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G/A1947 polymorphism in catechol-O-methyltransferase (COMT) gene in Parkinson's disease.

Identifieur interne : 004D17 ( Ncbi/Curation ); précédent : 004D16; suivant : 004D18

G/A1947 polymorphism in catechol-O-methyltransferase (COMT) gene in Parkinson's disease.

Auteurs : T. Xie [Hong Kong] ; S L Ho ; L S Li ; O C Ma

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1997.

RBID : pubmed:9159741

English descriptors

KwdEn :
- Aged, Alleles, Base Sequence, Catechol O-Methyltransferase (genetics), Catechol O-Methyltransferase (metabolism), DNA Primers, Female, Humans, Male, Methionine (genetics), Middle Aged, Molecular Sequence Data, Parkinson Disease (enzymology), Parkinson Disease (genetics), Polymerase Chain Reaction, Polymorphism, Genetic, Valine (genetics).
MESH :
- chemical , genetics : Catechol O-Methyltransferase, Methionine, Valine.
- chemical , metabolism : Catechol O-Methyltransferase.
- enzymology : Parkinson Disease.
- genetics : Parkinson Disease.
- Aged, Alleles, Base Sequence, DNA Primers, Female, Humans, Male, Middle Aged, Molecular Sequence Data, Polymerase Chain Reaction, Polymorphism, Genetic.

Abstract

High and low catechol-O-methyltransferase (COMT) activity is significantly determined by thermostability, which is caused by a valine/methionine108 polymorphism associated with polymorphic G/A1947 bases, in exon 4 of the COMT gene. Our allelic association study on this polymorphism did not find any statistically significant difference between our Chinese Parkinson's disease and that of control subjects. These results show that this polymorphism and hence the thermostability of COMT enzyme are not related to a risk of developing Parkinson's disease.

DOI: 10.1002/mds.870120325
PubMed: 9159741

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pubmed:9159741

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">G/A1947 polymorphism in catechol-O-methyltransferase (COMT) gene in Parkinson's disease.</title>
<author><name sortKey="Xie, T" sort="Xie, T" uniqKey="Xie T" first="T" last="Xie">T. Xie</name>
<affiliation wicri:level="1"><nlm:affiliation>University Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong.</nlm:affiliation>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>University Department of Medicine, University of Hong Kong, Queen Mary Hospital</wicri:regionArea>
<wicri:noRegion>Queen Mary Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ho, S L" sort="Ho, S L" uniqKey="Ho S" first="S L" last="Ho">S L Ho</name>
</author>
<author><name sortKey="Li, L S" sort="Li, L S" uniqKey="Li L" first="L S" last="Li">L S Li</name>
</author>
<author><name sortKey="Ma, O C" sort="Ma, O C" uniqKey="Ma O" first="O C" last="Ma">O C Ma</name>
</author>
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<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="1997">1997</date>
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<idno type="doi">10.1002/mds.870120325</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">G/A1947 polymorphism in catechol-O-methyltransferase (COMT) gene in Parkinson's disease.</title>
<author><name sortKey="Xie, T" sort="Xie, T" uniqKey="Xie T" first="T" last="Xie">T. Xie</name>
<affiliation wicri:level="1"><nlm:affiliation>University Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong.</nlm:affiliation>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>University Department of Medicine, University of Hong Kong, Queen Mary Hospital</wicri:regionArea>
<wicri:noRegion>Queen Mary Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ho, S L" sort="Ho, S L" uniqKey="Ho S" first="S L" last="Ho">S L Ho</name>
</author>
<author><name sortKey="Li, L S" sort="Li, L S" uniqKey="Li L" first="L S" last="Li">L S Li</name>
</author>
<author><name sortKey="Ma, O C" sort="Ma, O C" uniqKey="Ma O" first="O C" last="Ma">O C Ma</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="1997" type="published">1997</date>
</imprint>
</series>
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</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Alleles</term>
<term>Base Sequence</term>
<term>Catechol O-Methyltransferase (genetics)</term>
<term>Catechol O-Methyltransferase (metabolism)</term>
<term>DNA Primers</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Methionine (genetics)</term>
<term>Middle Aged</term>
<term>Molecular Sequence Data</term>
<term>Parkinson Disease (enzymology)</term>
<term>Parkinson Disease (genetics)</term>
<term>Polymerase Chain Reaction</term>
<term>Polymorphism, Genetic</term>
<term>Valine (genetics)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Catechol O-Methyltransferase</term>
<term>Methionine</term>
<term>Valine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Catechol O-Methyltransferase</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Alleles</term>
<term>Base Sequence</term>
<term>DNA Primers</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Molecular Sequence Data</term>
<term>Polymerase Chain Reaction</term>
<term>Polymorphism, Genetic</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">High and low catechol-O-methyltransferase (COMT) activity is significantly determined by thermostability, which is caused by a valine/methionine108 polymorphism associated with polymorphic G/A1947 bases, in exon 4 of the COMT gene. Our allelic association study on this polymorphism did not find any statistically significant difference between our Chinese Parkinson's disease and that of control subjects. These results show that this polymorphism and hence the thermostability of COMT enzyme are not related to a risk of developing Parkinson's disease.</div>
</front>
</TEI>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

G/A1947 polymorphism in catechol-O-methyltransferase (COMT) gene in Parkinson's disease.

G/A1947 polymorphism in catechol-O-methyltransferase (COMT) gene in Parkinson's disease.

Source :

English descriptors

Abstract

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Links to Exploration step

Le document en format XML

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Pour générer des pages wiki