Coordinated reset neuromodulation for Parkinson's disease: Proof-of-concept study
Identifieur interne : 004036 ( Ncbi/Merge ); précédent : 004035; suivant : 004037Coordinated reset neuromodulation for Parkinson's disease: Proof-of-concept study
Auteurs : Ilya Adamchic [Allemagne] ; Christian Hauptmann [Allemagne] ; Utako Brigit Barnikol [Allemagne] ; Norbert Pawelczyk [Allemagne] ; Oleksandr Popovych [Allemagne] ; Thomas Theo Barnikol [Allemagne] ; Alexander Silchenko [Allemagne] ; Jens Volkmann [Allemagne] ; Günter Deuschl [Allemagne] ; Wassilios G. Meissner [France] ; Mohammad Maarouf [Allemagne] ; Volker Sturm [Allemagne] ; Hans-Joachim Freund [Allemagne] ; Peter Alexander Tass [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2014.
English descriptors
- KwdEn :
- Aged, Biophysical Phenomena, Deep Brain Stimulation (methods), Electrodes, Implanted, Evoked Potentials (physiology), Female, Humans, Male, Middle Aged, Motor Activity (physiology), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Prospective Studies, Subthalamic Nucleus (physiology).
- MESH :
- methods : Deep Brain Stimulation.
- physiology : Evoked Potentials, Motor Activity, Subthalamic Nucleus.
- physiopathology : Parkinson Disease.
- therapy : Parkinson Disease.
- Aged, Biophysical Phenomena, Electrodes, Implanted, Female, Humans, Male, Middle Aged, Prospective Studies.
Abstract
The discovery of abnormal synchronization of neuronal activity in the basal ganglia in Parkinson's disease (PD) has prompted the development of novel neuromodulation paradigms. Coordinated reset neuromodulation intends to specifically counteract excessive synchronization and to induce cumulative unlearning of pathological synaptic connectivity and neuronal synchrony.
In this prospective case series, six PD patients were evaluated before and after coordinated reset neuromodulation according to a standardized protocol that included both electrophysiological recordings and clinical assessments.
Coordinated reset neuromodulation of the subthalamic nucleus (STN) applied to six PD patients in an externalized setting during three stimulation days induced a significant and cumulative reduction of beta band activity that correlated with a significant improvement of motor function.
These results highlight the potential effects of coordinated reset neuromodulation of the STN in PD patients and encourage further development of this approach as an alternative to conventional high-frequency deep brain stimulation in PD. © 2014 The Authors.
Url:
DOI: 10.1002/mds.25923
PubMed: 24976001
PubMed Central: 4282372
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PMC:4282372Le document en format XML
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<author><name sortKey="Popovych, Oleksandr" sort="Popovych, Oleksandr" uniqKey="Popovych O" first="Oleksandr" last="Popovych">Oleksandr Popovych</name>
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<series><title level="j">Movement Disorders</title>
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<term>Evoked Potentials (physiology)</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Motor Activity (physiology)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (therapy)</term>
<term>Prospective Studies</term>
<term>Subthalamic Nucleus (physiology)</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Evoked Potentials</term>
<term>Motor Activity</term>
<term>Subthalamic Nucleus</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Biophysical Phenomena</term>
<term>Electrodes, Implanted</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Prospective Studies</term>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>The discovery of abnormal synchronization of neuronal activity in the basal ganglia in Parkinson's disease (PD) has prompted the development of novel neuromodulation paradigms. Coordinated reset neuromodulation intends to specifically counteract excessive synchronization and to induce cumulative unlearning of pathological synaptic connectivity and neuronal synchrony.</p>
</sec>
<sec><title>Methods</title>
<p>In this prospective case series, six PD patients were evaluated before and after coordinated reset neuromodulation according to a standardized protocol that included both electrophysiological recordings and clinical assessments.</p>
</sec>
<sec><title>Results</title>
<p>Coordinated reset neuromodulation of the subthalamic nucleus (STN) applied to six PD patients in an externalized setting during three stimulation days induced a significant and cumulative reduction of beta band activity that correlated with a significant improvement of motor function.</p>
</sec>
<sec><title>Conclusions</title>
<p>These results highlight the potential effects of coordinated reset neuromodulation of the STN in PD patients and encourage further development of this approach as an alternative to conventional high-frequency deep brain stimulation in PD. © 2014 The Authors. <italic>Movement</italic>
Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.</p>
</sec>
</div>
</front>
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</analytic>
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<biblStruct><analytic><author><name sortKey="Tass, Pa" uniqKey="Tass P">PA Tass</name>
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<biblStruct></biblStruct>
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</biblStruct>
<biblStruct><analytic><author><name sortKey="Fahn, S" uniqKey="Fahn S">S Fahn</name>
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</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hauptmann, C" uniqKey="Hauptmann C">C Hauptmann</name>
</author>
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<biblStruct><analytic><author><name sortKey="Tass, Pa" uniqKey="Tass P">PA Tass</name>
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</biblStruct>
</listBibl>
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<double pmid="24976001"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Coordinated reset neuromodulation for Parkinson's disease: Proof-of-concept study</title>
<author><name sortKey="Adamchic, Ilya" sort="Adamchic, Ilya" uniqKey="Adamchic I" first="Ilya" last="Adamchic">Ilya Adamchic</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Institute of Neuroscience and Medicine-Neuromodulation, Jülich Research Center</institution>
<addr-line>Jülich, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Jülich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hauptmann, Christian" sort="Hauptmann, Christian" uniqKey="Hauptmann C" first="Christian" last="Hauptmann">Christian Hauptmann</name>
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<addr-line>Jülich, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Jülich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Barnikol, Utako Brigit" sort="Barnikol, Utako Brigit" uniqKey="Barnikol U" first="Utako Brigit" last="Barnikol">Utako Brigit Barnikol</name>
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<addr-line>Jülich, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Jülich</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Neuromodulation, University of Cologne</institution>
<addr-line>Cologne, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au3"><institution>Department of Child- and Adolescent Psychiatry, University of Cologne</institution>
<addr-line>Cologne, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au4"><institution>Clinic for Stereotactic and Functional Neurosurgery, University of Cologne</institution>
<addr-line>Cologne, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pawelczyk, Norbert" sort="Pawelczyk, Norbert" uniqKey="Pawelczyk N" first="Norbert" last="Pawelczyk">Norbert Pawelczyk</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Institute of Neuroscience and Medicine-Neuromodulation, Jülich Research Center</institution>
<addr-line>Jülich, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Jülich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Popovych, Oleksandr" sort="Popovych, Oleksandr" uniqKey="Popovych O" first="Oleksandr" last="Popovych">Oleksandr Popovych</name>
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<addr-line>Jülich, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Jülich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Barnikol, Thomas Theo" sort="Barnikol, Thomas Theo" uniqKey="Barnikol T" first="Thomas Theo" last="Barnikol">Thomas Theo Barnikol</name>
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<addr-line>Jülich, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Jülich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Silchenko, Alexander" sort="Silchenko, Alexander" uniqKey="Silchenko A" first="Alexander" last="Silchenko">Alexander Silchenko</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Institute of Neuroscience and Medicine-Neuromodulation, Jülich Research Center</institution>
<addr-line>Jülich, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Jülich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name>
<affiliation wicri:level="1"><nlm:aff id="au5"><institution>Department of Neurology, University Würzburg</institution>
<addr-line>Würzburg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Deuschl, Gunter" sort="Deuschl, Gunter" uniqKey="Deuschl G" first="Günter" last="Deuschl">Günter Deuschl</name>
<affiliation wicri:level="1"><nlm:aff id="au6"><institution>Department of Neurology, University Kiel</institution>
<addr-line>Kiel, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Kiel</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Meissner, Wassilios G" sort="Meissner, Wassilios G" uniqKey="Meissner W" first="Wassilios G" last="Meissner">Wassilios G. Meissner</name>
<affiliation wicri:level="1"><nlm:aff id="au7"><institution>Institut des Maladies Neurodégénératives, Univ. de Bordeaux</institution>
<addr-line>Bordeaux, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Bordeaux</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au8"><institution>CNRS Institut des Maladies Neurodégénératives</institution>
<addr-line>Bordeaux, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Bordeaux</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au9"><institution>Service de Neurologie, CHU de Bordeaux</institution>
<addr-line>Pessac, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Pessac</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au10"><institution>Centre de référence atrophie multisystématisée, CHU de Bordeaux</institution>
<addr-line>Pessac, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Pessac</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Maarouf, Mohammad" sort="Maarouf, Mohammad" uniqKey="Maarouf M" first="Mohammad" last="Maarouf">Mohammad Maarouf</name>
<affiliation wicri:level="1"><nlm:aff id="au4"><institution>Clinic for Stereotactic and Functional Neurosurgery, University of Cologne</institution>
<addr-line>Cologne, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sturm, Volker" sort="Sturm, Volker" uniqKey="Sturm V" first="Volker" last="Sturm">Volker Sturm</name>
<affiliation wicri:level="1"><nlm:aff id="au4"><institution>Clinic for Stereotactic and Functional Neurosurgery, University of Cologne</institution>
<addr-line>Cologne, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au5"><institution>Department of Neurology, University Würzburg</institution>
<addr-line>Würzburg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Freund, Hans Joachim" sort="Freund, Hans Joachim" uniqKey="Freund H" first="Hans-Joachim" last="Freund">Hans-Joachim Freund</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Institute of Neuroscience and Medicine-Neuromodulation, Jülich Research Center</institution>
<addr-line>Jülich, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Jülich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tass, Peter Alexander" sort="Tass, Peter Alexander" uniqKey="Tass P" first="Peter Alexander" last="Tass">Peter Alexander Tass</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Institute of Neuroscience and Medicine-Neuromodulation, Jülich Research Center</institution>
<addr-line>Jülich, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Jülich</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Neuromodulation, University of Cologne</institution>
<addr-line>Cologne, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au4"><institution>Clinic for Stereotactic and Functional Neurosurgery, University of Cologne</institution>
<addr-line>Cologne, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Cologne</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">24976001</idno>
<idno type="pmc">4282372</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282372</idno>
<idno type="RBID">PMC:4282372</idno>
<idno type="doi">10.1002/mds.25923</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">000453</idno>
<idno type="wicri:Area/Pmc/Curation">000453</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000040</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Coordinated reset neuromodulation for Parkinson's disease: Proof-of-concept study</title>
<author><name sortKey="Adamchic, Ilya" sort="Adamchic, Ilya" uniqKey="Adamchic I" first="Ilya" last="Adamchic">Ilya Adamchic</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Institute of Neuroscience and Medicine-Neuromodulation, Jülich Research Center</institution>
<addr-line>Jülich, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Jülich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hauptmann, Christian" sort="Hauptmann, Christian" uniqKey="Hauptmann C" first="Christian" last="Hauptmann">Christian Hauptmann</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Institute of Neuroscience and Medicine-Neuromodulation, Jülich Research Center</institution>
<addr-line>Jülich, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Jülich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Barnikol, Utako Brigit" sort="Barnikol, Utako Brigit" uniqKey="Barnikol U" first="Utako Brigit" last="Barnikol">Utako Brigit Barnikol</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Institute of Neuroscience and Medicine-Neuromodulation, Jülich Research Center</institution>
<addr-line>Jülich, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Jülich</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Neuromodulation, University of Cologne</institution>
<addr-line>Cologne, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au3"><institution>Department of Child- and Adolescent Psychiatry, University of Cologne</institution>
<addr-line>Cologne, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au4"><institution>Clinic for Stereotactic and Functional Neurosurgery, University of Cologne</institution>
<addr-line>Cologne, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pawelczyk, Norbert" sort="Pawelczyk, Norbert" uniqKey="Pawelczyk N" first="Norbert" last="Pawelczyk">Norbert Pawelczyk</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Institute of Neuroscience and Medicine-Neuromodulation, Jülich Research Center</institution>
<addr-line>Jülich, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Jülich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Popovych, Oleksandr" sort="Popovych, Oleksandr" uniqKey="Popovych O" first="Oleksandr" last="Popovych">Oleksandr Popovych</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Institute of Neuroscience and Medicine-Neuromodulation, Jülich Research Center</institution>
<addr-line>Jülich, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Jülich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Barnikol, Thomas Theo" sort="Barnikol, Thomas Theo" uniqKey="Barnikol T" first="Thomas Theo" last="Barnikol">Thomas Theo Barnikol</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Institute of Neuroscience and Medicine-Neuromodulation, Jülich Research Center</institution>
<addr-line>Jülich, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Jülich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Silchenko, Alexander" sort="Silchenko, Alexander" uniqKey="Silchenko A" first="Alexander" last="Silchenko">Alexander Silchenko</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Institute of Neuroscience and Medicine-Neuromodulation, Jülich Research Center</institution>
<addr-line>Jülich, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Jülich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name>
<affiliation wicri:level="1"><nlm:aff id="au5"><institution>Department of Neurology, University Würzburg</institution>
<addr-line>Würzburg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Deuschl, Gunter" sort="Deuschl, Gunter" uniqKey="Deuschl G" first="Günter" last="Deuschl">Günter Deuschl</name>
<affiliation wicri:level="1"><nlm:aff id="au6"><institution>Department of Neurology, University Kiel</institution>
<addr-line>Kiel, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Kiel</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Meissner, Wassilios G" sort="Meissner, Wassilios G" uniqKey="Meissner W" first="Wassilios G" last="Meissner">Wassilios G. Meissner</name>
<affiliation wicri:level="1"><nlm:aff id="au7"><institution>Institut des Maladies Neurodégénératives, Univ. de Bordeaux</institution>
<addr-line>Bordeaux, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Bordeaux</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au8"><institution>CNRS Institut des Maladies Neurodégénératives</institution>
<addr-line>Bordeaux, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Bordeaux</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au9"><institution>Service de Neurologie, CHU de Bordeaux</institution>
<addr-line>Pessac, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Pessac</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au10"><institution>Centre de référence atrophie multisystématisée, CHU de Bordeaux</institution>
<addr-line>Pessac, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Pessac</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Maarouf, Mohammad" sort="Maarouf, Mohammad" uniqKey="Maarouf M" first="Mohammad" last="Maarouf">Mohammad Maarouf</name>
<affiliation wicri:level="1"><nlm:aff id="au4"><institution>Clinic for Stereotactic and Functional Neurosurgery, University of Cologne</institution>
<addr-line>Cologne, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sturm, Volker" sort="Sturm, Volker" uniqKey="Sturm V" first="Volker" last="Sturm">Volker Sturm</name>
<affiliation wicri:level="1"><nlm:aff id="au4"><institution>Clinic for Stereotactic and Functional Neurosurgery, University of Cologne</institution>
<addr-line>Cologne, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au5"><institution>Department of Neurology, University Würzburg</institution>
<addr-line>Würzburg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Würzburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Freund, Hans Joachim" sort="Freund, Hans Joachim" uniqKey="Freund H" first="Hans-Joachim" last="Freund">Hans-Joachim Freund</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Institute of Neuroscience and Medicine-Neuromodulation, Jülich Research Center</institution>
<addr-line>Jülich, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Jülich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tass, Peter Alexander" sort="Tass, Peter Alexander" uniqKey="Tass P" first="Peter Alexander" last="Tass">Peter Alexander Tass</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Institute of Neuroscience and Medicine-Neuromodulation, Jülich Research Center</institution>
<addr-line>Jülich, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Jülich</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Neuromodulation, University of Cologne</institution>
<addr-line>Cologne, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au4"><institution>Clinic for Stereotactic and Functional Neurosurgery, University of Cologne</institution>
<addr-line>Cologne, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Cologne</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Movement Disorders</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
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<profileDesc><textClass></textClass>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>The discovery of abnormal synchronization of neuronal activity in the basal ganglia in Parkinson's disease (PD) has prompted the development of novel neuromodulation paradigms. Coordinated reset neuromodulation intends to specifically counteract excessive synchronization and to induce cumulative unlearning of pathological synaptic connectivity and neuronal synchrony.</p>
</sec>
<sec><title>Methods</title>
<p>In this prospective case series, six PD patients were evaluated before and after coordinated reset neuromodulation according to a standardized protocol that included both electrophysiological recordings and clinical assessments.</p>
</sec>
<sec><title>Results</title>
<p>Coordinated reset neuromodulation of the subthalamic nucleus (STN) applied to six PD patients in an externalized setting during three stimulation days induced a significant and cumulative reduction of beta band activity that correlated with a significant improvement of motor function.</p>
</sec>
<sec><title>Conclusions</title>
<p>These results highlight the potential effects of coordinated reset neuromodulation of the STN in PD patients and encourage further development of this approach as an alternative to conventional high-frequency deep brain stimulation in PD. © 2014 The Authors. <italic>Movement</italic>
Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.</p>
</sec>
</div>
</front>
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</analytic>
</biblStruct>
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</biblStruct>
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</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tass, Pa" uniqKey="Tass P">PA Tass</name>
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</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Meissner, W" uniqKey="Meissner W">W Meissner</name>
</author>
<author><name sortKey="Leblois, A" uniqKey="Leblois A">A Leblois</name>
</author>
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</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fahn, S" uniqKey="Fahn S">S Fahn</name>
</author>
<author><name sortKey="Elton, Rl" uniqKey="Elton R">RL Elton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hauptmann, C" uniqKey="Hauptmann C">C Hauptmann</name>
</author>
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</author>
<author><name sortKey="Niederhauser, Jj" uniqKey="Niederhauser J">JJ Niederhauser</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tass, Pa" uniqKey="Tass P">PA Tass</name>
</author>
<author><name sortKey="Smirnov, D" uniqKey="Smirnov D">D Smirnov</name>
</author>
<author><name sortKey="Karavaev, A" uniqKey="Karavaev A">A Karavaev</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
</pmc>
<pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Coordinated reset neuromodulation for Parkinson's disease: proof-of-concept study.</title>
<author><name sortKey="Adamchic, Ilya" sort="Adamchic, Ilya" uniqKey="Adamchic I" first="Ilya" last="Adamchic">Ilya Adamchic</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Neuroscience and Medicine-Neuromodulation, Jülich Research Center, Jülich, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Neuroscience and Medicine-Neuromodulation, Jülich Research Center, Jülich</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Juliers</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hauptmann, Christian" sort="Hauptmann, Christian" uniqKey="Hauptmann C" first="Christian" last="Hauptmann">Christian Hauptmann</name>
</author>
<author><name sortKey="Barnikol, Utako Brigit" sort="Barnikol, Utako Brigit" uniqKey="Barnikol U" first="Utako Brigit" last="Barnikol">Utako Brigit Barnikol</name>
</author>
<author><name sortKey="Pawelczyk, Norbert" sort="Pawelczyk, Norbert" uniqKey="Pawelczyk N" first="Norbert" last="Pawelczyk">Norbert Pawelczyk</name>
</author>
<author><name sortKey="Popovych, Oleksandr" sort="Popovych, Oleksandr" uniqKey="Popovych O" first="Oleksandr" last="Popovych">Oleksandr Popovych</name>
</author>
<author><name sortKey="Barnikol, Thomas Theo" sort="Barnikol, Thomas Theo" uniqKey="Barnikol T" first="Thomas Theo" last="Barnikol">Thomas Theo Barnikol</name>
</author>
<author><name sortKey="Silchenko, Alexander" sort="Silchenko, Alexander" uniqKey="Silchenko A" first="Alexander" last="Silchenko">Alexander Silchenko</name>
</author>
<author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name>
</author>
<author><name sortKey="Deuschl, Gunter" sort="Deuschl, Gunter" uniqKey="Deuschl G" first="Günter" last="Deuschl">Günter Deuschl</name>
</author>
<author><name sortKey="Meissner, Wassilios G" sort="Meissner, Wassilios G" uniqKey="Meissner W" first="Wassilios G" last="Meissner">Wassilios G. Meissner</name>
</author>
<author><name sortKey="Maarouf, Mohammad" sort="Maarouf, Mohammad" uniqKey="Maarouf M" first="Mohammad" last="Maarouf">Mohammad Maarouf</name>
</author>
<author><name sortKey="Sturm, Volker" sort="Sturm, Volker" uniqKey="Sturm V" first="Volker" last="Sturm">Volker Sturm</name>
</author>
<author><name sortKey="Freund, Hans Joachim" sort="Freund, Hans Joachim" uniqKey="Freund H" first="Hans-Joachim" last="Freund">Hans-Joachim Freund</name>
</author>
<author><name sortKey="Tass, Peter Alexander" sort="Tass, Peter Alexander" uniqKey="Tass P" first="Peter Alexander" last="Tass">Peter Alexander Tass</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2014">2014</date>
<idno type="RBID">pubmed:24976001</idno>
<idno type="pmid">24976001</idno>
<idno type="doi">10.1002/mds.25923</idno>
<idno type="wicri:Area/PubMed/Corpus">000467</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Coordinated reset neuromodulation for Parkinson's disease: proof-of-concept study.</title>
<author><name sortKey="Adamchic, Ilya" sort="Adamchic, Ilya" uniqKey="Adamchic I" first="Ilya" last="Adamchic">Ilya Adamchic</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Neuroscience and Medicine-Neuromodulation, Jülich Research Center, Jülich, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Neuroscience and Medicine-Neuromodulation, Jülich Research Center, Jülich</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Juliers</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hauptmann, Christian" sort="Hauptmann, Christian" uniqKey="Hauptmann C" first="Christian" last="Hauptmann">Christian Hauptmann</name>
</author>
<author><name sortKey="Barnikol, Utako Brigit" sort="Barnikol, Utako Brigit" uniqKey="Barnikol U" first="Utako Brigit" last="Barnikol">Utako Brigit Barnikol</name>
</author>
<author><name sortKey="Pawelczyk, Norbert" sort="Pawelczyk, Norbert" uniqKey="Pawelczyk N" first="Norbert" last="Pawelczyk">Norbert Pawelczyk</name>
</author>
<author><name sortKey="Popovych, Oleksandr" sort="Popovych, Oleksandr" uniqKey="Popovych O" first="Oleksandr" last="Popovych">Oleksandr Popovych</name>
</author>
<author><name sortKey="Barnikol, Thomas Theo" sort="Barnikol, Thomas Theo" uniqKey="Barnikol T" first="Thomas Theo" last="Barnikol">Thomas Theo Barnikol</name>
</author>
<author><name sortKey="Silchenko, Alexander" sort="Silchenko, Alexander" uniqKey="Silchenko A" first="Alexander" last="Silchenko">Alexander Silchenko</name>
</author>
<author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name>
</author>
<author><name sortKey="Deuschl, Gunter" sort="Deuschl, Gunter" uniqKey="Deuschl G" first="Günter" last="Deuschl">Günter Deuschl</name>
</author>
<author><name sortKey="Meissner, Wassilios G" sort="Meissner, Wassilios G" uniqKey="Meissner W" first="Wassilios G" last="Meissner">Wassilios G. Meissner</name>
</author>
<author><name sortKey="Maarouf, Mohammad" sort="Maarouf, Mohammad" uniqKey="Maarouf M" first="Mohammad" last="Maarouf">Mohammad Maarouf</name>
</author>
<author><name sortKey="Sturm, Volker" sort="Sturm, Volker" uniqKey="Sturm V" first="Volker" last="Sturm">Volker Sturm</name>
</author>
<author><name sortKey="Freund, Hans Joachim" sort="Freund, Hans Joachim" uniqKey="Freund H" first="Hans-Joachim" last="Freund">Hans-Joachim Freund</name>
</author>
<author><name sortKey="Tass, Peter Alexander" sort="Tass, Peter Alexander" uniqKey="Tass P" first="Peter Alexander" last="Tass">Peter Alexander Tass</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2014" type="published">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Biophysical Phenomena</term>
<term>Deep Brain Stimulation (methods)</term>
<term>Electrodes, Implanted</term>
<term>Evoked Potentials (physiology)</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Motor Activity (physiology)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (therapy)</term>
<term>Prospective Studies</term>
<term>Subthalamic Nucleus (physiology)</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Evoked Potentials</term>
<term>Motor Activity</term>
<term>Subthalamic Nucleus</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Biophysical Phenomena</term>
<term>Electrodes, Implanted</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Prospective Studies</term>
</keywords>
</textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en">The discovery of abnormal synchronization of neuronal activity in the basal ganglia in Parkinson's disease (PD) has prompted the development of novel neuromodulation paradigms. Coordinated reset neuromodulation intends to specifically counteract excessive synchronization and to induce cumulative unlearning of pathological synaptic connectivity and neuronal synchrony.</div>
</front>
</TEI>
</pubmed>
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