Obesity, Diabetes and Risk of Parkinson Disease
Identifieur interne : 000249 ( Pmc/Corpus ); précédent : 000248; suivant : 000250Obesity, Diabetes and Risk of Parkinson Disease
Auteurs : Natalia Palacios ; Xiang Gao ; Marjorie L. Mccullough ; Eric J. Jacobs ; Alpa V. Patel ; Tinisha Mayo ; Michael A. Schwarzschild ; Alberto AscherioSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2011.
Abstract
To investigate whether obesity and diabetes are related to risk of Parkinson disease (PD).
We prospectively followed 147,096 participants in the Cancer Prevention Study II Nutrition Cohort from 1992 to 2005. Participants provided information on anthropometric variables and medical history at baseline, and on waist circumference in 1997. Incident cases of PD (n = 656) were confirmed by treating neurologists and medical record review. Relative risks (RR) were estimated using proportional hazards models, adjusting for age, gender, smoking and other risk factors.
Neither BMI nor waist circumference significantly predicted PD risk. The RR comparing individuals with a baseline BMI of ≥ 30 to those with a BMI < 23 was 1.00 (95% CI: 0.75, 1.34; p-trend: 0.79), and that comparing individuals with a waist circumference in the top category (>=40.3 inches in men and >=35 inches in women) to those in the bottom category (<34.5 inches in men and <28 inches in women) was 1.35 (95% CI 0.95, 1.93; p-trend 0.08). History of diabetes was not significantly associated with PD risk (combined RR = 0.88; 95 % CI: 0.62, 1.25; p-heterogeneity = 0.96). In addition, neither BMI at age 18, nor changes in weight between age 18 and baseline were significantly associated with PD risk. The results did not differ significantly by gender
Our results do not provide evidence for a relationship between BMI, weight change, waist circumference or baseline diabetes and risk of PD.
Url:
DOI: 10.1002/mds.23855
PubMed: 21739472
PubMed Central: 3627531
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