Obesity, Diabetes and Risk of Parkinson Disease
Identifieur interne : 003344 ( Ncbi/Merge ); précédent : 003343; suivant : 003345Obesity, Diabetes and Risk of Parkinson Disease
Auteurs : Natalia Palacios [États-Unis] ; Xiang Gao [États-Unis] ; Marjorie L. Mccullough [États-Unis] ; Eric J. Jacobs [États-Unis] ; Alpa V. Patel [États-Unis] ; Tinisha Mayo [États-Unis] ; Michael A. Schwarzschild ; Alberto Ascherio [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2011.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Anthropometry, Body Mass Index, Cohort Studies, Diabetes Mellitus (epidemiology), Female, Humans, Male, Middle Aged, Obesity (epidemiology), Parkinson Disease (diagnosis), Parkinson Disease (epidemiology), Predictive Value of Tests, Proportional Hazards Models, Retrospective Studies, Risk.
- MESH :
- diagnosis : Parkinson Disease.
- epidemiology : Diabetes Mellitus, Obesity, Parkinson Disease.
- Aged, Aged, 80 and over, Anthropometry, Body Mass Index, Cohort Studies, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Proportional Hazards Models, Retrospective Studies, Risk.
Abstract
To investigate whether obesity and diabetes are related to risk of Parkinson disease (PD).
We prospectively followed 147,096 participants in the Cancer Prevention Study II Nutrition Cohort from 1992 to 2005. Participants provided information on anthropometric variables and medical history at baseline, and on waist circumference in 1997. Incident cases of PD (n = 656) were confirmed by treating neurologists and medical record review. Relative risks (RR) were estimated using proportional hazards models, adjusting for age, gender, smoking and other risk factors.
Neither BMI nor waist circumference significantly predicted PD risk. The RR comparing individuals with a baseline BMI of ≥ 30 to those with a BMI < 23 was 1.00 (95% CI: 0.75, 1.34; p-trend: 0.79), and that comparing individuals with a waist circumference in the top category (>=40.3 inches in men and >=35 inches in women) to those in the bottom category (<34.5 inches in men and <28 inches in women) was 1.35 (95% CI 0.95, 1.93; p-trend 0.08). History of diabetes was not significantly associated with PD risk (combined RR = 0.88; 95 % CI: 0.62, 1.25; p-heterogeneity = 0.96). In addition, neither BMI at age 18, nor changes in weight between age 18 and baseline were significantly associated with PD risk. The results did not differ significantly by gender
Our results do not provide evidence for a relationship between BMI, weight change, waist circumference or baseline diabetes and risk of PD.
Url:
DOI: 10.1002/mds.23855
PubMed: 21739472
PubMed Central: 3627531
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Jacobs</name><affiliation wicri:level="2"><nlm:aff id="A2">Epidemiology Research Program, American Cancer Society, 250 Williams St., Atlanta, GA 30303</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Epidemiology Research Program, American Cancer Society, 250 Williams St., Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Patel, Alpa V" sort="Patel, Alpa V" uniqKey="Patel A" first="Alpa V." last="Patel">Alpa V. Patel</name><affiliation wicri:level="2"><nlm:aff id="A2">Epidemiology Research Program, American Cancer Society, 250 Williams St., Atlanta, GA 30303</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Epidemiology Research Program, American Cancer Society, 250 Williams St., Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Mayo, Tinisha" sort="Mayo, Tinisha" uniqKey="Mayo T" first="Tinisha" last="Mayo">Tinisha Mayo</name><affiliation wicri:level="2"><nlm:aff id="A2">Epidemiology Research Program, American Cancer Society, 250 Williams St., Atlanta, GA 30303</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Epidemiology Research Program, American Cancer Society, 250 Williams St., Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Schwarzschild, Michael A" sort="Schwarzschild, Michael A" uniqKey="Schwarzschild M" first="Michael A." last="Schwarzschild">Michael A. Schwarzschild</name><affiliation><nlm:aff id="A3">Massachusetts General Hospital, Boston, MA, 02114</nlm:aff><wicri:noCountry code="subfield">02114</wicri:noCountry></affiliation></author><author><name sortKey="Ascherio, Alberto" sort="Ascherio, Alberto" uniqKey="Ascherio A" first="Alberto" last="Ascherio">Alberto Ascherio</name><affiliation wicri:level="2"><nlm:aff id="A1">Dept. of Nutrition, Harvard School of Public Health 655 Huntington Ave., Boston, MA 02115</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Dept. of Nutrition, Harvard School of Public Health 655 Huntington Ave., Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Dept. of Epidemiology, Harvard School of Public Health 677 Huntington Ave., Boston, MA 02115</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Dept. of Epidemiology, Harvard School of Public Health 677 Huntington Ave., Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A5">Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston, MA 02115</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston</wicri:cityArea></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Anthropometry</term><term>Body Mass Index</term><term>Cohort Studies</term><term>Diabetes Mellitus (epidemiology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Obesity (epidemiology)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (epidemiology)</term><term>Predictive Value of Tests</term><term>Proportional Hazards Models</term><term>Retrospective Studies</term><term>Risk</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Diabetes Mellitus</term><term>Obesity</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Anthropometry</term><term>Body Mass Index</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Predictive Value of Tests</term><term>Proportional Hazards Models</term><term>Retrospective Studies</term><term>Risk</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background and Objective</title><p id="P10">To investigate whether obesity and diabetes are related to risk of Parkinson disease (PD).</p></sec><sec id="S2"><title>Methods</title><p id="P11">We prospectively followed 147,096 participants in the Cancer Prevention Study II Nutrition Cohort from 1992 to 2005. Participants provided information on anthropometric variables and medical history at baseline, and on waist circumference in 1997. Incident cases of PD (n = 656) were confirmed by treating neurologists and medical record review. Relative risks (RR) were estimated using proportional hazards models, adjusting for age, gender, smoking and other risk factors.</p></sec><sec id="S3"><title>Results</title><p id="P12">Neither BMI nor waist circumference significantly predicted PD risk. The RR comparing individuals with a baseline BMI of ≥ 30 to those with a BMI < 23 was 1.00 (95% CI: 0.75, 1.34; p-trend: 0.79), and that comparing individuals with a waist circumference in the top category (>=40.3 inches in men and >=35 inches in women) to those in the bottom category (<34.5 inches in men and <28 inches in women) was 1.35 (95% CI 0.95, 1.93; p-trend 0.08). History of diabetes was not significantly associated with PD risk (combined RR = 0.88; 95 % CI: 0.62, 1.25; p-heterogeneity = 0.96). In addition, neither BMI at age 18, nor changes in weight between age 18 and baseline were significantly associated with PD risk. The results did not differ significantly by gender</p></sec><sec id="S4"><title>Conclusion</title><p id="P13">Our results do not provide evidence for a relationship between BMI, weight change, waist circumference or baseline diabetes and risk of PD.</p></sec></div></front></TEI><double pmid="21739472"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Obesity, Diabetes and Risk of Parkinson Disease</title><author><name sortKey="Palacios, Natalia" sort="Palacios, Natalia" uniqKey="Palacios N" first="Natalia" last="Palacios">Natalia Palacios</name><affiliation wicri:level="2"><nlm:aff id="A1">Dept. of Nutrition, Harvard School of Public Health 655 Huntington Ave., Boston, MA 02115</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Dept. of Nutrition, Harvard School of Public Health 655 Huntington Ave., Boston</wicri:cityArea></affiliation></author><author><name sortKey="Gao, Xiang" sort="Gao, Xiang" uniqKey="Gao X" first="Xiang" last="Gao">Xiang Gao</name><affiliation wicri:level="2"><nlm:aff id="A1">Dept. of Nutrition, Harvard School of Public Health 655 Huntington Ave., Boston, MA 02115</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Dept. of Nutrition, Harvard School of Public Health 655 Huntington Ave., Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A5">Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston, MA 02115</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Mccullough, Marjorie L" sort="Mccullough, Marjorie L" uniqKey="Mccullough M" first="Marjorie L." last="Mccullough">Marjorie L. Mccullough</name><affiliation wicri:level="2"><nlm:aff id="A2">Epidemiology Research Program, American Cancer Society, 250 Williams St., Atlanta, GA 30303</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Epidemiology Research Program, American Cancer Society, 250 Williams St., Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Jacobs, Eric J" sort="Jacobs, Eric J" uniqKey="Jacobs E" first="Eric J." last="Jacobs">Eric J. Jacobs</name><affiliation wicri:level="2"><nlm:aff id="A2">Epidemiology Research Program, American Cancer Society, 250 Williams St., Atlanta, GA 30303</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Epidemiology Research Program, American Cancer Society, 250 Williams St., Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Patel, Alpa V" sort="Patel, Alpa V" uniqKey="Patel A" first="Alpa V." last="Patel">Alpa V. Patel</name><affiliation wicri:level="2"><nlm:aff id="A2">Epidemiology Research Program, American Cancer Society, 250 Williams St., Atlanta, GA 30303</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Epidemiology Research Program, American Cancer Society, 250 Williams St., Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Mayo, Tinisha" sort="Mayo, Tinisha" uniqKey="Mayo T" first="Tinisha" last="Mayo">Tinisha Mayo</name><affiliation wicri:level="2"><nlm:aff id="A2">Epidemiology Research Program, American Cancer Society, 250 Williams St., Atlanta, GA 30303</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Epidemiology Research Program, American Cancer Society, 250 Williams St., Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Schwarzschild, Michael A" sort="Schwarzschild, Michael A" uniqKey="Schwarzschild M" first="Michael A." last="Schwarzschild">Michael A. Schwarzschild</name><affiliation><nlm:aff id="A3">Massachusetts General Hospital, Boston, MA, 02114</nlm:aff><wicri:noCountry code="subfield">02114</wicri:noCountry></affiliation></author><author><name sortKey="Ascherio, Alberto" sort="Ascherio, Alberto" uniqKey="Ascherio A" first="Alberto" last="Ascherio">Alberto Ascherio</name><affiliation wicri:level="2"><nlm:aff id="A1">Dept. of Nutrition, Harvard School of Public Health 655 Huntington Ave., Boston, MA 02115</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Dept. of Nutrition, Harvard School of Public Health 655 Huntington Ave., Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Dept. of Epidemiology, Harvard School of Public Health 677 Huntington Ave., Boston, MA 02115</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Dept. of Epidemiology, Harvard School of Public Health 677 Huntington Ave., Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A5">Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston, MA 02115</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21739472</idno><idno type="pmc">3627531</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627531</idno><idno type="RBID">PMC:3627531</idno><idno type="doi">10.1002/mds.23855</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000249</idno><idno type="wicri:Area/Pmc/Curation">000249</idno><idno type="wicri:Area/Pmc/Checkpoint">000248</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Obesity, Diabetes and Risk of Parkinson Disease</title><author><name sortKey="Palacios, Natalia" sort="Palacios, Natalia" uniqKey="Palacios N" first="Natalia" last="Palacios">Natalia Palacios</name><affiliation wicri:level="2"><nlm:aff id="A1">Dept. of Nutrition, Harvard School of Public Health 655 Huntington Ave., Boston, MA 02115</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Dept. of Nutrition, Harvard School of Public Health 655 Huntington Ave., Boston</wicri:cityArea></affiliation></author><author><name sortKey="Gao, Xiang" sort="Gao, Xiang" uniqKey="Gao X" first="Xiang" last="Gao">Xiang Gao</name><affiliation wicri:level="2"><nlm:aff id="A1">Dept. of Nutrition, Harvard School of Public Health 655 Huntington Ave., Boston, MA 02115</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Dept. of Nutrition, Harvard School of Public Health 655 Huntington Ave., Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A5">Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston, MA 02115</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Mccullough, Marjorie L" sort="Mccullough, Marjorie L" uniqKey="Mccullough M" first="Marjorie L." last="Mccullough">Marjorie L. Mccullough</name><affiliation wicri:level="2"><nlm:aff id="A2">Epidemiology Research Program, American Cancer Society, 250 Williams St., Atlanta, GA 30303</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Epidemiology Research Program, American Cancer Society, 250 Williams St., Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Jacobs, Eric J" sort="Jacobs, Eric J" uniqKey="Jacobs E" first="Eric J." last="Jacobs">Eric J. Jacobs</name><affiliation wicri:level="2"><nlm:aff id="A2">Epidemiology Research Program, American Cancer Society, 250 Williams St., Atlanta, GA 30303</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Epidemiology Research Program, American Cancer Society, 250 Williams St., Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Patel, Alpa V" sort="Patel, Alpa V" uniqKey="Patel A" first="Alpa V." last="Patel">Alpa V. Patel</name><affiliation wicri:level="2"><nlm:aff id="A2">Epidemiology Research Program, American Cancer Society, 250 Williams St., Atlanta, GA 30303</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Epidemiology Research Program, American Cancer Society, 250 Williams St., Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Mayo, Tinisha" sort="Mayo, Tinisha" uniqKey="Mayo T" first="Tinisha" last="Mayo">Tinisha Mayo</name><affiliation wicri:level="2"><nlm:aff id="A2">Epidemiology Research Program, American Cancer Society, 250 Williams St., Atlanta, GA 30303</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Epidemiology Research Program, American Cancer Society, 250 Williams St., Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Schwarzschild, Michael A" sort="Schwarzschild, Michael A" uniqKey="Schwarzschild M" first="Michael A." last="Schwarzschild">Michael A. Schwarzschild</name><affiliation><nlm:aff id="A3">Massachusetts General Hospital, Boston, MA, 02114</nlm:aff><wicri:noCountry code="subfield">02114</wicri:noCountry></affiliation></author><author><name sortKey="Ascherio, Alberto" sort="Ascherio, Alberto" uniqKey="Ascherio A" first="Alberto" last="Ascherio">Alberto Ascherio</name><affiliation wicri:level="2"><nlm:aff id="A1">Dept. of Nutrition, Harvard School of Public Health 655 Huntington Ave., Boston, MA 02115</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Dept. of Nutrition, Harvard School of Public Health 655 Huntington Ave., Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Dept. of Epidemiology, Harvard School of Public Health 677 Huntington Ave., Boston, MA 02115</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Dept. of Epidemiology, Harvard School of Public Health 677 Huntington Ave., Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A5">Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston, MA 02115</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston</wicri:cityArea></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background and Objective</title><p id="P10">To investigate whether obesity and diabetes are related to risk of Parkinson disease (PD).</p></sec><sec id="S2"><title>Methods</title><p id="P11">We prospectively followed 147,096 participants in the Cancer Prevention Study II Nutrition Cohort from 1992 to 2005. Participants provided information on anthropometric variables and medical history at baseline, and on waist circumference in 1997. Incident cases of PD (n = 656) were confirmed by treating neurologists and medical record review. Relative risks (RR) were estimated using proportional hazards models, adjusting for age, gender, smoking and other risk factors.</p></sec><sec id="S3"><title>Results</title><p id="P12">Neither BMI nor waist circumference significantly predicted PD risk. The RR comparing individuals with a baseline BMI of ≥ 30 to those with a BMI < 23 was 1.00 (95% CI: 0.75, 1.34; p-trend: 0.79), and that comparing individuals with a waist circumference in the top category (>=40.3 inches in men and >=35 inches in women) to those in the bottom category (<34.5 inches in men and <28 inches in women) was 1.35 (95% CI 0.95, 1.93; p-trend 0.08). History of diabetes was not significantly associated with PD risk (combined RR = 0.88; 95 % CI: 0.62, 1.25; p-heterogeneity = 0.96). In addition, neither BMI at age 18, nor changes in weight between age 18 and baseline were significantly associated with PD risk. The results did not differ significantly by gender</p></sec><sec id="S4"><title>Conclusion</title><p id="P13">Our results do not provide evidence for a relationship between BMI, weight change, waist circumference or baseline diabetes and risk of PD.</p></sec></div></front></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Obesity, diabetes, and risk of Parkinson's disease.</title><author><name sortKey="Palacios, Natalia" sort="Palacios, Natalia" uniqKey="Palacios N" first="Natalia" last="Palacios">Natalia Palacios</name><affiliation wicri:level="2"><nlm:affiliation>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA. palacios@hsph.harvard.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Gao, Xiang" sort="Gao, Xiang" uniqKey="Gao X" first="Xiang" last="Gao">Xiang Gao</name></author><author><name sortKey="Mccullough, Marjorie L" sort="Mccullough, Marjorie L" uniqKey="Mccullough M" first="Marjorie L" last="Mccullough">Marjorie L. Mccullough</name></author><author><name sortKey="Jacobs, Eric J" sort="Jacobs, Eric J" uniqKey="Jacobs E" first="Eric J" last="Jacobs">Eric J. Jacobs</name></author><author><name sortKey="Patel, Alpa V" sort="Patel, Alpa V" uniqKey="Patel A" first="Alpa V" last="Patel">Alpa V. Patel</name></author><author><name sortKey="Mayo, Tinisha" sort="Mayo, Tinisha" uniqKey="Mayo T" first="Tinisha" last="Mayo">Tinisha Mayo</name></author><author><name sortKey="Schwarzschild, Michael A" sort="Schwarzschild, Michael A" uniqKey="Schwarzschild M" first="Michael A" last="Schwarzschild">Michael A. Schwarzschild</name></author><author><name sortKey="Ascherio, Alberto" sort="Ascherio, Alberto" uniqKey="Ascherio A" first="Alberto" last="Ascherio">Alberto Ascherio</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="doi">10.1002/mds.23855</idno><idno type="RBID">pubmed:21739472</idno><idno type="pmid">21739472</idno><idno type="wicri:Area/PubMed/Corpus">001085</idno><idno type="wicri:Area/PubMed/Curation">001085</idno><idno type="wicri:Area/PubMed/Checkpoint">001200</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Obesity, diabetes, and risk of Parkinson's disease.</title><author><name sortKey="Palacios, Natalia" sort="Palacios, Natalia" uniqKey="Palacios N" first="Natalia" last="Palacios">Natalia Palacios</name><affiliation wicri:level="2"><nlm:affiliation>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA. palacios@hsph.harvard.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Gao, Xiang" sort="Gao, Xiang" uniqKey="Gao X" first="Xiang" last="Gao">Xiang Gao</name></author><author><name sortKey="Mccullough, Marjorie L" sort="Mccullough, Marjorie L" uniqKey="Mccullough M" first="Marjorie L" last="Mccullough">Marjorie L. Mccullough</name></author><author><name sortKey="Jacobs, Eric J" sort="Jacobs, Eric J" uniqKey="Jacobs E" first="Eric J" last="Jacobs">Eric J. Jacobs</name></author><author><name sortKey="Patel, Alpa V" sort="Patel, Alpa V" uniqKey="Patel A" first="Alpa V" last="Patel">Alpa V. Patel</name></author><author><name sortKey="Mayo, Tinisha" sort="Mayo, Tinisha" uniqKey="Mayo T" first="Tinisha" last="Mayo">Tinisha Mayo</name></author><author><name sortKey="Schwarzschild, Michael A" sort="Schwarzschild, Michael A" uniqKey="Schwarzschild M" first="Michael A" last="Schwarzschild">Michael A. Schwarzschild</name></author><author><name sortKey="Ascherio, Alberto" sort="Ascherio, Alberto" uniqKey="Ascherio A" first="Alberto" last="Ascherio">Alberto Ascherio</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Anthropometry</term><term>Body Mass Index</term><term>Cohort Studies</term><term>Diabetes Mellitus (epidemiology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Obesity (epidemiology)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (epidemiology)</term><term>Predictive Value of Tests</term><term>Proportional Hazards Models</term><term>Retrospective Studies</term><term>Risk</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Diabetes Mellitus</term><term>Obesity</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Anthropometry</term><term>Body Mass Index</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Predictive Value of Tests</term><term>Proportional Hazards Models</term><term>Retrospective Studies</term><term>Risk</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of this work was to investigate whether obesity and diabetes are related to risk of Parkinson's disease. We prospectively followed 147,096 participants in the Cancer Prevention Study II Nutrition Cohort from 1992 to 2005. Participants provided information on anthropometric variables and medical history at baseline and on waist circumference in 1997. Incident cases of Parkinson's disease (n = 656) were confirmed by treating neurologists and medical record review. Relative risks were estimated using proportional hazards models, adjusting for age, gender, smoking, and other risk factors. Neither body mass index nor waist circumference significantly predicted Parkinson's disease risk. Relative risk comparing individuals with a baseline body mass index of ≥ 30 to those with a body mass index <23 was 1.00 (95% confidence interval: 0.75, 1.34; P trend: 0.79), and that comparing individuals with a waist circumference in the top category (≥ 40.3 inches in men and ≥ 35 inches in women) to those in the bottom category (<34.5 inches in men and <28 inches in women) was 1.35 (95% confidence interval: 0.95, 1.93; P trend: 0.08). History of diabetes was not significantly associated with Parkinson's disease risk (combined relative risks = 0.88; 95% confidence interval: 0.62, 1.25; P heterogeneity = 0.96). In addition, neither body mass index at age 18 nor changes in weight between age 18 and baseline were significantly associated with Parkinson's disease risk. The results did not differ significantly by gender. Our results do not provide evidence for a relationship between body mass index, weight change, waist circumference, or baseline diabetes and risk of Parkinson's disease.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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