MovDisordV3, PascalFrancis, Checkpoint, bibRecord, 000669

Clinical Correlates of Similar Pathologies in Parkinsonian Syndromes

Identifieur interne : 000669 ( PascalFrancis/Checkpoint ); précédent : 000668; suivant : 000670

Clinical Correlates of Similar Pathologies in Parkinsonian Syndromes

Auteurs : Yun Ju Christine Song [Australie] ; YUE HUANG [Australie] ; Glenda Margaret Halliday [Australie]

Source :

Movement disorders [ 0885-3185 ] ; 2011.

RBID : Pascal:11-0211283

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Atrophie multisystématisée, Pathologie du système nerveux, Anatomopathologie, Ophtalmoplégie supranucléaire.

English descriptors

KwdEn :
- Anatomic pathology, Multiple system atrophy, Nervous system diseases, Parkinson disease, Supranuclear ophthalmoplegia.

Abstract

Background: There have been no previous studies assessing the severity of regional atrophy, cell loss and lesion densities between the overlapping conditions of Parkinson's disease (PD), progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) and relating these pathologies to different clinical features. Methods: Clinical indices and basal ganglia, brainstem, and cerebellar pathology from 43 longitudinally studied cases (PD = 8, PSP = 15, MSA = 12, controls = 8) were compared. A point-counting method was used to evaluate subregional volumes, and α-synuclein and phospho-tau immunohistochemistry was used to assess pathological inclusions and stage disease severity. Logistic regression analyses were used to identify pathological associations with clinical features. Results: All PD, PSP, and MSA cases had severe degeneration of the substantia nigra. Clinical features correlated with tissue loss and the severity of inclusion pathologies. Levodopa responsiveness and a lack of resting tremor was associated with preservation of pallidal volume, the presence of gait ataxia was associated with atrophy of the putamen, and the parkinsonian-plus phenotype with early falls and supranuclear vertical gaze abnormalities had more substantial midbrain atrophy and greater inclusion pathology in the caudate nucleus. Discussion: This is the first study to compare the severity of regional pathologies across parkinsonian conditions. The data show that tissue loss and inclusion densities in certain regions correlate with clinical indices, with regional volume changes likely to be the best indicator of clinical progression of disease.

Affiliations:

Australie

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Movement Disorders (revue)

Clinical Correlates of Similar Pathologies in Parkinsonian Syndromes

Clinical Correlates of Similar Pathologies in Parkinsonian Syndromes

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri