The Pill Questionnaire in a Nondemented Parkinson's Disease Population
Identifieur interne : 000022 ( PascalFrancis/Checkpoint ); précédent : 000021; suivant : 000023The Pill Questionnaire in a Nondemented Parkinson's Disease Population
Auteurs : William Reginold [Canada] ; Melissa J. Armstrong [Canada] ; Sarah Duff-Canning [Canada] ; Anthony Lang [Canada] ; David Tang-Wai [Canada] ; Susan Fox [Canada] ; Brandon Rothberg [Canada] ; Cindy Zadikoff [États-Unis] ; Nancy Kennedy [États-Unis] ; David Gill [États-Unis] ; Paul Eslinger [États-Unis] ; Mark Mapstone [États-Unis] ; Kelvin Chou [États-Unis] ; Carol Persad [États-Unis] ; Irene Litvan [États-Unis] ; Benjamin Mast [États-Unis] ; Connie Marras [Canada]Source :
- Movement disorders [ 0885-3185 ] ; 2012.
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Abstract
We assessed the Pill Questionnaire as a screen for mild cognitive impairment in nondemented Parkinson's disease patients. The relationship between ability to remember medications for Parkinson's disease in the Pill Questionnaire, mild cognitive impairment, and deficits on neuropsychological tests performed 2-3 weeks later blind to Pill Questionnaire results was assessed in movement disorders clinic patients. In 109 subjects, inaccurate medication reporting on the Pill Questionnaire was associated with lower scores on the Montreal Cognitive Assessment, Scales for Outcomes in Parkinson's Disease-Cognition and with deficits in memory, attention, executive function-inhibitory control, processing speed, visuospatial function, and language. Inaccurate medication reporting was also associated with an adjusted odds ratio of 2.4 (95% CI, 0.91-5.88; P = .06) for mild cognitive impairment, with a specificity of 80% and sensitivity of 41 %. The Pill Questionnaire is neither sensitive nor specific enough to be used as the sole screening or diagnostic tool for mild cognitive impairment. However, inaccurate medication reporting is associated with deficits spanning many cognitive domains and should alert a clinician to a higher likelihood of cognitive impairment.
Affiliations:
- Canada, États-Unis
- Illinois, Kentucky, Michigan, Ontario, Pennsylvanie, État de New York
- Toronto
- Université de Toronto
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Safra Program in Parkinson's Disease</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, Ontario</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Medicine (Neurology), University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Fox, Susan" sort="Fox, Susan" uniqKey="Fox S" first="Susan" last="Fox">Susan Fox</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Hospital Movement Disorders Centre, and the Edmond J. Safra Program in Parkinson's Disease</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, Ontario</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Medicine (Neurology), University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Rothberg, Brandon" sort="Rothberg, Brandon" uniqKey="Rothberg B" first="Brandon" last="Rothberg">Brandon Rothberg</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Hospital Movement Disorders Centre, and the Edmond J. Safra Program in Parkinson's Disease</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Zadikoff, Cindy" sort="Zadikoff, Cindy" uniqKey="Zadikoff C" first="Cindy" last="Zadikoff">Cindy Zadikoff</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Neurology, Northwestern University</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Kennedy, Nancy" sort="Kennedy, Nancy" uniqKey="Kennedy N" first="Nancy" last="Kennedy">Nancy Kennedy</name><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Department of Psychiatry and Behavioral Science, Northwestern University</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Gill, David" sort="Gill, David" uniqKey="Gill D" first="David" last="Gill">David Gill</name><affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Department of Neurology, PennState Hershey</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Eslinger, Paul" sort="Eslinger, Paul" uniqKey="Eslinger P" first="Paul" last="Eslinger">Paul Eslinger</name><affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Department of Neurology, PennState Hershey</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Mapstone, Mark" sort="Mapstone, Mark" uniqKey="Mapstone M" first="Mark" last="Mapstone">Mark Mapstone</name><affiliation wicri:level="2"><inist:fA14 i1="07"><s1>Department of Neurology, University of Rochester</s1><s2>Rochester, New York</s2><s3>USA</s3><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Chou, Kelvin" sort="Chou, Kelvin" uniqKey="Chou K" first="Kelvin" last="Chou">Kelvin Chou</name><affiliation wicri:level="2"><inist:fA14 i1="08"><s1>Department of Neurology, University of Michigan</s1><s2>Ann Arbor, Michigan</s2><s3>USA</s3><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Persad, Carol" sort="Persad, Carol" uniqKey="Persad C" first="Carol" last="Persad">Carol Persad</name><affiliation wicri:level="2"><inist:fA14 i1="09"><s1>Department of Psychiatry, University of Michigan</s1><s2>Ann Arbor, Michigan</s2><s3>USA</s3><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Litvan, Irene" sort="Litvan, Irene" uniqKey="Litvan I" first="Irene" last="Litvan">Irene Litvan</name><affiliation wicri:level="2"><inist:fA14 i1="10"><s1>Department of Neurology, University of Louisville</s1><s2>Louisville, Kentucky</s2><s3>USA</s3><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Kentucky</region></placeName></affiliation></author><author><name sortKey="Mast, Benjamin" sort="Mast, Benjamin" uniqKey="Mast B" first="Benjamin" last="Mast">Benjamin Mast</name><affiliation wicri:level="2"><inist:fA14 i1="11"><s1>Psychological & Brain Sciences, University of Louisville</s1><s2>Louisville, Kentucky</s2><s3>USA</s3><sZ>16 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Kentucky</region></placeName></affiliation></author><author><name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Hospital Movement Disorders Centre, and the Edmond J. Safra Program in Parkinson's Disease</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, Ontario</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Medicine (Neurology), University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0369640</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 12-0369640 INIST</idno><idno type="RBID">Pascal:12-0369640</idno><idno type="wicri:Area/PascalFrancis/Corpus">000086</idno><idno type="wicri:Area/PascalFrancis/Curation">002C28</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000022</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">The Pill Questionnaire in a Nondemented Parkinson's Disease Population</title><author><name sortKey="Reginold, William" sort="Reginold, William" uniqKey="Reginold W" first="William" last="Reginold">William Reginold</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Hospital Movement Disorders Centre, and the Edmond J. Safra Program in Parkinson's Disease</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, Ontario</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Medicine (Neurology), University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Armstrong, Melissa J" sort="Armstrong, Melissa J" uniqKey="Armstrong M" first="Melissa J." last="Armstrong">Melissa J. Armstrong</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Hospital Movement Disorders Centre, and the Edmond J. Safra Program in Parkinson's Disease</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, Ontario</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Medicine (Neurology), University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Duff Canning, Sarah" sort="Duff Canning, Sarah" uniqKey="Duff Canning S" first="Sarah" last="Duff-Canning">Sarah Duff-Canning</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neuropsychology, Toronto Western Hospital</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Lang, Anthony" sort="Lang, Anthony" uniqKey="Lang A" first="Anthony" last="Lang">Anthony Lang</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Hospital Movement Disorders Centre, and the Edmond J. Safra Program in Parkinson's Disease</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, Ontario</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Medicine (Neurology), University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Tang Wai, David" sort="Tang Wai, David" uniqKey="Tang Wai D" first="David" last="Tang-Wai">David Tang-Wai</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Hospital Movement Disorders Centre, and the Edmond J. Safra Program in Parkinson's Disease</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, Ontario</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Medicine (Neurology), University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Fox, Susan" sort="Fox, Susan" uniqKey="Fox S" first="Susan" last="Fox">Susan Fox</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Hospital Movement Disorders Centre, and the Edmond J. Safra Program in Parkinson's Disease</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, Ontario</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Medicine (Neurology), University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Rothberg, Brandon" sort="Rothberg, Brandon" uniqKey="Rothberg B" first="Brandon" last="Rothberg">Brandon Rothberg</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Hospital Movement Disorders Centre, and the Edmond J. Safra Program in Parkinson's Disease</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Zadikoff, Cindy" sort="Zadikoff, Cindy" uniqKey="Zadikoff C" first="Cindy" last="Zadikoff">Cindy Zadikoff</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Neurology, Northwestern University</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Kennedy, Nancy" sort="Kennedy, Nancy" uniqKey="Kennedy N" first="Nancy" last="Kennedy">Nancy Kennedy</name><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Department of Psychiatry and Behavioral Science, Northwestern University</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Gill, David" sort="Gill, David" uniqKey="Gill D" first="David" last="Gill">David Gill</name><affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Department of Neurology, PennState Hershey</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Eslinger, Paul" sort="Eslinger, Paul" uniqKey="Eslinger P" first="Paul" last="Eslinger">Paul Eslinger</name><affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Department of Neurology, PennState Hershey</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Mapstone, Mark" sort="Mapstone, Mark" uniqKey="Mapstone M" first="Mark" last="Mapstone">Mark Mapstone</name><affiliation wicri:level="2"><inist:fA14 i1="07"><s1>Department of Neurology, University of Rochester</s1><s2>Rochester, New York</s2><s3>USA</s3><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Chou, Kelvin" sort="Chou, Kelvin" uniqKey="Chou K" first="Kelvin" last="Chou">Kelvin Chou</name><affiliation wicri:level="2"><inist:fA14 i1="08"><s1>Department of Neurology, University of Michigan</s1><s2>Ann Arbor, Michigan</s2><s3>USA</s3><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Persad, Carol" sort="Persad, Carol" uniqKey="Persad C" first="Carol" last="Persad">Carol Persad</name><affiliation wicri:level="2"><inist:fA14 i1="09"><s1>Department of Psychiatry, University of Michigan</s1><s2>Ann Arbor, Michigan</s2><s3>USA</s3><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Litvan, Irene" sort="Litvan, Irene" uniqKey="Litvan I" first="Irene" last="Litvan">Irene Litvan</name><affiliation wicri:level="2"><inist:fA14 i1="10"><s1>Department of Neurology, University of Louisville</s1><s2>Louisville, Kentucky</s2><s3>USA</s3><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Kentucky</region></placeName></affiliation></author><author><name sortKey="Mast, Benjamin" sort="Mast, Benjamin" uniqKey="Mast B" first="Benjamin" last="Mast">Benjamin Mast</name><affiliation wicri:level="2"><inist:fA14 i1="11"><s1>Psychological & Brain Sciences, University of Louisville</s1><s2>Louisville, Kentucky</s2><s3>USA</s3><sZ>16 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Kentucky</region></placeName></affiliation></author><author><name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Hospital Movement Disorders Centre, and the Edmond J. Safra Program in Parkinson's Disease</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, Ontario</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Medicine (Neurology), University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cognitive disorder</term><term>Medical screening</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Questionnaire</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Trouble cognitif</term><term>Pathologie du système nerveux</term><term>Questionnaire</term><term>Dépistage</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We assessed the Pill Questionnaire as a screen for mild cognitive impairment in nondemented Parkinson's disease patients. The relationship between ability to remember medications for Parkinson's disease in the Pill Questionnaire, mild cognitive impairment, and deficits on neuropsychological tests performed 2-3 weeks later blind to Pill Questionnaire results was assessed in movement disorders clinic patients. In 109 subjects, inaccurate medication reporting on the Pill Questionnaire was associated with lower scores on the Montreal Cognitive Assessment, Scales for Outcomes in Parkinson's Disease-Cognition and with deficits in memory, attention, executive function-inhibitory control, processing speed, visuospatial function, and language. Inaccurate medication reporting was also associated with an adjusted odds ratio of 2.4 (95% CI, 0.91-5.88; P = .06) for mild cognitive impairment, with a specificity of 80% and sensitivity of 41 %. The Pill Questionnaire is neither sensitive nor specific enough to be used as the sole screening or diagnostic tool for mild cognitive impairment. However, inaccurate medication reporting is associated with deficits spanning many cognitive domains and should alert a clinician to a higher likelihood of cognitive impairment.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>27</s2></fA05><fA06><s2>10</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>The Pill Questionnaire in a Nondemented Parkinson's Disease Population</s1></fA08><fA11 i1="01" i2="1"><s1>REGINOLD (William)</s1></fA11><fA11 i1="02" i2="1"><s1>ARMSTRONG (Melissa J.)</s1></fA11><fA11 i1="03" i2="1"><s1>DUFF-CANNING (Sarah)</s1></fA11><fA11 i1="04" i2="1"><s1>LANG (Anthony)</s1></fA11><fA11 i1="05" i2="1"><s1>TANG-WAI (David)</s1></fA11><fA11 i1="06" i2="1"><s1>FOX (Susan)</s1></fA11><fA11 i1="07" i2="1"><s1>ROTHBERG (Brandon)</s1></fA11><fA11 i1="08" i2="1"><s1>ZADIKOFF (Cindy)</s1></fA11><fA11 i1="09" i2="1"><s1>KENNEDY (Nancy)</s1></fA11><fA11 i1="10" i2="1"><s1>GILL (David)</s1></fA11><fA11 i1="11" i2="1"><s1>ESLINGER (Paul)</s1></fA11><fA11 i1="12" i2="1"><s1>MAPSTONE (Mark)</s1></fA11><fA11 i1="13" i2="1"><s1>CHOU (Kelvin)</s1></fA11><fA11 i1="14" i2="1"><s1>PERSAD (Carol)</s1></fA11><fA11 i1="15" i2="1"><s1>LITVAN (Irene)</s1></fA11><fA11 i1="16" i2="1"><s1>MAST (Benjamin)</s1></fA11><fA11 i1="17" i2="1"><s1>MARRAS (Connie)</s1></fA11><fA14 i1="01"><s1>Toronto Western Hospital Movement Disorders Centre, and the Edmond J. Safra Program in Parkinson's Disease</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>17 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Medicine (Neurology), University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Neuropsychology, Toronto Western Hospital</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>3 aut.</sZ></fA14><fA14 i1="04"><s1>Department of Neurology, Northwestern University</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>8 aut.</sZ></fA14><fA14 i1="05"><s1>Department of Psychiatry and Behavioral Science, Northwestern University</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>9 aut.</sZ></fA14><fA14 i1="06"><s1>Department of Neurology, PennState Hershey</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ></fA14><fA14 i1="07"><s1>Department of Neurology, University of Rochester</s1><s2>Rochester, New York</s2><s3>USA</s3><sZ>12 aut.</sZ></fA14><fA14 i1="08"><s1>Department of Neurology, University of Michigan</s1><s2>Ann Arbor, Michigan</s2><s3>USA</s3><sZ>13 aut.</sZ></fA14><fA14 i1="09"><s1>Department of Psychiatry, University of Michigan</s1><s2>Ann Arbor, Michigan</s2><s3>USA</s3><sZ>14 aut.</sZ></fA14><fA14 i1="10"><s1>Department of Neurology, University of Louisville</s1><s2>Louisville, Kentucky</s2><s3>USA</s3><sZ>15 aut.</sZ></fA14><fA14 i1="11"><s1>Psychological & Brain Sciences, University of Louisville</s1><s2>Louisville, Kentucky</s2><s3>USA</s3><sZ>16 aut.</sZ></fA14><fA20><s1>1308-1311</s1></fA20><fA21><s1>2012</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000502011860210</s5></fA43><fA44><s0>0000</s0><s1>© 2012 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>15 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>12-0369640</s0></fA47><fA60><s1>P</s1><s3>CC</s3></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>We assessed the Pill Questionnaire as a screen for mild cognitive impairment in nondemented Parkinson's disease patients. The relationship between ability to remember medications for Parkinson's disease in the Pill Questionnaire, mild cognitive impairment, and deficits on neuropsychological tests performed 2-3 weeks later blind to Pill Questionnaire results was assessed in movement disorders clinic patients. In 109 subjects, inaccurate medication reporting on the Pill Questionnaire was associated with lower scores on the Montreal Cognitive Assessment, Scales for Outcomes in Parkinson's Disease-Cognition and with deficits in memory, attention, executive function-inhibitory control, processing speed, visuospatial function, and language. Inaccurate medication reporting was also associated with an adjusted odds ratio of 2.4 (95% CI, 0.91-5.88; P = .06) for mild cognitive impairment, with a specificity of 80% and sensitivity of 41 %. The Pill Questionnaire is neither sensitive nor specific enough to be used as the sole screening or diagnostic tool for mild cognitive impairment. However, inaccurate medication reporting is associated with deficits spanning many cognitive domains and should alert a clinician to a higher likelihood of cognitive impairment.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17G</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Maladie de Parkinson</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Trouble cognitif</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Cognitive disorder</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Trastorno cognitivo</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Questionnaire</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Questionnaire</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Cuestionario</s0><s5>09</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Dépistage</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Medical screening</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Descubrimiento</s0><s5>10</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>40</s5></fC07><fN21><s1>289</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Illinois</li><li>Kentucky</li><li>Michigan</li><li>Ontario</li><li>Pennsylvanie</li><li>État de New York</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Reginold, William" sort="Reginold, William" uniqKey="Reginold W" first="William" last="Reginold">William Reginold</name></noRegion><name sortKey="Armstrong, Melissa J" sort="Armstrong, Melissa J" uniqKey="Armstrong M" first="Melissa J." last="Armstrong">Melissa J. Armstrong</name><name sortKey="Armstrong, Melissa J" sort="Armstrong, Melissa J" uniqKey="Armstrong M" first="Melissa J." last="Armstrong">Melissa J. Armstrong</name><name sortKey="Duff Canning, Sarah" sort="Duff Canning, Sarah" uniqKey="Duff Canning S" first="Sarah" last="Duff-Canning">Sarah Duff-Canning</name><name sortKey="Fox, Susan" sort="Fox, Susan" uniqKey="Fox S" first="Susan" last="Fox">Susan Fox</name><name sortKey="Fox, Susan" sort="Fox, Susan" uniqKey="Fox S" first="Susan" last="Fox">Susan Fox</name><name sortKey="Lang, Anthony" sort="Lang, Anthony" uniqKey="Lang A" first="Anthony" last="Lang">Anthony Lang</name><name sortKey="Lang, Anthony" sort="Lang, Anthony" uniqKey="Lang A" first="Anthony" last="Lang">Anthony Lang</name><name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name><name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name><name sortKey="Reginold, William" sort="Reginold, William" uniqKey="Reginold W" first="William" last="Reginold">William Reginold</name><name sortKey="Rothberg, Brandon" sort="Rothberg, Brandon" uniqKey="Rothberg B" first="Brandon" last="Rothberg">Brandon Rothberg</name><name sortKey="Tang Wai, David" sort="Tang Wai, David" uniqKey="Tang Wai D" first="David" last="Tang-Wai">David Tang-Wai</name><name sortKey="Tang Wai, David" sort="Tang Wai, David" uniqKey="Tang Wai D" first="David" last="Tang-Wai">David Tang-Wai</name></country><country name="États-Unis"><region name="Illinois"><name sortKey="Zadikoff, Cindy" sort="Zadikoff, Cindy" uniqKey="Zadikoff C" first="Cindy" last="Zadikoff">Cindy Zadikoff</name></region><name sortKey="Chou, Kelvin" sort="Chou, Kelvin" uniqKey="Chou K" first="Kelvin" last="Chou">Kelvin Chou</name><name sortKey="Eslinger, Paul" sort="Eslinger, Paul" uniqKey="Eslinger P" first="Paul" last="Eslinger">Paul Eslinger</name><name sortKey="Gill, David" sort="Gill, David" uniqKey="Gill D" first="David" last="Gill">David Gill</name><name sortKey="Kennedy, Nancy" sort="Kennedy, Nancy" uniqKey="Kennedy N" first="Nancy" last="Kennedy">Nancy Kennedy</name><name sortKey="Litvan, Irene" sort="Litvan, Irene" uniqKey="Litvan I" first="Irene" last="Litvan">Irene Litvan</name><name sortKey="Mapstone, Mark" sort="Mapstone, Mark" uniqKey="Mapstone M" first="Mark" last="Mapstone">Mark Mapstone</name><name sortKey="Mast, Benjamin" sort="Mast, Benjamin" uniqKey="Mast B" first="Benjamin" last="Mast">Benjamin Mast</name><name sortKey="Persad, Carol" sort="Persad, Carol" uniqKey="Persad C" first="Carol" last="Persad">Carol Persad</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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