The relationship between obsessive-compulsive symptoms and PARKIN genotype: The CORE-PD study.
Identifieur interne : 000344 ( PubMed/Curation ); précédent : 000343; suivant : 000345The relationship between obsessive-compulsive symptoms and PARKIN genotype: The CORE-PD study.
Auteurs : Madeleine E. Sharp [États-Unis] ; Elise Caccappolo ; Helen Mejia-Santana ; Ming-X Tang ; Llency Rosado ; Martha Orbe Reilly ; Diana Ruiz ; Elan D. Louis ; Cynthia Comella ; Martha Nance ; Susan Bressman ; William K. Scott ; Caroline Tanner ; Cheryl Waters ; Stanley Fahn ; Lucien Cote ; Blair Ford ; Michael Rezak ; Kevin Novak ; Joseph H. Friedman ; Ronald Pfeiffer ; Haydeh Payami ; Eric Molho ; Stuart A. Factor ; John Nutt ; Carmen Serrano ; Maritza Arroyo ; Michael W. Pauciulo ; William C. Nichols ; Lorraine N. Clark ; Roy N. Alcalay ; Karen S. MarderSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
English descriptors
- KwdEn :
- Adult, Age of Onset, Aged, Female, Genetic Predisposition to Disease, Genetic Testing, Genotype, Heterozygote, Humans, Male, Middle Aged, Mutation (genetics), Obsessive-Compulsive Disorder (etiology), Obsessive-Compulsive Disorder (genetics), Parkinson Disease (complications), Parkinson Disease (genetics), Ubiquitin-Protein Ligases (genetics).
- MESH :
- chemical , genetics : Ubiquitin-Protein Ligases.
- complications : Parkinson Disease.
- etiology : Obsessive-Compulsive Disorder.
- genetics : Mutation, Obsessive-Compulsive Disorder, Parkinson Disease.
- Adult, Age of Onset, Aged, Female, Genetic Predisposition to Disease, Genetic Testing, Genotype, Heterozygote, Humans, Male, Middle Aged.
Abstract
Few studies have systematically investigated the association between PARKIN genotype and psychiatric co-morbidities of Parkison's disease (PD). PARKIN-associated PD is characterized by severe nigral dopaminergic neuronal loss, a finding that may have implications for behaviors rooted in dopaminergic circuits such as obsessive-compulsive symptoms (OCS).
DOI: 10.1002/mds.26065
PubMed: 25393808
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Sharp</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea></affiliation></author><author><name sortKey="Caccappolo, Elise" sort="Caccappolo, Elise" uniqKey="Caccappolo E" first="Elise" last="Caccappolo">Elise Caccappolo</name></author><author><name sortKey="Mejia Santana, Helen" sort="Mejia Santana, Helen" uniqKey="Mejia Santana H" first="Helen" last="Mejia-Santana">Helen Mejia-Santana</name></author><author><name sortKey="Tang, Ming X" sort="Tang, Ming X" uniqKey="Tang M" first="Ming-X" last="Tang">Ming-X Tang</name></author><author><name sortKey="Rosado, Llency" sort="Rosado, Llency" uniqKey="Rosado L" first="Llency" last="Rosado">Llency Rosado</name></author><author><name sortKey="Orbe Reilly, Martha" sort="Orbe Reilly, Martha" uniqKey="Orbe Reilly M" first="Martha" last="Orbe Reilly">Martha Orbe Reilly</name></author><author><name sortKey="Ruiz, Diana" sort="Ruiz, Diana" uniqKey="Ruiz D" first="Diana" last="Ruiz">Diana Ruiz</name></author><author><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D" last="Louis">Elan D. 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Friedman</name></author><author><name sortKey="Pfeiffer, Ronald" sort="Pfeiffer, Ronald" uniqKey="Pfeiffer R" first="Ronald" last="Pfeiffer">Ronald Pfeiffer</name></author><author><name sortKey="Payami, Haydeh" sort="Payami, Haydeh" uniqKey="Payami H" first="Haydeh" last="Payami">Haydeh Payami</name></author><author><name sortKey="Molho, Eric" sort="Molho, Eric" uniqKey="Molho E" first="Eric" last="Molho">Eric Molho</name></author><author><name sortKey="Factor, Stuart A" sort="Factor, Stuart A" uniqKey="Factor S" first="Stuart A" last="Factor">Stuart A. Factor</name></author><author><name sortKey="Nutt, John" sort="Nutt, John" uniqKey="Nutt J" first="John" last="Nutt">John Nutt</name></author><author><name sortKey="Serrano, Carmen" sort="Serrano, Carmen" uniqKey="Serrano C" first="Carmen" last="Serrano">Carmen Serrano</name></author><author><name sortKey="Arroyo, Maritza" sort="Arroyo, Maritza" uniqKey="Arroyo M" first="Maritza" last="Arroyo">Maritza Arroyo</name></author><author><name sortKey="Pauciulo, Michael W" sort="Pauciulo, Michael W" uniqKey="Pauciulo M" first="Michael W" last="Pauciulo">Michael W. Pauciulo</name></author><author><name sortKey="Nichols, William C" sort="Nichols, William C" uniqKey="Nichols W" first="William C" last="Nichols">William C. Nichols</name></author><author><name sortKey="Clark, Lorraine N" sort="Clark, Lorraine N" uniqKey="Clark L" first="Lorraine N" last="Clark">Lorraine N. Clark</name></author><author><name sortKey="Alcalay, Roy N" sort="Alcalay, Roy N" uniqKey="Alcalay R" first="Roy N" last="Alcalay">Roy N. Alcalay</name></author><author><name sortKey="Marder, Karen S" sort="Marder, Karen S" uniqKey="Marder K" first="Karen S" last="Marder">Karen S. Marder</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25393808</idno><idno type="pmid">25393808</idno><idno type="doi">10.1002/mds.26065</idno><idno type="wicri:Area/PubMed/Corpus">000344</idno><idno type="wicri:Area/PubMed/Curation">000344</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The relationship between obsessive-compulsive symptoms and PARKIN genotype: The CORE-PD study.</title><author><name sortKey="Sharp, Madeleine E" sort="Sharp, Madeleine E" uniqKey="Sharp M" first="Madeleine E" last="Sharp">Madeleine E. Sharp</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea></affiliation></author><author><name sortKey="Caccappolo, Elise" sort="Caccappolo, Elise" uniqKey="Caccappolo E" first="Elise" last="Caccappolo">Elise Caccappolo</name></author><author><name sortKey="Mejia Santana, Helen" sort="Mejia Santana, Helen" uniqKey="Mejia Santana H" first="Helen" last="Mejia-Santana">Helen Mejia-Santana</name></author><author><name sortKey="Tang, Ming X" sort="Tang, Ming X" uniqKey="Tang M" first="Ming-X" last="Tang">Ming-X Tang</name></author><author><name sortKey="Rosado, Llency" sort="Rosado, Llency" uniqKey="Rosado L" first="Llency" last="Rosado">Llency Rosado</name></author><author><name sortKey="Orbe Reilly, Martha" sort="Orbe Reilly, Martha" uniqKey="Orbe Reilly M" first="Martha" last="Orbe Reilly">Martha Orbe Reilly</name></author><author><name sortKey="Ruiz, Diana" sort="Ruiz, Diana" uniqKey="Ruiz D" first="Diana" last="Ruiz">Diana Ruiz</name></author><author><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D" last="Louis">Elan D. Louis</name></author><author><name sortKey="Comella, Cynthia" sort="Comella, Cynthia" uniqKey="Comella C" first="Cynthia" last="Comella">Cynthia Comella</name></author><author><name sortKey="Nance, Martha" sort="Nance, Martha" uniqKey="Nance M" first="Martha" last="Nance">Martha Nance</name></author><author><name sortKey="Bressman, Susan" sort="Bressman, Susan" uniqKey="Bressman S" first="Susan" last="Bressman">Susan Bressman</name></author><author><name sortKey="Scott, William K" sort="Scott, William K" uniqKey="Scott W" first="William K" last="Scott">William K. Scott</name></author><author><name sortKey="Tanner, Caroline" sort="Tanner, Caroline" uniqKey="Tanner C" first="Caroline" last="Tanner">Caroline Tanner</name></author><author><name sortKey="Waters, Cheryl" sort="Waters, Cheryl" uniqKey="Waters C" first="Cheryl" last="Waters">Cheryl Waters</name></author><author><name sortKey="Fahn, Stanley" sort="Fahn, Stanley" uniqKey="Fahn S" first="Stanley" last="Fahn">Stanley Fahn</name></author><author><name sortKey="Cote, Lucien" sort="Cote, Lucien" uniqKey="Cote L" first="Lucien" last="Cote">Lucien Cote</name></author><author><name sortKey="Ford, Blair" sort="Ford, Blair" uniqKey="Ford B" first="Blair" last="Ford">Blair Ford</name></author><author><name sortKey="Rezak, Michael" sort="Rezak, Michael" uniqKey="Rezak M" first="Michael" last="Rezak">Michael Rezak</name></author><author><name sortKey="Novak, Kevin" sort="Novak, Kevin" uniqKey="Novak K" first="Kevin" last="Novak">Kevin Novak</name></author><author><name sortKey="Friedman, Joseph H" sort="Friedman, Joseph H" uniqKey="Friedman J" first="Joseph H" last="Friedman">Joseph H. Friedman</name></author><author><name sortKey="Pfeiffer, Ronald" sort="Pfeiffer, Ronald" uniqKey="Pfeiffer R" first="Ronald" last="Pfeiffer">Ronald Pfeiffer</name></author><author><name sortKey="Payami, Haydeh" sort="Payami, Haydeh" uniqKey="Payami H" first="Haydeh" last="Payami">Haydeh Payami</name></author><author><name sortKey="Molho, Eric" sort="Molho, Eric" uniqKey="Molho E" first="Eric" last="Molho">Eric Molho</name></author><author><name sortKey="Factor, Stuart A" sort="Factor, Stuart A" uniqKey="Factor S" first="Stuart A" last="Factor">Stuart A. Factor</name></author><author><name sortKey="Nutt, John" sort="Nutt, John" uniqKey="Nutt J" first="John" last="Nutt">John Nutt</name></author><author><name sortKey="Serrano, Carmen" sort="Serrano, Carmen" uniqKey="Serrano C" first="Carmen" last="Serrano">Carmen Serrano</name></author><author><name sortKey="Arroyo, Maritza" sort="Arroyo, Maritza" uniqKey="Arroyo M" first="Maritza" last="Arroyo">Maritza Arroyo</name></author><author><name sortKey="Pauciulo, Michael W" sort="Pauciulo, Michael W" uniqKey="Pauciulo M" first="Michael W" last="Pauciulo">Michael W. Pauciulo</name></author><author><name sortKey="Nichols, William C" sort="Nichols, William C" uniqKey="Nichols W" first="William C" last="Nichols">William C. Nichols</name></author><author><name sortKey="Clark, Lorraine N" sort="Clark, Lorraine N" uniqKey="Clark L" first="Lorraine N" last="Clark">Lorraine N. Clark</name></author><author><name sortKey="Alcalay, Roy N" sort="Alcalay, Roy N" uniqKey="Alcalay R" first="Roy N" last="Alcalay">Roy N. Alcalay</name></author><author><name sortKey="Marder, Karen S" sort="Marder, Karen S" uniqKey="Marder K" first="Karen S" last="Marder">Karen S. Marder</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Age of Onset</term><term>Aged</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Genetic Testing</term><term>Genotype</term><term>Heterozygote</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Mutation (genetics)</term><term>Obsessive-Compulsive Disorder (etiology)</term><term>Obsessive-Compulsive Disorder (genetics)</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (genetics)</term><term>Ubiquitin-Protein Ligases (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Ubiquitin-Protein Ligases</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Obsessive-Compulsive Disorder</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Mutation</term><term>Obsessive-Compulsive Disorder</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age of Onset</term><term>Aged</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Genetic Testing</term><term>Genotype</term><term>Heterozygote</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Few studies have systematically investigated the association between PARKIN genotype and psychiatric co-morbidities of Parkison's disease (PD). PARKIN-associated PD is characterized by severe nigral dopaminergic neuronal loss, a finding that may have implications for behaviors rooted in dopaminergic circuits such as obsessive-compulsive symptoms (OCS).</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">25393808</PMID><DateCreated><Year>2015</Year><Month>02</Month><Day>04</Day></DateCreated><DateCompleted><Year>2015</Year><Month>10</Month><Day>22</Day></DateCompleted><DateRevised><Year>2015</Year><Month>07</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>30</Volume><Issue>2</Issue><PubDate><Year>2015</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>The relationship between obsessive-compulsive symptoms and PARKIN genotype: The CORE-PD study.</ArticleTitle><Pagination><MedlinePgn>278-83</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.26065</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Few studies have systematically investigated the association between PARKIN genotype and psychiatric co-morbidities of Parkison's disease (PD). PARKIN-associated PD is characterized by severe nigral dopaminergic neuronal loss, a finding that may have implications for behaviors rooted in dopaminergic circuits such as obsessive-compulsive symptoms (OCS).</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The Schedule of Compulsions and Obsessions Patient Inventory (SCOPI) was administered to 104 patients with early-onset PD and 257 asymptomatic first-degree relatives. Carriers of one and two PARKIN mutations were compared with noncarriers.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Among patients, carriers scored lower than noncarriers in adjusted models (one-mutation: 13.9 point difference, P = 0.03; two-mutation: 24.1, P = 0.001), where lower scores indicate less OCS. Among asymptomatic relatives, a trend toward the opposite was seen: mutation carriers scored higher than noncarriers (one mutation, P = 0.05; two mutations, P = 0.13).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">First, a significant association was found between PARKIN mutation status and obsessive-compulsive symptom level in both PD and asymptomatic patients, suggesting that OCS might represent an early non-motor dopamine-dependent feature. Second, irrespective of disease status, heterozygotes were significantly different from noncarriers, suggesting that PARKIN heterozygosity may contribute to phenotype. © 2014 International Parkinson and Movement Disorder Society.</AbstractText><CopyrightInformation>© 2014 International Parkinson and Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sharp</LastName><ForeName>Madeleine E</ForeName><Initials>ME</Initials><AffiliationInfo><Affiliation>Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Caccappolo</LastName><ForeName>Elise</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Mejia-Santana</LastName><ForeName>Helen</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Ming-X</ForeName><Initials>MX</Initials></Author><Author ValidYN="Y"><LastName>Rosado</LastName><ForeName>Llency</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Orbe Reilly</LastName><ForeName>Martha</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Ruiz</LastName><ForeName>Diana</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Louis</LastName><ForeName>Elan D</ForeName><Initials>ED</Initials></Author><Author ValidYN="Y"><LastName>Comella</LastName><ForeName>Cynthia</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Nance</LastName><ForeName>Martha</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Bressman</LastName><ForeName>Susan</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Scott</LastName><ForeName>William K</ForeName><Initials>WK</Initials></Author><Author ValidYN="Y"><LastName>Tanner</LastName><ForeName>Caroline</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Waters</LastName><ForeName>Cheryl</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Fahn</LastName><ForeName>Stanley</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Cote</LastName><ForeName>Lucien</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Ford</LastName><ForeName>Blair</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Rezak</LastName><ForeName>Michael</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Novak</LastName><ForeName>Kevin</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Friedman</LastName><ForeName>Joseph H</ForeName><Initials>JH</Initials></Author><Author ValidYN="Y"><LastName>Pfeiffer</LastName><ForeName>Ronald</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Payami</LastName><ForeName>Haydeh</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Molho</LastName><ForeName>Eric</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Factor</LastName><ForeName>Stuart A</ForeName><Initials>SA</Initials></Author><Author ValidYN="Y"><LastName>Nutt</LastName><ForeName>John</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Serrano</LastName><ForeName>Carmen</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Arroyo</LastName><ForeName>Maritza</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Pauciulo</LastName><ForeName>Michael W</ForeName><Initials>MW</Initials></Author><Author ValidYN="Y"><LastName>Nichols</LastName><ForeName>William C</ForeName><Initials>WC</Initials></Author><Author ValidYN="Y"><LastName>Clark</LastName><ForeName>Lorraine N</ForeName><Initials>LN</Initials></Author><Author ValidYN="Y"><LastName>Alcalay</LastName><ForeName>Roy N</ForeName><Initials>RN</Initials></Author><Author ValidYN="Y"><LastName>Marder</LastName><ForeName>Karen S</ForeName><Initials>KS</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>K02 NS080915</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>K02NS080915</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>NS036630</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>NS050487</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>NS36960</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P50 NS039764</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P50 NS071674</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P50 NS071674</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 NS036630</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R56 NS036630</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>RR024156</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>TL1 RR024158</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>11</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>EC 6.3.2.19</RegistryNumber><NameOfSubstance UI="D044767">Ubiquitin-Protein Ligases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 6.3.2.19</RegistryNumber><NameOfSubstance UI="C111567">parkin protein</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 2001 Mar;49(3):367-76</RefSource><PMID Version="1">11261512</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biol Psychiatry. 2014 Apr 15;75(8):595-605</RefSource><PMID Version="1">24314349</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain. 2003 Jun;126(Pt 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Version="1">11911988</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D017668">Age of Onset</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D020022">Genetic Predisposition to Disease</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005820">Genetic Testing</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005838">Genotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006579">Heterozygote</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009154">Mutation</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009771">Obsessive-Compulsive Disorder</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000209">etiology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000150">complications</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D044767">Ubiquitin-Protein Ligases</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">NIHMS634055 [Available on 02/01/16]</OtherID><OtherID Source="NLM">PMC4318772 [Available on 02/01/16]</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Parkinson's</Keyword><Keyword MajorTopicYN="N">neuropsychological</Keyword><Keyword MajorTopicYN="N">obsessive-compulsive</Keyword><Keyword MajorTopicYN="N">parkin</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>5</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>8</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>9</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2014</Year><Month>11</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>11</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>11</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>10</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pmc-release"><Year>2016</Year><Month>2</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25393808</ArticleId><ArticleId IdType="doi">10.1002/mds.26065</ArticleId><ArticleId IdType="pmc">PMC4318772</ArticleId><ArticleId IdType="mid">NIHMS634055</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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