Movement Disorders (revue)

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The effect of deep brain stimulation randomized by site on balance in Parkinson's disease.

Identifieur interne : 000577 ( PubMed/Corpus ); précédent : 000576; suivant : 000578

The effect of deep brain stimulation randomized by site on balance in Parkinson's disease.

Auteurs : Rebecca J. St George ; Patricia Carlson-Kuhta ; John G. Nutt ; Penelope Hogarth ; Kim J. Burchiel ; Fay B. Horak

Source :

RBID : pubmed:24532106

English descriptors

Abstract

The effect of the surgical site of DBS on balance and gait in Parkinson's Disease (PD) is uncertain. This is the first double-blind study of subjects randomized to either the STN (N = 14) or GPi (N = 14) who were assessed on a range of clinical balance measures.

DOI: 10.1002/mds.25831
PubMed: 24532106

Links to Exploration step

pubmed:24532106

Le document en format XML

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<title xml:lang="en">The effect of deep brain stimulation randomized by site on balance in Parkinson's disease.</title>
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<name sortKey="St George, Rebecca J" sort="St George, Rebecca J" uniqKey="St George R" first="Rebecca J" last="St George">Rebecca J. St George</name>
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<nlm:affiliation>Department of Neurology, Oregon Health & Science University, Portland, Oregon, USA.</nlm:affiliation>
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<name sortKey="Carlson Kuhta, Patricia" sort="Carlson Kuhta, Patricia" uniqKey="Carlson Kuhta P" first="Patricia" last="Carlson-Kuhta">Patricia Carlson-Kuhta</name>
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<name sortKey="Nutt, John G" sort="Nutt, John G" uniqKey="Nutt J" first="John G" last="Nutt">John G. Nutt</name>
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<name sortKey="Hogarth, Penelope" sort="Hogarth, Penelope" uniqKey="Hogarth P" first="Penelope" last="Hogarth">Penelope Hogarth</name>
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<name sortKey="Burchiel, Kim J" sort="Burchiel, Kim J" uniqKey="Burchiel K" first="Kim J" last="Burchiel">Kim J. Burchiel</name>
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<name sortKey="Horak, Fay B" sort="Horak, Fay B" uniqKey="Horak F" first="Fay B" last="Horak">Fay B. Horak</name>
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<name sortKey="Nutt, John G" sort="Nutt, John G" uniqKey="Nutt J" first="John G" last="Nutt">John G. Nutt</name>
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<name sortKey="Hogarth, Penelope" sort="Hogarth, Penelope" uniqKey="Hogarth P" first="Penelope" last="Hogarth">Penelope Hogarth</name>
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<name sortKey="Burchiel, Kim J" sort="Burchiel, Kim J" uniqKey="Burchiel K" first="Kim J" last="Burchiel">Kim J. Burchiel</name>
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<title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<term>Activities of Daily Living</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Deep Brain Stimulation</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Gait (physiology)</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (therapy)</term>
<term>Postural Balance (physiology)</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en">
<term>Gait</term>
<term>Postural Balance</term>
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<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en">
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en">
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Activities of Daily Living</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Deep Brain Stimulation</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Humans</term>
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<term>Treatment Outcome</term>
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<div type="abstract" xml:lang="en">The effect of the surgical site of DBS on balance and gait in Parkinson's Disease (PD) is uncertain. This is the first double-blind study of subjects randomized to either the STN (N = 14) or GPi (N = 14) who were assessed on a range of clinical balance measures.</div>
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<Volume>29</Volume>
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<Month>Jun</Month>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
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<ArticleTitle>The effect of deep brain stimulation randomized by site on balance in Parkinson's disease.</ArticleTitle>
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<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The effect of the surgical site of DBS on balance and gait in Parkinson's Disease (PD) is uncertain. This is the first double-blind study of subjects randomized to either the STN (N = 14) or GPi (N = 14) who were assessed on a range of clinical balance measures.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Balance testing occurred before and 6 months postsurgery. A control PD group was tested over the same period without surgery (N = 9). All subjects were tested on and off medication and DBS subjects were also tested on and off DBS. The Postural Instability and Gait Disability items of the UPDRS and additional functional tests, which we call the Balance and Gait scale, were assessed. Activities of Balance Confidence and Activities of Daily Living questionnaires were also recorded.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Balance was not different between the best-treated states before and after DBS surgery for both sites. Switching DBS on improved balance scores, and scores further improved with medication, compared to the off state. The GPi group showed improved performance in the postsurgery off state and better ratings of balance confidence after surgery, compared to the STN group.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Clinical measures of balance function for both the STN and GPi sites showed that balance did not improve beyond the best medically treated state before surgery. Both clinical balance testing in the off/off state and self-reported balance confidence after surgery showed better performance in the GPi than the STN group.</AbstractText>
<CopyrightInformation>© 2014 International Parkinson and Movement Disorder Society.</CopyrightInformation>
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<ForeName>Rebecca J</ForeName>
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