Albrect-Universitat</s1><s2>Kiel</s2><s3>DEU</s3><sZ>6 aut.</sZ></fA14><fA14 i1="07"><s1>Department of Neurology, Sant Pau Hospital, Autonomous University of Barcelona, CIBERNED</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>7 aut.</sZ><sZ>25 aut.</sZ></fA14><fA14 i1="08"><s1>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED</s1><s2>Pamplona</s2><s3>ESP</s3><sZ>8 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ></fA14><fA14 i1="09"><s1>Istituto Nazionale Neurologico C. Besta and Università Cattolica</s1><s2>Milano</s2><s3>ITA</s3><sZ>9 aut.</sZ><sZ>30 aut.</sZ></fA14><fA14 i1="10"><s1>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore</s1><s2>Roma</s2><s3>ITA</s3><sZ>9 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>31 aut.</sZ></fA14><fA14 i1="11"><s1>Institute of Neurology, Queen Square</s1><s2>London</s2><s3>GBR</s3><sZ>10 aut.</sZ></fA14><fA14 i1="12"><s1>Department of Neurosurgery, University Hospital of Northern Sweden</s1><s2>Umeå</s2><s3>SWE</s3><sZ>10 aut.</sZ></fA14><fA14 i1="13"><s1>Department of Neurology, Academic Medical Center</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>12 aut.</sZ><sZ>29 aut.</sZ></fA14><fA14 i1="14"><s1>Service de Neurologie, CHU de Poitiers, University of Poitiers</s1><s2>Poitiers</s2><s3>FRA</s3><sZ>17 aut.</sZ></fA14><fA14 i1="15"><s1>Department of Neurology and Institute of Clinical Neurosciences, Heinrich-Heine-Universitat Duesseldorf</s1><s2>Duesseldorf</s2><s3>DEU</s3><sZ>22 aut.</sZ><sZ>23 aut.</sZ><sZ>24 aut.</sZ></fA14><fA14 i1="16"><s1>Department of Neurology, University Hospital</s1><s2>Cologne</s2><s3>DEU</s3><sZ>23 aut.</sZ></fA14><fA14 i1="17"><s1>Dipartimento di Neuroscienze, Sezione di Neurochirurgia, Universitd Politecnica delle Marche</s1><s2>Ancona</s2><s3>ITA</s3><sZ>31 aut.</sZ></fA14><fA14 i1="18"><s1>Bakken Research Center</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>32 aut.</sZ></fA14><fA20><s1>578-586</s1></fA20><fA21><s1>2010</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000181079390090</s5></fA43><fA44><s0>0000</s0><s1>© 2010 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>25 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>10-0233216</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>We report the 5 to 6 year follow-up of a multicenter study of bilateral subthalamic nucleus (STN) and globus pallidus intemus (GPi) deep brain stimulation (DBS) in advanced Parkinson's disease (PD) patients. Thirty-five STN patients and 16 GPi patients were assessed at 5 to 6 years after DBS surgery. Primary outcome measure was the stimulation effect on the motor Unified Parkinson's Disease Rating Scale (UPDRS) assessed with a prospective cross-over double-blind assessment without medications (stimulation was randomly switched on or off). Secondary outcomes were motor UPDRS changes with unblinded assessments in off-and on-medication states with and without stimulation, activities of daily living (ADL), anti-PD medications, and dyskinesias. In double-blind assessment, both STN and GPi DBS were significantly effective in improving the motor UPDRS scores (STN, P < 0.0001, 45.4%; GPi, P = 0.008, 20.0%) compared with off-stimulation, regardless of the sequence of stimulation. In open assessment, both STN- and GPi-DBS significantly improved the off-medication motor UPDRS when compared with before surgery (STN, P < 0.001, 50.5%; GPi, P = 0.002, 35.6%). Dyskinesias and ADL were significantly improved in both groups. Anti-PD medications were significantly reduced only in the STN group. Adverse events were more frequent in the STN group. These results confirm the long-term efficacy of STN and GPi DBS in advanced PD. Although the surgical targets were not randomized, there was a trend to a better outcome of motor signs in the STN-DBS patients and fewer adverse events in the GPi-DBS group.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17G</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Maladie de Parkinson</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Long terme</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Long term</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Largo plazo</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Etude multicentrique</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Multicenter study</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Estudio multicéntrico</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Noyau sousthalamique</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Subthalamic nucleus</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Núcleo subtalámico</s0><s5>11</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Stimulation cérébrale profonde</s0><s4>CD</s4><s5>96</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Deep brain stimulation</s0><s4>CD</s4><s5>96</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>40</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Encéphale</s0><s5>42</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Encephalon</s0><s5>42</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Encéfalo</s0><s5>42</s5></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Système nerveux central</s0><s5>43</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Central nervous system</s0><s5>43</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervioso central</s0><s5>43</s5></fC07><fN21><s1>158</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Allemagne</li><li>Canada</li><li>Espagne</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suède</li></country><region><li>Angleterre</li><li>Auvergne-Rhône-Alpes</li><li>Catalogne</li><li>Grand Londres</li><li>Hollande-Septentrionale</li><li>Latium</li><li>Rhône-Alpes</li><li>Schleswig-Holstein</li><li>Île-de-France</li></region><settlement><li>Amsterdam</li><li>Barcelone</li><li>Grenoble</li><li>Kiel</li><li>Londres</li><li>Paris</li><li>Poitiers</li><li>Rome</li></settlement><orgName><li>Centre hospitalier universitaire Grenoble Alpes</li><li>Hôpital de la Salpêtrière</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name></noRegion><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name><name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P." last="Quinn">Niall P. Quinn</name></country><country name="France"><noRegion><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name></noRegion><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name><name sortKey="Benabid, Alim L" sort="Benabid, Alim L" uniqKey="Benabid A" first="Alim L." last="Benabid">Alim-Louis Benabid</name><name sortKey="Cornu, Philippe" sort="Cornu, Philippe" uniqKey="Cornu P" first="Philippe" last="Cornu">Philippe Cornu</name><name sortKey="Dormont, Didier" sort="Dormont, Didier" uniqKey="Dormont D" first="Didier" last="Dormont">Didier Dormont</name><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valerie" last="Fraix">Valerie Fraix</name><name sortKey="Houeto, Jean Luc" sort="Houeto, Jean Luc" uniqKey="Houeto J" first="Jean-Luc" last="Houeto">Jean-Luc Houeto</name><name sortKey="Houeto, Jean Luc" sort="Houeto, Jean Luc" uniqKey="Houeto J" first="Jean-Luc" last="Houeto">Jean-Luc Houeto</name><name sortKey="Mendes, Alexandre" sort="Mendes, Alexandre" uniqKey="Mendes A" first="Alexandre" last="Mendes">Alexandre Mendes</name><name sortKey="Welter, Marie Laure" sort="Welter, Marie Laure" uniqKey="Welter M" first="Marie-Laure" last="Welter">Marie-Laure Welter</name></country><country name="Suède"><noRegion><name sortKey="Rehncrona, Stig" sort="Rehncrona, Stig" uniqKey="Rehncrona S" first="Stig" last="Rehncrona">Stig Rehncrona</name></noRegion><name sortKey="Ekberg, Ron" sort="Ekberg, Ron" uniqKey="Ekberg R" first="Ron" last="Ekberg">Ron Ekberg</name><name sortKey="Hariz, Marwan I" sort="Hariz, Marwan I" uniqKey="Hariz M" first="Marwan I." last="Hariz">Marwan I. Hariz</name><name sortKey="Tornqvist, Annalena L" sort="Tornqvist, Annalena L" uniqKey="Tornqvist A" first="Annalena L." last="Tornqvist">Annalena L. Tornqvist</name></country><country name="Allemagne"><region name="Schleswig-Holstein"><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name></region><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name><name sortKey="Wojtecki, Lars" sort="Wojtecki, Lars" uniqKey="Wojtecki L" first="Lars" last="Wojtecki">Lars Wojtecki</name></country><country name="Espagne"><region name="Catalogne"><name sortKey="Kulisevsky, Jaime" sort="Kulisevsky, Jaime" uniqKey="Kulisevsky J" first="Jaime" last="Kulisevsky">Jaime Kulisevsky</name></region><name sortKey="Gironell, Andres" sort="Gironell, Andres" uniqKey="Gironell A" first="Andres" last="Gironell">Andres Gironell</name><name sortKey="Guridi, Jorge" sort="Guridi, Jorge" uniqKey="Guridi J" first="Jorge" last="Guridi">Jorge Guridi</name><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="Jose A." last="Obeso">Jose A. Obeso</name><name sortKey="Rodriguez Oroz, Maria C" sort="Rodriguez Oroz, Maria C" uniqKey="Rodriguez Oroz M" first="Maria C." last="Rodriguez-Oroz">Maria C. Rodriguez-Oroz</name></country><country name="Italie"><noRegion><name sortKey="Albanese, Alberto" sort="Albanese, Alberto" uniqKey="Albanese A" first="Alberto" last="Albanese">Alberto Albanese</name></noRegion><name sortKey="Albanese, Alberto" sort="Albanese, Alberto" uniqKey="Albanese A" first="Alberto" last="Albanese">Alberto Albanese</name><name sortKey="Bentivoglio, Anna R" sort="Bentivoglio, Anna R" uniqKey="Bentivoglio A" first="Anna R." last="Bentivoglio">Anna R. Bentivoglio</name><name sortKey="Contarino, Maria F" sort="Contarino, Maria F" uniqKey="Contarino M" first="Maria F." last="Contarino">Maria F. Contarino</name><name sortKey="Romito, Luigi" sort="Romito, Luigi" uniqKey="Romito L" first="Luigi" last="Romito">Luigi Romito</name><name sortKey="Scerrati, Massimo" sort="Scerrati, Massimo" uniqKey="Scerrati M" first="Massimo" last="Scerrati">Massimo Scerrati</name><name sortKey="Scerrati, Massimo" sort="Scerrati, Massimo" uniqKey="Scerrati M" first="Massimo" last="Scerrati">Massimo Scerrati</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Hariz, Marwan I" sort="Hariz, Marwan I" uniqKey="Hariz M" first="Marwan I." last="Hariz">Marwan I. Hariz</name></region></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Speelman, Jans D" sort="Speelman, Jans D" uniqKey="Speelman J" first="Jans D." last="Speelman">Jans D. Speelman</name></region><name sortKey="Contarino, Maria F" sort="Contarino, Maria F" uniqKey="Contarino M" first="Maria F." last="Contarino">Maria F. Contarino</name><name sortKey="Janssens, Marc" sort="Janssens, Marc" uniqKey="Janssens M" first="Marc" last="Janssens">Marc Janssens</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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