Association of a polymorphism in the dopamine-transporter gene with Parkinson's disease.
Identifieur interne : 004D89 ( Ncbi/Merge ); précédent : 004D88; suivant : 004D90Association of a polymorphism in the dopamine-transporter gene with Parkinson's disease.
Auteurs : D G Le Couteur [Australie] ; P W Leighton ; S J Mccann ; S M PondSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1997.
English descriptors
- KwdEn :
- Age of Onset, Aged, Alleles, Carrier Proteins (genetics), Case-Control Studies, Chi-Square Distribution, Confidence Intervals, Disease Susceptibility, Dopamine Plasma Membrane Transport Proteins, Female, Gene Frequency, Genotype, Humans, Male, Membrane Glycoproteins, Membrane Transport Proteins, Nerve Tissue Proteins, Odds Ratio, Parkinson Disease (genetics), Polymorphism, Genetic (genetics), Repetitive Sequences, Nucleic Acid (genetics), Repetitive Sequences, Nucleic Acid (physiology).
- MESH :
- chemical , genetics : Carrier Proteins.
- genetics : Parkinson Disease, Polymorphism, Genetic, Repetitive Sequences, Nucleic Acid.
- physiology : Repetitive Sequences, Nucleic Acid.
- Age of Onset, Aged, Alleles, Case-Control Studies, Chi-Square Distribution, Confidence Intervals, Disease Susceptibility, Dopamine Plasma Membrane Transport Proteins, Female, Gene Frequency, Genotype, Humans, Male, Membrane Glycoproteins, Membrane Transport Proteins, Nerve Tissue Proteins, Odds Ratio.
Abstract
The presynaptic dopamine transporter in nigral dopaminergic neurons confers susceptibility to the cytotoxic effects of the neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Polymorphisms in the dopamine transporter might influence the susceptibility to such toxins. Therefore, we investigated whether a polymorphic region in the 3'-untranslated region of the dopamine-transporter gene is associated with idiopathic Parkinson's disease (PD). The frequency distribution of the alleles was significantly different between the patients (n = 100) and controls (n = 200, p < 0.05). The rare 11-copy allele was more common in the patients (odds ratio = 10.2, 95% confidence interval - 1.2-87.9, p < 0.025). The susceptibility of some people to PD may be conferred by polymorphisms in the dopamine-transporter gene that could lead to increased cellular accumulation of neurotoxic compounds in dopaminergic neurons.
DOI: 10.1002/mds.870120523
PubMed: 9380062
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 004594
- to stream PubMed, to step Curation: 004594
- to stream PubMed, to step Checkpoint: 004713
Links to Exploration step
pubmed:9380062Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Association of a polymorphism in the dopamine-transporter gene with Parkinson's disease.</title>
<author><name sortKey="Le Couteur, D G" sort="Le Couteur, D G" uniqKey="Le Couteur D" first="D G" last="Le Couteur">D G Le Couteur</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Queensland, Department of Medicine, Princess Alexandra Hospital, Woolloongabba, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>University of Queensland, Department of Medicine, Princess Alexandra Hospital, Woolloongabba</wicri:regionArea>
<wicri:noRegion>Woolloongabba</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Leighton, P W" sort="Leighton, P W" uniqKey="Leighton P" first="P W" last="Leighton">P W Leighton</name>
</author>
<author><name sortKey="Mccann, S J" sort="Mccann, S J" uniqKey="Mccann S" first="S J" last="Mccann">S J Mccann</name>
</author>
<author><name sortKey="Pond, S M" sort="Pond, S M" uniqKey="Pond S" first="S M" last="Pond">S M Pond</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="1997">1997</date>
<idno type="RBID">pubmed:9380062</idno>
<idno type="pmid">9380062</idno>
<idno type="doi">10.1002/mds.870120523</idno>
<idno type="wicri:Area/PubMed/Corpus">004594</idno>
<idno type="wicri:Area/PubMed/Curation">004594</idno>
<idno type="wicri:Area/PubMed/Checkpoint">004713</idno>
<idno type="wicri:Area/Ncbi/Merge">004D89</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Association of a polymorphism in the dopamine-transporter gene with Parkinson's disease.</title>
<author><name sortKey="Le Couteur, D G" sort="Le Couteur, D G" uniqKey="Le Couteur D" first="D G" last="Le Couteur">D G Le Couteur</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Queensland, Department of Medicine, Princess Alexandra Hospital, Woolloongabba, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>University of Queensland, Department of Medicine, Princess Alexandra Hospital, Woolloongabba</wicri:regionArea>
<wicri:noRegion>Woolloongabba</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Leighton, P W" sort="Leighton, P W" uniqKey="Leighton P" first="P W" last="Leighton">P W Leighton</name>
</author>
<author><name sortKey="Mccann, S J" sort="Mccann, S J" uniqKey="Mccann S" first="S J" last="Mccann">S J Mccann</name>
</author>
<author><name sortKey="Pond, S M" sort="Pond, S M" uniqKey="Pond S" first="S M" last="Pond">S M Pond</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="1997" type="published">1997</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age of Onset</term>
<term>Aged</term>
<term>Alleles</term>
<term>Carrier Proteins (genetics)</term>
<term>Case-Control Studies</term>
<term>Chi-Square Distribution</term>
<term>Confidence Intervals</term>
<term>Disease Susceptibility</term>
<term>Dopamine Plasma Membrane Transport Proteins</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Membrane Glycoproteins</term>
<term>Membrane Transport Proteins</term>
<term>Nerve Tissue Proteins</term>
<term>Odds Ratio</term>
<term>Parkinson Disease (genetics)</term>
<term>Polymorphism, Genetic (genetics)</term>
<term>Repetitive Sequences, Nucleic Acid (genetics)</term>
<term>Repetitive Sequences, Nucleic Acid (physiology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Carrier Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term>
<term>Polymorphism, Genetic</term>
<term>Repetitive Sequences, Nucleic Acid</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Repetitive Sequences, Nucleic Acid</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Age of Onset</term>
<term>Aged</term>
<term>Alleles</term>
<term>Case-Control Studies</term>
<term>Chi-Square Distribution</term>
<term>Confidence Intervals</term>
<term>Disease Susceptibility</term>
<term>Dopamine Plasma Membrane Transport Proteins</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Membrane Glycoproteins</term>
<term>Membrane Transport Proteins</term>
<term>Nerve Tissue Proteins</term>
<term>Odds Ratio</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The presynaptic dopamine transporter in nigral dopaminergic neurons confers susceptibility to the cytotoxic effects of the neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Polymorphisms in the dopamine transporter might influence the susceptibility to such toxins. Therefore, we investigated whether a polymorphic region in the 3'-untranslated region of the dopamine-transporter gene is associated with idiopathic Parkinson's disease (PD). The frequency distribution of the alleles was significantly different between the patients (n = 100) and controls (n = 200, p < 0.05). The rare 11-copy allele was more common in the patients (odds ratio = 10.2, 95% confidence interval - 1.2-87.9, p < 0.025). The susceptibility of some people to PD may be conferred by polymorphisms in the dopamine-transporter gene that could lead to increased cellular accumulation of neurotoxic compounds in dopaminergic neurons.</div>
</front>
</TEI>
<pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">9380062</PMID>
<DateCreated><Year>1997</Year>
<Month>11</Month>
<Day>07</Day>
</DateCreated>
<DateCompleted><Year>1997</Year>
<Month>11</Month>
<Day>07</Day>
</DateCompleted>
<DateRevised><Year>2006</Year>
<Month>11</Month>
<Day>15</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN>
<JournalIssue CitedMedium="Print"><Volume>12</Volume>
<Issue>5</Issue>
<PubDate><Year>1997</Year>
<Month>Sep</Month>
</PubDate>
</JournalIssue>
<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
</Journal>
<ArticleTitle>Association of a polymorphism in the dopamine-transporter gene with Parkinson's disease.</ArticleTitle>
<Pagination><MedlinePgn>760-3</MedlinePgn>
</Pagination>
<Abstract><AbstractText>The presynaptic dopamine transporter in nigral dopaminergic neurons confers susceptibility to the cytotoxic effects of the neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Polymorphisms in the dopamine transporter might influence the susceptibility to such toxins. Therefore, we investigated whether a polymorphic region in the 3'-untranslated region of the dopamine-transporter gene is associated with idiopathic Parkinson's disease (PD). The frequency distribution of the alleles was significantly different between the patients (n = 100) and controls (n = 200, p < 0.05). The rare 11-copy allele was more common in the patients (odds ratio = 10.2, 95% confidence interval - 1.2-87.9, p < 0.025). The susceptibility of some people to PD may be conferred by polymorphisms in the dopamine-transporter gene that could lead to increased cellular accumulation of neurotoxic compounds in dopaminergic neurons.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Le Couteur</LastName>
<ForeName>D G</ForeName>
<Initials>DG</Initials>
<AffiliationInfo><Affiliation>University of Queensland, Department of Medicine, Princess Alexandra Hospital, Woolloongabba, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Leighton</LastName>
<ForeName>P W</ForeName>
<Initials>PW</Initials>
</Author>
<Author ValidYN="Y"><LastName>McCann</LastName>
<ForeName>S J</ForeName>
<Initials>SJ</Initials>
</Author>
<Author ValidYN="Y"><LastName>Pond</LastName>
<ForeName>S m</ForeName>
<Initials>Sm</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>UNITED STATES</Country>
<MedlineTA>Mov Disord</MedlineTA>
<NlmUniqueID>8610688</NlmUniqueID>
<ISSNLinking>0885-3185</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D002352">Carrier Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D050483">Dopamine Plasma Membrane Transport Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D008562">Membrane Glycoproteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D026901">Membrane Transport Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D009419">Nerve Tissue Proteins</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D017668">Age of Onset</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D000483">Alleles</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D002352">Carrier Proteins</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D016022">Case-Control Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D016009">Chi-Square Distribution</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D016001">Confidence Intervals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D004198">Disease Susceptibility</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D050483">Dopamine Plasma Membrane Transport Proteins</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D005787">Gene Frequency</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D005838">Genotype</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="Y" UI="D008562">Membrane Glycoproteins</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="Y" UI="D026901">Membrane Transport Proteins</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="Y" UI="D009419">Nerve Tissue Proteins</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D016017">Odds Ratio</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D011110">Polymorphism, Genetic</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D012091">Repetitive Sequences, Nucleic Acid</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1997</Year>
<Month>9</Month>
<Day>26</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>1997</Year>
<Month>9</Month>
<Day>26</Day>
<Hour>0</Hour>
<Minute>1</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>1997</Year>
<Month>9</Month>
<Day>26</Day>
<Hour>0</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">9380062</ArticleId>
<ArticleId IdType="doi">10.1002/mds.870120523</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Australie</li>
</country>
</list>
<tree><noCountry><name sortKey="Leighton, P W" sort="Leighton, P W" uniqKey="Leighton P" first="P W" last="Leighton">P W Leighton</name>
<name sortKey="Mccann, S J" sort="Mccann, S J" uniqKey="Mccann S" first="S J" last="Mccann">S J Mccann</name>
<name sortKey="Pond, S M" sort="Pond, S M" uniqKey="Pond S" first="S M" last="Pond">S M Pond</name>
</noCountry>
<country name="Australie"><noRegion><name sortKey="Le Couteur, D G" sort="Le Couteur, D G" uniqKey="Le Couteur D" first="D G" last="Le Couteur">D G Le Couteur</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004D89 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 004D89 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Ncbi |étape= Merge |type= RBID |clé= pubmed:9380062 |texte= Association of a polymorphism in the dopamine-transporter gene with Parkinson's disease. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:9380062" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \ | NlmPubMed2Wicri -a MovDisordV3
![]() | This area was generated with Dilib version V0.6.23. | ![]() |