The Pill Questionnaire in a Nondemented Parkinson's Disease Population
Identifieur interne : 000086 ( PascalFrancis/Corpus ); précédent : 000085; suivant : 000087The Pill Questionnaire in a Nondemented Parkinson's Disease Population
Auteurs : William Reginold ; Melissa J. Armstrong ; Sarah Duff-Canning ; Anthony Lang ; David Tang-Wai ; Susan Fox ; Brandon Rothberg ; Cindy Zadikoff ; Nancy Kennedy ; David Gill ; Paul Eslinger ; Mark Mapstone ; Kelvin Chou ; Carol Persad ; Irene Litvan ; Benjamin Mast ; Connie MarrasSource :
- Movement disorders [ 0885-3185 ] ; 2012.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
We assessed the Pill Questionnaire as a screen for mild cognitive impairment in nondemented Parkinson's disease patients. The relationship between ability to remember medications for Parkinson's disease in the Pill Questionnaire, mild cognitive impairment, and deficits on neuropsychological tests performed 2-3 weeks later blind to Pill Questionnaire results was assessed in movement disorders clinic patients. In 109 subjects, inaccurate medication reporting on the Pill Questionnaire was associated with lower scores on the Montreal Cognitive Assessment, Scales for Outcomes in Parkinson's Disease-Cognition and with deficits in memory, attention, executive function-inhibitory control, processing speed, visuospatial function, and language. Inaccurate medication reporting was also associated with an adjusted odds ratio of 2.4 (95% CI, 0.91-5.88; P = .06) for mild cognitive impairment, with a specificity of 80% and sensitivity of 41 %. The Pill Questionnaire is neither sensitive nor specific enough to be used as the sole screening or diagnostic tool for mild cognitive impairment. However, inaccurate medication reporting is associated with deficits spanning many cognitive domains and should alert a clinician to a higher likelihood of cognitive impairment.
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Format Inist (serveur)
| NO : | PASCAL 12-0369640 INIST |
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| ET : | The Pill Questionnaire in a Nondemented Parkinson's Disease Population |
| AU : | REGINOLD (William); ARMSTRONG (Melissa J.); DUFF-CANNING (Sarah); LANG (Anthony); TANG-WAI (David); FOX (Susan); ROTHBERG (Brandon); ZADIKOFF (Cindy); KENNEDY (Nancy); GILL (David); ESLINGER (Paul); MAPSTONE (Mark); CHOU (Kelvin); PERSAD (Carol); LITVAN (Irene); MAST (Benjamin); MARRAS (Connie) |
| AF : | Toronto Western Hospital Movement Disorders Centre, and the Edmond J. Safra Program in Parkinson's Disease/Toronto, Ontario/Canada (1 aut., 2 aut., 4 aut., 5 aut., 6 aut., 7 aut., 17 aut.); Department of Medicine (Neurology), University of Toronto/Toronto, Ontario/Canada (1 aut., 2 aut., 4 aut., 5 aut., 6 aut., 17 aut.); Department of Neuropsychology, Toronto Western Hospital/Toronto, Ontario/Canada (3 aut.); Department of Neurology, Northwestern University/Chicago, Illinois/Etats-Unis (8 aut.); Department of Psychiatry and Behavioral Science, Northwestern University/Chicago, Illinois/Etats-Unis (9 aut.); Department of Neurology, PennState Hershey/Hershey, Pennsylvania/Etats-Unis (10 aut., 11 aut.); Department of Neurology, University of Rochester/Rochester, New York/Etats-Unis (12 aut.); Department of Neurology, University of Michigan/Ann Arbor, Michigan/Etats-Unis (13 aut.); Department of Psychiatry, University of Michigan/Ann Arbor, Michigan/Etats-Unis (14 aut.); Department of Neurology, University of Louisville/Louisville, Kentucky/Etats-Unis (15 aut.); Psychological & Brain Sciences, University of Louisville/Louisville, Kentucky/Etats-Unis (16 aut.) |
| DT : | Publication en série; Courte communication, note brève; Niveau analytique |
| SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2012; Vol. 27; No. 10; Pp. 1308-1311; Bibl. 15 ref. |
| LA : | Anglais |
| EA : | We assessed the Pill Questionnaire as a screen for mild cognitive impairment in nondemented Parkinson's disease patients. The relationship between ability to remember medications for Parkinson's disease in the Pill Questionnaire, mild cognitive impairment, and deficits on neuropsychological tests performed 2-3 weeks later blind to Pill Questionnaire results was assessed in movement disorders clinic patients. In 109 subjects, inaccurate medication reporting on the Pill Questionnaire was associated with lower scores on the Montreal Cognitive Assessment, Scales for Outcomes in Parkinson's Disease-Cognition and with deficits in memory, attention, executive function-inhibitory control, processing speed, visuospatial function, and language. Inaccurate medication reporting was also associated with an adjusted odds ratio of 2.4 (95% CI, 0.91-5.88; P = .06) for mild cognitive impairment, with a specificity of 80% and sensitivity of 41 %. The Pill Questionnaire is neither sensitive nor specific enough to be used as the sole screening or diagnostic tool for mild cognitive impairment. However, inaccurate medication reporting is associated with deficits spanning many cognitive domains and should alert a clinician to a higher likelihood of cognitive impairment. |
| CC : | 002B17; 002B17G |
| FD : | Maladie de Parkinson; Trouble cognitif; Pathologie du système nerveux; Questionnaire; Dépistage |
| FG : | Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central |
| ED : | Parkinson disease; Cognitive disorder; Nervous system diseases; Questionnaire; Medical screening |
| EG : | Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease |
| SD : | Parkinson enfermedad; Trastorno cognitivo; Sistema nervioso patología; Cuestionario; Descubrimiento |
| LO : | INIST-20953.354000502011860210 |
| ID : | 12-0369640 |
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Pascal:12-0369640Le document en format XML
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Safra Program in Parkinson's Disease</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>Department of Medicine (Neurology), University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0369640</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 12-0369640 INIST</idno><idno type="RBID">Pascal:12-0369640</idno><idno type="wicri:Area/PascalFrancis/Corpus">000086</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">The Pill Questionnaire in a Nondemented Parkinson's Disease Population</title><author><name sortKey="Reginold, William" sort="Reginold, William" uniqKey="Reginold W" first="William" last="Reginold">William Reginold</name><affiliation><inist:fA14 i1="01"><s1>Toronto Western Hospital Movement Disorders Centre, and the Edmond J. Safra Program in Parkinson's Disease</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>Department of Medicine (Neurology), University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Armstrong, Melissa J" sort="Armstrong, Melissa J" uniqKey="Armstrong M" first="Melissa J." last="Armstrong">Melissa J. Armstrong</name><affiliation><inist:fA14 i1="01"><s1>Toronto Western Hospital Movement Disorders Centre, and the Edmond J. Safra Program in Parkinson's Disease</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>Department of Medicine (Neurology), University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Duff Canning, Sarah" sort="Duff Canning, Sarah" uniqKey="Duff Canning S" first="Sarah" last="Duff-Canning">Sarah Duff-Canning</name><affiliation><inist:fA14 i1="03"><s1>Department of Neuropsychology, Toronto Western Hospital</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>3 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Lang, Anthony" sort="Lang, Anthony" uniqKey="Lang A" first="Anthony" last="Lang">Anthony Lang</name><affiliation><inist:fA14 i1="01"><s1>Toronto Western Hospital Movement Disorders Centre, and the Edmond J. Safra Program in Parkinson's Disease</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>Department of Medicine (Neurology), University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Tang Wai, David" sort="Tang Wai, David" uniqKey="Tang Wai D" first="David" last="Tang-Wai">David Tang-Wai</name><affiliation><inist:fA14 i1="01"><s1>Toronto Western Hospital Movement Disorders Centre, and the Edmond J. Safra Program in Parkinson's Disease</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>Department of Medicine (Neurology), University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Fox, Susan" sort="Fox, Susan" uniqKey="Fox S" first="Susan" last="Fox">Susan Fox</name><affiliation><inist:fA14 i1="01"><s1>Toronto Western Hospital Movement Disorders Centre, and the Edmond J. Safra Program in Parkinson's Disease</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>Department of Medicine (Neurology), University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Rothberg, Brandon" sort="Rothberg, Brandon" uniqKey="Rothberg B" first="Brandon" last="Rothberg">Brandon Rothberg</name><affiliation><inist:fA14 i1="01"><s1>Toronto Western Hospital Movement Disorders Centre, and the Edmond J. Safra Program in Parkinson's Disease</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Zadikoff, Cindy" sort="Zadikoff, Cindy" uniqKey="Zadikoff C" first="Cindy" last="Zadikoff">Cindy Zadikoff</name><affiliation><inist:fA14 i1="04"><s1>Department of Neurology, Northwestern University</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Kennedy, Nancy" sort="Kennedy, Nancy" uniqKey="Kennedy N" first="Nancy" last="Kennedy">Nancy Kennedy</name><affiliation><inist:fA14 i1="05"><s1>Department of Psychiatry and Behavioral Science, Northwestern University</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Gill, David" sort="Gill, David" uniqKey="Gill D" first="David" last="Gill">David Gill</name><affiliation><inist:fA14 i1="06"><s1>Department of Neurology, PennState Hershey</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Eslinger, Paul" sort="Eslinger, Paul" uniqKey="Eslinger P" first="Paul" last="Eslinger">Paul Eslinger</name><affiliation><inist:fA14 i1="06"><s1>Department of Neurology, PennState Hershey</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Mapstone, Mark" sort="Mapstone, Mark" uniqKey="Mapstone M" first="Mark" last="Mapstone">Mark Mapstone</name><affiliation><inist:fA14 i1="07"><s1>Department of Neurology, University of Rochester</s1><s2>Rochester, New York</s2><s3>USA</s3><sZ>12 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Chou, Kelvin" sort="Chou, Kelvin" uniqKey="Chou K" first="Kelvin" last="Chou">Kelvin Chou</name><affiliation><inist:fA14 i1="08"><s1>Department of Neurology, University of Michigan</s1><s2>Ann Arbor, Michigan</s2><s3>USA</s3><sZ>13 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Persad, Carol" sort="Persad, Carol" uniqKey="Persad C" first="Carol" last="Persad">Carol Persad</name><affiliation><inist:fA14 i1="09"><s1>Department of Psychiatry, University of Michigan</s1><s2>Ann Arbor, Michigan</s2><s3>USA</s3><sZ>14 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Litvan, Irene" sort="Litvan, Irene" uniqKey="Litvan I" first="Irene" last="Litvan">Irene Litvan</name><affiliation><inist:fA14 i1="10"><s1>Department of Neurology, University of Louisville</s1><s2>Louisville, Kentucky</s2><s3>USA</s3><sZ>15 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Mast, Benjamin" sort="Mast, Benjamin" uniqKey="Mast B" first="Benjamin" last="Mast">Benjamin Mast</name><affiliation><inist:fA14 i1="11"><s1>Psychological & Brain Sciences, University of Louisville</s1><s2>Louisville, Kentucky</s2><s3>USA</s3><sZ>16 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name><affiliation><inist:fA14 i1="01"><s1>Toronto Western Hospital Movement Disorders Centre, and the Edmond J. Safra Program in Parkinson's Disease</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>Department of Medicine (Neurology), University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cognitive disorder</term><term>Medical screening</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Questionnaire</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Trouble cognitif</term><term>Pathologie du système nerveux</term><term>Questionnaire</term><term>Dépistage</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We assessed the Pill Questionnaire as a screen for mild cognitive impairment in nondemented Parkinson's disease patients. The relationship between ability to remember medications for Parkinson's disease in the Pill Questionnaire, mild cognitive impairment, and deficits on neuropsychological tests performed 2-3 weeks later blind to Pill Questionnaire results was assessed in movement disorders clinic patients. In 109 subjects, inaccurate medication reporting on the Pill Questionnaire was associated with lower scores on the Montreal Cognitive Assessment, Scales for Outcomes in Parkinson's Disease-Cognition and with deficits in memory, attention, executive function-inhibitory control, processing speed, visuospatial function, and language. Inaccurate medication reporting was also associated with an adjusted odds ratio of 2.4 (95% CI, 0.91-5.88; P = .06) for mild cognitive impairment, with a specificity of 80% and sensitivity of 41 %. The Pill Questionnaire is neither sensitive nor specific enough to be used as the sole screening or diagnostic tool for mild cognitive impairment. However, inaccurate medication reporting is associated with deficits spanning many cognitive domains and should alert a clinician to a higher likelihood of cognitive impairment.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>27</s2></fA05><fA06><s2>10</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>The Pill Questionnaire in a Nondemented Parkinson's Disease Population</s1></fA08><fA11 i1="01" i2="1"><s1>REGINOLD (William)</s1></fA11><fA11 i1="02" i2="1"><s1>ARMSTRONG (Melissa J.)</s1></fA11><fA11 i1="03" i2="1"><s1>DUFF-CANNING (Sarah)</s1></fA11><fA11 i1="04" i2="1"><s1>LANG (Anthony)</s1></fA11><fA11 i1="05" i2="1"><s1>TANG-WAI (David)</s1></fA11><fA11 i1="06" i2="1"><s1>FOX (Susan)</s1></fA11><fA11 i1="07" i2="1"><s1>ROTHBERG (Brandon)</s1></fA11><fA11 i1="08" i2="1"><s1>ZADIKOFF (Cindy)</s1></fA11><fA11 i1="09" i2="1"><s1>KENNEDY (Nancy)</s1></fA11><fA11 i1="10" i2="1"><s1>GILL (David)</s1></fA11><fA11 i1="11" i2="1"><s1>ESLINGER (Paul)</s1></fA11><fA11 i1="12" i2="1"><s1>MAPSTONE (Mark)</s1></fA11><fA11 i1="13" i2="1"><s1>CHOU (Kelvin)</s1></fA11><fA11 i1="14" i2="1"><s1>PERSAD (Carol)</s1></fA11><fA11 i1="15" i2="1"><s1>LITVAN (Irene)</s1></fA11><fA11 i1="16" i2="1"><s1>MAST (Benjamin)</s1></fA11><fA11 i1="17" i2="1"><s1>MARRAS (Connie)</s1></fA11><fA14 i1="01"><s1>Toronto Western Hospital Movement Disorders Centre, and the Edmond J. Safra Program in Parkinson's Disease</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>17 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Medicine (Neurology), University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Neuropsychology, Toronto Western Hospital</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>3 aut.</sZ></fA14><fA14 i1="04"><s1>Department of Neurology, Northwestern University</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>8 aut.</sZ></fA14><fA14 i1="05"><s1>Department of Psychiatry and Behavioral Science, Northwestern University</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>9 aut.</sZ></fA14><fA14 i1="06"><s1>Department of Neurology, PennState Hershey</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ></fA14><fA14 i1="07"><s1>Department of Neurology, University of Rochester</s1><s2>Rochester, New York</s2><s3>USA</s3><sZ>12 aut.</sZ></fA14><fA14 i1="08"><s1>Department of Neurology, University of Michigan</s1><s2>Ann Arbor, Michigan</s2><s3>USA</s3><sZ>13 aut.</sZ></fA14><fA14 i1="09"><s1>Department of Psychiatry, University of Michigan</s1><s2>Ann Arbor, Michigan</s2><s3>USA</s3><sZ>14 aut.</sZ></fA14><fA14 i1="10"><s1>Department of Neurology, University of Louisville</s1><s2>Louisville, Kentucky</s2><s3>USA</s3><sZ>15 aut.</sZ></fA14><fA14 i1="11"><s1>Psychological & Brain Sciences, University of Louisville</s1><s2>Louisville, Kentucky</s2><s3>USA</s3><sZ>16 aut.</sZ></fA14><fA20><s1>1308-1311</s1></fA20><fA21><s1>2012</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000502011860210</s5></fA43><fA44><s0>0000</s0><s1>© 2012 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>15 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>12-0369640</s0></fA47><fA60><s1>P</s1><s3>CC</s3></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>We assessed the Pill Questionnaire as a screen for mild cognitive impairment in nondemented Parkinson's disease patients. The relationship between ability to remember medications for Parkinson's disease in the Pill Questionnaire, mild cognitive impairment, and deficits on neuropsychological tests performed 2-3 weeks later blind to Pill Questionnaire results was assessed in movement disorders clinic patients. In 109 subjects, inaccurate medication reporting on the Pill Questionnaire was associated with lower scores on the Montreal Cognitive Assessment, Scales for Outcomes in Parkinson's Disease-Cognition and with deficits in memory, attention, executive function-inhibitory control, processing speed, visuospatial function, and language. Inaccurate medication reporting was also associated with an adjusted odds ratio of 2.4 (95% CI, 0.91-5.88; P = .06) for mild cognitive impairment, with a specificity of 80% and sensitivity of 41 %. The Pill Questionnaire is neither sensitive nor specific enough to be used as the sole screening or diagnostic tool for mild cognitive impairment. However, inaccurate medication reporting is associated with deficits spanning many cognitive domains and should alert a clinician to a higher likelihood of cognitive impairment.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17G</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Maladie de Parkinson</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Trouble cognitif</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Cognitive disorder</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Trastorno cognitivo</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Questionnaire</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Questionnaire</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Cuestionario</s0><s5>09</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Dépistage</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Medical screening</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Descubrimiento</s0><s5>10</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>40</s5></fC07><fN21><s1>289</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard><server><NO>PASCAL 12-0369640 INIST</NO><ET>The Pill Questionnaire in a Nondemented Parkinson's Disease Population</ET><AU>REGINOLD (William); ARMSTRONG (Melissa J.); DUFF-CANNING (Sarah); LANG (Anthony); TANG-WAI (David); FOX (Susan); ROTHBERG (Brandon); ZADIKOFF (Cindy); KENNEDY (Nancy); GILL (David); ESLINGER (Paul); MAPSTONE (Mark); CHOU (Kelvin); PERSAD (Carol); LITVAN (Irene); MAST (Benjamin); MARRAS (Connie)</AU><AF>Toronto Western Hospital Movement Disorders Centre, and the Edmond J. Safra Program in Parkinson's Disease/Toronto, Ontario/Canada (1 aut., 2 aut., 4 aut., 5 aut., 6 aut., 7 aut., 17 aut.); Department of Medicine (Neurology), University of Toronto/Toronto, Ontario/Canada (1 aut., 2 aut., 4 aut., 5 aut., 6 aut., 17 aut.); Department of Neuropsychology, Toronto Western Hospital/Toronto, Ontario/Canada (3 aut.); Department of Neurology, Northwestern University/Chicago, Illinois/Etats-Unis (8 aut.); Department of Psychiatry and Behavioral Science, Northwestern University/Chicago, Illinois/Etats-Unis (9 aut.); Department of Neurology, PennState Hershey/Hershey, Pennsylvania/Etats-Unis (10 aut., 11 aut.); Department of Neurology, University of Rochester/Rochester, New York/Etats-Unis (12 aut.); Department of Neurology, University of Michigan/Ann Arbor, Michigan/Etats-Unis (13 aut.); Department of Psychiatry, University of Michigan/Ann Arbor, Michigan/Etats-Unis (14 aut.); Department of Neurology, University of Louisville/Louisville, Kentucky/Etats-Unis (15 aut.); Psychological & Brain Sciences, University of Louisville/Louisville, Kentucky/Etats-Unis (16 aut.)</AF><DT>Publication en série; Courte communication, note brève; Niveau analytique</DT><SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2012; Vol. 27; No. 10; Pp. 1308-1311; Bibl. 15 ref.</SO><LA>Anglais</LA><EA>We assessed the Pill Questionnaire as a screen for mild cognitive impairment in nondemented Parkinson's disease patients. The relationship between ability to remember medications for Parkinson's disease in the Pill Questionnaire, mild cognitive impairment, and deficits on neuropsychological tests performed 2-3 weeks later blind to Pill Questionnaire results was assessed in movement disorders clinic patients. In 109 subjects, inaccurate medication reporting on the Pill Questionnaire was associated with lower scores on the Montreal Cognitive Assessment, Scales for Outcomes in Parkinson's Disease-Cognition and with deficits in memory, attention, executive function-inhibitory control, processing speed, visuospatial function, and language. Inaccurate medication reporting was also associated with an adjusted odds ratio of 2.4 (95% CI, 0.91-5.88; P = .06) for mild cognitive impairment, with a specificity of 80% and sensitivity of 41 %. The Pill Questionnaire is neither sensitive nor specific enough to be used as the sole screening or diagnostic tool for mild cognitive impairment. However, inaccurate medication reporting is associated with deficits spanning many cognitive domains and should alert a clinician to a higher likelihood of cognitive impairment.</EA><CC>002B17; 002B17G</CC><FD>Maladie de Parkinson; Trouble cognitif; Pathologie du système nerveux; Questionnaire; Dépistage</FD><FG>Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central</FG><ED>Parkinson disease; Cognitive disorder; Nervous system diseases; Questionnaire; Medical screening</ED><EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG><SD>Parkinson enfermedad; Trastorno cognitivo; Sistema nervioso patología; Cuestionario; Descubrimiento</SD><LO>INIST-20953.354000502011860210</LO><ID>12-0369640</ID></server></inist></record>Pour manipuler ce document sous Unix (Dilib)
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