Glucocerebrosidase Mutations Confer a Greater Risk of Dementia during Parkinson's Disease Course
Identifieur interne : 000180 ( PascalFrancis/Checkpoint ); précédent : 000179; suivant : 000181Glucocerebrosidase Mutations Confer a Greater Risk of Dementia during Parkinson's Disease Course
Auteurs : Núria Seto-Salvia [Espagne] ; Javier Pagonabarraga [Espagne] ; Henry Houlden [Royaume-Uni] ; Berta Pascual-Sedano [Espagne] ; Oriol Dols-Icardo [Espagne] ; Arianna Tucci [Royaume-Uni] ; Coro Paisan-Ruiz [États-Unis] ; Antonia Campolongo [Espagne] ; Sofia Anton-Aguirre [Espagne] ; Inés Martin [Espagne] ; Laia Munoz [Espagne] ; Enric Bufill [Espagne] ; Lluïsa Vilageliu [Espagne] ; Daniel Grinberg [Espagne] ; M Nica Cozar [Espagne] ; Rafael Blesa [Espagne] ; Alberto Lleo [Espagne] ; John Hardy [Royaume-Uni] ; Jaime Kulisevsky [Espagne] ; Jordi Clarimon [Espagne]Source :
- Movement disorders [ 0885-3185 ] ; 2012.
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- Pascal (Inist)
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Abstract
Mutations in the glucocerebrosidase gene are associated with Parkinson's disease and Lewy body dementia. However, whether these alterations have any effect on the clinical course of Parkinson's disease is not clear. The glucocerebrosidase coding region was fully sequenced in 225 Parkinson's disease patients, 17 pathologically confirmed Lewy body dementia patients, and 186 controls from Spain. Twenty-two Parkinson's disease patients (9.8%) and 2 Lewy body dementia patients (11.8%) carried mutations in the glucocerebrosidase gene, compared with only 1 control (0.5%); P = .016 and P = .021 for Parkinson's disease and Lewy body dementia, respectively. The N370S and the L444P mutations represented 50% of the alterations. Two novel variants, L144V and S488T, and 7 previously described alterations were also found. Alterations in glucocerebrosidase were associated with a significant risk of dementia during the clinical course of Parkinson's disease (age at onset, years of evolution, and sex-adjusted odds ratio, 5.8; P = .001). Mutation carriers did not show worse motor symptoms, had good response to L-dopa, and tended to present the intermediate parkinsonian phenotype. Our findings suggest that mutations in the glucocerebrosidase gene not only increase the risk of both Parkinson's disease and Lewy body dementia but also strongly influence the course of Parkinson's disease with respect to the appearance of dementia.
Affiliations:
- Espagne, Royaume-Uni, États-Unis
- Angleterre, Catalogne, Communauté de Madrid, Grand Londres, État de New York
- Barcelone, Londres, Madrid
- Université autonome de Barcelone
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Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED)</s1><s2>Madrid</s2><s3>ESP</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Dols Icardo, Oriol" sort="Dols Icardo, Oriol" uniqKey="Dols Icardo O" first="Oriol" last="Dols-Icardo">Oriol Dols-Icardo</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Neurology Department. 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Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation></author><author><name sortKey="Martin, Ines" sort="Martin, Ines" uniqKey="Martin I" first="Inés" last="Martin">Inés Martin</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Neurology Department. Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation></author><author><name sortKey="Munoz, Laia" sort="Munoz, Laia" uniqKey="Munoz L" first="Laia" last="Munoz">Laia Munoz</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Neurology Department. Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation></author><author><name sortKey="Bufill, Enric" sort="Bufill, Enric" uniqKey="Bufill E" first="Enric" last="Bufill">Enric Bufill</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Neurology Service. Hospital General de Vic.</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>12 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Vilageliu, Lluisa" sort="Vilageliu, Lluisa" uniqKey="Vilageliu L" first="Lluïsa" last="Vilageliu">Lluïsa Vilageliu</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Departament de Genètica, Universitat de Barcelona, IBUB, CIBERER</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Grinberg, Daniel" sort="Grinberg, Daniel" uniqKey="Grinberg D" first="Daniel" last="Grinberg">Daniel Grinberg</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Departament de Genètica, Universitat de Barcelona, IBUB, CIBERER</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Cozar, M Nica" sort="Cozar, M Nica" uniqKey="Cozar M" first="M Nica" last="Cozar">M Nica Cozar</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Departament de Genètica, Universitat de Barcelona, IBUB, CIBERER</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Blesa, Rafael" sort="Blesa, Rafael" uniqKey="Blesa R" first="Rafael" last="Blesa">Rafael Blesa</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Neurology Department. Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED)</s1><s2>Madrid</s2><s3>ESP</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Lleo, Alberto" sort="Lleo, Alberto" uniqKey="Lleo A" first="Alberto" last="Lleo">Alberto Lleo</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Neurology Department. Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED)</s1><s2>Madrid</s2><s3>ESP</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Molecular Neuroscience and Reta Lila Weston Laboratories, Institute of Neurology, University College London (UCL), Queen Square</s1><s2>London</s2><s3>GBR</s3><sZ>6 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Kulisevsky, Jaime" sort="Kulisevsky, Jaime" uniqKey="Kulisevsky J" first="Jaime" last="Kulisevsky">Jaime Kulisevsky</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Neurology Department. Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED)</s1><s2>Madrid</s2><s3>ESP</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Clarimon, Jordi" sort="Clarimon, Jordi" uniqKey="Clarimon J" first="Jordi" last="Clarimon">Jordi Clarimon</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Neurology Department. Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED)</s1><s2>Madrid</s2><s3>ESP</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0198682</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 12-0198682 INIST</idno><idno type="RBID">Pascal:12-0198682</idno><idno type="wicri:Area/PascalFrancis/Corpus">000217</idno><idno type="wicri:Area/PascalFrancis/Curation">002A97</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000180</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Glucocerebrosidase Mutations Confer a Greater Risk of Dementia during Parkinson's Disease Course</title><author><name sortKey="Seto Salvia, Nuria" sort="Seto Salvia, Nuria" uniqKey="Seto Salvia N" first="Núria" last="Seto-Salvia">Núria Seto-Salvia</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Neurology Department. Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Area de Prehistoria, Universitat Rovira i Virgili</s1><s2>Tarragona</s2><s3>ESP</s3><sZ>1 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Tarragona</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institut Català de Paleoecologia Humana i Evolució Social (IPHES)</s1><s2>Tarragona</s2><s3>ESP</s3><sZ>1 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Institut Català de Paleoecologia Humana i Evolució Social (IPHES)</wicri:noRegion></affiliation></author><author><name sortKey="Pagonabarraga, Javier" sort="Pagonabarraga, Javier" uniqKey="Pagonabarraga J" first="Javier" last="Pagonabarraga">Javier Pagonabarraga</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Neurology Department. Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED)</s1><s2>Madrid</s2><s3>ESP</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Houlden, Henry" sort="Houlden, Henry" uniqKey="Houlden H" first="Henry" last="Houlden">Henry Houlden</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Molecular Neuroscience, Institute of Neurology, University College London (UCL), Queen Square</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Pascual Sedano, Berta" sort="Pascual Sedano, Berta" uniqKey="Pascual Sedano B" first="Berta" last="Pascual-Sedano">Berta Pascual-Sedano</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Neurology Department. Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED)</s1><s2>Madrid</s2><s3>ESP</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Dols Icardo, Oriol" sort="Dols Icardo, Oriol" uniqKey="Dols Icardo O" first="Oriol" last="Dols-Icardo">Oriol Dols-Icardo</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Neurology Department. Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation></author><author><name sortKey="Tucci, Arianna" sort="Tucci, Arianna" uniqKey="Tucci A" first="Arianna" last="Tucci">Arianna Tucci</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Molecular Neuroscience and Reta Lila Weston Laboratories, Institute of Neurology, University College London (UCL), Queen Square</s1><s2>London</s2><s3>GBR</s3><sZ>6 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Paisan Ruiz, Coro" sort="Paisan Ruiz, Coro" uniqKey="Paisan Ruiz C" first="Coro" last="Paisan-Ruiz">Coro Paisan-Ruiz</name><affiliation wicri:level="2"><inist:fA14 i1="07"><s1>Departments of Neurology, Psychiatry, Genetics and Genomics Sciences, and The Friedman Brain Institute, Mount Sinai School of Medicne</s1><s2>New York, New York</s2><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Campolongo, Antonia" sort="Campolongo, Antonia" uniqKey="Campolongo A" first="Antonia" last="Campolongo">Antonia Campolongo</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Neurology Department. Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED)</s1><s2>Madrid</s2><s3>ESP</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Anton Aguirre, Sofia" sort="Anton Aguirre, Sofia" uniqKey="Anton Aguirre S" first="Sofia" last="Anton-Aguirre">Sofia Anton-Aguirre</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Neurology Department. Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation></author><author><name sortKey="Martin, Ines" sort="Martin, Ines" uniqKey="Martin I" first="Inés" last="Martin">Inés Martin</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Neurology Department. Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation></author><author><name sortKey="Munoz, Laia" sort="Munoz, Laia" uniqKey="Munoz L" first="Laia" last="Munoz">Laia Munoz</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Neurology Department. Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation></author><author><name sortKey="Bufill, Enric" sort="Bufill, Enric" uniqKey="Bufill E" first="Enric" last="Bufill">Enric Bufill</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Neurology Service. Hospital General de Vic.</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>12 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Vilageliu, Lluisa" sort="Vilageliu, Lluisa" uniqKey="Vilageliu L" first="Lluïsa" last="Vilageliu">Lluïsa Vilageliu</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Departament de Genètica, Universitat de Barcelona, IBUB, CIBERER</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Grinberg, Daniel" sort="Grinberg, Daniel" uniqKey="Grinberg D" first="Daniel" last="Grinberg">Daniel Grinberg</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Departament de Genètica, Universitat de Barcelona, IBUB, CIBERER</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Cozar, M Nica" sort="Cozar, M Nica" uniqKey="Cozar M" first="M Nica" last="Cozar">M Nica Cozar</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Departament de Genètica, Universitat de Barcelona, IBUB, CIBERER</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Blesa, Rafael" sort="Blesa, Rafael" uniqKey="Blesa R" first="Rafael" last="Blesa">Rafael Blesa</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Neurology Department. Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED)</s1><s2>Madrid</s2><s3>ESP</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Lleo, Alberto" sort="Lleo, Alberto" uniqKey="Lleo A" first="Alberto" last="Lleo">Alberto Lleo</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Neurology Department. Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED)</s1><s2>Madrid</s2><s3>ESP</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Molecular Neuroscience and Reta Lila Weston Laboratories, Institute of Neurology, University College London (UCL), Queen Square</s1><s2>London</s2><s3>GBR</s3><sZ>6 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Kulisevsky, Jaime" sort="Kulisevsky, Jaime" uniqKey="Kulisevsky J" first="Jaime" last="Kulisevsky">Jaime Kulisevsky</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Neurology Department. Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED)</s1><s2>Madrid</s2><s3>ESP</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Clarimon, Jordi" sort="Clarimon, Jordi" uniqKey="Clarimon J" first="Jordi" last="Clarimon">Jordi Clarimon</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Neurology Department. Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED)</s1><s2>Madrid</s2><s3>ESP</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Lewy body dementia</term><term>Lewy body disease</term><term>Mutation</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Risk factor</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Démence à corps de Lewy</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Mutation</term><term>Facteur risque</term><term>Corps Lewy maladie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Mutations in the glucocerebrosidase gene are associated with Parkinson's disease and Lewy body dementia. However, whether these alterations have any effect on the clinical course of Parkinson's disease is not clear. The glucocerebrosidase coding region was fully sequenced in 225 Parkinson's disease patients, 17 pathologically confirmed Lewy body dementia patients, and 186 controls from Spain. Twenty-two Parkinson's disease patients (9.8%) and 2 Lewy body dementia patients (11.8%) carried mutations in the glucocerebrosidase gene, compared with only 1 control (0.5%); P = .016 and P = .021 for Parkinson's disease and Lewy body dementia, respectively. The N370S and the L444P mutations represented 50% of the alterations. Two novel variants, L144V and S488T, and 7 previously described alterations were also found. Alterations in glucocerebrosidase were associated with a significant risk of dementia during the clinical course of Parkinson's disease (age at onset, years of evolution, and sex-adjusted odds ratio, 5.8; P = .001). Mutation carriers did not show worse motor symptoms, had good response to <sub>L</sub>-dopa, and tended to present the intermediate parkinsonian phenotype. Our findings suggest that mutations in the glucocerebrosidase gene not only increase the risk of both Parkinson's disease and Lewy body dementia but also strongly influence the course of Parkinson's disease with respect to the appearance of dementia.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>27</s2></fA05><fA06><s2>3</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Glucocerebrosidase Mutations Confer a Greater Risk of Dementia during Parkinson's Disease Course</s1></fA08><fA11 i1="01" i2="1"><s1>SETO-SALVIA (Núria)</s1></fA11><fA11 i1="02" i2="1"><s1>PAGONABARRAGA (Javier)</s1></fA11><fA11 i1="03" i2="1"><s1>HOULDEN (Henry)</s1></fA11><fA11 i1="04" i2="1"><s1>PASCUAL-SEDANO (Berta)</s1></fA11><fA11 i1="05" i2="1"><s1>DOLS-ICARDO (Oriol)</s1></fA11><fA11 i1="06" i2="1"><s1>TUCCI (Arianna)</s1></fA11><fA11 i1="07" i2="1"><s1>PAISAN-RUIZ (Coro)</s1></fA11><fA11 i1="08" i2="1"><s1>CAMPOLONGO (Antonia)</s1></fA11><fA11 i1="09" i2="1"><s1>ANTON-AGUIRRE (Sofia)</s1></fA11><fA11 i1="10" i2="1"><s1>MARTIN (Inés)</s1></fA11><fA11 i1="11" i2="1"><s1>MUNOZ (Laia)</s1></fA11><fA11 i1="12" i2="1"><s1>BUFILL (Enric)</s1></fA11><fA11 i1="13" i2="1"><s1>VILAGELIU (Lluïsa)</s1></fA11><fA11 i1="14" i2="1"><s1>GRINBERG (Daniel)</s1></fA11><fA11 i1="15" i2="1"><s1>COZAR (Mónica)</s1></fA11><fA11 i1="16" i2="1"><s1>BLESA (Rafael)</s1></fA11><fA11 i1="17" i2="1"><s1>LLEO (Alberto)</s1></fA11><fA11 i1="18" i2="1"><s1>HARDY (John)</s1></fA11><fA11 i1="19" i2="1"><s1>KULISEVSKY (Jaime)</s1></fA11><fA11 i1="20" i2="1"><s1>CLARIMON (Jordi)</s1></fA11><fA14 i1="01"><s1>Neurology Department. Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></fA14><fA14 i1="02"><s1>Area de Prehistoria, Universitat Rovira i Virgili</s1><s2>Tarragona</s2><s3>ESP</s3><sZ>1 aut.</sZ></fA14><fA14 i1="03"><s1>Institut Català de Paleoecologia Humana i Evolució Social (IPHES)</s1><s2>Tarragona</s2><s3>ESP</s3><sZ>1 aut.</sZ></fA14><fA14 i1="04"><s1>Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED)</s1><s2>Madrid</s2><s3>ESP</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></fA14><fA14 i1="05"><s1>Department of Molecular Neuroscience, Institute of Neurology, University College London (UCL), Queen Square</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ></fA14><fA14 i1="06"><s1>Department of Molecular Neuroscience and Reta Lila Weston Laboratories, Institute of Neurology, University College London (UCL), Queen Square</s1><s2>London</s2><s3>GBR</s3><sZ>6 aut.</sZ><sZ>18 aut.</sZ></fA14><fA14 i1="07"><s1>Departments of Neurology, Psychiatry, Genetics and Genomics Sciences, and The Friedman Brain Institute, Mount Sinai School of Medicne</s1><s2>New York, New York</s2><s3>USA</s3><sZ>7 aut.</sZ></fA14><fA14 i1="08"><s1>Neurology Service. Hospital General de Vic.</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>12 aut.</sZ></fA14><fA14 i1="09"><s1>Departament de Genètica, Universitat de Barcelona, IBUB, CIBERER</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></fA14><fA20><s1>393-399</s1></fA20><fA21><s1>2012</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000506923350120</s5></fA43><fA44><s0>0000</s0><s1>© 2012 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>46 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>12-0198682</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Mutations in the glucocerebrosidase gene are associated with Parkinson's disease and Lewy body dementia. However, whether these alterations have any effect on the clinical course of Parkinson's disease is not clear. The glucocerebrosidase coding region was fully sequenced in 225 Parkinson's disease patients, 17 pathologically confirmed Lewy body dementia patients, and 186 controls from Spain. Twenty-two Parkinson's disease patients (9.8%) and 2 Lewy body dementia patients (11.8%) carried mutations in the glucocerebrosidase gene, compared with only 1 control (0.5%); P = .016 and P = .021 for Parkinson's disease and Lewy body dementia, respectively. The N370S and the L444P mutations represented 50% of the alterations. Two novel variants, L144V and S488T, and 7 previously described alterations were also found. Alterations in glucocerebrosidase were associated with a significant risk of dementia during the clinical course of Parkinson's disease (age at onset, years of evolution, and sex-adjusted odds ratio, 5.8; P = .001). Mutation carriers did not show worse motor symptoms, had good response to <sub>L</sub>-dopa, and tended to present the intermediate parkinsonian phenotype. Our findings suggest that mutations in the glucocerebrosidase gene not only increase the risk of both Parkinson's disease and Lewy body dementia but also strongly influence the course of Parkinson's disease with respect to the appearance of dementia.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17G</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Démence à corps de Lewy</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Lewy body dementia</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Demencia cuerpos Lewy</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Maladie de Parkinson</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Parkinson disease</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Mutation</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Mutation</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Mutación</s0><s5>09</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Facteur risque</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Risk factor</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Factor riesgo</s0><s5>10</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Corps Lewy maladie</s0><s4>CD</s4><s5>96</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Lewy body disease</s0><s4>CD</s4><s5>96</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Cuerpo Lewy enfermedad</s0><s4>CD</s4><s5>96</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0><s5>41</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>41</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>41</s5></fC07><fN21><s1>156</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Espagne</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Catalogne</li><li>Communauté de Madrid</li><li>Grand Londres</li><li>État de New York</li></region><settlement><li>Barcelone</li><li>Londres</li><li>Madrid</li></settlement><orgName><li>Université autonome de Barcelone</li></orgName></list><tree><country name="Espagne"><region name="Catalogne"><name sortKey="Seto Salvia, Nuria" sort="Seto Salvia, Nuria" uniqKey="Seto Salvia N" first="Núria" last="Seto-Salvia">Núria Seto-Salvia</name></region><name sortKey="Anton Aguirre, Sofia" sort="Anton Aguirre, Sofia" uniqKey="Anton Aguirre S" first="Sofia" last="Anton-Aguirre">Sofia Anton-Aguirre</name><name sortKey="Blesa, Rafael" sort="Blesa, Rafael" uniqKey="Blesa R" first="Rafael" last="Blesa">Rafael Blesa</name><name sortKey="Blesa, Rafael" sort="Blesa, Rafael" uniqKey="Blesa R" first="Rafael" last="Blesa">Rafael Blesa</name><name sortKey="Bufill, Enric" sort="Bufill, Enric" uniqKey="Bufill E" first="Enric" last="Bufill">Enric Bufill</name><name sortKey="Campolongo, Antonia" sort="Campolongo, Antonia" uniqKey="Campolongo A" first="Antonia" last="Campolongo">Antonia Campolongo</name><name sortKey="Campolongo, Antonia" sort="Campolongo, Antonia" uniqKey="Campolongo A" first="Antonia" last="Campolongo">Antonia Campolongo</name><name sortKey="Clarimon, Jordi" sort="Clarimon, Jordi" uniqKey="Clarimon J" first="Jordi" last="Clarimon">Jordi Clarimon</name><name sortKey="Clarimon, Jordi" sort="Clarimon, Jordi" uniqKey="Clarimon J" first="Jordi" last="Clarimon">Jordi Clarimon</name><name sortKey="Cozar, M Nica" sort="Cozar, M Nica" uniqKey="Cozar M" first="M Nica" last="Cozar">M Nica Cozar</name><name sortKey="Dols Icardo, Oriol" sort="Dols Icardo, Oriol" uniqKey="Dols Icardo O" first="Oriol" last="Dols-Icardo">Oriol Dols-Icardo</name><name sortKey="Grinberg, Daniel" sort="Grinberg, Daniel" uniqKey="Grinberg D" first="Daniel" last="Grinberg">Daniel Grinberg</name><name sortKey="Kulisevsky, Jaime" sort="Kulisevsky, Jaime" uniqKey="Kulisevsky J" first="Jaime" last="Kulisevsky">Jaime Kulisevsky</name><name sortKey="Kulisevsky, Jaime" sort="Kulisevsky, Jaime" uniqKey="Kulisevsky J" first="Jaime" last="Kulisevsky">Jaime Kulisevsky</name><name sortKey="Lleo, Alberto" sort="Lleo, Alberto" uniqKey="Lleo A" first="Alberto" last="Lleo">Alberto Lleo</name><name sortKey="Lleo, Alberto" sort="Lleo, Alberto" uniqKey="Lleo A" first="Alberto" last="Lleo">Alberto Lleo</name><name sortKey="Martin, Ines" sort="Martin, Ines" uniqKey="Martin I" first="Inés" last="Martin">Inés Martin</name><name sortKey="Munoz, Laia" sort="Munoz, Laia" uniqKey="Munoz L" first="Laia" last="Munoz">Laia Munoz</name><name sortKey="Pagonabarraga, Javier" sort="Pagonabarraga, Javier" uniqKey="Pagonabarraga J" first="Javier" last="Pagonabarraga">Javier Pagonabarraga</name><name sortKey="Pagonabarraga, Javier" sort="Pagonabarraga, Javier" uniqKey="Pagonabarraga J" first="Javier" last="Pagonabarraga">Javier Pagonabarraga</name><name sortKey="Pascual Sedano, Berta" sort="Pascual Sedano, Berta" uniqKey="Pascual Sedano B" first="Berta" last="Pascual-Sedano">Berta Pascual-Sedano</name><name sortKey="Pascual Sedano, Berta" sort="Pascual Sedano, Berta" uniqKey="Pascual Sedano B" first="Berta" last="Pascual-Sedano">Berta Pascual-Sedano</name><name sortKey="Seto Salvia, Nuria" sort="Seto Salvia, Nuria" uniqKey="Seto Salvia N" first="Núria" last="Seto-Salvia">Núria Seto-Salvia</name><name sortKey="Seto Salvia, Nuria" sort="Seto Salvia, Nuria" uniqKey="Seto Salvia N" first="Núria" last="Seto-Salvia">Núria Seto-Salvia</name><name sortKey="Vilageliu, Lluisa" sort="Vilageliu, Lluisa" uniqKey="Vilageliu L" first="Lluïsa" last="Vilageliu">Lluïsa Vilageliu</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Houlden, Henry" sort="Houlden, Henry" uniqKey="Houlden H" first="Henry" last="Houlden">Henry Houlden</name></region><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name><name sortKey="Tucci, Arianna" sort="Tucci, Arianna" uniqKey="Tucci A" first="Arianna" last="Tucci">Arianna Tucci</name></country><country name="États-Unis"><region name="État de New York"><name sortKey="Paisan Ruiz, Coro" sort="Paisan Ruiz, Coro" uniqKey="Paisan Ruiz C" first="Coro" last="Paisan-Ruiz">Coro Paisan-Ruiz</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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