Motor unit changes in sporadic idiopathic Parkinson's disease.
Identifieur interne : 004030 ( PubMed/Curation ); précédent : 004029; suivant : 004031Motor unit changes in sporadic idiopathic Parkinson's disease.
Auteurs : J N Caviness [États-Unis] ; B E Smith ; J C Stevens ; C H Adler ; R J Caselli ; C A Reiners ; J G Hentz ; M D MuenterSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2000.
English descriptors
- KwdEn :
- Aged, Electromyography, Female, Humans, Male, Middle Aged, Motor Neuron Disease (diagnosis), Motor Neuron Disease (physiopathology), Motor Neurons (physiology), Muscle, Skeletal (innervation), Nerve Degeneration (diagnosis), Nerve Degeneration (physiopathology), Neural Pathways (physiopathology), Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Peripheral Nerves (physiopathology), Reaction Time (physiology), Reference Values, Signal Processing, Computer-Assisted.
- MESH :
- diagnosis : Motor Neuron Disease, Nerve Degeneration, Parkinson Disease.
- innervation : Muscle, Skeletal.
- physiology : Motor Neurons, Reaction Time.
- physiopathology : Motor Neuron Disease, Nerve Degeneration, Neural Pathways, Parkinson Disease, Peripheral Nerves.
- Aged, Electromyography, Female, Humans, Male, Middle Aged, Reference Values, Signal Processing, Computer-Assisted.
Abstract
We studied motor unit changes in 20 patients with Parkinson's disease (PD) and 20 age-matched control subjects to look for evidence of motorneuron degeneration in sporadic idiopathic PD. Patients and control subjects were screened by clinical criteria and nerve conduction studies to exclude those with peripheral neuropathic processes. Changes in motor unit morphology were investigated with subjective and computerized quantitative electromyography (QEMG) of the anterior tibialis (AT) and first dorsal interosseous. Multivariate comparisons showed a significant difference in the QEMG analysis for motor unit enlargement in patients with PD versus control subjects. Some of the univariate comparisons for both the subjective and QEMG analyses of the AT were also significant. These results demonstrate that motorneuron drop-out with reinnervation occurs in sporadic idiopathic PD. In summary, our findings provide evidence that clinically silent motorneuron disease occurs in typical cases of sporadic idiopathic PD, suggesting that it may be a normal part of the pathologic picture of PD. Any hypothesis concerning the pathogenic mechanism of PD would need to take into account such a finding.
PubMed: 10752572
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<author><name sortKey="Stevens, J C" sort="Stevens, J C" uniqKey="Stevens J" first="J C" last="Stevens">J C Stevens</name>
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<author><name sortKey="Reiners, C A" sort="Reiners, C A" uniqKey="Reiners C" first="C A" last="Reiners">C A Reiners</name>
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<front><div type="abstract" xml:lang="en">We studied motor unit changes in 20 patients with Parkinson's disease (PD) and 20 age-matched control subjects to look for evidence of motorneuron degeneration in sporadic idiopathic PD. Patients and control subjects were screened by clinical criteria and nerve conduction studies to exclude those with peripheral neuropathic processes. Changes in motor unit morphology were investigated with subjective and computerized quantitative electromyography (QEMG) of the anterior tibialis (AT) and first dorsal interosseous. Multivariate comparisons showed a significant difference in the QEMG analysis for motor unit enlargement in patients with PD versus control subjects. Some of the univariate comparisons for both the subjective and QEMG analyses of the AT were also significant. These results demonstrate that motorneuron drop-out with reinnervation occurs in sporadic idiopathic PD. In summary, our findings provide evidence that clinically silent motorneuron disease occurs in typical cases of sporadic idiopathic PD, suggesting that it may be a normal part of the pathologic picture of PD. Any hypothesis concerning the pathogenic mechanism of PD would need to take into account such a finding.</div>
</front>
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<Abstract><AbstractText>We studied motor unit changes in 20 patients with Parkinson's disease (PD) and 20 age-matched control subjects to look for evidence of motorneuron degeneration in sporadic idiopathic PD. Patients and control subjects were screened by clinical criteria and nerve conduction studies to exclude those with peripheral neuropathic processes. Changes in motor unit morphology were investigated with subjective and computerized quantitative electromyography (QEMG) of the anterior tibialis (AT) and first dorsal interosseous. Multivariate comparisons showed a significant difference in the QEMG analysis for motor unit enlargement in patients with PD versus control subjects. Some of the univariate comparisons for both the subjective and QEMG analyses of the AT were also significant. These results demonstrate that motorneuron drop-out with reinnervation occurs in sporadic idiopathic PD. In summary, our findings provide evidence that clinically silent motorneuron disease occurs in typical cases of sporadic idiopathic PD, suggesting that it may be a normal part of the pathologic picture of PD. Any hypothesis concerning the pathogenic mechanism of PD would need to take into account such a finding.</AbstractText>
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