MovDisordV3, Ncbi, Merge, bibRecord, 003F20

The effect of deep brain stimulation randomized by site on balance in Parkinson’s disease

Identifieur interne : 003F20 ( Ncbi/Merge ); précédent : 003F19; suivant : 003F21

The effect of deep brain stimulation randomized by site on balance in Parkinson’s disease

Auteurs : R. J. St George [États-Unis] ; P. Carlson-Kuhta [États-Unis] ; J. G. Nutt [États-Unis] ; P. Hogarth [États-Unis] ; K. J. Burchiel [États-Unis] ; F. B. Horak [États-Unis]

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2014.

RBID : PMC:4057940

English descriptors

KwdEn :
- Activities of Daily Living, Adult, Aged, Aged, 80 and over, Deep Brain Stimulation, Double-Blind Method, Female, Gait (physiology), Humans, Male, Middle Aged, Parkinson Disease (physiopathology), Parkinson Disease (therapy), Postural Balance (physiology), Treatment Outcome.
MESH :
- physiology : Gait, Postural Balance.
- physiopathology : Parkinson Disease.
- therapy : Parkinson Disease.
- Activities of Daily Living, Adult, Aged, Aged, 80 and over, Deep Brain Stimulation, Double-Blind Method, Female, Humans, Male, Middle Aged, Treatment Outcome.

Abstract

Background

The effect of the surgical site of Deep Brain Stimulation (DBS) on balance and gait in Parkinson’s Disease (PD) is uncertain. This is the first double-blind study of subjects randomized to either the Subthalamic Nucleus (STN, N=14) or Globus Pallidus interna (GPi, N=14) who were assessed on a range of clinical balance measures.

Methods

Balance testing occurred before and 6 months post-surgery. A control PD group was tested over the same time period without surgery (N=9). All subjects were tested on and off medication and DBS subjects were also tested on and off DBS. The Postural Instability and Gait Disability items of the Unified Parkinson’s Disease Rating Scale and additional functional tests we call the Balance and Gait scale were assessed. Activities of Balance Confidence and Activities of Daily Living questionnaires were also recorded.

Results

Balance was not different between the best-treated states before and after DBS surgery for both sites. Switching DBS on improved balance scores and scores further improved with medication compared to the off state. The GPi group showed improved performance in the post-surgery off state and better ratings of balance confidence after surgery compared to the STN group.

Conclusions

Clinical measures of balance function for both the STN and GPi sites showed that balance did not improve beyond the best medically-treated state prior to surgery. Both clinical balance testing in the OFF/OFF state and self-reported balance confidence after surgery showed better performance in the GPi than the STN group.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057940

DOI: 10.1002/mds.25831
PubMed: 24532106
PubMed Central: 4057940

Links toward previous steps (curation, corpus...)

to stream Pmc, to step Corpus: 000388
to stream Pmc, to step Curation: 000388
to stream Pmc, to step Checkpoint: 000006
to stream PubMed, to step Corpus: 000577
to stream PubMed, to step Curation: 000577
to stream PubMed, to step Checkpoint: 000396

Links to Exploration step

PMC:4057940

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The effect of deep brain stimulation randomized by site on balance in Parkinson’s disease</title>
<author><name sortKey="St George, R J" sort="St George, R J" uniqKey="St George R" first="R. J." last="St George">R. J. St George</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Department of Neurology, Oregon Health & Science University, Portland, Oregon, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Oregon Health & Science University, Portland, Oregon</wicri:regionArea>
<placeName><region type="state">Oregon</region>
<settlement type="city">Portland</settlement>
</placeName>
<orgName type="university">Université des sciences et de la médecine de l'Oregon</orgName>
</affiliation>
</author>
<author><name sortKey="Carlson Kuhta, P" sort="Carlson Kuhta, P" uniqKey="Carlson Kuhta P" first="P." last="Carlson-Kuhta">P. Carlson-Kuhta</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Department of Neurology, Oregon Health & Science University, Portland, Oregon, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Oregon Health & Science University, Portland, Oregon</wicri:regionArea>
<placeName><region type="state">Oregon</region>
<settlement type="city">Portland</settlement>
</placeName>
<orgName type="university">Université des sciences et de la médecine de l'Oregon</orgName>
</affiliation>
</author>
<author><name sortKey="Nutt, J G" sort="Nutt, J G" uniqKey="Nutt J" first="J. G." last="Nutt">J. G. Nutt</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Department of Neurology, Oregon Health & Science University, Portland, Oregon, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Oregon Health & Science University, Portland, Oregon</wicri:regionArea>
<placeName><region type="state">Oregon</region>
<settlement type="city">Portland</settlement>
</placeName>
<orgName type="university">Université des sciences et de la médecine de l'Oregon</orgName>
</affiliation>
</author>
<author><name sortKey="Hogarth, P" sort="Hogarth, P" uniqKey="Hogarth P" first="P." last="Hogarth">P. Hogarth</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Department of Neurology, Oregon Health & Science University, Portland, Oregon, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Oregon Health & Science University, Portland, Oregon</wicri:regionArea>
<placeName><region type="state">Oregon</region>
<settlement type="city">Portland</settlement>
</placeName>
<orgName type="university">Université des sciences et de la médecine de l'Oregon</orgName>
</affiliation>
</author>
<author><name sortKey="Burchiel, K J" sort="Burchiel, K J" uniqKey="Burchiel K" first="K. J." last="Burchiel">K. J. Burchiel</name>
<affiliation wicri:level="4"><nlm:aff id="A2">Department of Neurological Surgery, Oregon Health & Science University, Portland, Oregon, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurological Surgery, Oregon Health & Science University, Portland, Oregon</wicri:regionArea>
<placeName><region type="state">Oregon</region>
<settlement type="city">Portland</settlement>
</placeName>
<orgName type="university">Université des sciences et de la médecine de l'Oregon</orgName>
</affiliation>
</author>
<author><name sortKey="Horak, F B" sort="Horak, F B" uniqKey="Horak F" first="F. B." last="Horak">F. B. Horak</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Department of Neurology, Oregon Health & Science University, Portland, Oregon, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Oregon Health & Science University, Portland, Oregon</wicri:regionArea>
<placeName><region type="state">Oregon</region>
<settlement type="city">Portland</settlement>
</placeName>
<orgName type="university">Université des sciences et de la médecine de l'Oregon</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">24532106</idno>
<idno type="pmc">4057940</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057940</idno>
<idno type="RBID">PMC:4057940</idno>
<idno type="doi">10.1002/mds.25831</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">000388</idno>
<idno type="wicri:Area/Pmc/Curation">000388</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000006</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">000577</idno>
<idno type="wicri:Area/PubMed/Curation">000577</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000396</idno>
<idno type="wicri:Area/Ncbi/Merge">003F20</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The effect of deep brain stimulation randomized by site on balance in Parkinson’s disease</title>
<author><name sortKey="St George, R J" sort="St George, R J" uniqKey="St George R" first="R. J." last="St George">R. J. St George</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Department of Neurology, Oregon Health & Science University, Portland, Oregon, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Oregon Health & Science University, Portland, Oregon</wicri:regionArea>
<placeName><region type="state">Oregon</region>
<settlement type="city">Portland</settlement>
</placeName>
<orgName type="university">Université des sciences et de la médecine de l'Oregon</orgName>
</affiliation>
</author>
<author><name sortKey="Carlson Kuhta, P" sort="Carlson Kuhta, P" uniqKey="Carlson Kuhta P" first="P." last="Carlson-Kuhta">P. Carlson-Kuhta</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Department of Neurology, Oregon Health & Science University, Portland, Oregon, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Oregon Health & Science University, Portland, Oregon</wicri:regionArea>
<placeName><region type="state">Oregon</region>
<settlement type="city">Portland</settlement>
</placeName>
<orgName type="university">Université des sciences et de la médecine de l'Oregon</orgName>
</affiliation>
</author>
<author><name sortKey="Nutt, J G" sort="Nutt, J G" uniqKey="Nutt J" first="J. G." last="Nutt">J. G. Nutt</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Department of Neurology, Oregon Health & Science University, Portland, Oregon, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Oregon Health & Science University, Portland, Oregon</wicri:regionArea>
<placeName><region type="state">Oregon</region>
<settlement type="city">Portland</settlement>
</placeName>
<orgName type="university">Université des sciences et de la médecine de l'Oregon</orgName>
</affiliation>
</author>
<author><name sortKey="Hogarth, P" sort="Hogarth, P" uniqKey="Hogarth P" first="P." last="Hogarth">P. Hogarth</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Department of Neurology, Oregon Health & Science University, Portland, Oregon, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Oregon Health & Science University, Portland, Oregon</wicri:regionArea>
<placeName><region type="state">Oregon</region>
<settlement type="city">Portland</settlement>
</placeName>
<orgName type="university">Université des sciences et de la médecine de l'Oregon</orgName>
</affiliation>
</author>
<author><name sortKey="Burchiel, K J" sort="Burchiel, K J" uniqKey="Burchiel K" first="K. J." last="Burchiel">K. J. Burchiel</name>
<affiliation wicri:level="4"><nlm:aff id="A2">Department of Neurological Surgery, Oregon Health & Science University, Portland, Oregon, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurological Surgery, Oregon Health & Science University, Portland, Oregon</wicri:regionArea>
<placeName><region type="state">Oregon</region>
<settlement type="city">Portland</settlement>
</placeName>
<orgName type="university">Université des sciences et de la médecine de l'Oregon</orgName>
</affiliation>
</author>
<author><name sortKey="Horak, F B" sort="Horak, F B" uniqKey="Horak F" first="F. B." last="Horak">F. B. Horak</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Department of Neurology, Oregon Health & Science University, Portland, Oregon, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Oregon Health & Science University, Portland, Oregon</wicri:regionArea>
<placeName><region type="state">Oregon</region>
<settlement type="city">Portland</settlement>
</placeName>
<orgName type="university">Université des sciences et de la médecine de l'Oregon</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Activities of Daily Living</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Deep Brain Stimulation</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Gait (physiology)</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (therapy)</term>
<term>Postural Balance (physiology)</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Gait</term>
<term>Postural Balance</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Activities of Daily Living</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Deep Brain Stimulation</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Treatment Outcome</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">The effect of the surgical site of Deep Brain Stimulation (DBS) on balance and gait in Parkinson’s Disease (PD) is uncertain. This is the first double-blind study of subjects randomized to either the Subthalamic Nucleus (STN, N=14) or Globus Pallidus interna (GPi, N=14) who were assessed on a range of clinical balance measures.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Balance testing occurred before and 6 months post-surgery. A control PD group was tested over the same time period without surgery (N=9). All subjects were tested on and off medication and DBS subjects were also tested on and off DBS. The Postural Instability and Gait Disability items of the Unified Parkinson’s Disease Rating Scale and additional functional tests we call the Balance and Gait scale were assessed. Activities of Balance Confidence and Activities of Daily Living questionnaires were also recorded.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Balance was not different between the best-treated states before and after DBS surgery for both sites. Switching DBS on improved balance scores and scores further improved with medication compared to the off state. The GPi group showed improved performance in the post-surgery off state and better ratings of balance confidence after surgery compared to the STN group.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">Clinical measures of balance function for both the STN and GPi sites showed that balance did not improve beyond the best medically-treated state prior to surgery. Both clinical balance testing in the OFF/OFF state and self-reported balance confidence after surgery showed better performance in the GPi than the STN group.</p>
</sec>
</div>
</front>
</TEI>
<double pmid="24532106"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The effect of deep brain stimulation randomized by site on balance in Parkinson’s disease</title>
<author><name sortKey="St George, R J" sort="St George, R J" uniqKey="St George R" first="R. J." last="St George">R. J. St George</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Department of Neurology, Oregon Health & Science University, Portland, Oregon, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Oregon Health & Science University, Portland, Oregon</wicri:regionArea>
<placeName><region type="state">Oregon</region>
<settlement type="city">Portland</settlement>
</placeName>
<orgName type="university">Université des sciences et de la médecine de l'Oregon</orgName>
</affiliation>
</author>
<author><name sortKey="Carlson Kuhta, P" sort="Carlson Kuhta, P" uniqKey="Carlson Kuhta P" first="P." last="Carlson-Kuhta">P. Carlson-Kuhta</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Department of Neurology, Oregon Health & Science University, Portland, Oregon, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Oregon Health & Science University, Portland, Oregon</wicri:regionArea>
<placeName><region type="state">Oregon</region>
<settlement type="city">Portland</settlement>
</placeName>
<orgName type="university">Université des sciences et de la médecine de l'Oregon</orgName>
</affiliation>
</author>
<author><name sortKey="Nutt, J G" sort="Nutt, J G" uniqKey="Nutt J" first="J. G." last="Nutt">J. G. Nutt</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Department of Neurology, Oregon Health & Science University, Portland, Oregon, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Oregon Health & Science University, Portland, Oregon</wicri:regionArea>
<placeName><region type="state">Oregon</region>
<settlement type="city">Portland</settlement>
</placeName>
<orgName type="university">Université des sciences et de la médecine de l'Oregon</orgName>
</affiliation>
</author>
<author><name sortKey="Hogarth, P" sort="Hogarth, P" uniqKey="Hogarth P" first="P." last="Hogarth">P. Hogarth</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Department of Neurology, Oregon Health & Science University, Portland, Oregon, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Oregon Health & Science University, Portland, Oregon</wicri:regionArea>
<placeName><region type="state">Oregon</region>
<settlement type="city">Portland</settlement>
</placeName>
<orgName type="university">Université des sciences et de la médecine de l'Oregon</orgName>
</affiliation>
</author>
<author><name sortKey="Burchiel, K J" sort="Burchiel, K J" uniqKey="Burchiel K" first="K. J." last="Burchiel">K. J. Burchiel</name>
<affiliation wicri:level="4"><nlm:aff id="A2">Department of Neurological Surgery, Oregon Health & Science University, Portland, Oregon, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurological Surgery, Oregon Health & Science University, Portland, Oregon</wicri:regionArea>
<placeName><region type="state">Oregon</region>
<settlement type="city">Portland</settlement>
</placeName>
<orgName type="university">Université des sciences et de la médecine de l'Oregon</orgName>
</affiliation>
</author>
<author><name sortKey="Horak, F B" sort="Horak, F B" uniqKey="Horak F" first="F. B." last="Horak">F. B. Horak</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Department of Neurology, Oregon Health & Science University, Portland, Oregon, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Oregon Health & Science University, Portland, Oregon</wicri:regionArea>
<placeName><region type="state">Oregon</region>
<settlement type="city">Portland</settlement>
</placeName>
<orgName type="university">Université des sciences et de la médecine de l'Oregon</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">24532106</idno>
<idno type="pmc">4057940</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057940</idno>
<idno type="RBID">PMC:4057940</idno>
<idno type="doi">10.1002/mds.25831</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">000388</idno>
<idno type="wicri:Area/Pmc/Curation">000388</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000006</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The effect of deep brain stimulation randomized by site on balance in Parkinson’s disease</title>
<author><name sortKey="St George, R J" sort="St George, R J" uniqKey="St George R" first="R. J." last="St George">R. J. St George</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Department of Neurology, Oregon Health & Science University, Portland, Oregon, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Oregon Health & Science University, Portland, Oregon</wicri:regionArea>
<placeName><region type="state">Oregon</region>
<settlement type="city">Portland</settlement>
</placeName>
<orgName type="university">Université des sciences et de la médecine de l'Oregon</orgName>
</affiliation>
</author>
<author><name sortKey="Carlson Kuhta, P" sort="Carlson Kuhta, P" uniqKey="Carlson Kuhta P" first="P." last="Carlson-Kuhta">P. Carlson-Kuhta</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Department of Neurology, Oregon Health & Science University, Portland, Oregon, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Oregon Health & Science University, Portland, Oregon</wicri:regionArea>
<placeName><region type="state">Oregon</region>
<settlement type="city">Portland</settlement>
</placeName>
<orgName type="university">Université des sciences et de la médecine de l'Oregon</orgName>
</affiliation>
</author>
<author><name sortKey="Nutt, J G" sort="Nutt, J G" uniqKey="Nutt J" first="J. G." last="Nutt">J. G. Nutt</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Department of Neurology, Oregon Health & Science University, Portland, Oregon, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Oregon Health & Science University, Portland, Oregon</wicri:regionArea>
<placeName><region type="state">Oregon</region>
<settlement type="city">Portland</settlement>
</placeName>
<orgName type="university">Université des sciences et de la médecine de l'Oregon</orgName>
</affiliation>
</author>
<author><name sortKey="Hogarth, P" sort="Hogarth, P" uniqKey="Hogarth P" first="P." last="Hogarth">P. Hogarth</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Department of Neurology, Oregon Health & Science University, Portland, Oregon, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Oregon Health & Science University, Portland, Oregon</wicri:regionArea>
<placeName><region type="state">Oregon</region>
<settlement type="city">Portland</settlement>
</placeName>
<orgName type="university">Université des sciences et de la médecine de l'Oregon</orgName>
</affiliation>
</author>
<author><name sortKey="Burchiel, K J" sort="Burchiel, K J" uniqKey="Burchiel K" first="K. J." last="Burchiel">K. J. Burchiel</name>
<affiliation wicri:level="4"><nlm:aff id="A2">Department of Neurological Surgery, Oregon Health & Science University, Portland, Oregon, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurological Surgery, Oregon Health & Science University, Portland, Oregon</wicri:regionArea>
<placeName><region type="state">Oregon</region>
<settlement type="city">Portland</settlement>
</placeName>
<orgName type="university">Université des sciences et de la médecine de l'Oregon</orgName>
</affiliation>
</author>
<author><name sortKey="Horak, F B" sort="Horak, F B" uniqKey="Horak F" first="F. B." last="Horak">F. B. Horak</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Department of Neurology, Oregon Health & Science University, Portland, Oregon, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Oregon Health & Science University, Portland, Oregon</wicri:regionArea>
<placeName><region type="state">Oregon</region>
<settlement type="city">Portland</settlement>
</placeName>
<orgName type="university">Université des sciences et de la médecine de l'Oregon</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">The effect of the surgical site of Deep Brain Stimulation (DBS) on balance and gait in Parkinson’s Disease (PD) is uncertain. This is the first double-blind study of subjects randomized to either the Subthalamic Nucleus (STN, N=14) or Globus Pallidus interna (GPi, N=14) who were assessed on a range of clinical balance measures.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Balance testing occurred before and 6 months post-surgery. A control PD group was tested over the same time period without surgery (N=9). All subjects were tested on and off medication and DBS subjects were also tested on and off DBS. The Postural Instability and Gait Disability items of the Unified Parkinson’s Disease Rating Scale and additional functional tests we call the Balance and Gait scale were assessed. Activities of Balance Confidence and Activities of Daily Living questionnaires were also recorded.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Balance was not different between the best-treated states before and after DBS surgery for both sites. Switching DBS on improved balance scores and scores further improved with medication compared to the off state. The GPi group showed improved performance in the post-surgery off state and better ratings of balance confidence after surgery compared to the STN group.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">Clinical measures of balance function for both the STN and GPi sites showed that balance did not improve beyond the best medically-treated state prior to surgery. Both clinical balance testing in the OFF/OFF state and self-reported balance confidence after surgery showed better performance in the GPi than the STN group.</p>
</sec>
</div>
</front>
</TEI>
</pmc>
<pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The effect of deep brain stimulation randomized by site on balance in Parkinson's disease.</title>
<author><name sortKey="St George, Rebecca J" sort="St George, Rebecca J" uniqKey="St George R" first="Rebecca J" last="St George">Rebecca J. St George</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, Oregon Health & Science University, Portland, Oregon, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Oregon Health & Science University, Portland, Oregon</wicri:regionArea>
<placeName><region type="state">Oregon</region>
<settlement type="city">Portland</settlement>
</placeName>
<orgName type="university">Université des sciences et de la médecine de l'Oregon</orgName>
</affiliation>
</author>
<author><name sortKey="Carlson Kuhta, Patricia" sort="Carlson Kuhta, Patricia" uniqKey="Carlson Kuhta P" first="Patricia" last="Carlson-Kuhta">Patricia Carlson-Kuhta</name>
</author>
<author><name sortKey="Nutt, John G" sort="Nutt, John G" uniqKey="Nutt J" first="John G" last="Nutt">John G. Nutt</name>
</author>
<author><name sortKey="Hogarth, Penelope" sort="Hogarth, Penelope" uniqKey="Hogarth P" first="Penelope" last="Hogarth">Penelope Hogarth</name>
</author>
<author><name sortKey="Burchiel, Kim J" sort="Burchiel, Kim J" uniqKey="Burchiel K" first="Kim J" last="Burchiel">Kim J. Burchiel</name>
</author>
<author><name sortKey="Horak, Fay B" sort="Horak, Fay B" uniqKey="Horak F" first="Fay B" last="Horak">Fay B. Horak</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2014">2014</date>
<idno type="RBID">pubmed:24532106</idno>
<idno type="pmid">24532106</idno>
<idno type="doi">10.1002/mds.25831</idno>
<idno type="wicri:Area/PubMed/Corpus">000577</idno>
<idno type="wicri:Area/PubMed/Curation">000577</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000396</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">The effect of deep brain stimulation randomized by site on balance in Parkinson's disease.</title>
<author><name sortKey="St George, Rebecca J" sort="St George, Rebecca J" uniqKey="St George R" first="Rebecca J" last="St George">Rebecca J. St George</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, Oregon Health & Science University, Portland, Oregon, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Oregon Health & Science University, Portland, Oregon</wicri:regionArea>
<placeName><region type="state">Oregon</region>
<settlement type="city">Portland</settlement>
</placeName>
<orgName type="university">Université des sciences et de la médecine de l'Oregon</orgName>
</affiliation>
</author>
<author><name sortKey="Carlson Kuhta, Patricia" sort="Carlson Kuhta, Patricia" uniqKey="Carlson Kuhta P" first="Patricia" last="Carlson-Kuhta">Patricia Carlson-Kuhta</name>
</author>
<author><name sortKey="Nutt, John G" sort="Nutt, John G" uniqKey="Nutt J" first="John G" last="Nutt">John G. Nutt</name>
</author>
<author><name sortKey="Hogarth, Penelope" sort="Hogarth, Penelope" uniqKey="Hogarth P" first="Penelope" last="Hogarth">Penelope Hogarth</name>
</author>
<author><name sortKey="Burchiel, Kim J" sort="Burchiel, Kim J" uniqKey="Burchiel K" first="Kim J" last="Burchiel">Kim J. Burchiel</name>
</author>
<author><name sortKey="Horak, Fay B" sort="Horak, Fay B" uniqKey="Horak F" first="Fay B" last="Horak">Fay B. Horak</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2014" type="published">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Activities of Daily Living</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Deep Brain Stimulation</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Gait (physiology)</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (therapy)</term>
<term>Postural Balance (physiology)</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Gait</term>
<term>Postural Balance</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Activities of Daily Living</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Deep Brain Stimulation</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Treatment Outcome</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The effect of the surgical site of DBS on balance and gait in Parkinson's Disease (PD) is uncertain. This is the first double-blind study of subjects randomized to either the STN (N = 14) or GPi (N = 14) who were assessed on a range of clinical balance measures.</div>
</front>
</TEI>
</pubmed>
</double>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Ncbi/Merge

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003F20 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 003F20 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Ncbi
   |étape=   Merge
   |type=    RBID
   |clé=     PMC:4057940
   |texte=   The effect of deep brain stimulation randomized by site on balance in Parkinson’s disease
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i   -Sk "pubmed:24532106" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd   \
       | NlmPubMed2Wicri -a MovDisordV3

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Movement Disorders (revue)

The effect of deep brain stimulation randomized by site on balance in Parkinson’s disease

The effect of deep brain stimulation randomized by site on balance in Parkinson’s disease

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki