Coordinated reset neuromodulation for Parkinson's disease: Proof-of-concept study
Identifieur interne : 000453 ( Pmc/Corpus ); précédent : 000452; suivant : 000454Coordinated reset neuromodulation for Parkinson's disease: Proof-of-concept study
Auteurs : Ilya Adamchic ; Christian Hauptmann ; Utako Brigit Barnikol ; Norbert Pawelczyk ; Oleksandr Popovych ; Thomas Theo Barnikol ; Alexander Silchenko ; Jens Volkmann ; Günter Deuschl ; Wassilios G. Meissner ; Mohammad Maarouf ; Volker Sturm ; Hans-Joachim Freund ; Peter Alexander TassSource :
- Movement Disorders [ 0885-3185 ] ; 2014.
Abstract
The discovery of abnormal synchronization of neuronal activity in the basal ganglia in Parkinson's disease (PD) has prompted the development of novel neuromodulation paradigms. Coordinated reset neuromodulation intends to specifically counteract excessive synchronization and to induce cumulative unlearning of pathological synaptic connectivity and neuronal synchrony.
In this prospective case series, six PD patients were evaluated before and after coordinated reset neuromodulation according to a standardized protocol that included both electrophysiological recordings and clinical assessments.
Coordinated reset neuromodulation of the subthalamic nucleus (STN) applied to six PD patients in an externalized setting during three stimulation days induced a significant and cumulative reduction of beta band activity that correlated with a significant improvement of motor function.
These results highlight the potential effects of coordinated reset neuromodulation of the STN in PD patients and encourage further development of this approach as an alternative to conventional high-frequency deep brain stimulation in PD. © 2014 The Authors.
Url:
DOI: 10.1002/mds.25923
PubMed: 24976001
PubMed Central: 4282372
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