Motor unit changes in sporadic idiopathic Parkinson's disease.
Identifieur interne : 000221 ( Ncbi/Merge ); précédent : 000220; suivant : 000222Motor unit changes in sporadic idiopathic Parkinson's disease.
Auteurs : J N Caviness [États-Unis] ; B E Smith ; J C Stevens ; C H Adler ; R J Caselli ; C A Reiners ; J G Hentz ; M D MuenterSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2000.
English descriptors
- KwdEn :
- Aged, Electromyography, Female, Humans, Male, Middle Aged, Motor Neuron Disease (diagnosis), Motor Neuron Disease (physiopathology), Motor Neurons (physiology), Muscle, Skeletal (innervation), Nerve Degeneration (diagnosis), Nerve Degeneration (physiopathology), Neural Pathways (physiopathology), Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Peripheral Nerves (physiopathology), Reaction Time (physiology), Reference Values, Signal Processing, Computer-Assisted.
- MESH :
- diagnosis : Motor Neuron Disease, Nerve Degeneration, Parkinson Disease.
- innervation : Muscle, Skeletal.
- physiology : Motor Neurons, Reaction Time.
- physiopathology : Motor Neuron Disease, Nerve Degeneration, Neural Pathways, Parkinson Disease, Peripheral Nerves.
- Aged, Electromyography, Female, Humans, Male, Middle Aged, Reference Values, Signal Processing, Computer-Assisted.
Abstract
We studied motor unit changes in 20 patients with Parkinson's disease (PD) and 20 age-matched control subjects to look for evidence of motorneuron degeneration in sporadic idiopathic PD. Patients and control subjects were screened by clinical criteria and nerve conduction studies to exclude those with peripheral neuropathic processes. Changes in motor unit morphology were investigated with subjective and computerized quantitative electromyography (QEMG) of the anterior tibialis (AT) and first dorsal interosseous. Multivariate comparisons showed a significant difference in the QEMG analysis for motor unit enlargement in patients with PD versus control subjects. Some of the univariate comparisons for both the subjective and QEMG analyses of the AT were also significant. These results demonstrate that motorneuron drop-out with reinnervation occurs in sporadic idiopathic PD. In summary, our findings provide evidence that clinically silent motorneuron disease occurs in typical cases of sporadic idiopathic PD, suggesting that it may be a normal part of the pathologic picture of PD. Any hypothesis concerning the pathogenic mechanism of PD would need to take into account such a finding.
PubMed: 10752572
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Motor unit changes in sporadic idiopathic Parkinson's disease.</title><author><name sortKey="Caviness, J N" sort="Caviness, J N" uniqKey="Caviness J" first="J N" last="Caviness">J N Caviness</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Mayo Clinic Scottsdale, Arizona 85259, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic Scottsdale, Arizona 85259</wicri:regionArea><wicri:noRegion>Arizona 85259</wicri:noRegion></affiliation></author><author><name sortKey="Smith, B E" sort="Smith, B E" uniqKey="Smith B" first="B E" last="Smith">B E Smith</name></author><author><name sortKey="Stevens, J C" sort="Stevens, J C" uniqKey="Stevens J" first="J C" last="Stevens">J C Stevens</name></author><author><name sortKey="Adler, C H" sort="Adler, C H" uniqKey="Adler C" first="C H" last="Adler">C H Adler</name></author><author><name sortKey="Caselli, R J" sort="Caselli, R J" uniqKey="Caselli R" first="R J" last="Caselli">R J Caselli</name></author><author><name sortKey="Reiners, C A" sort="Reiners, C A" uniqKey="Reiners C" first="C A" last="Reiners">C A Reiners</name></author><author><name sortKey="Hentz, J G" sort="Hentz, J G" uniqKey="Hentz J" first="J G" last="Hentz">J G Hentz</name></author><author><name sortKey="Muenter, M D" sort="Muenter, M D" uniqKey="Muenter M" first="M D" last="Muenter">M D Muenter</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2000">2000</date><idno type="RBID">pubmed:10752572</idno><idno type="pmid">10752572</idno><idno type="wicri:Area/PubMed/Corpus">004030</idno><idno type="wicri:Area/PubMed/Curation">004030</idno><idno type="wicri:Area/PubMed/Checkpoint">003F39</idno><idno type="wicri:Area/Ncbi/Merge">000221</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Motor unit changes in sporadic idiopathic Parkinson's disease.</title><author><name sortKey="Caviness, J N" sort="Caviness, J N" uniqKey="Caviness J" first="J N" last="Caviness">J N Caviness</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Mayo Clinic Scottsdale, Arizona 85259, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic Scottsdale, Arizona 85259</wicri:regionArea><wicri:noRegion>Arizona 85259</wicri:noRegion></affiliation></author><author><name sortKey="Smith, B E" sort="Smith, B E" uniqKey="Smith B" first="B E" last="Smith">B E Smith</name></author><author><name sortKey="Stevens, J C" sort="Stevens, J C" uniqKey="Stevens J" first="J C" last="Stevens">J C Stevens</name></author><author><name sortKey="Adler, C H" sort="Adler, C H" uniqKey="Adler C" first="C H" last="Adler">C H Adler</name></author><author><name sortKey="Caselli, R J" sort="Caselli, R J" uniqKey="Caselli R" first="R J" last="Caselli">R J Caselli</name></author><author><name sortKey="Reiners, C A" sort="Reiners, C A" uniqKey="Reiners C" first="C A" last="Reiners">C A Reiners</name></author><author><name sortKey="Hentz, J G" sort="Hentz, J G" uniqKey="Hentz J" first="J G" last="Hentz">J G Hentz</name></author><author><name sortKey="Muenter, M D" sort="Muenter, M D" uniqKey="Muenter M" first="M D" last="Muenter">M D Muenter</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2000" type="published">2000</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Electromyography</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Motor Neuron Disease (diagnosis)</term><term>Motor Neuron Disease (physiopathology)</term><term>Motor Neurons (physiology)</term><term>Muscle, Skeletal (innervation)</term><term>Nerve Degeneration (diagnosis)</term><term>Nerve Degeneration (physiopathology)</term><term>Neural Pathways (physiopathology)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (physiopathology)</term><term>Peripheral Nerves (physiopathology)</term><term>Reaction Time (physiology)</term><term>Reference Values</term><term>Signal Processing, Computer-Assisted</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Motor Neuron Disease</term><term>Nerve Degeneration</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Motor Neurons</term><term>Reaction Time</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Motor Neuron Disease</term><term>Nerve Degeneration</term><term>Neural Pathways</term><term>Parkinson Disease</term><term>Peripheral Nerves</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Electromyography</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Reference Values</term><term>Signal Processing, Computer-Assisted</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We studied motor unit changes in 20 patients with Parkinson's disease (PD) and 20 age-matched control subjects to look for evidence of motorneuron degeneration in sporadic idiopathic PD. Patients and control subjects were screened by clinical criteria and nerve conduction studies to exclude those with peripheral neuropathic processes. Changes in motor unit morphology were investigated with subjective and computerized quantitative electromyography (QEMG) of the anterior tibialis (AT) and first dorsal interosseous. Multivariate comparisons showed a significant difference in the QEMG analysis for motor unit enlargement in patients with PD versus control subjects. Some of the univariate comparisons for both the subjective and QEMG analyses of the AT were also significant. These results demonstrate that motorneuron drop-out with reinnervation occurs in sporadic idiopathic PD. In summary, our findings provide evidence that clinically silent motorneuron disease occurs in typical cases of sporadic idiopathic PD, suggesting that it may be a normal part of the pathologic picture of PD. Any hypothesis concerning the pathogenic mechanism of PD would need to take into account such a finding.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">10752572</PMID><DateCreated><Year>2000</Year><Month>06</Month><Day>09</Day></DateCreated><DateCompleted><Year>2000</Year><Month>06</Month><Day>09</Day></DateCompleted><DateRevised><Year>2004</Year><Month>11</Month><Day>17</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>15</Volume><Issue>2</Issue><PubDate><Year>2000</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Motor unit changes in sporadic idiopathic Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>238-43</MedlinePgn></Pagination><Abstract><AbstractText>We studied motor unit changes in 20 patients with Parkinson's disease (PD) and 20 age-matched control subjects to look for evidence of motorneuron degeneration in sporadic idiopathic PD. Patients and control subjects were screened by clinical criteria and nerve conduction studies to exclude those with peripheral neuropathic processes. Changes in motor unit morphology were investigated with subjective and computerized quantitative electromyography (QEMG) of the anterior tibialis (AT) and first dorsal interosseous. Multivariate comparisons showed a significant difference in the QEMG analysis for motor unit enlargement in patients with PD versus control subjects. Some of the univariate comparisons for both the subjective and QEMG analyses of the AT were also significant. These results demonstrate that motorneuron drop-out with reinnervation occurs in sporadic idiopathic PD. In summary, our findings provide evidence that clinically silent motorneuron disease occurs in typical cases of sporadic idiopathic PD, suggesting that it may be a normal part of the pathologic picture of PD. Any hypothesis concerning the pathogenic mechanism of PD would need to take into account such a finding.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Caviness</LastName><ForeName>J N</ForeName><Initials>JN</Initials><AffiliationInfo><Affiliation>Department of Neurology, Mayo Clinic Scottsdale, Arizona 85259, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>B E</ForeName><Initials>BE</Initials></Author><Author ValidYN="Y"><LastName>Stevens</LastName><ForeName>J C</ForeName><Initials>JC</Initials></Author><Author ValidYN="Y"><LastName>Adler</LastName><ForeName>C H</ForeName><Initials>CH</Initials></Author><Author ValidYN="Y"><LastName>Caselli</LastName><ForeName>R J</ForeName><Initials>RJ</Initials></Author><Author ValidYN="Y"><LastName>Reiners</LastName><ForeName>C A</ForeName><Initials>CA</Initials></Author><Author ValidYN="Y"><LastName>Hentz</LastName><ForeName>J G</ForeName><Initials>JG</Initials></Author><Author ValidYN="Y"><LastName>Muenter</LastName><ForeName>M D</ForeName><Initials>MD</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>UNITED STATES</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004576">Electromyography</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016472">Motor Neuron Disease</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009046">Motor Neurons</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D018482">Muscle, Skeletal</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000294">innervation</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009410">Nerve Degeneration</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009434">Neural Pathways</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010525">Peripheral Nerves</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011930">Reaction Time</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012016">Reference Values</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012815">Signal Processing, Computer-Assisted</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2000</Year><Month>4</Month><Day>7</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2000</Year><Month>6</Month><Day>17</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2000</Year><Month>4</Month><Day>7</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">10752572</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Adler, C H" sort="Adler, C H" uniqKey="Adler C" first="C H" last="Adler">C H Adler</name><name sortKey="Caselli, R J" sort="Caselli, R J" uniqKey="Caselli R" first="R J" last="Caselli">R J Caselli</name><name sortKey="Hentz, J G" sort="Hentz, J G" uniqKey="Hentz J" first="J G" last="Hentz">J G Hentz</name><name sortKey="Muenter, M D" sort="Muenter, M D" uniqKey="Muenter M" first="M D" last="Muenter">M D Muenter</name><name sortKey="Reiners, C A" sort="Reiners, C A" uniqKey="Reiners C" first="C A" last="Reiners">C A Reiners</name><name sortKey="Smith, B E" sort="Smith, B E" uniqKey="Smith B" first="B E" last="Smith">B E Smith</name><name sortKey="Stevens, J C" sort="Stevens, J C" uniqKey="Stevens J" first="J C" last="Stevens">J C Stevens</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Caviness, J N" sort="Caviness, J N" uniqKey="Caviness J" first="J N" last="Caviness">J N Caviness</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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