Long-term results with cisapride in Parkinson's disease.
Identifieur interne : 004D16 ( Ncbi/Curation ); précédent : 004D15; suivant : 004D17Long-term results with cisapride in Parkinson's disease.
Auteurs : W H Jost [Allemagne] ; K. SchimrigkSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1997.
English descriptors
- KwdEn :
- Aged, Cathartics (administration & dosage), Cathartics (therapeutic use), Cisapride, Constipation (complications), Constipation (drug therapy), Female, Humans, Male, Middle Aged, Parkinson Disease (complications), Peristalsis (drug effects), Piperidines (administration & dosage), Piperidines (pharmacology), Piperidines (therapeutic use), Severity of Illness Index, Treatment Outcome.
- MESH :
- chemical , administration & dosage : Cathartics, Piperidines.
- chemical , pharmacology : Piperidines.
- chemical , therapeutic use : Cathartics, Piperidines.
- complications : Constipation, Parkinson Disease.
- drug effects : Peristalsis.
- drug therapy : Constipation.
- Aged, Cisapride, Female, Humans, Male, Middle Aged, Severity of Illness Index, Treatment Outcome.
Abstract
In this study, we examined whether there is a long-term effect of cisapride on colonic transit in Parkinson's disease. Twenty-five patients (11 women, 14 men; average age, 64.4 years; moderate symptoms) were studied and treated initially with cisapride, 5 mg, twice a day, and after the first week with cisapride, 10 mg, twice a day. Colonic transit was measured by radioopaque markers at various stages: after 1 week, 6 months, and 1 year. In untreated patients, transit took 131 h; after 1 week with cisapride, it was accelerated to 81 h. After 6 months, colonic transit time amounted to 99 and 118 h, respectively, after 1 year. Cisapride seems to be highly effective initially. After 6 months, a significant but reduced effect was seen, and after 1 year, only a small effect could be demonstrated.
DOI: 10.1002/mds.870120324
PubMed: 9159740
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pubmed:9159740Le document en format XML
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<author><name sortKey="Jost, W H" sort="Jost, W H" uniqKey="Jost W" first="W H" last="Jost">W H Jost</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Deutsche Klinik für Diagnostik, Wiesbaden, Germany.</nlm:affiliation>
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<term>Cisapride</term>
<term>Constipation (complications)</term>
<term>Constipation (drug therapy)</term>
<term>Female</term>
<term>Humans</term>
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<front><div type="abstract" xml:lang="en">In this study, we examined whether there is a long-term effect of cisapride on colonic transit in Parkinson's disease. Twenty-five patients (11 women, 14 men; average age, 64.4 years; moderate symptoms) were studied and treated initially with cisapride, 5 mg, twice a day, and after the first week with cisapride, 10 mg, twice a day. Colonic transit was measured by radioopaque markers at various stages: after 1 week, 6 months, and 1 year. In untreated patients, transit took 131 h; after 1 week with cisapride, it was accelerated to 81 h. After 6 months, colonic transit time amounted to 99 and 118 h, respectively, after 1 year. Cisapride seems to be highly effective initially. After 6 months, a significant but reduced effect was seen, and after 1 year, only a small effect could be demonstrated.</div>
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