Remembered saccades with variable delay in Parkinson's disease.
Identifieur interne : 005100 ( Ncbi/Curation ); précédent : 005099; suivant : 005101Remembered saccades with variable delay in Parkinson's disease.
Auteurs : S. Shaunak [Royaume-Uni] ; E. O'Sullivan ; S. Blunt ; M. Lawden ; T. Crawford ; L. Henderson ; C. KennardSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1999.
English descriptors
- KwdEn :
- Attention (physiology), Corpus Striatum (physiopathology), Humans, Mental Recall (physiology), Neural Inhibition (physiology), Neural Pathways (physiopathology), Orientation (physiology), Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Prefrontal Cortex (physiopathology), Reaction Time (physiology), Reference Values, Reflex (physiology), Saccades (physiology), Superior Colliculi (physiopathology).
- MESH :
- diagnosis : Parkinson Disease.
- physiology : Attention, Mental Recall, Neural Inhibition, Orientation, Reaction Time, Reflex, Saccades.
- physiopathology : Corpus Striatum, Neural Pathways, Parkinson Disease, Prefrontal Cortex, Superior Colliculi.
- Humans, Reference Values.
Abstract
The effect of increasing delay on the metrics of remembered saccades was studied in 10 subjects with mild Parkinson's disease, none of whom was receiving treatment with L-dopa, and nine age-matched control subjects. Delays of 1 msec, 250 msec, 1000 msec, 2500 msec, and 5000 msec were used, and reflexive saccades used as a control condition. Results were analyzed for the gain of the primary saccade and the accuracy of the final eye position (FEP gain). Reflexive saccades were normal in subjects with Parkinson's disease, but remembered saccades showed marked hypometria of primary saccade gain at all delays. FEP gain was unimpaired in Parkinson's disease, and primary saccade gain and FEP gain did not vary as a function of delay. Hypometria of primary saccades is compatible with dysfunction in striato-collicular inhibitory pathways in Parkinson's disease, arising as a functional consequence of dopamine deficiency in the basal ganglia. Maintenance of an accurate FEP gain suggests no deficit in oculomotor spatial working memory in Parkinson's disease, at least at delays of up to 5 sec.
PubMed: 9918348
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :004283
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :004283
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :004117
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :005100
Links to Exploration step
pubmed:9918348Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Remembered saccades with variable delay in Parkinson's disease.</title>
<author><name sortKey="Shaunak, S" sort="Shaunak, S" uniqKey="Shaunak S" first="S" last="Shaunak">S. Shaunak</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Sensorimotor Systems, Imperial College School of Medicine, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Sensorimotor Systems, Imperial College School of Medicine, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="O Sullivan, E" sort="O Sullivan, E" uniqKey="O Sullivan E" first="E" last="O'Sullivan">E. O'Sullivan</name>
</author>
<author><name sortKey="Blunt, S" sort="Blunt, S" uniqKey="Blunt S" first="S" last="Blunt">S. Blunt</name>
</author>
<author><name sortKey="Lawden, M" sort="Lawden, M" uniqKey="Lawden M" first="M" last="Lawden">M. Lawden</name>
</author>
<author><name sortKey="Crawford, T" sort="Crawford, T" uniqKey="Crawford T" first="T" last="Crawford">T. Crawford</name>
</author>
<author><name sortKey="Henderson, L" sort="Henderson, L" uniqKey="Henderson L" first="L" last="Henderson">L. Henderson</name>
</author>
<author><name sortKey="Kennard, C" sort="Kennard, C" uniqKey="Kennard C" first="C" last="Kennard">C. Kennard</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="1999">1999</date>
<idno type="RBID">pubmed:9918348</idno>
<idno type="pmid">9918348</idno>
<idno type="wicri:Area/PubMed/Corpus">004283</idno>
<idno type="wicri:Area/PubMed/Curation">004283</idno>
<idno type="wicri:Area/PubMed/Checkpoint">004117</idno>
<idno type="wicri:Area/Ncbi/Merge">005100</idno>
<idno type="wicri:Area/Ncbi/Curation">005100</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Remembered saccades with variable delay in Parkinson's disease.</title>
<author><name sortKey="Shaunak, S" sort="Shaunak, S" uniqKey="Shaunak S" first="S" last="Shaunak">S. Shaunak</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Sensorimotor Systems, Imperial College School of Medicine, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Sensorimotor Systems, Imperial College School of Medicine, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="O Sullivan, E" sort="O Sullivan, E" uniqKey="O Sullivan E" first="E" last="O'Sullivan">E. O'Sullivan</name>
</author>
<author><name sortKey="Blunt, S" sort="Blunt, S" uniqKey="Blunt S" first="S" last="Blunt">S. Blunt</name>
</author>
<author><name sortKey="Lawden, M" sort="Lawden, M" uniqKey="Lawden M" first="M" last="Lawden">M. Lawden</name>
</author>
<author><name sortKey="Crawford, T" sort="Crawford, T" uniqKey="Crawford T" first="T" last="Crawford">T. Crawford</name>
</author>
<author><name sortKey="Henderson, L" sort="Henderson, L" uniqKey="Henderson L" first="L" last="Henderson">L. Henderson</name>
</author>
<author><name sortKey="Kennard, C" sort="Kennard, C" uniqKey="Kennard C" first="C" last="Kennard">C. Kennard</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="1999" type="published">1999</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Attention (physiology)</term>
<term>Corpus Striatum (physiopathology)</term>
<term>Humans</term>
<term>Mental Recall (physiology)</term>
<term>Neural Inhibition (physiology)</term>
<term>Neural Pathways (physiopathology)</term>
<term>Orientation (physiology)</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Prefrontal Cortex (physiopathology)</term>
<term>Reaction Time (physiology)</term>
<term>Reference Values</term>
<term>Reflex (physiology)</term>
<term>Saccades (physiology)</term>
<term>Superior Colliculi (physiopathology)</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Attention</term>
<term>Mental Recall</term>
<term>Neural Inhibition</term>
<term>Orientation</term>
<term>Reaction Time</term>
<term>Reflex</term>
<term>Saccades</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Corpus Striatum</term>
<term>Neural Pathways</term>
<term>Parkinson Disease</term>
<term>Prefrontal Cortex</term>
<term>Superior Colliculi</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Humans</term>
<term>Reference Values</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The effect of increasing delay on the metrics of remembered saccades was studied in 10 subjects with mild Parkinson's disease, none of whom was receiving treatment with L-dopa, and nine age-matched control subjects. Delays of 1 msec, 250 msec, 1000 msec, 2500 msec, and 5000 msec were used, and reflexive saccades used as a control condition. Results were analyzed for the gain of the primary saccade and the accuracy of the final eye position (FEP gain). Reflexive saccades were normal in subjects with Parkinson's disease, but remembered saccades showed marked hypometria of primary saccade gain at all delays. FEP gain was unimpaired in Parkinson's disease, and primary saccade gain and FEP gain did not vary as a function of delay. Hypometria of primary saccades is compatible with dysfunction in striato-collicular inhibitory pathways in Parkinson's disease, arising as a functional consequence of dopamine deficiency in the basal ganglia. Maintenance of an accurate FEP gain suggests no deficit in oculomotor spatial working memory in Parkinson's disease, at least at delays of up to 5 sec.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005100 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 005100 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Ncbi |étape= Curation |type= RBID |clé= pubmed:9918348 |texte= Remembered saccades with variable delay in Parkinson's disease. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:9918348" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \ | NlmPubMed2Wicri -a MovDisordV3
![]() | This area was generated with Dilib version V0.6.23. | ![]() |