Botulinum toxin A improves muscle spasms and rigidity in stiff-person syndrome.
Identifieur interne : 004E42 ( Ncbi/Curation ); précédent : 004E41; suivant : 004E43Botulinum toxin A improves muscle spasms and rigidity in stiff-person syndrome.
Auteurs : R. Liguori [Italie] ; C. Cordivari ; E. Lugaresi ; P. MontagnaSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1997.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Botulinum Toxins, Type A, Neuromuscular Agents.
- complications : Muscle Rigidity, Stiff-Person Syndrome.
- drug therapy : Muscle Rigidity.
- physiopathology : Muscle Rigidity, Muscle, Skeletal.
- Female, Humans, Middle Aged.
Abstract
We studied the effect of botulinum toxin A (BTA) on painful muscular spasms and rigidity in two bedridden patients with clinical, electrophysiologic, and immunologic evidence of stiff-person syndrome. We injected BTA or saline solution into several limb muscles with both the rater and patient blinded to the order of the injections. A physician, unaware of the treatment order, used an objective rating scale for rigidity and spasm frequency scale and independently assessed the treatment results. BTA administration significantly reduced rigidity and stopped the spasms in all limbs. Following BTA injection on one side, the spasm frequency decreased bilaterally possibly because of the spread of hematogenous toxin.
DOI: 10.1002/mds.870120636
PubMed: 9399238
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pubmed:9399238Le document en format XML
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