Remembered saccades with variable delay in Parkinson's disease.
Identifieur interne : 004283 ( PubMed/Curation ); précédent : 004282; suivant : 004284Remembered saccades with variable delay in Parkinson's disease.
Auteurs : S. Shaunak [Royaume-Uni] ; E. O'Sullivan ; S. Blunt ; M. Lawden ; T. Crawford ; L. Henderson ; C. KennardSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1999.
English descriptors
- KwdEn :
- Attention (physiology), Corpus Striatum (physiopathology), Humans, Mental Recall (physiology), Neural Inhibition (physiology), Neural Pathways (physiopathology), Orientation (physiology), Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Prefrontal Cortex (physiopathology), Reaction Time (physiology), Reference Values, Reflex (physiology), Saccades (physiology), Superior Colliculi (physiopathology).
- MESH :
- diagnosis : Parkinson Disease.
- physiology : Attention, Mental Recall, Neural Inhibition, Orientation, Reaction Time, Reflex, Saccades.
- physiopathology : Corpus Striatum, Neural Pathways, Parkinson Disease, Prefrontal Cortex, Superior Colliculi.
- Humans, Reference Values.
Abstract
The effect of increasing delay on the metrics of remembered saccades was studied in 10 subjects with mild Parkinson's disease, none of whom was receiving treatment with L-dopa, and nine age-matched control subjects. Delays of 1 msec, 250 msec, 1000 msec, 2500 msec, and 5000 msec were used, and reflexive saccades used as a control condition. Results were analyzed for the gain of the primary saccade and the accuracy of the final eye position (FEP gain). Reflexive saccades were normal in subjects with Parkinson's disease, but remembered saccades showed marked hypometria of primary saccade gain at all delays. FEP gain was unimpaired in Parkinson's disease, and primary saccade gain and FEP gain did not vary as a function of delay. Hypometria of primary saccades is compatible with dysfunction in striato-collicular inhibitory pathways in Parkinson's disease, arising as a functional consequence of dopamine deficiency in the basal ganglia. Maintenance of an accurate FEP gain suggests no deficit in oculomotor spatial working memory in Parkinson's disease, at least at delays of up to 5 sec.
PubMed: 9918348
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Lawden</name></author><author><name sortKey="Crawford, T" sort="Crawford, T" uniqKey="Crawford T" first="T" last="Crawford">T. Crawford</name></author><author><name sortKey="Henderson, L" sort="Henderson, L" uniqKey="Henderson L" first="L" last="Henderson">L. Henderson</name></author><author><name sortKey="Kennard, C" sort="Kennard, C" uniqKey="Kennard C" first="C" last="Kennard">C. Kennard</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1999">1999</date><idno type="RBID">pubmed:9918348</idno><idno type="pmid">9918348</idno><idno type="wicri:Area/PubMed/Corpus">004283</idno><idno type="wicri:Area/PubMed/Curation">004283</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Remembered saccades with variable delay in Parkinson's disease.</title><author><name sortKey="Shaunak, S" sort="Shaunak, S" uniqKey="Shaunak S" first="S" last="Shaunak">S. Shaunak</name><affiliation wicri:level="1"><nlm:affiliation>Department of Sensorimotor Systems, Imperial College School of Medicine, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Sensorimotor Systems, Imperial College School of Medicine, London</wicri:regionArea></affiliation></author><author><name sortKey="O Sullivan, E" sort="O Sullivan, E" uniqKey="O Sullivan E" first="E" last="O'Sullivan">E. O'Sullivan</name></author><author><name sortKey="Blunt, S" sort="Blunt, S" uniqKey="Blunt S" first="S" last="Blunt">S. Blunt</name></author><author><name sortKey="Lawden, M" sort="Lawden, M" uniqKey="Lawden M" first="M" last="Lawden">M. Lawden</name></author><author><name sortKey="Crawford, T" sort="Crawford, T" uniqKey="Crawford T" first="T" last="Crawford">T. Crawford</name></author><author><name sortKey="Henderson, L" sort="Henderson, L" uniqKey="Henderson L" first="L" last="Henderson">L. Henderson</name></author><author><name sortKey="Kennard, C" sort="Kennard, C" uniqKey="Kennard C" first="C" last="Kennard">C. Kennard</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1999" type="published">1999</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Attention (physiology)</term><term>Corpus Striatum (physiopathology)</term><term>Humans</term><term>Mental Recall (physiology)</term><term>Neural Inhibition (physiology)</term><term>Neural Pathways (physiopathology)</term><term>Orientation (physiology)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (physiopathology)</term><term>Prefrontal Cortex (physiopathology)</term><term>Reaction Time (physiology)</term><term>Reference Values</term><term>Reflex (physiology)</term><term>Saccades (physiology)</term><term>Superior Colliculi (physiopathology)</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Attention</term><term>Mental Recall</term><term>Neural Inhibition</term><term>Orientation</term><term>Reaction Time</term><term>Reflex</term><term>Saccades</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Corpus Striatum</term><term>Neural Pathways</term><term>Parkinson Disease</term><term>Prefrontal Cortex</term><term>Superior Colliculi</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Reference Values</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The effect of increasing delay on the metrics of remembered saccades was studied in 10 subjects with mild Parkinson's disease, none of whom was receiving treatment with L-dopa, and nine age-matched control subjects. Delays of 1 msec, 250 msec, 1000 msec, 2500 msec, and 5000 msec were used, and reflexive saccades used as a control condition. Results were analyzed for the gain of the primary saccade and the accuracy of the final eye position (FEP gain). Reflexive saccades were normal in subjects with Parkinson's disease, but remembered saccades showed marked hypometria of primary saccade gain at all delays. FEP gain was unimpaired in Parkinson's disease, and primary saccade gain and FEP gain did not vary as a function of delay. Hypometria of primary saccades is compatible with dysfunction in striato-collicular inhibitory pathways in Parkinson's disease, arising as a functional consequence of dopamine deficiency in the basal ganglia. Maintenance of an accurate FEP gain suggests no deficit in oculomotor spatial working memory in Parkinson's disease, at least at delays of up to 5 sec.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">9918348</PMID><DateCreated><Year>1999</Year><Month>04</Month><Day>01</Day></DateCreated><DateCompleted><Year>1999</Year><Month>04</Month><Day>01</Day></DateCompleted><DateRevised><Year>2007</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>14</Volume><Issue>1</Issue><PubDate><Year>1999</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Remembered saccades with variable delay in Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>80-6</MedlinePgn></Pagination><Abstract><AbstractText>The effect of increasing delay on the metrics of remembered saccades was studied in 10 subjects with mild Parkinson's disease, none of whom was receiving treatment with L-dopa, and nine age-matched control subjects. Delays of 1 msec, 250 msec, 1000 msec, 2500 msec, and 5000 msec were used, and reflexive saccades used as a control condition. Results were analyzed for the gain of the primary saccade and the accuracy of the final eye position (FEP gain). Reflexive saccades were normal in subjects with Parkinson's disease, but remembered saccades showed marked hypometria of primary saccade gain at all delays. FEP gain was unimpaired in Parkinson's disease, and primary saccade gain and FEP gain did not vary as a function of delay. Hypometria of primary saccades is compatible with dysfunction in striato-collicular inhibitory pathways in Parkinson's disease, arising as a functional consequence of dopamine deficiency in the basal ganglia. Maintenance of an accurate FEP gain suggests no deficit in oculomotor spatial working memory in Parkinson's disease, at least at delays of up to 5 sec.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Shaunak</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Sensorimotor Systems, Imperial College School of Medicine, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>O'Sullivan</LastName><ForeName>E</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Blunt</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Lawden</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Crawford</LastName><ForeName>T</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Henderson</LastName><ForeName>L</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Kennard</LastName><ForeName>C</ForeName><Initials>C</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>UNITED STATES</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001288">Attention</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003342">Corpus Striatum</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011939">Mental Recall</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009433">Neural Inhibition</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009434">Neural Pathways</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009949">Orientation</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D017397">Prefrontal Cortex</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011930">Reaction Time</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012016">Reference Values</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012018">Reflex</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012438">Saccades</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013477">Superior Colliculi</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1999</Year><Month>1</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1999</Year><Month>1</Month><Day>26</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1999</Year><Month>1</Month><Day>26</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">9918348</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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