The relationship between obsessive-compulsive symptoms and PARKIN genotype: The CORE-PD study.
Identifieur interne : 004161 ( Ncbi/Merge ); précédent : 004160; suivant : 004162The relationship between obsessive-compulsive symptoms and PARKIN genotype: The CORE-PD study.
Auteurs : Madeleine E. Sharp [États-Unis] ; Elise Caccappolo ; Helen Mejia-Santana ; Ming-X Tang ; Llency Rosado ; Martha Orbe Reilly ; Diana Ruiz ; Elan D. Louis ; Cynthia Comella ; Martha Nance ; Susan Bressman ; William K. Scott ; Caroline Tanner ; Cheryl Waters ; Stanley Fahn ; Lucien Cote ; Blair Ford ; Michael Rezak ; Kevin Novak ; Joseph H. Friedman ; Ronald Pfeiffer ; Haydeh Payami ; Eric Molho ; Stuart A. Factor ; John Nutt ; Carmen Serrano ; Maritza Arroyo ; Michael W. Pauciulo ; William C. Nichols ; Lorraine N. Clark ; Roy N. Alcalay ; Karen S. MarderSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
English descriptors
- KwdEn :
- Adult, Age of Onset, Aged, Female, Genetic Predisposition to Disease, Genetic Testing, Genotype, Heterozygote, Humans, Male, Middle Aged, Mutation (genetics), Obsessive-Compulsive Disorder (etiology), Obsessive-Compulsive Disorder (genetics), Parkinson Disease (complications), Parkinson Disease (genetics), Ubiquitin-Protein Ligases (genetics).
- MESH :
- chemical , genetics : Ubiquitin-Protein Ligases.
- complications : Parkinson Disease.
- etiology : Obsessive-Compulsive Disorder.
- genetics : Mutation, Obsessive-Compulsive Disorder, Parkinson Disease.
- Adult, Age of Onset, Aged, Female, Genetic Predisposition to Disease, Genetic Testing, Genotype, Heterozygote, Humans, Male, Middle Aged.
Abstract
Few studies have systematically investigated the association between PARKIN genotype and psychiatric co-morbidities of Parkison's disease (PD). PARKIN-associated PD is characterized by severe nigral dopaminergic neuronal loss, a finding that may have implications for behaviors rooted in dopaminergic circuits such as obsessive-compulsive symptoms (OCS).
DOI: 10.1002/mds.26065
PubMed: 25393808
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000344
- to stream PubMed, to step Curation: 000344
- to stream PubMed, to step Checkpoint: 000033
Links to Exploration step
pubmed:25393808Le document en format XML
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<term>Female</term>
<term>Genetic Predisposition to Disease</term>
<term>Genetic Testing</term>
<term>Genotype</term>
<term>Heterozygote</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Mutation (genetics)</term>
<term>Obsessive-Compulsive Disorder (etiology)</term>
<term>Obsessive-Compulsive Disorder (genetics)</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (genetics)</term>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Mutation</term>
<term>Obsessive-Compulsive Disorder</term>
<term>Parkinson Disease</term>
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<term>Age of Onset</term>
<term>Aged</term>
<term>Female</term>
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<term>Genetic Testing</term>
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<front><div type="abstract" xml:lang="en">Few studies have systematically investigated the association between PARKIN genotype and psychiatric co-morbidities of Parkison's disease (PD). PARKIN-associated PD is characterized by severe nigral dopaminergic neuronal loss, a finding that may have implications for behaviors rooted in dopaminergic circuits such as obsessive-compulsive symptoms (OCS).</div>
</front>
</TEI>
<pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">25393808</PMID>
<DateCreated><Year>2015</Year>
<Month>02</Month>
<Day>04</Day>
</DateCreated>
<DateCompleted><Year>2015</Year>
<Month>10</Month>
<Day>22</Day>
</DateCompleted>
<DateRevised><Year>2015</Year>
<Month>07</Month>
<Day>10</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>30</Volume>
<Issue>2</Issue>
<PubDate><Year>2015</Year>
<Month>Feb</Month>
</PubDate>
</JournalIssue>
<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
</Journal>
<ArticleTitle>The relationship between obsessive-compulsive symptoms and PARKIN genotype: The CORE-PD study.</ArticleTitle>
<Pagination><MedlinePgn>278-83</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.26065</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Few studies have systematically investigated the association between PARKIN genotype and psychiatric co-morbidities of Parkison's disease (PD). PARKIN-associated PD is characterized by severe nigral dopaminergic neuronal loss, a finding that may have implications for behaviors rooted in dopaminergic circuits such as obsessive-compulsive symptoms (OCS).</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">The Schedule of Compulsions and Obsessions Patient Inventory (SCOPI) was administered to 104 patients with early-onset PD and 257 asymptomatic first-degree relatives. Carriers of one and two PARKIN mutations were compared with noncarriers.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Among patients, carriers scored lower than noncarriers in adjusted models (one-mutation: 13.9 point difference, P = 0.03; two-mutation: 24.1, P = 0.001), where lower scores indicate less OCS. Among asymptomatic relatives, a trend toward the opposite was seen: mutation carriers scored higher than noncarriers (one mutation, P = 0.05; two mutations, P = 0.13).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">First, a significant association was found between PARKIN mutation status and obsessive-compulsive symptom level in both PD and asymptomatic patients, suggesting that OCS might represent an early non-motor dopamine-dependent feature. Second, irrespective of disease status, heterozygotes were significantly different from noncarriers, suggesting that PARKIN heterozygosity may contribute to phenotype. © 2014 International Parkinson and Movement Disorder Society.</AbstractText>
<CopyrightInformation>© 2014 International Parkinson and Movement Disorder Society.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sharp</LastName>
<ForeName>Madeleine E</ForeName>
<Initials>ME</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Caccappolo</LastName>
<ForeName>Elise</ForeName>
<Initials>E</Initials>
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<Author ValidYN="Y"><LastName>Mejia-Santana</LastName>
<ForeName>Helen</ForeName>
<Initials>H</Initials>
</Author>
<Author ValidYN="Y"><LastName>Tang</LastName>
<ForeName>Ming-X</ForeName>
<Initials>MX</Initials>
</Author>
<Author ValidYN="Y"><LastName>Rosado</LastName>
<ForeName>Llency</ForeName>
<Initials>L</Initials>
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<Author ValidYN="Y"><LastName>Orbe Reilly</LastName>
<ForeName>Martha</ForeName>
<Initials>M</Initials>
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<Author ValidYN="Y"><LastName>Ruiz</LastName>
<ForeName>Diana</ForeName>
<Initials>D</Initials>
</Author>
<Author ValidYN="Y"><LastName>Louis</LastName>
<ForeName>Elan D</ForeName>
<Initials>ED</Initials>
</Author>
<Author ValidYN="Y"><LastName>Comella</LastName>
<ForeName>Cynthia</ForeName>
<Initials>C</Initials>
</Author>
<Author ValidYN="Y"><LastName>Nance</LastName>
<ForeName>Martha</ForeName>
<Initials>M</Initials>
</Author>
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<ForeName>Susan</ForeName>
<Initials>S</Initials>
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<Author ValidYN="Y"><LastName>Scott</LastName>
<ForeName>William K</ForeName>
<Initials>WK</Initials>
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<Author ValidYN="Y"><LastName>Tanner</LastName>
<ForeName>Caroline</ForeName>
<Initials>C</Initials>
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<ForeName>Cheryl</ForeName>
<Initials>C</Initials>
</Author>
<Author ValidYN="Y"><LastName>Fahn</LastName>
<ForeName>Stanley</ForeName>
<Initials>S</Initials>
</Author>
<Author ValidYN="Y"><LastName>Cote</LastName>
<ForeName>Lucien</ForeName>
<Initials>L</Initials>
</Author>
<Author ValidYN="Y"><LastName>Ford</LastName>
<ForeName>Blair</ForeName>
<Initials>B</Initials>
</Author>
<Author ValidYN="Y"><LastName>Rezak</LastName>
<ForeName>Michael</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Novak</LastName>
<ForeName>Kevin</ForeName>
<Initials>K</Initials>
</Author>
<Author ValidYN="Y"><LastName>Friedman</LastName>
<ForeName>Joseph H</ForeName>
<Initials>JH</Initials>
</Author>
<Author ValidYN="Y"><LastName>Pfeiffer</LastName>
<ForeName>Ronald</ForeName>
<Initials>R</Initials>
</Author>
<Author ValidYN="Y"><LastName>Payami</LastName>
<ForeName>Haydeh</ForeName>
<Initials>H</Initials>
</Author>
<Author ValidYN="Y"><LastName>Molho</LastName>
<ForeName>Eric</ForeName>
<Initials>E</Initials>
</Author>
<Author ValidYN="Y"><LastName>Factor</LastName>
<ForeName>Stuart A</ForeName>
<Initials>SA</Initials>
</Author>
<Author ValidYN="Y"><LastName>Nutt</LastName>
<ForeName>John</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y"><LastName>Serrano</LastName>
<ForeName>Carmen</ForeName>
<Initials>C</Initials>
</Author>
<Author ValidYN="Y"><LastName>Arroyo</LastName>
<ForeName>Maritza</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Pauciulo</LastName>
<ForeName>Michael W</ForeName>
<Initials>MW</Initials>
</Author>
<Author ValidYN="Y"><LastName>Nichols</LastName>
<ForeName>William C</ForeName>
<Initials>WC</Initials>
</Author>
<Author ValidYN="Y"><LastName>Clark</LastName>
<ForeName>Lorraine N</ForeName>
<Initials>LN</Initials>
</Author>
<Author ValidYN="Y"><LastName>Alcalay</LastName>
<ForeName>Roy N</ForeName>
<Initials>RN</Initials>
</Author>
<Author ValidYN="Y"><LastName>Marder</LastName>
<ForeName>Karen S</ForeName>
<Initials>KS</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>K02 NS080915</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>K02NS080915</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>NS036630</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>NS050487</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
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